EP1053315A4 - Human hairless gene, protein and uses thereof - Google Patents

Human hairless gene, protein and uses thereof

Info

Publication number
EP1053315A4
EP1053315A4 EP99905596A EP99905596A EP1053315A4 EP 1053315 A4 EP1053315 A4 EP 1053315A4 EP 99905596 A EP99905596 A EP 99905596A EP 99905596 A EP99905596 A EP 99905596A EP 1053315 A4 EP1053315 A4 EP 1053315A4
Authority
EP
European Patent Office
Prior art keywords
protein
hairless gene
human hairless
human
gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP99905596A
Other languages
German (de)
French (fr)
Other versions
EP1053315A1 (en
Inventor
Angela M Christiano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Columbia University of New York
Original Assignee
Columbia University of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Columbia University of New York filed Critical Columbia University of New York
Publication of EP1053315A1 publication Critical patent/EP1053315A1/en
Publication of EP1053315A4 publication Critical patent/EP1053315A4/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/606—Nucleosides; Nucleotides; Nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A61Q7/02—Preparations for inhibiting or slowing hair growth
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/70—Biological properties of the composition as a whole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/86—Products or compounds obtained by genetic engineering
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
EP99905596A 1998-01-29 1999-01-29 Human hairless gene, protein and uses thereof Pending EP1053315A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7304398P 1998-01-29 1998-01-29
US73043P 1998-01-29
PCT/US1999/002128 WO1999038965A1 (en) 1998-01-29 1999-01-29 Human hairless gene, protein and uses thereof

Publications (2)

Publication Number Publication Date
EP1053315A1 EP1053315A1 (en) 2000-11-22
EP1053315A4 true EP1053315A4 (en) 2003-07-30

Family

ID=22111367

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99905596A Pending EP1053315A4 (en) 1998-01-29 1999-01-29 Human hairless gene, protein and uses thereof

Country Status (4)

Country Link
EP (1) EP1053315A4 (en)
AU (1) AU2572499A (en)
CA (1) CA2362320A1 (en)
WO (1) WO1999038965A1 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6348348B1 (en) 1998-04-07 2002-02-19 The Carnegie Institution Of Washington Human hairless gene and protein
GB0011269D0 (en) * 2000-05-11 2000-06-28 Univ Sheffield Protein over expression
US7468246B2 (en) 2001-03-07 2008-12-23 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Identification and use of inhibitors of hair growth
JP2005510204A (en) * 2001-04-13 2005-04-21 ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク Nucleic acids for inhibiting hairless protein expression and methods of use thereof
WO2003002756A1 (en) * 2001-06-26 2003-01-09 Anaderm Research Corporation Fkbp51/52 and cyp40-mediated mammalian hair growth
US7169564B1 (en) 2001-06-26 2007-01-30 Anaderm Research Corporation FKBP51/52 and CyP40-mediated mammalian hair growth
US7612196B2 (en) 2002-11-14 2009-11-03 Dharmacon, Inc. siRNA targeting cyclin-dependent kinase inhibitor 1B (p27, Kip1) (CDKN1B)
US9771586B2 (en) 2002-11-14 2017-09-26 Thermo Fisher Scientific Inc. RNAi targeting ZNF205
US9719094B2 (en) 2002-11-14 2017-08-01 Thermo Fisher Scientific Inc. RNAi targeting SEC61G
US9228186B2 (en) 2002-11-14 2016-01-05 Thermo Fisher Scientific Inc. Methods and compositions for selecting siRNA of improved functionality
JP2006507841A (en) 2002-11-14 2006-03-09 ダーマコン， インコーポレイテッド Functional and ultrafunctional siRNA
WO2006006948A2 (en) 2002-11-14 2006-01-19 Dharmacon, Inc. METHODS AND COMPOSITIONS FOR SELECTING siRNA OF IMPROVED FUNCTIONALITY
US9719092B2 (en) 2002-11-14 2017-08-01 Thermo Fisher Scientific Inc. RNAi targeting CNTD2
US9879266B2 (en) 2002-11-14 2018-01-30 Thermo Fisher Scientific Inc. Methods and compositions for selecting siRNA of improved functionality
US9839649B2 (en) 2002-11-14 2017-12-12 Thermo Fisher Scientific Inc. Methods and compositions for selecting siRNA of improved functionality
US10011836B2 (en) 2002-11-14 2018-07-03 Thermo Fisher Scientific Inc. Methods and compositions for selecting siRNA of improved functionality
US20050106141A1 (en) * 2003-11-13 2005-05-19 The Procter & Gamble Company Hairless protein-interacting partner complexes and methods thereof for the beautification and/or improvement of mammalian skin
WO2005105157A2 (en) 2004-04-23 2005-11-10 The Trustees Of Columbia University In The City Ofnew York INHIBITION OF HAIRLESS PROTEIN mRNA
US8168600B2 (en) 2004-04-23 2012-05-01 Isis Pharmaceuticals, Inc. Compositions and methods for topical delivery of oligonucleotides
WO2014022655A1 (en) * 2012-08-01 2014-02-06 The Trustees Of Columbia University In The City Of New York Methods for regulating hair growth disorders
EP2735303A1 (en) * 2012-11-23 2014-05-28 Pilosciences Hair growth compositions and methods
WO2019161805A1 (en) * 2018-02-26 2019-08-29 Biocytogen Jiangsu Co., Ltd. Hr knockout non-human animal
CN113717975B (en) * 2021-09-01 2023-09-26 中国农业大学 miRNA marker related to pig hairless character and application thereof

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
AHMAD W ET AL: "ALOPECIA UNIVERSALIS ASSOCIATED WITH A MUTATION IN THE HUMAN HAIRLESS GENE", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 279, 30 January 1998 (1998-01-30), pages 720 - 724, XP000971022, ISSN: 0036-8075 *
AHMAD WASIM ET AL: "A missense mutation in the zinc-finger domain of the human hairless gene underlies congenital atrichia in a family of Irish travellers.", AMERICAN JOURNAL OF HUMAN GENETICS, vol. 63, no. 4, October 1998 (1998-10-01), pages 984 - 991, XP002241689, ISSN: 0002-9297 *
CACHON-GONZALEZ M B ET AL: "STRUCTURE AND EXPRESSION OF THE HAIRLESS GENE OF MICE", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 91, August 1994 (1994-08-01), pages 7717 - 7721, XP002933874, ISSN: 0027-8424 *
CICHON S ET AL: "CLONING, GENOMIC ORGANIZATION, ALTERNATIVE TRANSCRIPTS AND MUTATIONAL ANALYSIS OF THE GENE RESPONSIBLE FOR AUTOSOMAL RECESSIVEUNIVERSAL CONGENITAL ALOPECIA", HUMAN MOLECULAR GENETICS, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 7, no. 11, October 1998 (1998-10-01), pages 1671 - 1679, XP000971023, ISSN: 0964-6906 *
DATABASE EMBL [online] 16 August 1996 (1996-08-16), HILLIER L. ET AL.: "ze85d02.r1 Soares_fetal_heart_NbHH19W Homo sapiens cDNA clone IMAGE:365763 5', mRNA sequence", XP002241691, Database accession no. AA025648 *
FRANK J ET AL: "Exposing the human nude phenotype.", NATURE. ENGLAND 8 APR 1999, vol. 398, no. 6727, 8 April 1999 (1999-04-08), pages 473 - 474, XP002241688, ISSN: 0028-0836 *
SCHORPP M ET AL: "CHARACTERIZATION OF MOUSE AND HUMAN NUDE GENES", IMMUNOGENETICS, SPRINGER VERLAG, BERLIN, DE, vol. 46, no. 6, November 1997 (1997-11-01), pages 509 - 515, XP000876601, ISSN: 0093-7711 *
See also references of WO9938965A1 *
SEGRE J A ET AL: "POSITIONAL CLONING OF THE NUDE LOCUS: GENETIC, PHYSICAL AND TRANSCRIPTION MAPS OF THE REGION AND MUTATIONS IN THE MOUSE AND RAT", GENOMICS, ACADEMIC PRESS, SAN DIEGO, US, vol. 28, no. 3, 10 August 1995 (1995-08-10), pages 549 - 559, XP001041492, ISSN: 0888-7543 *
THOMPSON CATHERINE C: "Thyroid hormone-responsive genes in developing cerebellum include a novel synaptotagmin and a hairless homolog.", JOURNAL OF NEUROSCIENCE, vol. 16, no. 24, 1996, pages 7832 - 7840, XP002241687, ISSN: 0270-6474 *
ZLOTOGORSKI ABRAHAM ET AL: "Congenital atrichia in five Arab Palestinian families resulting from a deletion mutation in the human hairless gene.", HUMAN GENETICS, vol. 103, no. 4, October 1998 (1998-10-01), pages 400 - 404, XP002241690, ISSN: 0340-6717 *

Also Published As

Publication number Publication date
WO1999038965A1 (en) 1999-08-05
EP1053315A1 (en) 2000-11-22
CA2362320A1 (en) 1999-08-05
AU2572499A (en) 1999-08-16

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