US20080091002A1 - Functional and hyperfunctional siRNA directed against Bcl-2 - Google Patents

Functional and hyperfunctional siRNA directed against Bcl-2 Download PDF

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Publication number
US20080091002A1
US20080091002A1 US11/974,865 US97486507A US2008091002A1 US 20080091002 A1 US20080091002 A1 US 20080091002A1 US 97486507 A US97486507 A US 97486507A US 2008091002 A1 US2008091002 A1 US 2008091002A1
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United States
Prior art keywords
seq
id
sirna
position
sirnas
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
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US11/974,865
Inventor
Anastasia Khvorova
Angela Reynolds
Devin Leake
William Marshall
Stephen Scaringe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Thermo Fisher Scientific Inc
Original Assignee
Dharmacon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US42613702P priority Critical
Priority to US50205003P priority
Priority to US10/714,333 priority patent/US8090542B2/en
Priority to US11/083,784 priority patent/US7820809B2/en
Application filed by Dharmacon Inc filed Critical Dharmacon Inc
Priority to US11/974,865 priority patent/US20080091002A1/en
Assigned to DHARMACON, INC. reassignment DHARMACON, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: KHVOROVA, ANASTASIA, LEAKE, DEVIN, MARSHALL, WILLIAM, REYNOLDS, ANGELA, SCARINGE, STEPHEN
Publication of US20080091002A1 publication Critical patent/US20080091002A1/en
Assigned to THERMO FISHER SCIENTIFIC INC. reassignment THERMO FISHER SCIENTIFIC INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: THERMO FISHER SCIENTIFIC BIOSCIENCES INC.
Assigned to DHARMACON, INC. reassignment DHARMACON, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: READ, STEVEN, MARSHALL, WILLIAM, KHVOROVA, ANASTASIA, LEAKE, DEVIN, SCARINGE, STEPHEN, REYNOLDS, ANGELA
Assigned to THERMO FISHER SCIENTIFIC BIOSCIENCES INC. reassignment THERMO FISHER SCIENTIFIC BIOSCIENCES INC. CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). Assignors: DHARMACON, INC.
Application status is Abandoned legal-status Critical

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