US20150079225A1 - Nutritional composition - Google Patents

Nutritional composition Download PDF

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Publication number
US20150079225A1
US20150079225A1 US14/391,494 US201314391494A US2015079225A1 US 20150079225 A1 US20150079225 A1 US 20150079225A1 US 201314391494 A US201314391494 A US 201314391494A US 2015079225 A1 US2015079225 A1 US 2015079225A1
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US
United States
Prior art keywords
nutritional composition
content
formula
composition according
composition
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Abandoned
Application number
US14/391,494
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English (en)
Inventor
Bo Lönnerdal
Olle Hernell
Lars-Börje Sjöberg
Catharina Tennefors
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hero AG
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Hero AG
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Filing date
Publication date
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Application filed by Hero AG filed Critical Hero AG
Assigned to HERO AG reassignment HERO AG ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: SJÖBERG, Lars-Börje, TENNEFORS, CATHARINA, HERNELL, OLLE, LÖNNERDAL, Bo
Publication of US20150079225A1 publication Critical patent/US20150079225A1/en
Abandoned legal-status Critical Current

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    • A23L1/296
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23JPROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J1/00Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
    • A23J1/20Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from milk, e.g. casein; from whey
    • A23J1/207Co-precipitates of casein and lactalbumine
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17Amino acids, peptides or proteins
    • A23L33/18Peptides; Protein hydrolysates
    • A23L1/293
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12Fatty acids or derivatives thereof
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17Amino acids, peptides or proteins
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17Amino acids, peptides or proteins
    • A23L33/19Dairy proteins
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/30Dietetic or nutritional methods, e.g. for losing weight
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/40Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs

Definitions

  • Phospholipids, sphingomyelin, sialic acid, gangliosides are all nutrients which are recognized as important nutrients for the infant.
  • the challenge has been to be able to incorporate suitable sources of these nutrients into the composition of the formula without negative effect on other important nutrients and the general composition of the product.
  • this incorporation has been performed in levels close to the level in breast milk without any negative effect on the total composition.
  • a nutritional composition according to the invention may also refer to the composition of the invention as a powder suitable for making a liquid composition after reconstitution with water.
  • a nutritional composition according to the present invention wherein the amino acid content in the composition is originated from sources selected from for example; sweet whey solids, casein solids, milk solids and cream solids.
  • a nutritional composition also referred to as a formula according to the invention is for example a powder intended to be mixed with water before use or a liquid ready-to-use product.
  • a nutritional composition according to the invention has low energy content in combination with low protein content.
  • a nutritional composition according to the invention is more nutritional complete and comprises several milk derived raw materials including sweet whey, whey protein concentrate rich in phospholipids, cream rich in cholesterol and also comprises gluco macro peptide (cGMP) which allows for a higher sialic acid content.
  • cGMP gluco macro peptide
  • Another important factor of the present invention is that it further may have low non-protein nitrogen content (NPN).
  • the formula according to the invention comprises a low level of protein and also a low level of total energy content.
  • the protein content of the ready to drink nutritional composition is for example lower than 1.25 g/100 ml or for example lower than 1.25 g/100 ml or for example between 1.1-1.25 g/100 ml or between 1.1 g/100 ml to lower than 1.25 g/100 ml.
  • rape seed oil contributes mainly with the essential fatty acid linolenic acid (n-3 18:3).
  • Other oils which also may be used are: rape seed oil (high oleic), soybean-, maize-, safflower-, evening primrose-, borage-, palm-, palm olein-, palm kernel-, coconut-, babassu-, fish oil, egg lipids, structured fat with high percent palmitic acid esterified to ⁇ -position in the triglycerides and lard. In order to even better mimic the fat composition in breast milk cream is used.
  • the levels of arachidonic acid (ARA) and docosahexaenoic acid (DHA) in the nutritional composition according to the invention are of similar levels as present in breast milk.
  • an infant formula needs a predetermined amino acid profile to fulfill the children's need. This is also regulated by the government Commission Directive 2006/141/EC.
  • the amino acid supply in an infant's first months of life must be sufficient in quantity as well as quality to fulfill the needs of this period of life. Guidelines, recommendations with minimum values have been established with regard to amino acid composition of infant formulas.
  • An amino acid profile of the nutritional composition according to the invention is presented in the table below. The clinical study confirms that the amino acid composition in the invention formula is adequate for the requirement for growth.
  • the formula according to the invention is according to one embodiment produced by mixing the below ingredients in kg per 1000 kg nutritional composition dry powder or kg per 8770 L finished nutritional composition.
  • the nutritional composition may further comprise vitamins, minerals, fats, lactose and/or other essential nutrients (for example choline, taurine, inositol, carnitine, nucleotides).
  • vitamins, minerals, fats, lactose and/or other essential nutrients for example choline, taurine, inositol, carnitine, nucleotides.
  • Whey protein concentrate solids rich in phospholipids used as a component in the nutritional composition according to the invention is a whey protein concentrate with a high concentration of bioactive proteins and lipids.
  • the whey protein concentrate has a high nutritional value, and is applicable in infant and clinical nutrition.
  • Whey protein concentrate solids rich in phospholipids contain most of the insoluble membrane protein fragments from MFGM originally present in the whey, in addition to residual whey components, proteins, lactose and salts.
  • the invention utilizes, whey protein concentrate solids rich in phospholipids obtained after removal of the major whey proteins by known industrial processing, such as filtration, ion-exchange chromatography, and the like.
  • Whey protein concentrate solids rich in phospholipids from bovine milk contain unique polar lipids and membrane specific proteins, for example lactoferrin, butyrophilin, MUC1 and PAS6/7 (lactadherin), CD14, TLR1, and TLR4 and phospholipids (including for example sphingomyelin and gangliosides). These components are recognized as nutritional and bioactive milk constituents and are present only scarcely in bovine milk compared to human milk.
  • Sodium caseinate or partly other salts of caseinates may be used in the invention formula.
  • the composition is a powder suitable for making a liquid composition after reconstitution with water.
  • the composition is a ready to use liquid product.
  • Formula A which is a nutritional composition according to the invention, with the ingredients described above, comprises the nutritional values presented below as ready for consumption (114 g of powder formula A is mixed with 900 ml water which gives 1000 ml ready to drink product);
  • the cholesterol level in breast milk is often said to contain about 120 mg/l, but is dependant of many factors. Most standard infant formula contains less than 10 mg/ of cholesterol.
  • the cholesterol level in the Formula A was increased by using a recipe containing milk cream, milk protein fractions containing MFGM (milk fat globule membrane) and other milk protein fractions containing cholesterol.

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pediatric Medicine (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biochemistry (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Dairy Products (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
US14/391,494 2012-04-10 2013-04-09 Nutritional composition Abandoned US20150079225A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE1250357A SE536599C3 (sv) 2012-04-10 2012-04-10 Näringssammansättning med lågt kalori- och lågt proteininnehåll
SE1250357-9 2012-04-10
PCT/EP2013/057405 WO2013153071A2 (en) 2012-04-10 2013-04-09 A nutritional composition

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2013/057405 A-371-Of-International WO2013153071A2 (en) 2012-04-10 2013-04-09 A nutritional composition

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US15/244,304 Continuation US11647777B2 (en) 2012-04-10 2016-08-23 Nutritional composition

Publications (1)

Publication Number Publication Date
US20150079225A1 true US20150079225A1 (en) 2015-03-19

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ID=48289048

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Application Number Title Priority Date Filing Date
US14/391,494 Abandoned US20150079225A1 (en) 2012-04-10 2013-04-09 Nutritional composition
US15/244,304 Active US11647777B2 (en) 2012-04-10 2016-08-23 Nutritional composition
US18/134,775 Pending US20230248043A1 (en) 2012-04-10 2023-04-14 Nutritional composition

Family Applications After (2)

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US15/244,304 Active US11647777B2 (en) 2012-04-10 2016-08-23 Nutritional composition
US18/134,775 Pending US20230248043A1 (en) 2012-04-10 2023-04-14 Nutritional composition

Country Status (11)

Country Link
US (3) US20150079225A1 (sv)
EP (4) EP2836084B1 (sv)
CN (3) CN107518410A (sv)
DK (4) DK2836084T3 (sv)
ES (4) ES2624541T3 (sv)
FI (1) FI3942944T3 (sv)
LT (4) LT3942944T (sv)
PT (4) PT3942944T (sv)
RU (1) RU2617606C2 (sv)
SE (1) SE536599C3 (sv)
WO (1) WO2013153071A2 (sv)

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WO2017102720A1 (en) * 2015-12-14 2017-06-22 Nestec S.A. Nutritional compositions and infant formulas to promote myelination in the brain
WO2017102717A1 (en) * 2015-12-14 2017-06-22 Nestec S.A. Nutritional composition and infant formula for promoting de novo myelination
US20180213833A1 (en) * 2017-01-29 2018-08-02 Samit Gupta Ketogenic nutritional composition and preparation method thereof
US11647777B2 (en) 2012-04-10 2023-05-16 Semper Ab Nutritional composition
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