US20160074476A1 - Modulation of Heparin-binding Epidermal Growth Factor Activity for Tympanic Membrane Healing - Google Patents

Modulation of Heparin-binding Epidermal Growth Factor Activity for Tympanic Membrane Healing Download PDF

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Publication number
US20160074476A1
US20160074476A1 US14/888,936 US201414888936A US2016074476A1 US 20160074476 A1 US20160074476 A1 US 20160074476A1 US 201414888936 A US201414888936 A US 201414888936A US 2016074476 A1 US2016074476 A1 US 2016074476A1
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US
United States
Prior art keywords
egf
formulation
perforation
tympanic membrane
chronic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US14/888,936
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English (en)
Inventor
Peter Luke Santa Maria
Yunzhi Peter Yang
Sungwoo KIM
Chloe Domville-Lewis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leland Stanford Junior University
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Leland Stanford Junior University
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Filing date
Publication date
Application filed by Leland Stanford Junior University filed Critical Leland Stanford Junior University
Priority to US14/888,936 priority Critical patent/US20160074476A1/en
Assigned to THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY reassignment THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: KIM, SUNGWOO, YANG, YUNZHI, DOMVILLE-LEWIS, Chloe, SANTA MARIA, PETER LUKE
Publication of US20160074476A1 publication Critical patent/US20160074476A1/en
Abandoned legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/1808Epidermal growth factor [EGF] urogastrone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F11/00Methods or devices for treatment of the ears or hearing sense; Non-electric hearing aids; Methods or devices for enabling ear patients to achieve auditory perception through physiological senses other than hearing sense; Protective devices for the ears, carried on the body or in the hand
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0046Ear
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7015Drug-containing film-forming compositions, e.g. spray-on
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0023Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061Use of materials characterised by their function or physical properties
    • A61L26/0066Medicaments; Biocides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061Use of materials characterised by their function or physical properties
    • A61L26/0076Sprayable compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/20Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/16Otologicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F11/00Methods or devices for treatment of the ears or hearing sense; Non-electric hearing aids; Methods or devices for enabling ear patients to achieve auditory perception through physiological senses other than hearing sense; Protective devices for the ears, carried on the body or in the hand
    • A61F11/20Ear surgery
    • A61F11/202Surgical middle-ear ventilation or drainage, e.g. permanent; Implants therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/18Internal ear or nose parts, e.g. ear-drums
    • A61F2002/183Ear parts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067Means for introducing or releasing pharmaceutical products into the body
    • A61F2250/0068Means for introducing or releasing pharmaceutical products into the body the pharmaceutical product being in a reservoir
US14/888,936 2013-05-15 2014-04-09 Modulation of Heparin-binding Epidermal Growth Factor Activity for Tympanic Membrane Healing Abandoned US20160074476A1 (en)

Priority Applications (1)

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US14/888,936 US20160074476A1 (en) 2013-05-15 2014-04-09 Modulation of Heparin-binding Epidermal Growth Factor Activity for Tympanic Membrane Healing

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361823749P 2013-05-15 2013-05-15
US14/888,936 US20160074476A1 (en) 2013-05-15 2014-04-09 Modulation of Heparin-binding Epidermal Growth Factor Activity for Tympanic Membrane Healing
PCT/US2014/033536 WO2014186075A2 (en) 2013-05-15 2014-04-09 Modulation of heparin-binding epidermal growth factor activity for tympanic membrane healing

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2014/033536 A-371-Of-International WO2014186075A2 (en) 2013-05-15 2014-04-09 Modulation of heparin-binding epidermal growth factor activity for tympanic membrane healing

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US15/981,642 Continuation US11235027B2 (en) 2013-05-15 2018-05-16 Modulation of heparin-binding epidermal growth factor activity for tympanic membrane healing

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US20160074476A1 true US20160074476A1 (en) 2016-03-17

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Application Number Title Priority Date Filing Date
US14/888,936 Abandoned US20160074476A1 (en) 2013-05-15 2014-04-09 Modulation of Heparin-binding Epidermal Growth Factor Activity for Tympanic Membrane Healing
US15/981,642 Active US11235027B2 (en) 2013-05-15 2018-05-16 Modulation of heparin-binding epidermal growth factor activity for tympanic membrane healing
US17/556,193 Active 2034-04-27 US11963998B2 (en) 2013-05-15 2021-12-20 Modulation of heparin-binding epidermal growth factor activity for tympanic membrane healing

Family Applications After (2)

Application Number Title Priority Date Filing Date
US15/981,642 Active US11235027B2 (en) 2013-05-15 2018-05-16 Modulation of heparin-binding epidermal growth factor activity for tympanic membrane healing
US17/556,193 Active 2034-04-27 US11963998B2 (en) 2013-05-15 2021-12-20 Modulation of heparin-binding epidermal growth factor activity for tympanic membrane healing

Country Status (27)

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US (3) US20160074476A1 (uk)
EP (2) EP2996709B1 (uk)
JP (1) JP6316943B2 (uk)
KR (1) KR102318748B1 (uk)
CN (2) CN105555296A (uk)
AU (2) AU2014265901B2 (uk)
BR (2) BR112015028367B1 (uk)
CA (1) CA2912411C (uk)
CY (1) CY1123464T1 (uk)
DK (1) DK2996709T3 (uk)
ES (1) ES2805002T3 (uk)
HK (1) HK1217166A1 (uk)
HR (1) HRP20200971T1 (uk)
HU (1) HUE049294T2 (uk)
IL (2) IL242454B (uk)
LT (1) LT2996709T (uk)
MX (2) MX2015015774A (uk)
PH (2) PH12015502577B1 (uk)
PL (1) PL2996709T3 (uk)
PT (1) PT2996709T (uk)
RS (1) RS60412B1 (uk)
RU (2) RU2018146249A (uk)
SG (1) SG11201509347UA (uk)
SI (1) SI2996709T1 (uk)
UA (1) UA120037C2 (uk)
WO (1) WO2014186075A2 (uk)
ZA (1) ZA201508289B (uk)

Cited By (1)

* Cited by examiner, † Cited by third party
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US10809614B2 (en) 2018-06-15 2020-10-20 Samsung Electronics Co., Ltd. Pellicle for photomask and method of fabricating the same

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* Cited by examiner, † Cited by third party
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KR20220041143A (ko) 2019-07-31 2022-03-31 아스텔라스세이야쿠 가부시키가이샤 귀내 투여용의 의약 조성물
WO2022065404A1 (ja) * 2020-09-25 2022-03-31 アステラス製薬株式会社 耳内投与用の医薬組成物

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US9814779B2 (en) * 2013-04-09 2017-11-14 The Board Of Trustees Of The Leland Stanford Junior University Crosslinked chitosan-lactide hydrogels

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US20150112244A1 (en) * 2012-06-28 2015-04-23 The Administrators Of The Tulane Educational Fund Selectively polymerizable compositions and methods of use in vivo
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10809614B2 (en) 2018-06-15 2020-10-20 Samsung Electronics Co., Ltd. Pellicle for photomask and method of fabricating the same
US11262648B2 (en) 2018-06-15 2022-03-01 Samsung Electronics Co., Ltd. Pellicle for photomask and method of fabricating the same

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Publication number Publication date
EP2996709B1 (en) 2020-05-06
EP3708181A1 (en) 2020-09-16
IL273329B (en) 2021-05-31
HRP20200971T1 (hr) 2020-10-02
US11963998B2 (en) 2024-04-23
PL2996709T3 (pl) 2021-02-08
MX2015015774A (es) 2016-07-26
LT2996709T (lt) 2020-08-10
KR20160013063A (ko) 2016-02-03
JP2016520080A (ja) 2016-07-11
CY1123464T1 (el) 2022-03-24
WO2014186075A3 (en) 2015-06-04
AU2014265901A1 (en) 2015-11-26
EP2996709A2 (en) 2016-03-23
CN105555296A (zh) 2016-05-04
ZA201508289B (en) 2019-02-27
RU2676483C2 (ru) 2018-12-29
ES2805002T3 (es) 2021-02-10
CA2912411C (en) 2022-10-25
PT2996709T (pt) 2020-07-14
WO2014186075A2 (en) 2014-11-20
PH12015502577A1 (en) 2016-02-29
AU2019200630A1 (en) 2019-02-21
BR122020011229B1 (pt) 2022-06-07
EP2996709A4 (en) 2016-11-16
RU2015148636A (ru) 2017-06-20
US20180256684A1 (en) 2018-09-13
IL273329A (en) 2020-04-30
UA120037C2 (uk) 2019-09-25
JP6316943B2 (ja) 2018-04-25
BR112015028367A2 (pt) 2017-07-25
CN113559242A (zh) 2021-10-29
AU2019200630B2 (en) 2020-08-27
RU2018146249A (ru) 2019-01-18
US11235027B2 (en) 2022-02-01
US20220111006A1 (en) 2022-04-14
HUE049294T2 (hu) 2020-09-28
PH12015502577B1 (en) 2016-02-29
HK1217166A1 (zh) 2016-12-30
DK2996709T3 (da) 2020-06-02
IL242454B (en) 2020-05-31
AU2014265901B2 (en) 2018-11-08
RS60412B1 (sr) 2020-07-31
KR102318748B1 (ko) 2021-10-27
SI2996709T1 (sl) 2020-09-30
CA2912411A1 (en) 2014-11-20
BR112015028367B1 (pt) 2020-12-01
MX2020001319A (es) 2020-03-20
SG11201509347UA (en) 2015-12-30
PH12020551126A1 (en) 2021-12-13

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Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:SANTA MARIA, PETER LUKE;DOMVILLE-LEWIS, CHLOE;YANG, YUNZHI;AND OTHERS;SIGNING DATES FROM 20140423 TO 20140519;REEL/FRAME:037006/0081

STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION