US20060194057A1 - Silicon dioxide-coated nanoparticulate uv protectant - Google Patents

Silicon dioxide-coated nanoparticulate uv protectant Download PDF

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US20060194057A1
US20060194057A1 US10/565,214 US56521404A US2006194057A1 US 20060194057 A1 US20060194057 A1 US 20060194057A1 US 56521404 A US56521404 A US 56521404A US 2006194057 A1 US2006194057 A1 US 2006194057A1
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nanoparticulate
protectant
composition
acid
range
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Frank Pfluecker
Bernd Hirthe
Heike Saenger
Stephan John
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Merck Patent GmbH
Venator Germany GmbH
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Merck Patent GmbH
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Publication of US20060194057A1 publication Critical patent/US20060194057A1/en
Priority to US12/432,949 priority Critical patent/US8758501B2/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/046—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/29—Titanium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09C—TREATMENT OF INORGANIC MATERIALS, OTHER THAN FIBROUS FILLERS, TO ENHANCE THEIR PIGMENTING OR FILLING PROPERTIES ; PREPARATION OF CARBON BLACK  ; PREPARATION OF INORGANIC MATERIALS WHICH ARE NO SINGLE CHEMICAL COMPOUNDS AND WHICH ARE MAINLY USED AS PIGMENTS OR FILLERS
    • C09C1/00—Treatment of specific inorganic materials other than fibrous fillers; Preparation of carbon black
    • C09C1/36—Compounds of titanium
    • C09C1/3607—Titanium dioxide
    • C09C1/3653—Treatment with inorganic compounds
    • C09C1/3661—Coating
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09C—TREATMENT OF INORGANIC MATERIALS, OTHER THAN FIBROUS FILLERS, TO ENHANCE THEIR PIGMENTING OR FILLING PROPERTIES ; PREPARATION OF CARBON BLACK  ; PREPARATION OF INORGANIC MATERIALS WHICH ARE NO SINGLE CHEMICAL COMPOUNDS AND WHICH ARE MAINLY USED AS PIGMENTS OR FILLERS
    • C09C3/00—Treatment in general of inorganic materials, other than fibrous fillers, to enhance their pigmenting or filling properties
    • C09C3/06—Treatment with inorganic compounds
    • C09C3/063—Coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/413—Nanosized, i.e. having sizes below 100 nm
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2004/00—Particle morphology
    • C01P2004/60—Particles characterised by their size
    • C01P2004/64—Nanometer sized, i.e. from 1-100 nanometer
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2004/00—Particle morphology
    • C01P2004/80—Particles consisting of a mixture of two or more inorganic phases
    • C01P2004/82—Particles consisting of a mixture of two or more inorganic phases two phases having the same anion, e.g. both oxidic phases
    • C01P2004/84—Particles consisting of a mixture of two or more inorganic phases two phases having the same anion, e.g. both oxidic phases one phase coated with the other
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y10T428/2993—Silicic or refractory material containing [e.g., tungsten oxide, glass, cement, etc.]

Definitions

  • the present invention relates to nanoparticulate UV protectants, to the preparation and use thereof.
  • the present invention furthermore relates to novel compositions for topical application which are intended, in particular, for light protection of the skin and/or the hair against UV radiation (compositions which are referred to below simply as sunscreen compositions), and to the use thereof in the above-mentioned cosmetic application.
  • the human epidermis can be tanned by light radiation having a wavelength in the range from 280 to 400 nm and that radiation having a wavelength in the range from 280 to 320 nm, which is known under the term UV-B, causes erythema and skin burning, which may be detrimental to the formation of a natural tan.
  • the UV-B radiation should therefore be filtered out.
  • UV-A radiation having a wavelength in the range from 320 to 400 nm, which tans the skin, can cause a change in the skin, in particular in the case of sensitive skin or skin which is exposed continuously to sunlight.
  • UV-A radiation causes, in particular, a loss in skin elasticity and wrinkling, which results in premature ageing. It favours the triggering of erythema formation or increases this reaction in some people, and it can even be the cause of toxic or allergic reactions triggered by light. It is therefore desirable also to filter out the UV-A radiation.
  • a group of UV-A filters which is particularly interesting in this respect currently consists of dibenzoylmethane derivatives, in particular 4,4′-methoxy-tert-butyldibenzoylmethane, which have a strong intrinsic absorption capacity.
  • dibenzoylmethane derivatives which are currently well-known products per se as filters which are effective in the UV-A region, are described, in particular, in the French patent applications FR-A-2 326 405 and FR-A-2 440 933 and in European patent application EP-A-0 114 607.
  • 4,4′-Methoxy-tert-butyldibenzoylmethane is in addition currently commercially available from Merck under the trade name Eusolex® 9020.
  • dibenzoylmethane derivatives can be combined with a UV-B filter in order to obtain complete protection over the entire spectrum of sunlight in the UV region.
  • Japanese patent application JP61-215314 recommended the use of masking agents selected from edetic acid, metaphosphoric acid, polyphosphoric acid and/or the salts of these acids in order to reduce the phenomenon of the yellow coloration.
  • this solution is not entirely satisfactory.
  • the specification WO-A-94/04131 discloses light-stable filter compositions which comprise a dibenzoylmethane derivative in combination with a benzylidenecamphor derivative in well-defined proportions.
  • the dibenzoylmethane derivative can be stabilised to light by the benzylidenecamphor in the stated proportions, i.e. its decomposition under the action of UV radiation and in particular UV-A radiation can be restricted.
  • these photostable compositions may furthermore comprise an organic pigment which blocks UV radiation and in particular a titanium dioxide pigment, which may be coated with a compound and in particular with a silicone-containing compound.
  • the present invention firstly relates to a nanoparticulate UV protectant which has a silicon dioxide coating which is obtainable by hydrothermal treatment of a nanoparticulate metal oxide and subsequent application of a silicon dioxide coating.
  • Hydrothermal treatment is taken to mean the heating of an aqueous solution or suspension or dispersion in a closed container, optionally under pressure (cf. also Ullmanns Enzyklopädie der Technischen Chemie [Ullmann's Encyclopaedia of Industrial Chemistry], 4th Edition, 1978, Volume 15, pp. 117 ff: K. Recker, The Growing of Single Crystals).
  • a nanoparticulate UV protectant is preferably taken to mean a nanoparticulate metal oxide with silicon dioxide coating.
  • the crystallite size of the nanoparticulate metal oxide in the nanoparticulate UV protectant is usually in the range from 5 nm to 100 nm, preferably in the range from 8 to 50 nm and particularly preferably below 25 nm.
  • the dimensions of the nanoparticulate metal oxide which can be determined in a transmission electron microscope, are usually at a length of 5 to 150 nm and a width of 5 to 60 nm. The length is preferably in the range from 20 to 60 nm and the width in the range from 8 to 30 nm.
  • the nanoparticulate metal oxides used here for the use according to the invention are, in particular, titanium dioxide, iron oxides, zinc oxide or also cerium oxides, where titanium dioxide is particularly preferred in accordance with the invention as metal oxide since it achieves the objects according to the invention in a particular manner.
  • Titanium dioxide can be in rutile or anatase form or in amorphous form, but preferably in rutile and/or anatase form here.
  • the preferred primary particle size is in the range from 5 to 50 nm.
  • the primary particles here, in particular in the case of anatase are preferably round, while rutile primary particles frequently occur in needle or spindle form right up to ovals (“egg-shaped”). However, round rutile primary particles can also be employed in accordance with the invention.
  • the silicon dioxide coating should cover the nanoparticulate metal oxide as completely as possible and, since it is, however, inert as UV filter, should nevertheless not be present in excessive amounts. It has been found that it is advantageous for the silicon dioxide content, based on the nanoparticulate UV protectant as a whole, to be 5 to 50% by weight, preferably 8 to 30% by weight and particularly preferably 12 to 20% by weight.
  • the resultant nanoparticulate UV protectant usually exhibits a particle size determined by the Scherrer method in the range from 5 nm to 100 nm, preferably in the range from 8 to 50 nm and particularly preferably below 25 nm.
  • the dimensions of the nanoparticulate UV protectant which can be determined in a transmission electron microscope, are usually at a length of 5 to 160 nm and a width of 10 to 70 nm. The length is preferably in the range from 30 to 70 nm and the width in the range from 18 to 40 nm.
  • the nanoparticulate metal oxide is doped with cerium or iron, preferably iron.
  • the nanoparticulate metal oxide is free from dopants.
  • the nanoparticulate UV protectants having the properties according to the invention are obtained, for example, if a certain preparation process is observed.
  • the present invention furthermore relates to a process for the preparation of a nanoparticulate metal oxide having light-protection properties which is characterised in that
  • the nanoparticulate metal oxide employed in step a) may be a nanoparticulate titanium dioxide, which may preferably be doped with iron.
  • the hydrothermal treatment here is preferably carried out at temperatures in the range from 40 to 360° C., preferably in the range from 80 to 220° C. and particularly preferably in the range from 140 to 200° C.
  • the hydrothermal treatment results in the formation of stable nanocrystallites of uniform size and shape.
  • “needle-shaped” crystallites form.
  • the crystallites With increasing temperature, the crystallites become rounded.
  • Oval shapes form which become round particles at very high temperatures.
  • uniform crystal growth occurs, which results in a reduction in the reactivity and photoactivity.
  • the silicon dioxide coating in step b) is preferably carried out as a sol-gel process, in which a water-glass solution is particularly preferably added to a suspension of the metal oxide.
  • the sol-gel process here is carried out with the pH kept constant.
  • step b) is carried out at elevated temperature, preferably at a temperature in the range from 50° C. to 110° C.
  • a maturing time after the coating is complete is advantageous.
  • the maturing time should be between 1 h and 8 h, preferably 2 h to 4 h, and should be carried out at a temperature of 50° C. to 110° C.
  • the present invention furthermore relates to a composition having light-protection properties which comprises at least one nanoparticulate UV protectant according to the invention.
  • compositions are preferably compositions which can be applied topically, for example cosmetic or dermatological formulations.
  • the compositions in this case comprise a cosmetically or dermatologically suitable carrier and, depending on the desired property profile, optionally further suitable ingredients.
  • compositions which are preferred in accordance with the invention are selected from the group consisting of fibres, textiles, including coatings thereof, paints, coating systems, films and packaging for the protection of foods, plants or industrial products.
  • the present invention furthermore relates to the use of a nanoparticulate UV protectant according to the invention or of a nanoparticulate UV protectant prepared by a process according to the invention for incorporation into paints, coating systems, films, packaging, fibres, textiles and rubber or silicone rubber mouldings, such as tyres or insulators.
  • the use of the nanoparticulate UV protectants according to the invention in compositions which are emulsions can, in particular, also contribute towards stabilisation of the emulsion. In general, this can reduce the use of emulsifiers or, in an individual case (Pickering emulsion), even obviate the use of emulsifiers entirely. Preference is therefore also given in accordance with the invention to emulsifier-free emulsions which comprise the nanoparticulate UV protectants according to the invention.
  • compositions having light-protection properties comprise at least one dibenzoylmethane derivative.
  • the dibenzoylmethane derivatives used for the purposes of the present invention are, as already indicated, products which are already well known per se and which are described, in particular, in the abovementioned specifications FR-A-2 326 405, FR-A-2 440 933 and EP-A-0 114 607.
  • the dibenzoylmethane derivatives which can be used in accordance with the invention can be selected, in particular, from the dibenzoylmethane derivatives of the following formula: in which R 1 , R 2 , R 3 and R 4 , which are identical or different from one another, denote hydrogen, a straight-chain or branched C 1-8 -alkyl group or a straight-chain or branched C 1-8 -alkoxy group.
  • R 1 , R 2 , R 3 and R 4 which are identical or different from one another, denote hydrogen, a straight-chain or branched C 1-8 -alkyl group or a straight-chain or branched C 1-8 -alkoxy group.
  • R 1 , R 2 , R 3 and R 4 which are identical or different from one another, denote hydrogen, a straight-chain or branched C 1-8 -alkyl group or a straight-chain or branched C 1-8 -alkoxy group.
  • a further dibenzoylmethane derivative which is preferred in accordance with the invention is 4-isopropyldibenzoylmethane.
  • compositions having light-protection properties comprise at least one benzophenone or benzophenone derivative, such as, particularly preferably, 2-hydroxy-4-methoxybenzophenone (for example Eusolex® 4360) or 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid and the sodium salt thereof (for example Uvinul® MS-40).
  • benzophenone or benzophenone derivative such as, particularly preferably, 2-hydroxy-4-methoxybenzophenone (for example Eusolex® 4360) or 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid and the sodium salt thereof (for example Uvinul® MS-40).
  • the dibenzoylmethane derivative(s) or the benzophenone derivative(s) may be present in the compositions according to the invention in proportions which are generally in the range from 0.1 to 10% by weight and preferably in proportions which are in the range from 0.3 to 5% by weight, where these proportions are based on the total weight of the composition.
  • the present invention furthermore also relates to the use of a nanoparticulate metal oxide having light-protection properties according to the invention for the stabilisation of UV filters, in particular dibenzoylmethane and dibenzoylmethane derivatives or benzophenone and benzophenone derivatives.
  • compositions may furthermore be preferred in accordance with the invention for the compositions to comprise further inorganic UV filters.
  • titanium dioxides such as, for example, coated titanium dioxide (for example Eusolex® T-2000, Eusolex® T-AQUA), zinc oxides (for example Sachtotec®), iron oxides, also cerium oxides.
  • These inorganic UV filters are generally incorporated into cosmetic compositions in an amount of 0.5 to 20 percent by weight, preferably 2-10%.
  • a nanoparticulate UV protectant according to the invention to be present in one phase in emulsions and a further inorganic UV filter to be present in the other phase.
  • composition according to the invention comprises at least one self-tanning agent.
  • juglone 5-hydroxy-1,4-naphthoquinone
  • lawsone 2-hydroxy-1,4-naphthoquinone
  • DHA 1,3-dihydroxyacetone
  • the present invention furthermore relates to the use of a nanoparticulate UV protectant according to the invention for the stabilisation of self-tanning agents, in particular dihydroxyacetone or dihydroxyacetone derivatives.
  • compositions according to the invention may also comprise dyes and coloured pigments.
  • the dyes and coloured pigments can be selected from the corresponding positive list in the German Cosmetics Regulation or the EC list of cosmetic colorants. In most cases, they are identical with the dyes approved for foods.
  • Advantageous coloured pigments are, for example, titanium dioxide, mica, iron oxides (for example Fe 2 O 3 , Fe 3 O 4 , FeO(OH)) and/or tin oxide.
  • Advantageous dyes are, for example, carmine, Berlin Blue, Chromium Oxide Green, Ultramarine Blue and/or Manganese Violet. It is particularly advantageous to select the dyes and/or coloured pigments from the following list.
  • oil-soluble natural dyes such as, for example, paprika extract, ⁇ -carotene or cochineal.
  • gel creams comprising pearlescent pigments.
  • pearlescent pigments Particular preference is given to the types of pearlescent pigment listed below:
  • the basis for pearlescent pigments is formed by, for example, pulverulent pigments or castor oil dispersions of bismuth oxychloride and/or titanium dioxide as well as bismuth oxychloride and/or titanium dioxide on mica.
  • the lustre pigment listed under CIN 77163, for example, is particularly advantageous.
  • pearlescent pigment types based on mica/metal oxide Group Coating/layer thickness Colour Silver-white pearlescent TiO 2 : 40-60 nm silver pigments Interference pigments TiO 2 : 60-80 nm yellow TiO 2 : 80-100 nm red TiO 2 : 100-140 nm blue TiO 2 : 120-160 nm green Coloured lustre pigments Fe 2 O 3 bronze Fe 2 O 3 copper Fe 2 O 3 red Fe 2 O 3 red-violet Fe 2 O 3 red-green Fe 2 O 3 black Combination pigments TiO 2 /Fe 2 O 3 gold shades TiO 2 /Cr 2 O 3 green TiO 2 /Berlin Blue dark blue
  • pearlescent pigments available from Merck under the trade names Timiron, Colorona or Dichrona.
  • pearlescent pigments which are advantageous for the purposes of the present invention can be obtained by numerous routes known per se.
  • other substrates apart from mica can also be coated with further metal oxides, such as, for example, silica and the like.
  • TiO 2 - and Fe 2 O 3 -coated SiO 2 particles (“Ronasphere” grades), which are marketed by Merck and are particularly suitable for the optical reduction of fine wrinkles, are advantageous.
  • a substrate such as mica.
  • pearlescent pigments prepared using SiO 2 are available, for example, from BASF under the trade name Sicopearl Fantastico.
  • Engelhard/Mearl pigments based on calcium sodium borosilicate coated with titanium dioxide. These are available under the name Reflecks. Due to their particle size of 40-80 ⁇ m, they have a glitter effect in addition to the colour.
  • effect pigments available from Flora Tech under the trade name Metasomes Standard/Glitter in various colours (yellow, red, green, blue).
  • the glitter particles here are in the form of mixtures with various assistants and dyes (such as, for example, the dyes with the colour index (CI) numbers 19140, 77007, 77289, 77491).
  • the dyes and pigments can be in individual form or in the form of a mixture and mutually coated with one another, with different colour effects generally being caused by different coating thicknesses.
  • the total amount of dyes and colouring pigments is advantageously selected from the range from, for example, 0.1% by weight to 30% by weight, preferably from 0.5 to 15% by weight, in particular from 1.0 to 10% by weight, in each case based on the total weight of the compositions.
  • the nanoparticulate UV protectants may also be provided with a surface treatment which strengthens the hydrophilic or hydrophobic properties.
  • Suitable for hydrophobic modification is, for example, a silicone or silane coating.
  • the silicones are, as is known, organosilicon polymers or oligomers having a straight-chain or cyclic, branched or crosslinked structure with various molecular weights which are obtained by polymerisation and/or polycondensation of suitably functionalised silanes and are essentially formed from recurring main units in which the silicon atoms are linked to one another via oxygen atoms (siloxane bond), where optionally substituted hydrocarbon groups are bonded directly to the silicon atoms via a carbon atom.
  • the commonest hydrocarbon groups are the alkyl groups and in particular methyl, the fluoroalkyl groups, the aryl groups and in particular phenyl and the alkenyl groups and in particular vinyl.
  • Further types of group which can be bonded to the siloxane chain either directly or via a hydrocarbon group are, in particular, hydrogen, the halogens and in particular chlorine, bromine or fluorine, the thiols, the alkoxy groups, the polyoxyalkylene groups (or polyethers) and in particular polyoxyethylene and/or polyoxypropylene, hydroxyl groups or hydroxyalkyl groups, the optionally substituted amino groups, the amide groups, the acyloxy groups or acyloxyalkyl groups, the hydroxyalkylamino groups or aminoalkyl groups, quaternary ammonium groups, amphoteric groups or betaine groups, anionic groups, such as carboxylates, thioglycolates, sulfosuccinates, thiosulfates, phosphates and sulfates, where this list is of course in no way limiting (so-called ‘organo-modified’ silicones).
  • sicones is also intended to encompass and cover the silanes and in particular the alkylsilanes required for their preparation.
  • the silicones which are suitable for the present invention, which can be used for sheathing the nanoparticulate UV protectants, are preferably selected from the alkylsilanes, the polydialkylsiloxanes and the polyalkylhydrogenosiloxanes.
  • the silicones are more preferably selected from octyltrimethylsilane, the polydimethylsiloxanes and the polymethylhydrogenosiloxanes.
  • the nanoparticulate UV protectants can be present in the compositions according to the invention in proportions which are generally in the range from 0.1 to 50% by weight and preferably in proportions which are in the range from 0.5 to 20% by weight, where these proportions are based on the total weight of the composition.
  • the sunscreen compositions according to the invention may of course comprise one or more additional hydrophilic or lipophilic sunscreen filters which are effective in the UV-A region and/or UV-B region and/or IR and/or VIS region (absorbers).
  • additional filters can be selected, in particular, from cinnamic acid derivatives, salicylic acid derivatives, camphor derivatives, triazine derivatives, ⁇ , ⁇ -diphenyl acrylate derivatives, p-aminobenzoic acid derivatives and polymeric filters and silicone filters, which are described in the application WO 93/04665. Further examples of organic filters are indicated in patent application EP-A 0 487 404.
  • UV filters are suitable for combination with the nanoparticulate UV protectants according to the invention. Particular preference is given to UV filters whose physiological acceptability has already been demonstrated. Both for UVA and UVB filters, there are many proven substances which are known from the specialist literature, for example
  • benzylidenecamphor derivatives such as 3-(4′-methylbenzylidene)-dl-camphor (for example Eusolex® 6300), 3-benzylidenecamphor (for example Mexoryl® SD), polymers of N- ⁇ (2 and 4)-[(2-oxoborn-3-ylidene)methyl]benzyl ⁇ acrylamide (for example Mexoryl® SW), N,N,N-trimethyl-4-(2-oxoborn-3-ylidenemethyl)anilinium methylsulfate (for example Mexoryl® SK) or (2-oxoborn-3-ylidene)toluene-4-sulfonic acid (for example Mexoryl® SL),
  • 3-(4′-methylbenzylidene)-dl-camphor for example Eusolex® 6300
  • 3-benzylidenecamphor for example Mexoryl® SD
  • methoxycinnamic acid esters such as octyl methoxycinnamate (for example Eusolex® 2292), isopentyl 4-methoxycinnamate, for example as a mixture of the isomers (for example Neo Heliopan® E 1000),
  • salicylate derivatives such as 2-ethylhexyl salicylate (for example Eusolexe OS), 4-isopropylbenzyl salicylate (for example Megasol®) or 3,3,5-trimethylcyclohexyl salicylate (for example Eusolex® HMS),
  • 4-aminobenzoic acid and derivatives such as 4-aminobenzoic acid, 2-ethylhexyl 4-(dimethylamino)benzoate (for example Eusolex® 6007), ethoxylated ethyl 4-aminobenzoate (for example Uvinul® P25),
  • phenylbenzimidazolesulfonic acids such as 2-phenylbenzimidazole-5-sulfonic acid and the potassium, sodium and triethanolamine salts thereof (for example Eusolex® 232), 2,2-(1,4-phenylene)bisbenzimidazole-4,6-disulfonic acid and salts thereof (for example Neoheliopan® AP) or 2,2-(1,4-phenylene)bisbenzimidazole-6-sulfonic acid;
  • organic UV filters are generally incorporated into cosmetic formulations in an amount of 0.5 to 20 percent by weight, preferably 1-10% by weight.
  • organic UV filters are, for example,
  • Organic UV filters are generally incorporated into cosmetic formulations in a total amount of 0.5 to 20 percent by weight, preferably 1-15%.
  • Preferred compounds having UV-filtering properties are 3-(4′-methylbenzylidene)-dl-camphor, 1-(4-tert-butylphenyl)-3-(4-methoxyphenyl)propane-1,3-dione, 4-isopropyldibenzoylmethane, 2-hydroxy-4-methoxybenzophenone, octyl methoxycinnamate, 3,3,5-trimethylcyclohexyl salicylate, 2-ethylhexyl 4-(dimethylamino)benzoate, 2-ethylhexyl 2-cyano-3,3-diphenylacrylate, 2-phenylbenzimidazole-5-sulfonic acid and the potassium, sodium and triethanolamine salts thereof.
  • compositions may also comprise compounds of the formula I
  • compositions according to the invention are, in particular, the UV light-filtering action and the good toleration by the skin.
  • the compounds of the formula I described here are colourless or only weakly coloured and thus, in contrast to many known naturally occurring flavonoids, do not result in discoloration of the compositions.
  • compositions according to the invention having light-protection properties comprise at least one compound of the formula I, where R 3 stands for
  • R 3 stands for straight-chain or branched C 1 - to C 20 -alkoxy groups, preferably methoxy, ethoxy or ethylhexyloxy
  • R 8 and R 9 are identical and stand for H or straight-chain or branched C 1 - to C 20 -alkoxy groups, preferably methoxy, ethoxy or ethylhexyloxy.
  • compositions having light-protection properties comprising at least one compound of the formula I which is characterised in that R 3 stands for straight-chain or branched C 1 - to C 20 -alkoxy groups, preferably methoxy, ethoxy or ethylhexyloxy, and R 8 and R 9 are identical and stand for H or straight-chain or branched C 1 - to C 20 -alkoxy groups, preferably methoxy, ethoxy or ethylhexyloxy. It is particularly preferred here if R 8 and R 9 stand for H.
  • the compounds of the formula I are typically employed in accordance with the invention in amounts of 0.01 to 20% by weight, preferably in amounts of 0.5% by weight to 10% by weight and particularly preferably in amounts of 1 to 8% by weight.
  • the person skilled in the art is presented with absolutely no difficulties at all in correspondingly selecting the amounts depending on the intended light protection factor of the composition.
  • compositions may comprise, for example, the combination of the organic UV filters 4′-methoxy-6-hydroxyflavone with 1-(4-tert-butylphenyl)-3-(4-methoxyphenyl)propane-1,3-dione and 3-(4′-methylbenzylidene)-di-camphor.
  • UV filters including the compounds of the formula I can also be employed in encapsulated form.
  • organic UV filters in encapsulated form.
  • one or more of the compounds of the formula I or the above-mentioned UV filters may therefore be preferred in accordance with the invention for one or more of the compounds of the formula I or the above-mentioned UV filters to be in encapsulated form. It is advantageous here for the capsules to be so small that they cannot be observed with the naked eye. In order to achieve the above-mentioned effects, it is furthermore necessary for the capsules to be sufficiently stable and the encapsulated active ingredient (UV filter) only to be released to the environment to a small extent, or not at all.
  • UV filter encapsulated active ingredient
  • Suitable capsules can have walls of inorganic or organic polymers.
  • U.S. Pat. No. 6,242,099 B1 describes the production of suitable capsules with walls of chitin, chitin derivatives or polyhydroxylated polyamines.
  • Capsules particularly preferably to be employed in accordance with the invention have walls which can be obtained by a sol-gel process, as described in the applications WO 00/09652, WO 00/72806 and WO 00/71084. Preference is in turn given here to capsules whose walls are built up from silica gel (silica; undefined silicon oxide hydroxide).
  • silica gel silica gel
  • the production of corresponding capsules is known to the person skilled in the art, for example from the cited patent applications, whose contents expressly also belong to the subject-matter of the present application.
  • the capsules are preferably present in compositions according to the invention in amounts which ensure that the encapsulated UV filters are present in the composition in the above-indicated amounts.
  • compositions according to the invention comprise compounds of the formula I containing free hydroxyl groups, they additionally, besides the properties described, exhibit an action as antioxidant and/or free-radical scavenger. Preference is therefore also given to compositions having light-protection properties comprising at least one compound of the formula I which is characterised in that at least one of the radicals R 1 to R 3 stands for OH, preferably with at least one of the radicals R 1 or R 2 standing for OH.
  • the compounds of the formula I are able to develop their positive action as free-radical scavengers particularly well on the skin, it may be preferred to allow the compounds of the formula I to penetrate into deeper skin layers.
  • the compounds of the formula I can have an adequate lipophilicity in order to be able to penetrate through the outer skin layer into epidermal layers.
  • corresponding transport agents for example liposomes, which enable transport of the compounds of the formula I through the outer skin layers may also be provided in the composition.
  • systemic transport of the compounds of the formula I is also conceivable.
  • the composition is then designed, for example, in such a way that it is suitable for oral administration.
  • the substances of the formula I act as free-radical scavengers.
  • Free radicals of this type are not generated only by sunlight, but instead are formed under various conditions. Examples are anoxia, which blocks the flow of electrons upstream of the cytochrome oxidases and causes the formation of superoxide free-radical anions; inflammation associated, inter alia, with the formation of superoxide anions by the membrane NADPH oxidase of the leucocytes, but also associated with the formation (through disproportionation in the presence of iron(II) ions) of the hydroxyl free radicals and other reactive species which are normally involved in the phenomenon of phagocytosis; and lipid autoxidation, which is generally initiated by a hydroxyl free radical and produces lipidic alkoxy free radicals and hydroperoxides.
  • preferred compounds of the formula I also act as enzyme inhibitors. They are thought to inhibit histidine decarboxylase, protein kinases, elastase, aldose reductase and hyaluronidase, and therefore enable the intactness of the basic substance of vascular sheaths to be maintained. Furthermore, they are thought to inhibit catechol O-methyl transferase non-specifically, causing the amount of available catecholamines and thus the vascular strength to be increased. Furthermore, they inhibit AMP phosphodiesterase, giving the substances potential for inhibiting thrombocyte aggregation.
  • compositions according to the invention are, in general, suitable for immune protection and for the protection of DNA and RNA.
  • the compositions are suitable for the protection of DNA and RNA against oxidative attack, against free radicals and against damage due to radiation, in particular UV radiation.
  • a further advantage of the compositions according to the invention is cell protection, in particular protection of Langerhans cells against damage due to the above-mentioned influences.
  • the present invention also expressly relates to all these uses and to the use of the compounds of the formula I for the preparation of compositions which can be employed correspondingly.
  • compositions according to the invention are also suitable for the treatment of skin diseases associated with a defect in keratinisation which affects differentiation and cell proliferation, in particular for the treatment of acne vulgaris, acne comedonica, polymorphic acne, acne rosaceae, nodular acne, acne conglobata, age-induced acne, acne which arises as a side effect, such as acne solaris, medicament-induced acne or acne professionalis, for the treatment of other defects in keratinisation, in particular ichthyosis, ichthyosiform states, Darier's disease, keratosis palmoplantaris, leucoplasia, leucoplasiform states, herpes of the skin and mucous membrane (buccal) (lichen), for the treatment of other skin diseases associated with a defect in keratinisation and which have an inflammatory and/or immunoallergic component and in particular all forms of psoriasis which affect the skin, mucous membranes and fingers and toenails, and ps
  • compositions comprise one or more antioxidants.
  • the composition is therefore a composition for the protection of body cells against oxidative stress, in particular for reducing skin ageing, characterised in that it preferably comprises one or more antioxidants.
  • antioxidants for example amino acids (for example glycine, histidine, tyrosine, tryptophan) and derivatives thereof, imidazoles (for example urocanic acid) and derivatives thereof, peptides, such as D,L-carnosine, D-carnosine, L-carnosine and derivatives thereof (for example anserine), carotinoids, carotenes (for example ⁇ -carotene, ⁇ -carotene, lycopene) and derivatives thereof, chlorogenic acid and derivatives thereof, lipoic acid and derivatives thereof (for example dihydrolipoic acid), aurothioglucose, propylthiouracil and other thiols (for example thioredoxin, glutathione, cysteine, cystine, cystamine and the glycosyl, N-acetyl, methyl, ethyl, propyl, amyl, butyl and
  • antioxidants are likewise suitable for use in the cosmetic compositions according to the invention.
  • Known and commercial mixtures are, for example, mixtures comprising, as active ingredients, lecithin, L-(+)-ascorbyl palmitate and citric acid (for example Oxynex® AP), natural tocopherols, L-(+)-ascorbyl palmitate, L-(+)-ascorbic acid and citric acid (for example Oxynex® K LIQUID), tocopherol extracts from natural sources, L-(+)-ascorbyl palmitate, L-(+)-ascorbic acid and citric acid (for example Oxynex® L LIQUID), DL- ⁇ -tocopherol, L-(+)-ascorbyl palmitate, citric acid and lecithin (for example Oxynex® LM) or butylhydroxytoluene (BHT), L-(+)-ascorbyl palmitate and citric acid (for example Oxyn
  • compositions according to the invention may comprise vitamins as further ingredients.
  • the cosmetic compositions according to the invention preferably comprise vitamins and vitamin derivatives selected from vitamin A, vitamin A propionate, vitamin A palmitate, vitamin A acetate, retinol, vitamin B, thiamine chloride hydrochloride (vitamin B 1 ), riboflavin (vitamin B 2 ), nicotinamide, vitamin C (ascorbic acid), vitamin D, ergocalciferol (vitamin D 2 ), vitamin E, DL- ⁇ -tocopherol, tocopherol E acetate, tocopherol hydrogensuccinate, vitamin K 1 , esculin (vitamin P active ingredient), thiamine (vitamin B 1 ), nicotinic acid (niacin), pyridoxine, pyridoxal, pyridoxamine (vitamin B 6 ), pantothenic acid, biotin, folic acid and cobalamine (vitamin B 12 ), particularly preferably vitamin A palmitate, vitamin C,
  • compositions according to the invention may in addition comprise further conventional skin-protecting or skin-care active ingredients. These can in principle be any active ingredients known to the person skilled in the art.
  • Particularly preferred active ingredients are pyrimidinecarboxylic acids and/or aryl oximes.
  • Pyrimidinecarboxylic acids occur in halophilic microorganisms and play a role in osmoregulation of these organisms (E. A. Galinski et al., Eur. J. Biochem., 149 (1985) pages 135-139).
  • pyrimidinecarboxylic acids particular mention should be made here of ectoin ((S)-1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid) and hydroxyectoin ((S,S)-1,4,5,6-tetrahydro-5-hydroxy-2-methyl-4-pyrimidinecarboxylic acid) and derivatives thereof.
  • ectoin ((S)-1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid)
  • hydroxyectoin (S,S)-1,4,5,6-tetrahydro-5-hydroxy-2-methyl-4-pyrimidinecarboxylic acid) and derivatives thereof.
  • These compounds stabili
  • Ectoin and ectoin derivatives can advantageously be used in medicaments.
  • hydroxyectoin can be employed for the preparation of a medicament for the treatment of skin diseases.
  • Other areas of application of hydroxyectoin and other ectoin derivatives are typically in areas in which, for example, trehalose is used as additive.
  • ectoin derivatives, such as hydroxyectoin can be used as protectant in dried yeast and bacteria cells.
  • Pharmaceutical products, such as non-glycosylated, pharmaceutically active peptides and proteins, for example t-PA can also be protected with ectoin or its derivatives.
  • European patent application EP-A-0 671 161 describes, in particular, that ectoin and hydroxyectoin are employed in cosmetic compositions, such as powders, soaps, surfactant-containing cleansing products, lipsticks, rouge, make-up, care creams and sunscreen preparations.
  • a pyrimidinecarboxylic acid of the following formula II in which R 1 is a radical H or C1-8-alkyl, R 2 is a radical H or C1-4-alkyl, and R 3 , R 4 , R 5 and R 6 are each, independently of one another, a radical from the group consisting of H, OH, NH 2 and C1-4-alkyl.
  • R 2 is a methyl or ethyl group
  • R 1 or R 5 and R 6 are H.
  • compositions according to the invention preferably comprise pyrimidinecarboxylic acids of this type in amounts of up to 15% by weight.
  • compositions which comprise 2-hydroxy-5-methyllaurophenone oxime are accordingly suitable for the treatment of skin diseases which are accompanied by inflammation. It is known that compositions of this type can be used, for example, for the therapy of psoriasis, various forms of eczema, irritative and toxic dermatitis, UV dermatitis and further allergic and/or inflammatory diseases of the skin and integumentary appendages.
  • compositions according to the invention which comprise aryl oximes, preferably 2-hydroxy-5-methyllaurophenone oxime, exhibit surprising antiinflammatory suitability.
  • the compositions here preferably comprise 0.01 to 10% by weight of the aryl oxime, it being particularly preferred for the composition to comprise 0.05 to 5% by weight of aryl oxime.
  • compositions according to the invention may also comprise at least one photostabiliser, preferably conforming to the formula III
  • compositions according to the invention can be prepared by processes which are well known to the person skilled in the art, in particular by the processes which serve for the preparation of oil-in-water emulsions or water-in-oil emulsions.
  • the present invention furthermore relates to a process for the preparation of a composition which is characterised in that at least one nanoparticulate UV protectant is mixed with a cosmetically or dermatologically suitable carrier, and to the use of nanoparticulate UV protectants for the preparation of a composition having light-protection properties.
  • compositions can be, in particular, in the form of simple or complex emulsions (O/W, W/O, O/W/O or W/O/W), such as creams, milks, gels or gel creams, powders and solid sticks, and they may, if desired, be formulated as aerosols and be in the form of foams or sprays.
  • O/W, W/O, O/W/O or W/O/W simple or complex emulsions
  • these compositions are preferably in the form of an O/N emulsion.
  • compositions according to the invention can be used as compositions for protection of the human epidermis or of the hair against UV radiation, as sunscreen compositions or make-up products.
  • the aqueous phase (which comprises, in particular, the hydrophilic filters) generally makes up 50 to 95% by weight and preferably 70 to 90% by weight, based on the formulation as a whole
  • the oil phase (which comprises, in particular, the lipophilic filters) makes up 5 to 50% by weight and preferably 10 to 30% by weight, based on the formulation as a whole
  • the (co)emulsifier or (co)emulsifiers make(s) up 0.5 to 20% by weight and preferably 2 to 10% by weight, based on the formulation as a whole.
  • compositions are those for external use, for example in the form of a cream, lotion or gel or as a solution which can be sprayed onto the skin.
  • Suitable for internal use are administration forms such as capsules, coated tablets, powders, tablet solutions or solutions.
  • compositions according to the invention examples are: solutions, suspensions, emulsions, PIT emulsions, pastes, ointments, gels, creams, lotions, powders, soaps, surfactant-containing cleansing preparations, oils, aerosols and sprays.
  • application forms are sticks, shampoos and shower products. Any desired customary carriers, auxiliaries and, if desired, further active ingredients may be added to the composition.
  • Preferred auxiliaries originate from the group consisting of preservatives, antioxidants, stabilisers, solubilisers, vitamins, colorants and odour improvers.
  • Ointments, pastes, creams and gels may comprise the customary carriers, for example animal and vegetable fats, waxes, paraffins, starch, tragacanth, cellulose derivatives, polyethylene glycols, silicones, bentonites, silica, talc and zinc oxide, or mixtures of these substances.
  • customary carriers for example animal and vegetable fats, waxes, paraffins, starch, tragacanth, cellulose derivatives, polyethylene glycols, silicones, bentonites, silica, talc and zinc oxide, or mixtures of these substances.
  • Powders and sprays may comprise the customary carriers, for example lactose, talc, silica, aluminium hydroxide, calcium silicate and polyamide powder, or mixtures of these substances.
  • Sprays may additionally comprise the customary propellants, for example chlorofluorocarbons, propane/butane or dimethyl ether.
  • Solutions and emulsions may comprise the customary carriers, such as solvents, solubilisers and emulsifiers, for example water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1,3-butyl glycol, oils, in particular cottonseed oil, peanut oil, wheatgerm oil, olive oil, castor oil and sesame oil, glycerol fatty acid esters, polyethylene glycols and fatty acid esters of sorbitan, or mixtures of these substances.
  • solvents such as solvents, solubilisers and emulsifiers, for example water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1,3-butyl glycol, oils, in particular cottonseed oil, peanut oil, wheatgerm oil
  • Suspensions may comprise the customary carriers, such as liquid diluents, for example water, ethanol or propylene glycol, suspending agents, for example ethoxylated isostearyl alcohols, polyoxyethylene sorbitol esters and polyoxyethylene sorbitan esters, microcrystalline cellulose, aluminium metahydroxide, bentonite, agar-agar and tragacanth, or mixtures of these substances.
  • liquid diluents for example water, ethanol or propylene glycol
  • suspending agents for example ethoxylated isostearyl alcohols, polyoxyethylene sorbitol esters and polyoxyethylene sorbitan esters, microcrystalline cellulose, aluminium metahydroxide, bentonite, agar-agar and tragacanth, or mixtures of these substances.
  • Soaps may comprise the customary carriers, such as alkali metal salts of fatty acids, salts of fatty acid monoesters, fatty acid protein hydrolysates, isethionates, lanolin, fatty alcohol, vegetable oils, plant extracts, glycerol, sugars, or mixtures of these substances.
  • customary carriers such as alkali metal salts of fatty acids, salts of fatty acid monoesters, fatty acid protein hydrolysates, isethionates, lanolin, fatty alcohol, vegetable oils, plant extracts, glycerol, sugars, or mixtures of these substances.
  • Surfactant-containing cleansing products may comprise the customary carriers, such as salts of fatty alcohol sulfates, fatty alcohol ether sulfates, sulfosuccinic acid monoesters, fatty acid protein hydrolysates, isethionates, imidazolinium derivatives, methyl taurates, sarcosinates, fatty acid amide ether sulfates, alkylamidobetaines, fatty alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable and synthetic oils, lanolin derivatives, ethoxylated glycerol fatty acid esters, or mixtures of these substances.
  • customary carriers such as salts of fatty alcohol sulfates, fatty alcohol ether sulfates, sulfosuccinic acid monoesters, fatty acid protein hydrolysates, isethionates, imidazolinium derivatives, methyl taurates, sarcosinates, fatty
  • Face and body oils may comprise the customary carriers, such as synthetic oils, such as fatty acid esters, fatty alcohols, silicone oils, natural oils, such as vegetable oils and oily plant extracts, paraffin oils, lanolin oils, or mixtures of these substances.
  • synthetic oils such as fatty acid esters, fatty alcohols, silicone oils, natural oils, such as vegetable oils and oily plant extracts, paraffin oils, lanolin oils, or mixtures of these substances.
  • compositions are also lipsticks, lip-care sticks, mascara, eyeliner, eye shadow, rouge, powder make-up, emulsion make-up and wax make-up, and sunscreen, pre-sun and after-sun preparations.
  • composition forms according to the invention include, in particular, emulsions.
  • Emulsions according to the invention are advantageous and comprise, for example, the said fats, oils, waxes and other fatty substances, as well as water and an emulsifier, as usually used for a composition of this type.
  • the oil phase of the emulsions, oleogels or hydrodispersions or lipodispersions is advantageously selected from the group consisting of esters of saturated and/or unsaturated, branched and/or unbranched alkanecarboxylic acids having a chain length of 3 to 30 C atoms and saturated and/or unsaturated, branched and/or unbranched alcohols having a chain length of 3 to 30 C atoms, or from the group consisting of esters of aromatic carboxylic acids and saturated and/or unsaturated, branched and/or unbranched alcohols having a chain length of 3 to 30 C atoms.
  • Ester oils of this type can then advantageously be selected from the group consisting of isopropyl myristate, isopropyl palmitate, isopropyl stearate, isopropyl oleate, n-butyl stearate, n-hexyl laurate, n-decyl oleate, isooctyl stearate, isononyl stearate, isononyl isononanoate, 2-ethylhexyl palmitate, 2-ethylhexyl laurate, 2-hexyldecyl stearate, 2-octyidodecyl palmitate, oleyl oleate, oleyl erucate, erucyl oleate, erucyl erucate and synthetic, semi-synthetic and natural mixtures of esters of this type, for example jojoba oil.
  • the oil phase may furthermore advantageously be selected from the group consisting of branched and unbranched hydrocarbons and waxes, silicone oils, dialkyl ethers, or the group consisting of saturated or unsaturated, branched or unbranched alcohols, and fatty acid triglycerides, specifically the triglycerol esters of saturated and/or unsaturated, branched and/or unbranched alkanecarboxylic acids having a chain length of 8 to 24 C atoms, in particular 12-18 C atoms.
  • the fatty acid triglycerides may advantageously be selected, for example, from the group consisting of synthetic, semi-synthetic and natural oils, for example olive oil, sunflower oil, soya oil, peanut oil, rapeseed oil, almond oil, palm oil, coconut oil, palm kernel oil and the like.
  • any desired mixtures of oil and wax components of this type may also advantageously be employed for the purposes of the present invention. It may also be advantageous to employ waxes, for example cetyl palmitate, as the only lipid component of the oil phase.
  • the oil phase is advantageously selected from the group consisting of 2-ethylhexyl isostearate, octyldodecanol, isotridecyl isononanoate, isoeicosane, 2-ethylhexyl cocoate, C 12-15 -alkyl benzoate, caprylic/capric acid triglyceride and dicapryl ether.
  • Particularly advantageous are mixtures of C 12-15 -alkyl benzoate and 2-ethylhexyl isostearate, mixtures of C 12-15 -alkyl benzoate and isotridecyl isononanoate, as well as mixtures of C 12-15 -alkyl benzoate, 2-ethylhexyl isostearate and isotridecyl isononanoate.
  • paraffin oil squalane and squalene may advantageously be used for the purposes of the present invention.
  • oil phase may also advantageously have a content of cyclic or linear silicone oils or consist entirely of oils of this type, although it is preferred to use an additional content of other oil-phase components in addition to the silicone oil or the silicone oils.
  • the silicone oil to be used in accordance with the invention is advantageously cyclomethicone (octamethylcyclotetrasiloxane). However, it is also advantageous for the purposes of the present invention to use other silicone oils, for example hexamethylcyclotrisiloxane, polydimethylsiloxane, poly(methylphenylsiloxane).
  • mixtures of cyclomethicone and isotridecyl isononanoate and of cyclomethicone and 2-ethylhexyl isostearate are particularly advantageous.
  • the aqueous phase of the compositions according to the invention optionally advantageously comprises alcohols, diols or polyols having a low carbon number, and ethers thereof, preferably ethanol, isopropanol, propylene glycol, glycerol, ethylene glycol, ethylene glycol monoethyl or monobutyl ether, propylene glycol monomethyl, monoethyl or monobutyl ether, diethylene glycol monomethyl or monoethyl ether and analogous products, furthermore alcohols having a low carbon number, for example ethanol, isopropanol, 1,2-propanediol, glycerol, and, in particular, one or more thickeners, which may advantageously be selected from the group consisting of silicon dioxide, aluminium silicates, polysaccharides and derivatives thereof, for example hyaluronic acid, xanthan gum, hydroxypropylmethylcellulose, particularly advantageously from the group consisting of the polyacrylates, preferably a
  • mixtures of the above-mentioned solvents are used.
  • water may be a further constituent.
  • Emulsions according to the invention are advantageous and comprise, for example, the said fats, oils, waxes and other fatty substances, as well as water and an emulsifier, as usually used for a formulation of this type.
  • compositions according to the invention comprise hydrophilic surfactants.
  • hydrophilic surfactants are preferably selected from the group consisting of the alkylglucosides, acyl lactylates, betaines and coconut amphoacetates.
  • alkylglucosides are themselves advantageously selected from the group consisting of the alkylglucosides which are distinguished by the structural formula where R represents a branched or unbranched alkyl radical having from 4 to 24 carbon atoms, and where ⁇ overscore ( ) ⁇ ,DP denotes a mean degree of glucosylation of up to 2.
  • the value DP takes into account the fact that alkylglucosides are generally, as a consequence of their preparation, in the form of mixtures of mono- and oligoglucosides.
  • Alkylglucosides which are particularly advantageously used in accordance with the invention are selected from the group consisting of octyl glucopyranoside, nonyl glucopyranoside, decyl glucopyranoside, undecyl glucopyranoside, dodecyl glucopyranoside, tetradecyl glucopyranoside and hexadecyl glucopyranoside.
  • acyllactylates are themselves advantageously selected from the group consisting of the substances which are distinguished by the structural formula where R 1 denotes a branched or unbranched alkyl radical having 1 to 30 carbon atoms, and M + is selected from the group consisting of the alkali metal ions and the group consisting of ammonium ions which are substituted by one or more alkyl and/or by one or more hydroxyalkyl radicals, or corresponds to half an equivalent of an alkaline earth metal ion.
  • sodium isostearyl lactylate for example the product Pathionic® ISL from the American Ingredients Company, is advantageous.
  • the betaines are advantageously selected from the group consisting of the substances which are distinguished by the structural formula where R 2 denotes a branched or unbranched alkyl radical having 1 to 30 carbon atoms.
  • R 2 particularly advantageously denotes a branched or unbranched alkyl radical having 6 to 12 carbon atoms.
  • capramidopropylbetaine for example the product Tego® Betain 810 from Th. Goldschmidt AG, is advantageous.
  • a coconut amphoacetate which is advantageously selected in accordance with the invention is, for example, sodium coconut amphoacetate, as available under the name Miranol® Ultra C32 from Miranol Chemical Corp.
  • compositions according to the invention are advantageously characterised in that the hydrophilic surfactant(s) is (are) present in concentrations of 0.01-20% by weight, preferably 0.05-10% by weight, particularly preferably 0.1-5% by weight, in each case based on the total weight of the composition.
  • the cosmetic and dermatological compositions according to the invention are applied to the skin and/or the hair in an adequate amount in the usual manner for cosmetics.
  • Cosmetic and dermatological compositions according to the invention may exist in various forms. Thus, they may be, for example, a solution, a water-free composition, an emulsion or microemulsion of the water-in-oil (W/O) type or of the oil-in-water (O/W) type, a multiple emulsion, for example of the water-in-oil-in-water (W/O/W) type, a gel, a solid stick, an ointment or an aerosol. It is also advantageous to administer ectoins in encapsulated form, for example in collagen matrices and other conventional encapsulation materials, for example as cellulose encapsulations, in gelatine, wax matrices or liposomally encapsulated.
  • wax matrices as described in DE-A 43 08 282, have proven favourable. Preference is given to emulsions. O/W emulsions are particularly preferred. Emulsions, W/O emulsions and O/W emulsions are obtainable in a conventional manner.
  • Emulsifiers that can be used are, for example, the known W/O and O/W emulsifiers. It is advantageous to use further conventional co-emulsifiers in the preferred O/W emulsions according to the invention.
  • An emulsifier that has proven to be particularly preferred in accordance with the invention for O/W emulsions is the commercial product Ceralution C from Sasol.
  • Co-emulsifiers which are advantageously selcted in accordance with the invention are, for example, O/W emulsifiers, principally from the group consisting of the substances having HLB values of 11-16, very particularly advantageously having HLB values of 14.5-15.5, so long as the O/W emulsifiers have saturated radicals R and R′. If the O/W emulsifiers have unsaturated radicals R and/or R′ or if isoalkyl derivatives are present, the preferred HLB value of such emulsifiers may also be lower or higher.
  • fatty alcohol ethoxylates from the group consisting of ethoxylated stearyl alcohols, cetyl alcohols, cetylstearyl alcohols (cetearyl alcohols).
  • Particular preference is given to the following: polyethylene glycol (13) stearyl ether (steareth-13), polyethylene glycol (14) stearyl ether (steareth-14), polyethylene glycol (15) stearyl ether (steareth-15), polyethylene glycol (16) stearyl ether (steareth-16), polyethylene glycol (17) stearyl ether (steareth-17), polyethylene glycol (18) stearyl ether (steareth-18), polyethylene glycol (19) stearyl ether (steareth-19), polyethylene glycol (20) stearyl ether (steareth-20), polyethylene glycol (12) isostearyl ether (isosteareth-12), polyethylene glycol (13) isostearyl ether (isosteareth-13), polyethylene glycol (1
  • An ethoxylated alkyl ether carboxylic acid or salt thereof which can advantageously be used is sodium laureth-11 carboxylate.
  • An alkyl ether sulfate which can advantageously be used is sodium laureth-14 sulfate.
  • An ethoxylated cholesterol derivative which can advantageously be used is polyethylene glycol (30) cholesteryl ether. Polyethylene glycol (25) soyasterol has also proven successful.
  • Ethoxylated triglycerides which can advantageously be used are the polyethylene glycol (60) evening primrose glycerides.
  • polyethylene glycol glycerol fatty acid esters from the group consisting of polyethylene glycol (20) glyceryl laurate, polyethylene glycol (21) glyceryl laurate, polyethylene glycol (22) glyceryl laurate, polyethylene glycol (23) glyceryl laurate, polyethylene glycol (6) glyceryl caprate/caprinate, polyethylene glycol (20) glyceryl oleate, polyethylene glycol (20) glyceryl isostearate, polyethylene glycol (18) glyceryl oleate/cocoate.
  • polyethylene glycol (20) glyceryl laurate polyethylene glycol (21) glyceryl laurate
  • polyethylene glycol (22) glyceryl laurate polyethylene glycol (23) glyceryl laurate
  • polyethylene glycol (6) glyceryl caprate/caprinate polyethylene glycol (20) glyceryl oleate
  • sorbitan esters from the group consisting of polyethylene glycol (20) sorbitan monolaurate, polyethylene glycol (20) sorbitan monostearate, polyethylene glycol (20) sorbitan monoisostearate, polyethylene glycol (20) sorbitan monopalmitate, polyethylene glycol (20) sorbitan monooleate.
  • fatty alcohols having 8 to 30 carbon atoms monoglycerol esters of saturated and/or unsaturated, branched and/or unbranched alkanecarboxylic acids having a chain length of 8 to 24, in particular 12-18 C atoms, diglycerol esters of saturated and/or unsaturated, branched and/or unbranched alkanecarboxylic acids having a chain length of 8 to 24, in particular 12-18 C atoms, monoglycerol ethers of saturated and/or unsaturated, branched and/or unbranched alcohols having a chain length of 8 to 24, in particular 12-18 C atoms, diglycerol ethers of saturated and/or unsaturated, branched and/or unbranched alcohols having a chain length of 8 to 24, in particular 12-18 C atoms, propylene glycol esters of saturated and/or unsaturated, branched and/or unbranched alkanecarboxylic acids having a chain length of 8 to 24, in particular 12-18 C atoms
  • W/O emulsifiers are glyceryl monostearate, glyceryl monoisostearate, glyceryl monomyristate, glyceryl monooleate, diglyceryl monostearate, diglyceryl monoisostearate, propylene glycol monostearate, propylene glycol monoisostearate, propylene glycol monocaprylate, propylene glycol monolaurate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monocaprylate, sorbitan monoisooleate, sucrose distearate, cetyl alcohol, stearyl alcohol, arachidyl alcohol, behenyl alcohol, isobehenyl alcohol, selachyl alcohol, chimyl alcohol, polyethylene glycol (2) stearyl ether (steareth-2), glyceryl monolaurate, glyceryl monocaprinate, glyceryl monocaprylate.
  • compositions which are preferred in accordance with the invention are particularly suitable for protecting human skin against UV-induced ageing processes and against oxidative stress, i.e. against damage caused by free radicals, as are generated, for example, by sunlight, heat or other influences.
  • they are in the various administration forms usually used for this application.
  • they may, in particular, be in the form of a lotion or emulsion, such as in the form of a cream or milk (O/W, W/O, O/W/O, W/O/W), in the form of oily-alcoholic, oily-aqueous or aqueous-alcoholic gels or solutions, in the form of solid sticks or may be formulated as an aerosol.
  • the composition may comprise cosmetic adjuvants that are usually used in this type of composition, such as, for example, thickeners, softeners, moisturisers, surface-active agents, emulsifiers, preservatives, antifoams, perfumes, waxes, lanolin, propellants, dyes and/or pigments which colour the composition itself or the skin, and other ingredients usually used in cosmetics.
  • cosmetic adjuvants such as, for example, thickeners, softeners, moisturisers, surface-active agents, emulsifiers, preservatives, antifoams, perfumes, waxes, lanolin, propellants, dyes and/or pigments which colour the composition itself or the skin, and other ingredients usually used in cosmetics.
  • the dispersant or solubiliser used can be an oil, wax or other fatty substance, a lower monoalcohol or a lower polyol or mixtures thereof.
  • Particularly preferred monoalcohols or polyols include ethanol, i-propanol, propylene glycol, glycerol and sorbitol.
  • a preferred embodiment of the invention is an emulsion in the form of a protective cream or milk which, apart from the compound(s) of the formula I, comprises, for example, fatty alcohols, fatty acids, fatty acid esters, in particular triglycerides of fatty acids, lanolin, natural and synthetic oils or waxes and emulsifiers in the presence of water.
  • a lower alcohol such as ethanol
  • a glycerol such as propylene glycol
  • a polyol such as glycerol
  • composition according to the invention may also be in the form of an alcoholic gel which comprises one or more lower alcohols or polyols, such as ethanol, propylene glycol or glycerol, and a thickener, such as siliceous earth.
  • the oily-alcoholic gels also comprise natural or synthetic oil or wax.
  • the solid sticks consist of natural or synthetic waxes and oils, fatty alcohols, fatty acids, fatty acid esters, lanolin and other fatty substances.
  • compositions are formulated as an aerosol
  • customary propellants such as alkanes, fluoroalkanes and chlorofluoroalkanes, are generally used.
  • the cosmetic composition may also be used to protect the hair against photochemical damage in order to prevent colour changes, bleaching or damage of a mechanical nature.
  • a suitable formulation is in the form of a rinse-out shampoo, lotion, gel or emulsion, the composition in question being applied before or after shampooing, before or after colouring or bleaching or before or after permanent waving. It is also possible to select a composition in the form of a lotion or gel for styling and treating the hair, in the form of a lotion or gel for brushing or laying a water wave, in the form of a hair lacquer, permanent-waving composition, colorant or bleach for the hair.
  • composition having light-protection properties may comprise various adjuvants used in this type of composition, such as surface-active agents, thickeners, polymers, softeners, preservatives, foam stabilisers, electrolytes, organic solvents, silicone derivatives, oils, waxes, antigrease agents, dyes and/or pigments which colour the composition itself or the hair, or other ingredients usually used for hair care.
  • adjuvants used in this type of composition, such as surface-active agents, thickeners, polymers, softeners, preservatives, foam stabilisers, electrolytes, organic solvents, silicone derivatives, oils, waxes, antigrease agents, dyes and/or pigments which colour the composition itself or the hair, or other ingredients usually used for hair care.
  • experiment product obtained from experiment 1a is subjected to further hydrothermal treatment in a pressure container at a temperature of 180° C. for a period of 2 h.
  • the resultant product exhibits oval crystallites ( FIG. 2 )
  • 1 l of the aqueous hydrochloric acid suspension of TiO 2 from Example 1b is brought to a pH of 6.5 using NaOH and heated to 80° C.
  • the product is subsequently washed to a conductivity of less than 100 ⁇ S/cm and dried.
  • 1 l of the aqueous hydrochloric acid suspension of TiO 2 from Example 1b is brought to a pH of 9.0 using NaOH and heated to 80° C.
  • pH 9.0 ⁇ 0.5, regulation by addition of H 2 SO 4 ).
  • the product is subsequently washed to a conductivity of less than 100 pS/cm and dried.
  • 1 l of the aqueous hydrochloric acid suspension of TiO 2 from Example 1b is brought to a pH of 2.0 using NaOH and heated to 80° C.
  • the product is subsequently washed to a conductivity of less than 100 pS/cm and dried.
  • 1 l of the aqueous hydrochloric acid suspension of TiO 2 from Example 1b is brought to a pH of 9.0 using NaOH and heated to 80° C.
  • 52 ml of water-glass solution (corresponding to 384 g of SiO 2 /l) are subsequently added to the suspension.
  • the pH rises to about 10.6.
  • the product is subsequently washed to a conductivity of less than 100 ⁇ S/cm and dried.
  • Formulations corresponding to Formulation Example 6 are prepared using the following titanium dioxide grades
  • the content of 4,4′-methoxy-tert-butyldibenzoylmethane in the formulations is determined by means of HPLC as a measure of the storage stability of this compound after storage of the formulations under various conditions.
  • variable UV detector 320 nm
  • Formulations are prepared as described in Formulation Example 6.
  • one comprises the titanium dioxide according to the invention from Examples 2a-d, while a commercially available titanium dioxide with trimethoxyoctylsilane coating (UvinulTM TiO 2 ; BASF) is employed in the comparative sample.
  • UvinulTM TiO 2 a commercially available titanium dioxide with trimethoxyoctylsilane coating
  • Example 2a white white With titanium dioxide acc. to Example 2b: white white With titanium dioxide acc. to Example 2c: white white With titanium dioxide acc. to Example 2d: white white With comparative substance: white yellowish
  • the titanium dioxides mentioned in the table are incorporated into the formulation described in accordance with the recipe described below and investigated microscopically immediately after preparation and after storage for 12 weeks at room temperature.
  • the formulations are stable for 3 months on storage at RT/5° C./40° C. and in the rocking test at ⁇ 5° C./40° C.
  • Titanium dioxide no crystals readily visible crystals - (aluminium-containing length about 10-100 ⁇ m coating)
  • Microscope used Zeiss, Axioskop 2; manual version with microscope camera and PC coupling, objectives 10x Ph1, 40x Ph2, 100x pH3; polarising filter ( ⁇ 4 leaves)
  • Example 2a The same results as with Example 2a are obtained with the products from Example 2b, 2c and 2d.
  • Formulations corresponding to Formulation Example 6 are prepared with the following titanium dioxide grades
  • the formulations are stored for 3 months at 50° C. in the dark.
  • the samples are subsequently measured in a plastic sample holder with quartz cover in a CE7000 calorimeter (Gretag-Macbeth) using a barium sulfate-lined Ulbricht sphere (measurement optics: diffuse; 8°; illuminant C, standard observer, no gloss).
  • the measurement is evaluated in accordance with the L*a*b* system (CIELab, DIN 6174).
  • the measurement values are shown in the following table and in FIG. 4 .
  • sample 6a comprising the titanium dioxide according to the invention is significantly less after storage for 3 months than the discoloration of the two samples comprising commercially available titanium dioxide grades.
  • a Product from Example 2d 5.00 Ethylhexyl methoxycinnamate, BHT 7.50 Benzophenone-3 2.50 PEG-100 stearate, glyceryl stearate 2.80 PPG-1-PEG-9 lauryl glycol ether 0.40 Dicapryl ether 4.50 Steareth-10 0.50 Stearyl alcohol 0.60 Dimethicone 2.00 B Dimethicone copolyol phosphate 2.50 Chitosan glycolate 2.00 Glycerin 2.50 Water 66.10 C PPG-1 trideceth-6, polyquaternium-37, propylene glycol 0.40 dicaprylate/dicaprate D Propylene glycol, DMMDM hydantoin, methylparaben, 0.70 propylparaben Preparation:
  • phase A and phase B separately to 80° C.
  • phase A to 80° C. Carefully incorporate the titanium dioxide (phase B) into the hot oil phase. Slowly add phase C to phase A/B with stirring (500 rpm, (Mig stirrer). Homogenise for 2 minutes at 1600 rpm. Cool to about 40° C. with stirring about 300 rpm) and again homogenise for 2 minutes at 1600 rpm.
  • UV-Pearl, OMC stands for the composition with the INCI name:
  • FIG. 1 Transmission electron photomicrograph of titanium dioxide crystallites produced as described in Example 1a.
  • FIG. 2 Transmission electron photomicrograph of titanium dioxide crystallites produced as described in Example 2a.
  • FIG. 3 Content of 4,4′-methoxy-tert-butyldibenzoylmethane (BMDBM) in formulations with titanium dioxide as a function of the storage conditions as described in Example 3; initial concentration 3% of BMDBM; (Example 3a: example according to the invention; Example 3b: comparative example)
  • BMDBM 4,4′-methoxy-tert-butyldibenzoylmethane
  • FIG. 4 b* values (L*a*b* system; CIELab, DIN 6174) of cosmetic formulations after storage for 3 months at 50° C. in the dark as described in Example 6.
US10/565,214 2003-07-21 2004-07-05 Silicon dioxide-coated nanoparticulate uv protectant Abandoned US20060194057A1 (en)

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DE10333029A1 (de) 2005-02-17
CN1826389A (zh) 2006-08-30
ES2611128T3 (es) 2017-05-05
JP2006528706A (ja) 2006-12-21
EP1660592B1 (de) 2016-10-19
US8758501B2 (en) 2014-06-24
WO2005019348A1 (de) 2005-03-03
US20090220441A1 (en) 2009-09-03
CN100519666C (zh) 2009-07-29
TW200505495A (en) 2005-02-16
JP4740845B2 (ja) 2011-08-03

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