US3823816A - Water-soluble package - Google Patents
Water-soluble package Download PDFInfo
- Publication number
- US3823816A US3823816A US00223123A US22312372A US3823816A US 3823816 A US3823816 A US 3823816A US 00223123 A US00223123 A US 00223123A US 22312372 A US22312372 A US 22312372A US 3823816 A US3823816 A US 3823816A
- Authority
- US
- United States
- Prior art keywords
- water
- shell
- capsule
- film
- apertures
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002775 capsule Substances 0.000 claims abstract description 44
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 19
- 230000004888 barrier function Effects 0.000 claims abstract description 11
- 239000000126 substance Substances 0.000 claims description 10
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 8
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 8
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 5
- 239000007903 gelatin capsule Substances 0.000 claims description 2
- 239000000843 powder Substances 0.000 abstract description 7
- 238000004090 dissolution Methods 0.000 abstract description 5
- 239000008187 granular material Substances 0.000 abstract description 4
- 239000007887 hard shell capsule Substances 0.000 abstract description 3
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract description 2
- 239000011248 coating agent Substances 0.000 description 7
- 238000000576 coating method Methods 0.000 description 7
- 108010010803 Gelatin Proteins 0.000 description 3
- 229920000159 gelatin Polymers 0.000 description 3
- 239000008273 gelatin Substances 0.000 description 3
- 235000019322 gelatine Nutrition 0.000 description 3
- 235000011852 gelatine desserts Nutrition 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 235000010980 cellulose Nutrition 0.000 description 2
- 238000004891 communication Methods 0.000 description 2
- 239000007888 film coating Substances 0.000 description 2
- 238000009501 film coating Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- -1 hydroxypropylmethyl Chemical group 0.000 description 2
- 239000013618 particulate matter Substances 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 238000009736 wetting Methods 0.000 description 2
- 101100517284 Caenorhabditis elegans nsun-1 gene Proteins 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 230000001680 brushing effect Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000006193 liquid solution Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
- A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
Definitions
- ABSTRACT A water-soluble package is provided in the formof a hard shell capsule filled with powder, granules, or the like.
- the capsule shell is apertured, and the apertures or holes are covered over by a water-soluble barrier film which seals the holes and blocks any escape of the contents from the shell.
- the film is more watersoluble than the cap and body parts of the shell so that when thepackage is contacted with water, as in the digestive tract, the film rather than the shell dissolves first exposing the contents for dissolution and/or release by way of the apertures while the shell is still intact.
- This invention relates to a novel water-soluble or water-reactive package in the form of an apertured cap and body capsule containing a particulate solid fill.
- capsules have been a preferred means for packaging dry powder, granules or other particulate matter.
- the objective was in some instances not obtained because the capsule shell remained intact and failed to dissolve as quickly as desired.
- the apertures allowed the dry contents to leak out. While the slightest leakage is intolerable for many applications, fast-release loss-proof capsules have hitherto not been available.
- FIG. 1 is a side view of a packaged article according to a preferred embodiment of the invention.
- FIG. 2 is a fragmented expanded view in vertical section taken on line 2--2 of F IG. 1 showing the construction of the sealed wall of the article;
- FIG. 3 is a plan view of the article when incorporated with a body of water according to the invention.
- the article in the form illustrated has a cap part 11 and a matching telescopicallyengaged body part 12 which together provide a closed envelope shell.
- the cap 11 and the body 12 each have open ends (not shown) and closed ends 11b and 12b as well as cylindrical walls 110 and 120.
- the walls overlap in a double-walled portion 13.
- the capsule shell contains a particulate fill l4, and the walls include aperture means 15 extending through the thickness (FIG. 2, single or double wall) toprovide open communication'with the ,shell interior containing the fill 14.
- a continuous film or barrier 17 overlies each aperture means 15 and seals the same.
- the film is in a single strip form covering a row of apertures, as illustrated in FIG. 1.
- the film 17 is generallyof uniform thickness, being slightly thicker within the, margin of the apertures where it occupies the spacewithin each aperture in the form of plugs 16 (FIG.'2).
- the film can, according to the invention, have various shapes and is not limited to the strip shape illustrated.
- the capsule may conveniently cover the entire outer surface of the capsule or it may cover discontinuqi sal a s qh EQYQFELEE. siss seaata e 9255992 9 apertures.
- the shape should be such that it alone, or in combination with other barrier films (having the same or different shapes), completely covers and seals all of the apertures. It is an advantageous feature that in the embodiment where the barrier film covers both the cap and body surface, for example, in a single strip (as in FIGS. 1 and 2) or the entire capsule surface, the film serves to lock the capsule parts to- 'gether.
- the packaged articles of the invention are conveniently prepared in several steps. First, empty capsules (preferably pharmaceutical-grade gelatin or an equivalent) are filled with the selected particulate substance (e.g., medicament, chemical, or other substance) and are joined, using conventional means. The apertures 15 are then made in the filled joined capsules in a perforating step, using any suitable hole-forming means such as heated needles, knives, drills or the like. The apertured filled capsules are next treated with a liquid solution of the film-forming substance as by spraying, dipping, brushing, printing or the like to produce the desired film bridging and sealing the holes in the capsule wall. Any of various water-soluble film-forming substances will be suitable for the purpose such as polyvinylpyrrolidone, gelatin, hydroxypropylmethyl.
- the selected particulate substance e.g., medicament, chemical, or other substance
- Polyvinylpyrrolidone is a preferred film-forming substance. Conveniently, it is used for film-forming purposes as a dilute (e.g., 5-10 percent) aqueous or alcoholic solution and the capsules to be film-coated are dipped in a bath of the solution to completely coat the outer surface of each capsule with the film solution. Area coating, such as the preferred strip configuration 17 illustrated in FIG. 1, can be printed as a moist film over the apertures using conventional machinery. The coating film following application is dried until tack-free and sufficiently firm and-dimensionally stable to seal the apertures and prevent escape of the granular fill.
- the size, shape, number and distribution of the apertures 15 in the capsule shell can be varied widely, as desired. Aperture sizes made with hypodermic needles, for example, ranging from No. 27 (OD, 0.41 mm.) to No. 21 (0.81 mm.) have been particularly satisfactory.
- the holes can be round, crescent-shaped, square, etc although round holes are preferred. Numerous holes can be used, and the distribution can be spaced over the end and/or wall surfaces of the capsule. However, in general it is found that from one to six aperturesin the capsule issufficient for purposes of the invention.
- the in-line configuration illustrated is one preferred embodiment, usually with two to six apertures.
- Another preferred embodiment is a single-hole configuration centered at one or both ends of the capsule shell. In test procedures measuring solubility.
- the invention contemplates as contents for the package or capsule any particulate substance which, al-
- the shell or envelope is reactive-or soluble in water or any of various aqueous media such as gastro-intestinal fluid.
- the invention is particularly well-suited in this respect to particulate fill material, which effervesces in the presence of water either as an active ingredient, for example, of a, pharmaceutical dosage form or as an aid per se to promote a mixing or dissolving effect for other components in the fill.
- the typical capsule filled, for example, with low density powder usually floats (capsule A, FIG. 3) on the surface 20'of the water.
- the capsule Unless stirred or otherwise moved, the capsule remains afloat for a brief period until the film 17 is wetted and dissolved in the area of the apertures 15.
- the capsule sinks of its own accord into the body 21 of the liquid (capsule B, FIG. 3) while the dissolving and release actions continue and, because of the increased wetting contact, even at a greater rate.
- an ingestible water-reactive unit package including a cylindrical hard shell capsule having matching water-soluble cap and body parts telescopically joined to define a closed envelope shell, the cap and body each having an open end, a closed end, and side walls overlapping in a double-walled portion, a particulate solid fill in the shell, and aperture means in the shell providing open communication between the interior and the exterior of the shell, the improvement characterized by a water-soluble barrier in the form of a dimensionally stable film bridging the aperture means comprising a plurality of apertures located in line, the film occupying space within each aperture in the form of plugs in sealing engagement therewith sufficient to block escape of solid fill from the shell, the barrier being substantially more water-soluble than the cap and body parts such that continued contact of the package with water in an aqueous environment causes the barrier to dissolve prior to dissolution of the shell thereby affording direct access of water to the fill while the shell is intact.
- aperture means comprises at least one aperture located at the end of the capsule.
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Packages (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Priority Applications (13)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BE794951D BE794951A (fr) | 1972-02-03 | Conditionnement soluble dans l'eau | |
US00223123A US3823816A (en) | 1972-02-03 | 1972-02-03 | Water-soluble package |
GB543573A GB1377452A (en) | 1972-02-03 | 1973-02-02 | Water-soluble capsules |
DE2305280A DE2305280C2 (de) | 1972-02-03 | 1973-02-02 | Wasserlösliche hartschalige Gelatinekapsel |
ZA730766A ZA73766B (en) | 1972-02-03 | 1973-02-02 | Water-soluble package |
JP1299073A JPS5532381B2 (pt) | 1972-02-03 | 1973-02-02 | |
AR246401A AR196325A1 (es) | 1972-02-03 | 1973-02-02 | Envase soluble en agua |
ES411206A ES411206A1 (es) | 1972-02-03 | 1973-02-02 | Una disposicion mejorada de embase unitario reactivo con elagua. |
BR73827A BR7300827D0 (pt) | 1972-02-03 | 1973-02-02 | Embalagem soluvel em agua |
CA162,753A CA990238A (en) | 1972-02-03 | 1973-02-02 | Water-soluble package |
FR7303665A FR2170751A5 (pt) | 1972-02-03 | 1973-02-02 | |
AU51719/73A AU463254B2 (en) | 1972-02-03 | 1973-02-02 | Water-soluble package |
IT48043/73A IT977185B (it) | 1972-02-03 | 1973-02-02 | Perfezionamento nelle capsule o contenitori solubili in acqua |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US00223123A US3823816A (en) | 1972-02-03 | 1972-02-03 | Water-soluble package |
Publications (1)
Publication Number | Publication Date |
---|---|
US3823816A true US3823816A (en) | 1974-07-16 |
Family
ID=22835140
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US00223123A Expired - Lifetime US3823816A (en) | 1972-02-03 | 1972-02-03 | Water-soluble package |
Country Status (13)
Country | Link |
---|---|
US (1) | US3823816A (pt) |
JP (1) | JPS5532381B2 (pt) |
AR (1) | AR196325A1 (pt) |
AU (1) | AU463254B2 (pt) |
BE (1) | BE794951A (pt) |
BR (1) | BR7300827D0 (pt) |
CA (1) | CA990238A (pt) |
DE (1) | DE2305280C2 (pt) |
ES (1) | ES411206A1 (pt) |
FR (1) | FR2170751A5 (pt) |
GB (1) | GB1377452A (pt) |
IT (1) | IT977185B (pt) |
ZA (1) | ZA73766B (pt) |
Cited By (69)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4088864A (en) * | 1974-11-18 | 1978-05-09 | Alza Corporation | Process for forming outlet passageways in pills using a laser |
US4478658A (en) * | 1982-12-20 | 1984-10-23 | Warner-Lambert Company | Method for sealing non-enteric capsules |
US4503030A (en) * | 1983-06-06 | 1985-03-05 | Alza Corporation | Device for delivering drug to certain pH environments |
US4567613A (en) * | 1984-05-08 | 1986-02-04 | Frank Meehan | Method and article for neutralizing offensive odors |
US4609403A (en) * | 1984-03-12 | 1986-09-02 | Warner-Lambert Company | Foam soft gelatin capsules and their method of manufacture |
US4719112A (en) * | 1982-10-29 | 1988-01-12 | Warner-Lambert Company | Foam capsules |
US4800056A (en) * | 1984-03-21 | 1989-01-24 | Alza Corporation | Process for making dispenser with cooperating elements |
US4876003A (en) * | 1988-05-09 | 1989-10-24 | Olin Corporation | Encased pool chemical tablet with domed ends |
US4923618A (en) * | 1988-05-09 | 1990-05-08 | Olin Corporation | Method of chlorinating a swimming pool |
US4928813A (en) * | 1989-06-02 | 1990-05-29 | Olin Corporation | Encased pool chemical capsule with extended ends and method of making the same |
WO1994001239A1 (en) * | 1992-07-07 | 1994-01-20 | Merck & Co., Inc. | High speed process for preparing orifices in pharmaceutical dosage forms |
US5958451A (en) * | 1996-09-03 | 1999-09-28 | Yung Shin Pharm Ind. Co., Ltd. | Process for producing porous, controlled-release capsules and encapsulated composition |
WO2001007107A2 (en) * | 1999-07-23 | 2001-02-01 | Pharmaceutical Discovery Corporation | Unit dose capsules and dry powder inhaler |
WO2001055293A2 (en) * | 2000-01-25 | 2001-08-02 | The Victoria University Of Manchester | Delayed release of fluids |
WO2002085737A1 (en) * | 2001-04-20 | 2002-10-31 | Reckitt Benckiser (Uk) Limited | Water-soluble container having at least two openings |
WO2002092456A1 (en) * | 2001-05-17 | 2002-11-21 | Reckitt Benckiser (Uk) Limited | A water-soluble injection moulded container |
WO2002092455A1 (en) * | 2001-05-17 | 2002-11-21 | Reckitt Benckiser (Uk) Limited | A water-soluble injection moulded container |
EP1299006A1 (en) | 2000-05-03 | 2003-04-09 | Societe Des Produits Nestle S.A. | Confectionery product having an enhanced cooling effect |
GB2386069A (en) * | 2002-02-20 | 2003-09-10 | Mach Ind Etablissements | Consumable container |
WO2003084836A1 (de) * | 2002-04-10 | 2003-10-16 | Henkel Kommaditgesellschaft Auf Aktien | 'wasserlöslicher behälter' |
US20030219484A1 (en) * | 2001-09-28 | 2003-11-27 | Sowden Harry S. | Immediate release dosage form comprising shell having openings therein |
WO2004028513A1 (en) * | 2002-09-28 | 2004-04-08 | Mcneil-Ppc, Inc. | Immediate release dosage form comprising shell having openings therein |
US20040182387A1 (en) * | 1999-07-23 | 2004-09-23 | Mannkind Corporation | Unit dose cartridge and dry powder inhaler |
US20050152970A1 (en) * | 2004-01-13 | 2005-07-14 | Rinker Roger A. | Rapidly disintegrating gelatinous coated tablets |
EP1602363A1 (en) | 2004-06-04 | 2005-12-07 | McNeil-PPC, Inc. | Immediate release dosage form comprising shell having openings therein |
US20060118991A1 (en) * | 2004-12-07 | 2006-06-08 | Sowden Harry S | System and process for providing at least one opening in dosage forms |
US20060121145A1 (en) * | 2004-12-07 | 2006-06-08 | Sowden Harry S | System and process for providing at least one opening in dosage forms |
US7305986B1 (en) | 1999-07-23 | 2007-12-11 | Mannkind Corporation | Unit dose capsules for use in a dry powder inhaler |
US20080011779A1 (en) * | 1994-07-25 | 2008-01-17 | Klima William L | Dispensing devices, and systems |
US20080102116A1 (en) * | 2004-09-13 | 2008-05-01 | Perrigo Company | Quick Dissolve Medicament and Method of Manufacturing |
AU2003225945B2 (en) * | 2002-09-28 | 2009-04-23 | Mcneil-Ppc, Inc. | Immediate release dosage form comprising shell having openings therein |
US20090108492A1 (en) * | 2007-10-15 | 2009-04-30 | Mcallister Stephen Mark | Method and apparatus for manufacturing filled linkers |
US20090110721A1 (en) * | 2007-10-15 | 2009-04-30 | Mcallister Stephen Mark | Paneled capsule shells for release of pharmaceutical compositions |
US20090110723A1 (en) * | 2007-10-15 | 2009-04-30 | Mcallister Stephen Mark | Linkers for multipart dosage forms for release of one or more pharmaceutical compositions, and the resulting dosage forms |
US20090241949A1 (en) * | 2008-03-27 | 2009-10-01 | Smutney Chad C | Dry powder inhalation system |
US8067029B2 (en) | 2004-01-13 | 2011-11-29 | Mcneil-Ppc, Inc. | Rapidly disintegrating gelatinous coated tablets |
CN102939925A (zh) * | 2012-11-15 | 2013-02-27 | 浙江海洋学院 | 乌贼放流种群强化装置 |
US20150072915A1 (en) * | 2013-09-06 | 2015-03-12 | The Procter & Gamble Company | Pouches comprising apertured film wall materials and methods for making same |
CN104555111A (zh) * | 2014-12-05 | 2015-04-29 | 中国农业科学院兰州畜牧与兽药研究所 | 一种当归药材的储藏方法 |
US9192675B2 (en) | 2008-06-13 | 2015-11-24 | Mankind Corporation | Dry powder inhaler and system for drug delivery |
US9220687B2 (en) | 2008-12-29 | 2015-12-29 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
US9233159B2 (en) | 2011-10-24 | 2016-01-12 | Mannkind Corporation | Methods and compositions for treating pain |
US9241903B2 (en) | 2006-02-22 | 2016-01-26 | Mannkind Corporation | Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent |
US9283193B2 (en) | 2005-09-14 | 2016-03-15 | Mannkind Corporation | Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents |
US9346766B2 (en) | 2004-08-20 | 2016-05-24 | Mannkind Corporation | Catalysis of diketopiperazine synthesis |
US9364619B2 (en) | 2008-06-20 | 2016-06-14 | Mannkind Corporation | Interactive apparatus and method for real-time profiling of inhalation efforts |
US9364436B2 (en) | 2011-06-17 | 2016-06-14 | Mannkind Corporation | High capacity diketopiperazine microparticles and methods |
US9630930B2 (en) | 2009-06-12 | 2017-04-25 | Mannkind Corporation | Diketopiperazine microparticles with defined specific surface areas |
US9662461B2 (en) | 2008-06-13 | 2017-05-30 | Mannkind Corporation | Dry powder drug delivery system and methods |
US9675674B2 (en) | 2004-08-23 | 2017-06-13 | Mannkind Corporation | Diketopiperazine salts for drug delivery and related methods |
US9700690B2 (en) | 2002-03-20 | 2017-07-11 | Mannkind Corporation | Inhalation apparatus |
US9706944B2 (en) | 2009-11-03 | 2017-07-18 | Mannkind Corporation | Apparatus and method for simulating inhalation efforts |
US9801925B2 (en) | 1999-06-29 | 2017-10-31 | Mannkind Corporation | Potentiation of glucose elimination |
US9802012B2 (en) | 2012-07-12 | 2017-10-31 | Mannkind Corporation | Dry powder drug delivery system and methods |
US9925144B2 (en) | 2013-07-18 | 2018-03-27 | Mannkind Corporation | Heat-stable dry powder pharmaceutical compositions and methods |
US9943571B2 (en) | 2008-08-11 | 2018-04-17 | Mannkind Corporation | Use of ultrarapid acting insulin |
US9983108B2 (en) | 2009-03-11 | 2018-05-29 | Mannkind Corporation | Apparatus, system and method for measuring resistance of an inhaler |
US10159644B2 (en) | 2012-10-26 | 2018-12-25 | Mannkind Corporation | Inhalable vaccine compositions and methods |
US10307464B2 (en) | 2014-03-28 | 2019-06-04 | Mannkind Corporation | Use of ultrarapid acting insulin |
EP3452003A4 (en) * | 2016-05-05 | 2019-06-26 | Triastek, Inc. | PHARMACEUTICAL FORM WITH CONTROLLED RELEASE |
US10342938B2 (en) | 2008-06-13 | 2019-07-09 | Mannkind Corporation | Dry powder drug delivery system |
US10421729B2 (en) | 2013-03-15 | 2019-09-24 | Mannkind Corporation | Microcrystalline diketopiperazine compositions and methods |
US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
US10625034B2 (en) | 2011-04-01 | 2020-04-21 | Mannkind Corporation | Blister package for pharmaceutical cartridges |
EP3651721A4 (en) * | 2017-07-10 | 2021-04-21 | Gel Cap Technologies, LLC | DUAL RELEASE CAPSULE AND METHODS, DEVICES AND SYSTEMS FOR THEIR MANUFACTURE |
US11173125B2 (en) * | 2010-06-03 | 2021-11-16 | Catalent Ontario Limited | Multiphase soft gel capsules, apparatus and method thereof |
US11278499B2 (en) | 2015-06-03 | 2022-03-22 | Triastek, Inc. | Oral drug dosage form comprising various release profiles |
US11446127B2 (en) | 2013-08-05 | 2022-09-20 | Mannkind Corporation | Insufflation apparatus and methods |
US11571391B2 (en) | 2018-01-09 | 2023-02-07 | Triastek, Inc. | Oral drug dosage forms compromising a fixed-dose of an ADHD non-stimulant and an ADHD stimulant |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2650649A1 (de) * | 1976-11-05 | 1978-05-11 | Bosch Gmbh Robert | Verfahren und vorrichtung zum fuellen und verschliessen von hartgelatinekapseln |
DE2722807A1 (de) * | 1977-05-20 | 1978-11-23 | Capsugel Ag | Verfahren zum herstellen einer mit viskosem stoff gefuellten steckkapsel |
US5342624A (en) * | 1989-02-16 | 1994-08-30 | British Technology Group Ltd. | Dispensing device |
DE3907973A1 (de) * | 1989-03-11 | 1990-09-13 | Merck Patent Gmbh | Trockenmittel-tablette |
GB9004702D0 (en) * | 1990-03-02 | 1990-04-25 | Polysystems Limited | Dispensing device |
DE19537671A1 (de) * | 1995-10-10 | 1997-04-17 | Bosch Gmbh Robert | Wasch-, Spül- oder Reinigungsmittelverpackung |
DE19849848A1 (de) * | 1998-10-29 | 2000-05-04 | Lohmann Therapie Syst Lts | Oral applizierbare, mit Flüssigkeit spontan zerfallende therapeutische Darreichungsform und Verfahren zu ihrer Herstellung |
DE19941480B4 (de) * | 1999-09-01 | 2005-06-02 | Henkel Kgaa | Wasch- oder Reinigungsmittel-Portion mit wasserdurchlässiger Umfassung |
DE102009010091A1 (de) * | 2009-02-24 | 2010-08-26 | Beiersdorf Ag | Stabilisierte Peelingkapsel |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1324662A (en) * | 1919-12-09 | Preparation op coffee | ||
US1393045A (en) * | 1918-09-24 | 1921-10-11 | Arbuckle Brothers | Process for producing soluble concentrated coffee |
US1527610A (en) * | 1924-05-10 | 1925-02-24 | Scott Mary Thompson | Capsule |
US1576735A (en) * | 1921-10-08 | 1926-03-16 | Reginald A Fessenden | Infusor |
US1931765A (en) * | 1932-05-09 | 1933-10-24 | Basil E Leever | Beverage capsule |
US2292101A (en) * | 1941-04-22 | 1942-08-04 | Brown William Francis | Beverage cartridge |
US2537453A (en) * | 1947-04-23 | 1951-01-09 | Frangialli Filippo | Capsule for producing an alcoholic beverage |
US3620759A (en) * | 1969-04-01 | 1971-11-16 | Parke Davis & Co | Food capsule |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3466842A (en) * | 1967-05-10 | 1969-09-16 | Smithkline Corp | Machine for treating capsules |
-
0
- BE BE794951D patent/BE794951A/xx not_active IP Right Cessation
-
1972
- 1972-02-03 US US00223123A patent/US3823816A/en not_active Expired - Lifetime
-
1973
- 1973-02-02 AU AU51719/73A patent/AU463254B2/en not_active Expired
- 1973-02-02 ES ES411206A patent/ES411206A1/es not_active Expired
- 1973-02-02 GB GB543573A patent/GB1377452A/en not_active Expired
- 1973-02-02 AR AR246401A patent/AR196325A1/es active
- 1973-02-02 IT IT48043/73A patent/IT977185B/it active
- 1973-02-02 DE DE2305280A patent/DE2305280C2/de not_active Expired
- 1973-02-02 JP JP1299073A patent/JPS5532381B2/ja not_active Expired
- 1973-02-02 FR FR7303665A patent/FR2170751A5/fr not_active Expired
- 1973-02-02 CA CA162,753A patent/CA990238A/en not_active Expired
- 1973-02-02 BR BR73827A patent/BR7300827D0/pt unknown
- 1973-02-02 ZA ZA730766A patent/ZA73766B/xx unknown
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1324662A (en) * | 1919-12-09 | Preparation op coffee | ||
US1393045A (en) * | 1918-09-24 | 1921-10-11 | Arbuckle Brothers | Process for producing soluble concentrated coffee |
US1576735A (en) * | 1921-10-08 | 1926-03-16 | Reginald A Fessenden | Infusor |
US1527610A (en) * | 1924-05-10 | 1925-02-24 | Scott Mary Thompson | Capsule |
US1931765A (en) * | 1932-05-09 | 1933-10-24 | Basil E Leever | Beverage capsule |
US2292101A (en) * | 1941-04-22 | 1942-08-04 | Brown William Francis | Beverage cartridge |
US2537453A (en) * | 1947-04-23 | 1951-01-09 | Frangialli Filippo | Capsule for producing an alcoholic beverage |
US3620759A (en) * | 1969-04-01 | 1971-11-16 | Parke Davis & Co | Food capsule |
Non-Patent Citations (1)
Title |
---|
Condensed Chem. Dict., 7th Ed., 1966, pages 769 770. * |
Cited By (120)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4088864A (en) * | 1974-11-18 | 1978-05-09 | Alza Corporation | Process for forming outlet passageways in pills using a laser |
US4719112A (en) * | 1982-10-29 | 1988-01-12 | Warner-Lambert Company | Foam capsules |
US4478658A (en) * | 1982-12-20 | 1984-10-23 | Warner-Lambert Company | Method for sealing non-enteric capsules |
US4503030A (en) * | 1983-06-06 | 1985-03-05 | Alza Corporation | Device for delivering drug to certain pH environments |
US4609403A (en) * | 1984-03-12 | 1986-09-02 | Warner-Lambert Company | Foam soft gelatin capsules and their method of manufacture |
US4800056A (en) * | 1984-03-21 | 1989-01-24 | Alza Corporation | Process for making dispenser with cooperating elements |
US4567613A (en) * | 1984-05-08 | 1986-02-04 | Frank Meehan | Method and article for neutralizing offensive odors |
US4876003A (en) * | 1988-05-09 | 1989-10-24 | Olin Corporation | Encased pool chemical tablet with domed ends |
US4923618A (en) * | 1988-05-09 | 1990-05-08 | Olin Corporation | Method of chlorinating a swimming pool |
US4928813A (en) * | 1989-06-02 | 1990-05-29 | Olin Corporation | Encased pool chemical capsule with extended ends and method of making the same |
WO1994001239A1 (en) * | 1992-07-07 | 1994-01-20 | Merck & Co., Inc. | High speed process for preparing orifices in pharmaceutical dosage forms |
US5376771A (en) * | 1992-07-07 | 1994-12-27 | Merck & Co., Inc. | High speed process for preparing orifices in pharmaceutical dosage forms |
US20080011779A1 (en) * | 1994-07-25 | 2008-01-17 | Klima William L | Dispensing devices, and systems |
US5958451A (en) * | 1996-09-03 | 1999-09-28 | Yung Shin Pharm Ind. Co., Ltd. | Process for producing porous, controlled-release capsules and encapsulated composition |
US9801925B2 (en) | 1999-06-29 | 2017-10-31 | Mannkind Corporation | Potentiation of glucose elimination |
US9061111B2 (en) | 1999-07-23 | 2015-06-23 | Mannkind Corporation | Unit dose capsules and dry powder inhaler |
US20080053437A1 (en) * | 1999-07-23 | 2008-03-06 | Mannkind Corporation | Unit dose capsules and dry powder inhaler |
US8146588B2 (en) | 1999-07-23 | 2012-04-03 | Mannkind Corporation | Unit dose capsules and dry powder inhaler |
US8156936B2 (en) | 1999-07-23 | 2012-04-17 | Mannkind Corporation | Unit dose capsules and dry powder inhaler |
US8215300B2 (en) | 1999-07-23 | 2012-07-10 | Mannkind Corporation | Unit dose cartridge and dry powder inhaler |
US7464706B2 (en) | 1999-07-23 | 2008-12-16 | Mannkind Corporation | Unit dose cartridge and dry powder inhaler |
US20080190425A1 (en) * | 1999-07-23 | 2008-08-14 | Steiner Solomon S | Unit dose cartridge and dry powder inhaler |
US8671937B2 (en) | 1999-07-23 | 2014-03-18 | Mannkind Corporation | Unit dose capsules and dry powder inhaler |
US20080127970A1 (en) * | 1999-07-23 | 2008-06-05 | Mannkind Corporation | Unit Dose Capsules and Dry Powder Inhaler |
US8950397B2 (en) | 1999-07-23 | 2015-02-10 | Mannkind Corporation | Unit dose cartridge and dry powder inhaler |
WO2001007107A2 (en) * | 1999-07-23 | 2001-02-01 | Pharmaceutical Discovery Corporation | Unit dose capsules and dry powder inhaler |
US7305986B1 (en) | 1999-07-23 | 2007-12-11 | Mannkind Corporation | Unit dose capsules for use in a dry powder inhaler |
WO2001007107A3 (en) * | 1999-07-23 | 2001-06-21 | Pharmaceutical Discovery Corp | Unit dose capsules and dry powder inhaler |
US20040182387A1 (en) * | 1999-07-23 | 2004-09-23 | Mannkind Corporation | Unit dose cartridge and dry powder inhaler |
US20030175853A1 (en) * | 2000-01-25 | 2003-09-18 | Clarke David J | Delayed release of fluids |
WO2001055293A3 (en) * | 2000-01-25 | 2001-12-27 | Univ Manchester | Delayed release of fluids |
WO2001055293A2 (en) * | 2000-01-25 | 2001-08-02 | The Victoria University Of Manchester | Delayed release of fluids |
EP1299006A1 (en) | 2000-05-03 | 2003-04-09 | Societe Des Produits Nestle S.A. | Confectionery product having an enhanced cooling effect |
WO2002085737A1 (en) * | 2001-04-20 | 2002-10-31 | Reckitt Benckiser (Uk) Limited | Water-soluble container having at least two openings |
US7105478B2 (en) | 2001-04-20 | 2006-09-12 | Reckitt Benckiser (Uk) Limited | Water-soluble container having at least two openings |
US20040118738A1 (en) * | 2001-04-20 | 2004-06-24 | Marcus Guzmann | Water-soluble container having at least two openings |
US20040154952A1 (en) * | 2001-05-17 | 2004-08-12 | Ralf Wiedemann | Water-soluble injection moulded container |
WO2002092456A1 (en) * | 2001-05-17 | 2002-11-21 | Reckitt Benckiser (Uk) Limited | A water-soluble injection moulded container |
WO2002092455A1 (en) * | 2001-05-17 | 2002-11-21 | Reckitt Benckiser (Uk) Limited | A water-soluble injection moulded container |
US20030219484A1 (en) * | 2001-09-28 | 2003-11-27 | Sowden Harry S. | Immediate release dosage form comprising shell having openings therein |
GB2386069A (en) * | 2002-02-20 | 2003-09-10 | Mach Ind Etablissements | Consumable container |
GB2386069B (en) * | 2002-02-20 | 2006-04-12 | Mach Ind Etablissements | Consumable container |
US9700690B2 (en) | 2002-03-20 | 2017-07-11 | Mannkind Corporation | Inhalation apparatus |
WO2003084836A1 (de) * | 2002-04-10 | 2003-10-16 | Henkel Kommaditgesellschaft Auf Aktien | 'wasserlöslicher behälter' |
WO2004028513A1 (en) * | 2002-09-28 | 2004-04-08 | Mcneil-Ppc, Inc. | Immediate release dosage form comprising shell having openings therein |
AU2003225945B2 (en) * | 2002-09-28 | 2009-04-23 | Mcneil-Ppc, Inc. | Immediate release dosage form comprising shell having openings therein |
EP2255795A1 (en) | 2002-09-28 | 2010-12-01 | McNeil-PPC, Inc. | Immediate release dosage form comprising shell having openings therein |
US20050152970A1 (en) * | 2004-01-13 | 2005-07-14 | Rinker Roger A. | Rapidly disintegrating gelatinous coated tablets |
US11298324B2 (en) | 2004-01-13 | 2022-04-12 | Johnson & Johnson Consumer Inc. | Rapidly disintegrating gelatinous coated tablets |
US8815290B2 (en) | 2004-01-13 | 2014-08-26 | Mcneil-Ppc, Inc. | Rapidly disintegrating gelatinous coated tablets |
US7879354B2 (en) | 2004-01-13 | 2011-02-01 | Mcneil-Ppc, Inc. | Rapidly disintegrating gelatinous coated tablets |
US20110086098A1 (en) * | 2004-01-13 | 2011-04-14 | Rinker Roger A | Rapidly disintegrating gelatinous coated tablets |
US8067029B2 (en) | 2004-01-13 | 2011-11-29 | Mcneil-Ppc, Inc. | Rapidly disintegrating gelatinous coated tablets |
US10092521B2 (en) | 2004-01-13 | 2018-10-09 | Johnson & Johnson Consumer Inc. | Rapidly disintegrating gelatinous coated tablets |
US9149438B2 (en) | 2004-01-13 | 2015-10-06 | Johnson & Johnson Consumer Inc. | Rapidly disintegrating gelatinous coated tablets |
US10632078B2 (en) | 2004-01-13 | 2020-04-28 | Johnson & Johnson Consumer Inc. | Rapidly disintegrating gelatinous coated tablets |
EP1602363A1 (en) | 2004-06-04 | 2005-12-07 | McNeil-PPC, Inc. | Immediate release dosage form comprising shell having openings therein |
US9796688B2 (en) | 2004-08-20 | 2017-10-24 | Mannkind Corporation | Catalysis of diketopiperazine synthesis |
US9346766B2 (en) | 2004-08-20 | 2016-05-24 | Mannkind Corporation | Catalysis of diketopiperazine synthesis |
US10130685B2 (en) | 2004-08-23 | 2018-11-20 | Mannkind Corporation | Diketopiperazine salts for drug delivery and related methods |
US9675674B2 (en) | 2004-08-23 | 2017-06-13 | Mannkind Corporation | Diketopiperazine salts for drug delivery and related methods |
US20080102116A1 (en) * | 2004-09-13 | 2008-05-01 | Perrigo Company | Quick Dissolve Medicament and Method of Manufacturing |
US20060118991A1 (en) * | 2004-12-07 | 2006-06-08 | Sowden Harry S | System and process for providing at least one opening in dosage forms |
US20060121145A1 (en) * | 2004-12-07 | 2006-06-08 | Sowden Harry S | System and process for providing at least one opening in dosage forms |
US7404708B2 (en) | 2004-12-07 | 2008-07-29 | Mcneil-Ppc, Inc. | System and process for providing at least one opening in dosage forms |
US7530804B2 (en) | 2004-12-07 | 2009-05-12 | Mcneil-Ppc, Inc. | System and process for providing at least one opening in dosage forms |
US10143655B2 (en) | 2005-09-14 | 2018-12-04 | Mannkind Corporation | Method of drug formulation |
US9717689B2 (en) | 2005-09-14 | 2017-08-01 | Mannkind Corporation | Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents |
US9446001B2 (en) | 2005-09-14 | 2016-09-20 | Mannkind Corporation | Increasing drug affinity for crystalline microparticle surfaces |
US9283193B2 (en) | 2005-09-14 | 2016-03-15 | Mannkind Corporation | Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents |
US9241903B2 (en) | 2006-02-22 | 2016-01-26 | Mannkind Corporation | Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent |
US10130581B2 (en) | 2006-02-22 | 2018-11-20 | Mannkind Corporation | Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent |
US8454992B2 (en) | 2007-10-15 | 2013-06-04 | Capsugel Belgium Nv | Paneled capsule shells for release of pharmaceutical compositions |
US8293159B2 (en) | 2007-10-15 | 2012-10-23 | Capsugel Belgium | Method and apparatus for manufacturing filled linkers |
US20090108492A1 (en) * | 2007-10-15 | 2009-04-30 | Mcallister Stephen Mark | Method and apparatus for manufacturing filled linkers |
US20090110721A1 (en) * | 2007-10-15 | 2009-04-30 | Mcallister Stephen Mark | Paneled capsule shells for release of pharmaceutical compositions |
US20090110723A1 (en) * | 2007-10-15 | 2009-04-30 | Mcallister Stephen Mark | Linkers for multipart dosage forms for release of one or more pharmaceutical compositions, and the resulting dosage forms |
US20090241949A1 (en) * | 2008-03-27 | 2009-10-01 | Smutney Chad C | Dry powder inhalation system |
US9192675B2 (en) | 2008-06-13 | 2015-11-24 | Mankind Corporation | Dry powder inhaler and system for drug delivery |
US10201672B2 (en) | 2008-06-13 | 2019-02-12 | Mannkind Corporation | Dry powder inhaler and system for drug delivery |
US9339615B2 (en) | 2008-06-13 | 2016-05-17 | Mannkind Corporation | Dry powder inhaler and system for drug delivery |
US9662461B2 (en) | 2008-06-13 | 2017-05-30 | Mannkind Corporation | Dry powder drug delivery system and methods |
US10751488B2 (en) | 2008-06-13 | 2020-08-25 | Mannkind Corporation | Dry powder inhaler and system for drug delivery |
US9511198B2 (en) | 2008-06-13 | 2016-12-06 | Mannkind Corporation | Dry powder inhaler and system for drug delivery |
US10342938B2 (en) | 2008-06-13 | 2019-07-09 | Mannkind Corporation | Dry powder drug delivery system |
US9446133B2 (en) | 2008-06-13 | 2016-09-20 | Mannkind Corporation | Dry powder inhaler and system for drug delivery |
US10675421B2 (en) | 2008-06-20 | 2020-06-09 | Mannkind Corporation | Interactive apparatus and method for real-time profiling of inhalation efforts |
US9364619B2 (en) | 2008-06-20 | 2016-06-14 | Mannkind Corporation | Interactive apparatus and method for real-time profiling of inhalation efforts |
US9943571B2 (en) | 2008-08-11 | 2018-04-17 | Mannkind Corporation | Use of ultrarapid acting insulin |
US9655850B2 (en) | 2008-12-29 | 2017-05-23 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
US10172850B2 (en) | 2008-12-29 | 2019-01-08 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
US9220687B2 (en) | 2008-12-29 | 2015-12-29 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
US9983108B2 (en) | 2009-03-11 | 2018-05-29 | Mannkind Corporation | Apparatus, system and method for measuring resistance of an inhaler |
US9630930B2 (en) | 2009-06-12 | 2017-04-25 | Mannkind Corporation | Diketopiperazine microparticles with defined specific surface areas |
US9706944B2 (en) | 2009-11-03 | 2017-07-18 | Mannkind Corporation | Apparatus and method for simulating inhalation efforts |
US11173125B2 (en) * | 2010-06-03 | 2021-11-16 | Catalent Ontario Limited | Multiphase soft gel capsules, apparatus and method thereof |
US10625034B2 (en) | 2011-04-01 | 2020-04-21 | Mannkind Corporation | Blister package for pharmaceutical cartridges |
US9364436B2 (en) | 2011-06-17 | 2016-06-14 | Mannkind Corporation | High capacity diketopiperazine microparticles and methods |
US10130709B2 (en) | 2011-06-17 | 2018-11-20 | Mannkind Corporation | High capacity diketopiperazine microparticles and methods |
US9610351B2 (en) | 2011-10-24 | 2017-04-04 | Mannkind Corporation | Methods and compositions for treating pain |
US9233159B2 (en) | 2011-10-24 | 2016-01-12 | Mannkind Corporation | Methods and compositions for treating pain |
US10258664B2 (en) | 2011-10-24 | 2019-04-16 | Mannkind Corporation | Methods and compositions for treating pain |
US9802012B2 (en) | 2012-07-12 | 2017-10-31 | Mannkind Corporation | Dry powder drug delivery system and methods |
US10159644B2 (en) | 2012-10-26 | 2018-12-25 | Mannkind Corporation | Inhalable vaccine compositions and methods |
CN102939925A (zh) * | 2012-11-15 | 2013-02-27 | 浙江海洋学院 | 乌贼放流种群强化装置 |
US10421729B2 (en) | 2013-03-15 | 2019-09-24 | Mannkind Corporation | Microcrystalline diketopiperazine compositions and methods |
US9925144B2 (en) | 2013-07-18 | 2018-03-27 | Mannkind Corporation | Heat-stable dry powder pharmaceutical compositions and methods |
US11446127B2 (en) | 2013-08-05 | 2022-09-20 | Mannkind Corporation | Insufflation apparatus and methods |
US20150072915A1 (en) * | 2013-09-06 | 2015-03-12 | The Procter & Gamble Company | Pouches comprising apertured film wall materials and methods for making same |
US10723983B2 (en) * | 2013-09-06 | 2020-07-28 | The Procter & Gamble Company | Pouches comprising apertured film wall materials and methods for making same |
US10307464B2 (en) | 2014-03-28 | 2019-06-04 | Mannkind Corporation | Use of ultrarapid acting insulin |
US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
CN104555111A (zh) * | 2014-12-05 | 2015-04-29 | 中国农业科学院兰州畜牧与兽药研究所 | 一种当归药材的储藏方法 |
US11278499B2 (en) | 2015-06-03 | 2022-03-22 | Triastek, Inc. | Oral drug dosage form comprising various release profiles |
US12042562B2 (en) | 2015-06-03 | 2024-07-23 | Triastek, Inc. | 3D printing methods for compartmented pharmaceutical dosage forms |
EP3981392A1 (en) * | 2016-05-05 | 2022-04-13 | Triastek, Inc. | Controlled release dosage form |
EP3452003A4 (en) * | 2016-05-05 | 2019-06-26 | Triastek, Inc. | PHARMACEUTICAL FORM WITH CONTROLLED RELEASE |
EP3651721A4 (en) * | 2017-07-10 | 2021-04-21 | Gel Cap Technologies, LLC | DUAL RELEASE CAPSULE AND METHODS, DEVICES AND SYSTEMS FOR THEIR MANUFACTURE |
US11944707B2 (en) | 2017-07-10 | 2024-04-02 | Gel Cap Technologies, LLC | Dual release dosage form capsule and methods, devices and systems for making same |
US11571391B2 (en) | 2018-01-09 | 2023-02-07 | Triastek, Inc. | Oral drug dosage forms compromising a fixed-dose of an ADHD non-stimulant and an ADHD stimulant |
Also Published As
Publication number | Publication date |
---|---|
BR7300827D0 (pt) | 1973-10-25 |
AR196325A1 (es) | 1973-12-18 |
GB1377452A (en) | 1974-12-18 |
ES411206A1 (es) | 1976-04-01 |
ZA73766B (en) | 1974-09-25 |
IT977185B (it) | 1974-09-10 |
JPS4882025A (pt) | 1973-11-02 |
AU463254B2 (en) | 1975-07-17 |
FR2170751A5 (pt) | 1973-09-14 |
AU5171973A (en) | 1974-08-08 |
BE794951A (fr) | 1973-05-29 |
DE2305280C2 (de) | 1983-12-29 |
CA990238A (en) | 1976-06-01 |
JPS5532381B2 (pt) | 1980-08-25 |
DE2305280A1 (de) | 1973-08-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US3823816A (en) | Water-soluble package | |
US4138013A (en) | Enteric capsules | |
US4816259A (en) | Process for coating gelatin capsules | |
US4302440A (en) | Easily-swallowed, powder-free and gastric-disintegrable aspirin tablet thinly-coated with hydroxypropyl methylcellulose and aqueous spray-coating preparation thereof | |
FI102515B (fi) | Asymmetrisiä kalvoja käsittävä väline, joka pystyy kontrolloidusti vap auttamaan aktiivista ainetta sekä menetelmiä välineiden valmistamiseks i | |
US3444290A (en) | Dosage unit forms for the administration of medicaments | |
US4196564A (en) | Method of manufacturing a joined capsule filled with viscous material | |
US5750143A (en) | Controlled release device | |
CA1321754B (en) | Delivery system | |
US5576019A (en) | Method for blinding a medication | |
NL8502930A (nl) | Therapeutisch afgiftesysteem voor het colon. | |
US2491475A (en) | Enteric capsule | |
FR2524311A1 (fr) | Gelule compartimentee aux fins d'ingestions simultanees a effets differes | |
EP0781541A3 (en) | Method and apparatus for manufacturing pharmaceutical cellulose capsules - sizing the capsule | |
EP0435726B1 (en) | Capsule and caplet combination | |
US2924920A (en) | Sealing hard-shell gelatin capsules | |
IE65251B1 (en) | Controlled release capsules | |
IE38792L (en) | Capsules | |
CA1062613A (en) | Enteric capsules | |
JPS61221117A (ja) | 腸溶性硬カプセル剤 | |
MX2013002195A (es) | Agente de revestimiento para preparacion solida farmaceutica, formulacion de pelicula farmaceutica, y preparacion solida farmaceutica revestida. | |
US2846353A (en) | Capsule and method of production | |
US2990334A (en) | Gelatin capsules enclosing a watermiscible vehicle | |
ES2730695T3 (es) | Envase soluble en agua | |
JPS6471Y2 (pt) |