US20080064664A1 - Skin Beautifier - Google Patents
Skin Beautifier Download PDFInfo
- Publication number
- US20080064664A1 US20080064664A1 US10/594,661 US59466105A US2008064664A1 US 20080064664 A1 US20080064664 A1 US 20080064664A1 US 59466105 A US59466105 A US 59466105A US 2008064664 A1 US2008064664 A1 US 2008064664A1
- Authority
- US
- United States
- Prior art keywords
- skin
- sphingomyelin
- effects
- food
- feed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 235000013305 food Nutrition 0.000 claims abstract description 31
- 239000004615 ingredient Substances 0.000 claims abstract description 11
- 235000020247 cow milk Nutrition 0.000 claims description 4
- 230000000694 effects Effects 0.000 abstract description 35
- 230000003020 moisturizing effect Effects 0.000 abstract description 12
- 230000002633 protecting effect Effects 0.000 abstract description 12
- 206010013786 Dry skin Diseases 0.000 abstract description 11
- 230000003796 beauty Effects 0.000 abstract description 11
- 230000037406 food intake Effects 0.000 abstract description 9
- 150000003904 phospholipids Chemical class 0.000 abstract description 7
- 210000003491 skin Anatomy 0.000 description 40
- 239000000243 solution Substances 0.000 description 21
- 239000002994 raw material Substances 0.000 description 20
- 239000000203 mixture Substances 0.000 description 13
- 229940106189 ceramide Drugs 0.000 description 11
- 230000036572 transepidermal water loss Effects 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 150000001783 ceramides Chemical class 0.000 description 9
- 239000008367 deionised water Substances 0.000 description 9
- 229910021641 deionized water Inorganic materials 0.000 description 9
- 210000000434 stratum corneum Anatomy 0.000 description 9
- 241000699666 Mus <mouse, genus> Species 0.000 description 8
- 230000037396 body weight Effects 0.000 description 7
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- 150000002632 lipids Chemical class 0.000 description 5
- 238000002156 mixing Methods 0.000 description 5
- LRYZPFWEZHSTHD-HEFFAWAOSA-O 2-[[(e,2s,3r)-2-formamido-3-hydroxyoctadec-4-enoxy]-hydroxyphosphoryl]oxyethyl-trimethylazanium Chemical class CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](NC=O)COP(O)(=O)OCC[N+](C)(C)C LRYZPFWEZHSTHD-HEFFAWAOSA-O 0.000 description 4
- 229910052500 inorganic mineral Inorganic materials 0.000 description 4
- 239000011707 mineral Substances 0.000 description 4
- 235000010755 mineral Nutrition 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 230000008591 skin barrier function Effects 0.000 description 4
- 235000000346 sugar Nutrition 0.000 description 4
- WWUZIQQURGPMPG-UHFFFAOYSA-N (-)-D-erythro-Sphingosine Natural products CCCCCCCCCCCCCC=CC(O)C(N)CO WWUZIQQURGPMPG-UHFFFAOYSA-N 0.000 description 3
- 241000699670 Mus sp. Species 0.000 description 3
- WORJEOGGNQDSOE-UHFFFAOYSA-N chloroform;methanol Chemical compound OC.ClC(Cl)Cl WORJEOGGNQDSOE-UHFFFAOYSA-N 0.000 description 3
- 239000002537 cosmetic Substances 0.000 description 3
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- 229930195729 fatty acid Natural products 0.000 description 3
- 150000004665 fatty acids Chemical class 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
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- 235000016709 nutrition Nutrition 0.000 description 3
- 230000035764 nutrition Effects 0.000 description 3
- WWUZIQQURGPMPG-KRWOKUGFSA-N sphingosine Chemical compound CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)CO WWUZIQQURGPMPG-KRWOKUGFSA-N 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- 229940088594 vitamin Drugs 0.000 description 3
- 229930003231 vitamin Natural products 0.000 description 3
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- 239000011782 vitamin Substances 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 241000699660 Mus musculus Species 0.000 description 2
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 description 2
- 108010046377 Whey Proteins Proteins 0.000 description 2
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- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 210000002969 egg yolk Anatomy 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 235000013402 health food Nutrition 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 235000013336 milk Nutrition 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- 239000008267 milk Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 description 2
- 238000011580 nude mouse model Methods 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 150000003722 vitamin derivatives Chemical class 0.000 description 2
- 235000021119 whey protein Nutrition 0.000 description 2
- OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 description 1
- 244000247812 Amorphophallus rivieri Species 0.000 description 1
- 235000001206 Amorphophallus rivieri Nutrition 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- ILKBHIBYKSHTKQ-UHFFFAOYSA-N Diisopropylamine dichloroacetate Chemical compound OC(=O)C(Cl)Cl.CC(C)NC(C)C ILKBHIBYKSHTKQ-UHFFFAOYSA-N 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 229920002752 Konjac Polymers 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 235000019482 Palm oil Nutrition 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 235000004347 Perilla Nutrition 0.000 description 1
- 244000124853 Perilla frutescens Species 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- 108010073771 Soybean Proteins Proteins 0.000 description 1
- 102000011971 Sphingomyelin Phosphodiesterase Human genes 0.000 description 1
- 108010061312 Sphingomyelin Phosphodiesterase Proteins 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 239000013566 allergen Substances 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000005013 brain tissue Anatomy 0.000 description 1
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 description 1
- 229960002401 calcium lactate Drugs 0.000 description 1
- 239000001527 calcium lactate Substances 0.000 description 1
- 235000011086 calcium lactate Nutrition 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 125000001549 ceramide group Chemical group 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 230000037319 collagen production Effects 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 239000002285 corn oil Substances 0.000 description 1
- 235000005687 corn oil Nutrition 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 239000008406 cosmetic ingredient Substances 0.000 description 1
- 238000000326 densiometry Methods 0.000 description 1
- 235000021185 dessert Nutrition 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 229940084113 diisopropylamine dichloroacetate Drugs 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 235000013345 egg yolk Nutrition 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 235000021323 fish oil Nutrition 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 150000002254 galactosylceramides Chemical class 0.000 description 1
- 229960003692 gamma aminobutyric acid Drugs 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 150000002305 glucosylceramides Chemical class 0.000 description 1
- 235000020251 goat milk Nutrition 0.000 description 1
- 230000036074 healthy skin Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000000252 konjac Substances 0.000 description 1
- 235000010485 konjac Nutrition 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 239000000845 maltitol Substances 0.000 description 1
- 235000010449 maltitol Nutrition 0.000 description 1
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 1
- 229940035436 maltitol Drugs 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 235000020124 milk-based beverage Nutrition 0.000 description 1
- 239000005445 natural material Substances 0.000 description 1
- 210000000944 nerve tissue Anatomy 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 239000002540 palm oil Substances 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 125000002525 phosphocholine group Chemical group OP(=O)(OCC[N+](C)(C)C)O* 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
- 238000010898 silica gel chromatography Methods 0.000 description 1
- 235000020183 skimmed milk Nutrition 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 229940001941 soy protein Drugs 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000012414 sterilization procedure Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000012431 wafers Nutrition 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
- 235000013618 yogurt Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J7/00—Phosphatide compositions for foodstuffs, e.g. lecithin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/158—Fatty acids; Fats; Products containing oils or fats
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/688—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols both hydroxy compounds having nitrogen atoms, e.g. sphingomyelins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/92—Oral administration
Definitions
- the present invention relates to a skin beautifier containing sphingomyelin as an effective ingredient and providing beauty effects, such as skin-moisturizing, skin-beautifying, skin-roughness-preventing, and wrinkle-preventing effects, by oral ingestion thereof, and relates to a skin-beautifying food/drink and a feed containing sphingomyelin.
- the skin is an interface of an organism with the environment, prevents moisture loss from the body, and has a skin barrier function preventing the invasion of biotoxic substances, such as microorganisms and allergens, from the environment. Intercorneocyte lipids, ceramides in particular, and sebum in the stratum corneum are said to bear these functions. It is said that the stratum corneum must contain 10 to 20% moisture to function normally and maintain a healthy condition. The moisture is retained in the stratum corneum by the skin barrier function and flexibility and elasticity of the skin are thereby maintained.
- TEWL transepidermal water loss
- a healthy condition of the skin i.e., a beautified skin condition
- a healthy condition of the skin can be achieved by increasing the moisture content of the skin or suppressing an increase in TEWL.
- Ceramides are one of human skin components and have skin-moisturizing and protecting functions and skin-roughness-preventing and improving effects.
- cosmetics utilizing ceramides skin cosmetic products containing a member of ceramide family, such as ceramides, glucosylceramides, and galactosylceramides, and diisopropylamine dichloroacetate or ⁇ -aminobutyric acid are known (Patent Document 1) .
- Patent Document 1 there are problems such that ceramides applied to the skin cannot reach nor be absorbed in the skin due to a barrier of epidermal lipids and that cosmetic ingredients other than ceramides cause irritation and inflammation.
- Patent Document 2 health foods containing ceramides composed of sphingosine, a fatty acid, and a sugar, as an effective ingredient are also known (Patent Document 2).
- the raw materials for the ceramides composed of sphingosine, a fatty acid, and a sugar, those derived from Amorphophalus konjac and rice are commercially available.
- these raw materials contain ceramides in a low amount less than 3%. Therefore, in order to achieve the effects by oral ingestion, it is necessary to blend a large amount of the raw materials.
- the health foods are unsatisfactory. Therefore, materials which can be readily ingested from daily food are desired.
- Sphingomyelin accounts for about 30% of phospholipids in milk and has a structure in which phosphocholine is bonded to a ceramide skeleton composed of sphingosine and a fatty acid. Sphingomyelin is known to be present in the brain and nerve tissues in large amounts (Non-Patent Document 1). It is also known that sphingomyelin is slightly contained in food such as yolk.
- Non-Patent Document 2 It is reported that a sphingomyelin is absorbed through the small intestine in blood vessels when orally ingested.
- Non-Patent Document 3 it is known that a sphingomyelin in the stratum glanulosum of the skin is hydrolyzed by sphingomyelinase into a ceramide to be supplied to the stratum corneum.
- Patent Document 1 Japanese Patent Laid-Open No. Hei 01-22810
- Patent Document 2 Japanese Patent Laid-Open No. Hei 11-113530
- Non-Patent Document 1 Harper's Biochemistry, 24th Ed. 1997, 162.
- Non-Patent Document 2 Schmelz, et al. J. Nutr. 1994, 124, 702-712.
- Non-Patent Document 3 Uchida, et al. Seikagaku (The Journal of Japanese Biochemical Society) 2001, 73(4), 269-272.
- a skin-beautifying food or feed which has beauty effects, such as skin-moisturizing and protecting effects, skin-roughness-preventing and improving effects, and a wrinkle-preventing effect, by oral ingestion thereof and which includes a safe raw material derived from food.
- the present inventors have conducted intensive searching for a component which has beauty effects, such as skin-moisturizing and protecting effects, skin-roughness-preventing and improving effects, and a wrinkle-preventing effect, by oral ingestion thereof, and have found that beauty effects, such as skin-moisturizing and protecting effects, skin-roughness-preventing and improving effects, and a wrinkle-preventing effect, can be obtained by orally ingesting a sphingomyelin, which is a phospholipid.
- the skin-beautifying feed in the present invention refers to the feed which exerts having skin-moisturizing and protecting effects in an animal to improve a skin condition thereof.
- a skin beautifier containing a sphingomyelin as an effective ingredient and a skin-beautifying food or feed containing a sphingomyelin can be provided. Since the effective ingredient of the skin beautifier according to the present invention is derived from food, the skin beautifier is safe and can achieve the beauty effects, such as skin-moisturizing and protecting effects, skin-roughness-preventing and improving effects, and a wrinkle-preventing effect, by oral ingestion thereof.
- the present invention is characterized by using a sphingomyelin, a phospholipid, as an effective ingredient.
- Sphingomyelins which can be used in the present invention are derived from natural substances.
- sphingomyelins derived from milk such as cow milk and goat milk and egg yolk of hens can be used.
- an inexpensive sphingomyelin raw material derived from cow milk, which contains sphingomyelins in a high concentration of 25% or more, is available at a market. Such a raw material may be advantageously used.
- the above-mentioned sphingomyelin may be used as a skin beautifier without modification or may be used as a nutrition composition by blending the sphingomyelin with raw materials, such as sugars, lipids, proteins, vitamins, minerals, and flavorings which are generally used in medicines, food, and feed.
- the sphingomyelin may be formulated into powder, granules, tablets, capsules, or drink according to a known method.
- other components having an effect on beauty for example, collagen which accelerates collagen production in the skin, vitamin C, or iron, can be used with the sphingomyelin.
- the effective dose of the skin beautifier according to the present invention it was confirmed by an animal study using nude mice described below that the moisture content of the skin was increased and the transepidermal water loss (TEWL) through skin was decreased by oral administration of 2 mg or more, preferably 5 mg or more, of sphingomyelin per kg of mouse body weight. Therefore, generally, the beauty effects, such as skin-moisturizing and protecting effects, skin-roughness-preventing and improving effects, and a wrinkle-preventing effect, can be expected by administration of 2 mg or more, preferably 5 mg or more of sphingomyelin per day for an adult. Therefore, this amount may be necessarily ingested.
- TEWL transepidermal water loss
- sphingomyelin may be blended with general food, for example, yogurt, milk-based drink, wafers, or dessert.
- general food for example, yogurt, milk-based drink, wafers, or dessert.
- 100 g of the food preferably contains 0.1 to 400 mg of sphingomyelin in order to administer 2 mg or more of sphingomyelin per day for an adult.
- sphingomyelin may be blended with general feed, for example, livestock feed or pet food.
- general feed for example, livestock feed or pet food.
- 100 g of the feed preferably contains 0.1 to 400 mg of sphingomyelin in order to administer 2 mg or more of sphingomyelin per day.
- the method for blending the sphingomyelin is not specifically limited.
- sphingomyelin when sphingomyelin is added to or blended in a solution, sphingomyelin may be used after prepared into a form of a medicine, food, or feed by suspending or dissolving a sphingomyelin raw material in deionized water and stirring and mixing the resulting mixture.
- the stirring and mixing may be conducted under any conditions as long as sphingomyelin can be uniformly mixed, and may be conducted with an ultradisperser or a TK homomixer.
- This sphingomyelin solution may be concentrated by using an RO membrane or may be dried by lyophilization, if necessary, in order to be readily used for a medicine, food, or feed.
- sterilization procedures which are generally conducted in the manufacturing of a medicine, food, or feed can be employed. If a product is in a form of powder, dry-heat sterilization can be also employed. Therefore, according to the present invention, a medicine, food, and feed containing the sphingomyelin can be manufactured in various forms such as a solution, gel, powder, or granules.
- a sphingomyelin raw material (Phospholac 500; manufactured by NZMP) containing 10% of sphingomyelins was dissolved in deionized water as shown in Table 1. The solution was heated to 50° C. and then mixed under stirring with an ultradisperser (ULTRA-TURRAXT-25; manufactured by IKA Japan) at 9500 rpm for 20 minutes to prepare Test Feeds 1 to 3.
- mice Five-week old CD-1 (ICR)-nu/nu mice were divided into the following 4 test groups (10 mice in each group), namely, (Group A) a group receiving 10 g of physiological saline per kg of mouse body weight, (Group B) a group receiving 10 g of the Test Feed 1 per kg of mouse body weight, (Group C) a group receiving 10 g of the Test Feed 2 per kg of mouse body weight, and (Group D) a group receiving 10 g of the Test Feed 3 per kg of mouse body weight. Mice in all the groups were fed by orally administering the feed once daily by gavage feeding for 4 weeks. Moisture contents and transepidermal water losses in the tail skin of each mouse were measured at the start and the end of the feeding.
- a reaction solution prepared by adding protease to an aqueous solution containing 10% of whey protein concentrate (WPC) was extracted with a solution of chloroform-methanol (2:1).
- the extract was concentrated and then was further extracted with acetone to obtain a complex lipid fraction.
- this complex lipid fraction was subjected to a florisil-column chromatography and eluted successively with chloroform-methanol solutions to obtain a fraction containing phospholipid.
- This phospholipid fraction was subjected to a silica-gel chromatography and eluted successively with chloroform-methanol solutions to obtain a fraction phospholipid.
- This fraction was lyophilized to obtain a sphingomyelin raw material.
- This sphingomyelin raw material was developed on a thin-layer chromatography, followed by color development with the Dittmer reagent. The sphingomyelin content was measured by densitometry to be 95.2%.
- This spingomyelin raw material can be used as a skin beautifier according to the present invention without modification.
- Raw materials were mixed at the blending quantities shown in Table 3, and then were made into tablets each weighing 1 g by a known method to manufacture the skin beautifier according to the present invention.
- sphingomyelin raw material ⁇ -Lipid; manufactured by NZMP
- TK homomixer manufactured by Tokushu Kika Kogyo
- This sphingomyelin solution (4.0 kg) was blended with 5.0 kg of casein, 5.0 kg of soy protein, 1.0 kg of fish oil, 3.0 kg of perilla oil, 18.0 kg of dextrin, 6.0 kg of mineral mixture, 1.95 kg of vitamin mixture, 2.0 kg of an emulsifier, 4.0 kg of a stabilizer, and 0.05 kg of flavoring, and the mixture was packed in 200-ml retort pouches. Then, sterilization by a retort sterilizer (First-class pressure vessel, TYPE: RCS-4CRTGN; manufactured by HISAKA WORKS) at 121° C. for 20 minutes was performed to manufacture 50 kg of a skin-beautifying liquid nutrition composition according to the present invention. In 100 g of this skin-beautifying liquid nutrition composition, 20 mg of sphingomyelin was contained.
- TYPE First-class pressure vessel, TYPE: RCS-4CRTGN; manufactured by HISAKA WORKS
- sphingomyelin raw material Phospholac 500; manufactured by NZMP
- sphingomyelin raw material Phospholac 500; manufactured by NZMP
- the solution was heated to 50° C. and then mixed under stirring with an ultradisperser (ULTRA-TURRAXT-25; manufactured by IKA Japan) at 9500 rpm for 30 minutes.
- an ultradisperser ULTRA-TURRAXT-25; manufactured by IKA Japan
- 40 g of sorbitol, 2 g of an acidifier, 2 g of flavoring, 5 g of pectin, 5 g of whey protein concentrate, 1 g of calcium lactate, and 235 g of deionized water were added.
- the mixture was stirred and mixed and then was packed in 200-ml pouches with a screw cap. After the sterilization at 85° C. for 20 minutes, the packs were hermetically sealed to prepare 5 bags (each 200 g) of skin-beautifying gel-type food according to the present invention. No precipitate was observed and no abnormal flavor was detected in all thus obtained skin-beautifying gel-type food. In 100 g of this skin-beautifying gel-type food, 100 mg of sphingomyelin was contained.
- the bottles were hermetically sealed to prepare 10 bottles (each 100 ml) of skin-beautifying drink according to the present invention. No precipitate was observed and no abnormal flavor was detected in all thus obtained skin-beautifying drink. In 100 g of this skin-beautifying drink, 250 mg of sphingomyelin was contained.
- SM-4 sphingomyelin raw material
- TK homomixer MLK II 160 type; manufactured by Kokusyu Kika Kogyo
- This sphingomyelin solution (10 kg) was blended with 12 kg of soybean cake, 14 kg of skimmed milk powder, 4 kg of soybean oil, 2 kg of corn oil, 23.2 kg of palm oil, 14 kg of corn starch, 9 kg of flour, 2 kg of bran, 5 kg of a vitamin mixture, 2.8 kg of cellulose, and 2 kg of a mineral mixture.
- the mixture was sterilized at 120° C. for 4 minutes to prepare 100 kg of skin-beautifying dog food according to the present invention. In 100 g of this skin-beautifying dog food, 8 mg of sphingomyelin was contained.
- the skin beautifier according to the present invention is safe because the effective ingredient is derived from food, and provides beauty effects, such as skin-moisturizing and protecting effects, skin-roughness-preventing and improving effects, and a wrinkle-preventing effect, by oral ingestion thereof.
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JP2004101142A JP2005281257A (ja) | 2004-03-30 | 2004-03-30 | 美肌剤 |
JP2004-101142 | 2004-03-30 | ||
PCT/JP2005/006030 WO2005094839A1 (ja) | 2004-03-30 | 2005-03-30 | 美肌剤 |
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US12/947,891 Division US8920822B2 (en) | 2004-03-30 | 2010-11-17 | Skin beautifier |
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US20080064664A1 true US20080064664A1 (en) | 2008-03-13 |
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US10/594,661 Abandoned US20080064664A1 (en) | 2004-03-30 | 2005-03-30 | Skin Beautifier |
US12/947,891 Expired - Fee Related US8920822B2 (en) | 2004-03-30 | 2010-11-17 | Skin beautifier |
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US12/947,891 Expired - Fee Related US8920822B2 (en) | 2004-03-30 | 2010-11-17 | Skin beautifier |
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US (2) | US20080064664A1 (de) |
EP (1) | EP1736159B1 (de) |
JP (1) | JP2005281257A (de) |
KR (1) | KR101094693B1 (de) |
CN (1) | CN1997376B (de) |
AU (1) | AU2005228742B2 (de) |
CA (1) | CA2561729C (de) |
DK (1) | DK1736159T3 (de) |
ES (1) | ES2402299T3 (de) |
HK (1) | HK1105361A1 (de) |
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Cited By (1)
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US20090312291A1 (en) * | 2006-08-04 | 2009-12-17 | Hiroshi Kawakami | Agent for preventing infection |
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EP1872668A4 (de) * | 2005-04-13 | 2009-07-29 | Snow Brand Milk Products Co Ltd | Nährstoffzusammensetzung |
JP5208428B2 (ja) * | 2007-01-30 | 2013-06-12 | 雪印メグミルク株式会社 | 美肌剤 |
US20120100222A1 (en) * | 2009-05-20 | 2012-04-26 | Yotsuba Milk Products Co., Ltd., | Skin function-improving composition |
JP5922862B2 (ja) * | 2010-02-03 | 2016-05-24 | 花王株式会社 | ミトコンドリア機能向上剤 |
JP5922863B2 (ja) * | 2010-02-03 | 2016-05-24 | 花王株式会社 | 運動機能改善剤 |
JP5818300B2 (ja) * | 2010-12-27 | 2015-11-18 | 雪印メグミルク株式会社 | ミルクセラミド含有食品及びその製造方法 |
SG11201700758SA (en) * | 2014-08-04 | 2017-02-27 | Meiji Co Ltd | Agent for promoting production of ceramide covalently bound to horny layer cell |
JP6225199B2 (ja) * | 2016-02-01 | 2017-11-01 | 花王株式会社 | 運動機能改善剤 |
JP7013619B2 (ja) * | 2019-12-26 | 2022-01-31 | マルハニチロ株式会社 | 多価不飽和脂肪酸が結合したリン脂質を含む魚卵脂質組成物 |
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US20060240115A1 (en) * | 2003-03-14 | 2006-10-26 | Yoshihiro Kanamaru | Composition against injection with and process for producting the same |
US7511010B2 (en) * | 2000-11-14 | 2009-03-31 | Laboratoires Expanscience | Pharmaceutical or cosmetic composition and use of a PKC inhibitor with an MMP inhibitor for inhibiting Langerhans' cell migration |
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2005
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- 2005-03-30 ES ES05727923T patent/ES2402299T3/es active Active
- 2005-03-30 AU AU2005228742A patent/AU2005228742B2/en not_active Ceased
- 2005-03-30 WO PCT/JP2005/006030 patent/WO2005094839A1/ja active Application Filing
- 2005-03-30 DK DK05727923.4T patent/DK1736159T3/da active
- 2005-03-30 KR KR1020067021806A patent/KR101094693B1/ko active IP Right Grant
- 2005-03-30 NZ NZ550269A patent/NZ550269A/en not_active IP Right Cessation
- 2005-03-30 CN CN200580010224XA patent/CN1997376B/zh not_active Expired - Fee Related
- 2005-03-30 PT PT57279234T patent/PT1736159E/pt unknown
- 2005-03-30 US US10/594,661 patent/US20080064664A1/en not_active Abandoned
- 2005-03-30 EP EP05727923A patent/EP1736159B1/de not_active Not-in-force
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2007
- 2007-10-04 HK HK07110734.3A patent/HK1105361A1/xx not_active IP Right Cessation
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Also Published As
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US20110065670A1 (en) | 2011-03-17 |
EP1736159A1 (de) | 2006-12-27 |
KR20070002062A (ko) | 2007-01-04 |
KR101094693B1 (ko) | 2011-12-20 |
EP1736159A4 (de) | 2009-07-29 |
AU2005228742B2 (en) | 2011-07-28 |
JP2005281257A (ja) | 2005-10-13 |
WO2005094839A1 (ja) | 2005-10-13 |
CN1997376A (zh) | 2007-07-11 |
HK1105361A1 (en) | 2008-02-15 |
PT1736159E (pt) | 2013-04-03 |
US8920822B2 (en) | 2014-12-30 |
CA2561729A1 (en) | 2005-10-13 |
CA2561729C (en) | 2013-10-15 |
ES2402299T3 (es) | 2013-04-30 |
EP1736159B1 (de) | 2013-01-09 |
DK1736159T3 (da) | 2013-02-11 |
NZ550269A (en) | 2010-05-28 |
AU2005228742A1 (en) | 2005-10-13 |
CN1997376B (zh) | 2011-05-11 |
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