US20070244113A1 - Compounds and therapeutical use thereof - Google Patents

Compounds and therapeutical use thereof Download PDF

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Publication number
US20070244113A1
US20070244113A1 US11/680,843 US68084307A US2007244113A1 US 20070244113 A1 US20070244113 A1 US 20070244113A1 US 68084307 A US68084307 A US 68084307A US 2007244113 A1 US2007244113 A1 US 2007244113A1
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US
United States
Prior art keywords
alkyl
methyl
independently
halo
amine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US11/680,843
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English (en)
Inventor
Sui Cai
Nilantha Sirisoma
Azra Pervin
John Drewe
Shailaja Kasibhatla
Songchun Jiang
Hong Zhang
Chris Pleiman
Vijay Baichwal
John Manfredi
Leena Bhoite
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Myrexis Inc
Cytovia Therapeutics LLC
Original Assignee
Myriad Genetics Inc
Cytovia Inc
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Publication date
Application filed by Myriad Genetics Inc, Cytovia Inc filed Critical Myriad Genetics Inc
Priority to US11/680,843 priority Critical patent/US20070244113A1/en
Publication of US20070244113A1 publication Critical patent/US20070244113A1/en
Assigned to MYRIAD PHARMACEUTICALS, INC. reassignment MYRIAD PHARMACEUTICALS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: MYRIAD GENETICS, INC.
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
US11/680,843 2003-07-03 2007-03-01 Compounds and therapeutical use thereof Abandoned US20070244113A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US11/680,843 US20070244113A1 (en) 2003-07-03 2007-03-01 Compounds and therapeutical use thereof

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US48432503P 2003-07-03 2003-07-03
US49300603P 2003-08-07 2003-08-07
US55755604P 2004-03-29 2004-03-29
US57128804P 2004-05-14 2004-05-14
US10/885,903 US7618975B2 (en) 2003-07-03 2004-07-06 4-arylamino-quinazolines and analogs as activators of caspases and inducers of apoptosis and the use thereof
US11/680,843 US20070244113A1 (en) 2003-07-03 2007-03-01 Compounds and therapeutical use thereof

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US10/885,903 Continuation US7618975B2 (en) 2003-07-03 2004-07-06 4-arylamino-quinazolines and analogs as activators of caspases and inducers of apoptosis and the use thereof

Publications (1)

Publication Number Publication Date
US20070244113A1 true US20070244113A1 (en) 2007-10-18

Family

ID=33568832

Family Applications (7)

Application Number Title Priority Date Filing Date
US10/885,903 Expired - Fee Related US7618975B2 (en) 2003-07-03 2004-07-06 4-arylamino-quinazolines and analogs as activators of caspases and inducers of apoptosis and the use thereof
US11/620,498 Abandoned US20070208044A1 (en) 2003-07-03 2007-01-05 Compounds and therapeutical use thereof
US11/680,843 Abandoned US20070244113A1 (en) 2003-07-03 2007-03-01 Compounds and therapeutical use thereof
US11/693,432 Abandoned US20070249601A1 (en) 2003-07-03 2007-03-29 Compounds and therapeutical use thereof
US11/779,086 Abandoned US20080032974A1 (en) 2003-07-03 2007-07-17 Compounds and therapeutical use thereof
US11/781,660 Abandoned US20080039479A1 (en) 2003-07-03 2007-07-23 Compounds and therapeutical use thereof
US15/081,530 Abandoned US20170050937A1 (en) 2003-07-03 2016-03-25 Compounds and therapeutical use thereof

Family Applications Before (2)

Application Number Title Priority Date Filing Date
US10/885,903 Expired - Fee Related US7618975B2 (en) 2003-07-03 2004-07-06 4-arylamino-quinazolines and analogs as activators of caspases and inducers of apoptosis and the use thereof
US11/620,498 Abandoned US20070208044A1 (en) 2003-07-03 2007-01-05 Compounds and therapeutical use thereof

Family Applications After (4)

Application Number Title Priority Date Filing Date
US11/693,432 Abandoned US20070249601A1 (en) 2003-07-03 2007-03-29 Compounds and therapeutical use thereof
US11/779,086 Abandoned US20080032974A1 (en) 2003-07-03 2007-07-17 Compounds and therapeutical use thereof
US11/781,660 Abandoned US20080039479A1 (en) 2003-07-03 2007-07-23 Compounds and therapeutical use thereof
US15/081,530 Abandoned US20170050937A1 (en) 2003-07-03 2016-03-25 Compounds and therapeutical use thereof

Country Status (9)

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US (7) US7618975B2 (US20070244113A1-20071018-C00204.png)
EP (1) EP1660092A2 (US20070244113A1-20071018-C00204.png)
JP (2) JP5129957B2 (US20070244113A1-20071018-C00204.png)
KR (1) KR101218213B1 (US20070244113A1-20071018-C00204.png)
CN (1) CN1984660B (US20070244113A1-20071018-C00204.png)
AU (1) AU2004253967B2 (US20070244113A1-20071018-C00204.png)
CA (1) CA2531327A1 (US20070244113A1-20071018-C00204.png)
NZ (1) NZ544472A (US20070244113A1-20071018-C00204.png)
WO (1) WO2005003100A2 (US20070244113A1-20071018-C00204.png)

Cited By (10)

* Cited by examiner, † Cited by third party
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US20070244114A1 (en) * 2004-07-06 2007-10-18 Myriad Genetics, Incorporated Compounds and therapeutical use thereof
US20080004297A1 (en) * 2003-07-03 2008-01-03 Myriad Genetics, Inc. Compounds and therapeutical use thereof
US20080032974A1 (en) * 2003-07-03 2008-02-07 Myriad Genetics, Incorporated Compounds and therapeutical use thereof
US20080051398A1 (en) * 2005-01-03 2008-02-28 Myriad Genetics, Inc. Method of treating brain cancer
US20080319048A1 (en) * 2007-06-22 2008-12-25 Scidose Llc Solubilized formulation of docetaxel without tween 80
US7772274B1 (en) 2009-10-19 2010-08-10 Scidose, Llc Docetaxel formulations with lipoic acid
US20110092579A1 (en) * 2009-10-19 2011-04-21 Scidose Llc Solubilized formulation of docetaxel
US20110092580A1 (en) * 2009-10-19 2011-04-21 Scidose Llc Docetaxel formulations with lipoic acid and/or dihydrolipoic acid
US8309562B2 (en) 2003-07-03 2012-11-13 Myrexis, Inc. Compounds and therapeutical use thereof
US8912228B2 (en) 2009-10-19 2014-12-16 Scidose Llc Docetaxel formulations with lipoic acid

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KR20060079121A (ko) * 2004-12-31 2006-07-05 에스케이케미칼주식회사 당뇨 및 비만 치료예방에 유효한 퀴나졸린 유도체
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JP2009501232A (ja) * 2005-07-15 2009-01-15 シェーリング コーポレイション 癌の処置に有用なキナゾリン誘導体
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US20050137213A1 (en) 2005-06-23
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US7618975B2 (en) 2009-11-17
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