Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
  • A61K36/18—Magnoliophyta (angiosperms)
  • A61K36/185—Magnoliopsida (dicotyledons)
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
  • A61K36/18—Magnoliophyta (angiosperms)
  • A61K36/185—Magnoliopsida (dicotyledons)
  • A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
  • A61K36/18—Magnoliophyta (angiosperms)
  • A61K36/185—Magnoliopsida (dicotyledons)
  • A61K36/22—Anacardiaceae (Sumac family), e.g. smoketree, sumac or poison oak
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
  • A61K36/18—Magnoliophyta (angiosperms)
  • A61K36/185—Magnoliopsida (dicotyledons)
  • A61K36/24—Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
  • A61K36/18—Magnoliophyta (angiosperms)
  • A61K36/185—Magnoliopsida (dicotyledons)
  • A61K36/27—Asclepiadaceae (Milkweed family), e.g. hoya
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
  • A61K36/18—Magnoliophyta (angiosperms)
  • A61K36/185—Magnoliopsida (dicotyledons)
  • A61K36/74—Rubiaceae (Madder family)
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
  • A61K36/18—Magnoliophyta (angiosperms)
  • A61K36/88—Liliopsida (monocotyledons)
  • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
  • A61P1/10—Laxatives
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P11/00—Drugs for disorders of the respiratory system
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
  • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P17/00—Drugs for dermatological disorders
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
  • A61P31/04—Antibacterial agents
  • A61P31/06—Antibacterial agents for tuberculosis
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
  • A61P31/12—Antivirals
  • A61P31/14—Antivirals for RNA viruses
  • A61P31/18—Antivirals for RNA viruses for HIV
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P37/00—Drugs for immunological or allergic disorders
  • A61P37/02—Immunomodulators

Definitions

• This invention relates to a composition for treating AIDS and related conditions, and more particular, to a composition comprising at least one extract of a selected plant.
• HTLV-III/LAV human T-cell lymphotropic virus type III/lymphadenopathy-associated virus
• the clinical manifestations of (HTLV-III/LAV) infection may be directly attributable to infection with this virus or the result of secondary condtions occurring as a consequence of immune dysfunction caused by the underlying infection with (HTLV-III/LAV).
• the range of manifestations may include none, nonspecific signs and symptoms of illness, autoimmune and neurologic disorders, a variety of opportunistic infections, and several types of malignacy.
• AIDS was defined for national reporting before its etiology was known and has encompassed only certain secondary conditions that reliably reflected the presence of a sever immune dysfunction. Current laboratory tests to detect (HTLV-III/LAV) antibody make it possible to include additional serious conditions in the syndrome, as well as to further improve the specificity of the definition used for reporting cases.
• any of the following diseases will be considered indicative of AIDS if the patient has a positive serologic or virologic test for HTLV-III/LAV:
• Han et al. Disclosed a process for preparing an extracted substance from a mixture of a non-fat starch from Ricini Semen and a root of Coptis sp for therapeutic applications of AIDS [U.S. Pat. No. 5,928,645]. The authors maintain that the extracted substance was effective in treating AIDS but provided no clinical data as to the effect of this substance in AIDS patients.
• Han et al. demonstrated significant anti-oxidant capacity of their Ricini Semen extract using a chemiluminescence assay [Hong, E. K., Kim, Y. K. Lee, W. C., Shin, H. K., and Kim, J.
• the extract medicament comprised a basis part consisting of equal amounts of ground, powdered, and mixed clove, frankincense, myrrha, fhizama arisaematis, pinellia, monkshood (root) or kusnezoff monkshood (root), and tuber of bamboo-leaved orchid, and an adjuvant part consisting of equal amounts of round, powdered, and mixed borneol, powdered soy bean, borax, coptis root and/or phellodendron amureause, and sepia aculeata.
• the medicine is used in such a manner that the powdered basis part is mixed and stirred with tea water until it becomes plaster-like, and the adjuvant part is scattered in dry form onto the wound or swollen area caused by the black foot disease before the plaster-like basis part is applied to the wound or swollen area about 0.5 cm in thickness.
• the wound is then bandaged and the medicine is renewed once or twice a day until fresh flesh appears in the wound. Thereafter, the medicine is continuously applied but in a dry form until the wound is completely healed.
• the extract medicament composition taught by Chen et al. does not have any impact on AIDS itself as a systemic disease.
• the present invention is related to a composition for treating AIDS and associated conditions related to AIDS.
• the composition comprises a medicament which is an extract of at least one plant family.
• the present invention relates to a novel extract medicament for use in treating AIDS, an immune deficiency or immunologically compromised disease, as well as a variety of AIDS related ailments, including recurrent and persistent fever, chronic diarrhea, dermatitis, generalized lymphodenpathy, persistent cough, general pain, tuberculosis, and amenorrhea.
• the extract is prepared from the bark, leaf, root and stems of at least one plant from within the apocynaceae, annonaceae, dichapetalaceae, annoceae, cynocynaceae, asclepiadaceae, combretaceae, amaranthaceae, araceae, cyperaceae, anacardiaceae, bignoniaceae, bombacaceae, and caricacea plant families.
• a suitable plant is selected.
• a mixture of at least two plants is selected.
• Suitable plants are selected from a family of plants including (1) apocynaceae, (2) annonaceae, (3) dichapetalaceae, (4) annoceae, (5) cynocynaceae, (6) asclepiadaceae, (7) combretaceae, (8) amaranthaceae, (9) araceae, (10) cyperaceae, (11) anacardiaceae, (12) bignoniaceae, (13) bombacaceae, (14) anarcardiaceae and caricaceae plant families.
• These plants are tropical herbs that grow naturally and can be thus cultivated in tropical, savanna, grassland or lightly wooded forests of West Africa. These desert plants can also be found in other tropical regions of the world, including Asia, Asia Minor, South America, and possibly the South-Western, Western and Plains regions of the United States.
• the active medicaments from these plants include, but are not limited to glyceryl esters, saponins and several derivatives of alkaloids, glycosides, proteins, fats, and sugars.
• the plants per se are not employed as the requisite medicament, but rather the extract of such selected plant or plants.
• the extraction process for the medicaments from the respective plants comprises the following:
• the resultant concentrate may also be further concentrated into powder under reduced temperature/pressure conditions, e.g, by tray drying, solvent extraction, solvent exclusion, or spray drying, to result in a yellowish-brown amporphous, powder for use as an injectable or solid product such as a tablet; or by subjecting the resultant product to a filtration through a membrane filter and then a lypohilization to give powders; and then packaging the resulting mixed extracts in appropriate closure systems for clinical use.
• the resultant concentrated extract contains the following compounds for each plant concentrate obtained: [see L. Watson and M. J. Dallwitz (1992) onwards).
• iridoids verbascosides Genera 164; Acokanthera, Adenium, Aganonerion, proanthocyanidins, cyanidins Aganosma, Alafia, Allamanda, Allomarkgrafia, delphinidins, flavonols, Allowoodsonia, Alstonia, Alyxia, Amocalyx, Ambelania, kaempferols, quercetins, Amsonia, Ancylobotrys, Anechites, Angadenia, Anodendron, ellagic acid, ursolic acid, Apocynum, Arduina, Artia, Asketanthera, Aspidosperma, saponins/sapogenins, Baissea, Beaumontia, Bousigonia, Cabucala, Callichilia, aluminum salts, sucrose, Calocrater, Cameraria, Carissa, Carpodinus, Carruthersia, oligosaccharides
• Genera 126 quercetins, ellagic acid, Afroguatteria, Alphonsea, Ambavia, Anaxagorea, Ancana, sucrose, oligosaccharides Annickia, Annona, Anomianthus, Anonidium, Artabotrys, Asimina, Asteranthe, Balonga, Bocagea, Bocageopsis, Highlanda, Cananga, Cardiopetalum, Chieniodendron, Cleistochlamys, Cleistopholis, Cremastosperma, Cyathocalyx, Cyathostemma, Cymbopetalum, Dasoclema, Dasymaschalon, Deeringothamnus, Dendrokingstonia, Dennettia, Desmopsis, Desmos, Diclinanona, Dielsiothamnus, Disepalum, Duckeanthus, Duguetia, Ellipeia, Ellipeiopsis, Enicosanthum, Ephedrant
• Genera 3 Dichapetalum, Stephanopodium, Tapura, (Gonypetalum, Falya) (4) Annoceae Schefferomitra subaequalis , Goniothalamus sesquipedalis Alkaloids, cyanidins, flavonols, eg.
• Genera 250 acid a complex mixture of at Absolmsia, Adelostemma, Aidomene, Amblyopetalum, least 9 closely related acidic Amblystigma, Anatropanthus, Anisopus, Anisotoma, glucosides, flavonols Anomotassa, Araujia, Asclepias, Aspidoglossum, including kaempferol, Astephanus, Barjonia, Belostemma, Bidaria, Biondia, kaempferol and quercetin, Blepharodon, Blyttia, Brachystelma, Calotropis, aluminium, sucrose and Campestigma, Caralluma, Ceropegia, Cibirhiza, Cionura, oligosaccharides, iridoids.
• Cyanogenics alkaloids, Dahlgren's Superorder Caryophylliflorae; Caryophyllales. flavonols, quercetin, ellagic Cronquist's Subclass Caryophyllidae; Caryophyllales.
• APG acid betalains, saponins, (1998) Eudicot; core Eudicot; neither Rosid nor Asterid; sapogenins, oxalates Caryophyllales. Species 850.
• Genera 74 Achyranthes, Achyropsis, Aerva, Allmania, Alternanthera, Amaranthus, Arthraerua, Blutaparon, Bosea, Brayulinea, Calicorema, Celosia, Centema, Centemopsis, Centrostachys, Chamissoa, Charpentiera, Chionothrix, Cyathula, Dasysphaera, Dasysphaera, Deeringia, Digera, Eriostylos, Froelichia, Gomphrena, Gossypianthus, Guilleminea, Hebanthe, Hemichroa ( ⁇ Chenopodiaceae), Henonia, Herbstia, Hermbstaedtia, Indobanalia, Irenella, Iresine, Kyphocarpa, Lagrezia, Leucosphaera, Lithophila, Lopriorea, Marcelliopsis, Mechowia, Nelsia
• Genera 106 Aglaodorum, alkaloids, proanthocyanidins, Aglaonema, Alloschemone, Alocasia, Ambrosina, cyanidin, flavonols, Amorphophallus, Amydrium, Anadendrum, Anaphyllopsis, kaempferol, quercetin, and Anaphyllum, Anchomanes, Anthurium, Anubias, Aridarum, quercetin Ariopsis, Arisaema, Arisarum, Arophyton, Arum, Asterostigma, Biarum, Bognera, Bucephalandra, Caladium, Calla, Callopsis, Carlephyton, Cercestis, Chlorospatha, Colletogyne, Colocasia, Cryptocoryne, Culcasia, Cyrtosperma, Dieffenbachia, Dracontioides, Dracontium, Dracunculus, Eminium, Epipremnum, Fila
• kaempferol about 70; Actinocheita, Anacardium, Androtium, quercetin, and myricetin; Antrocaryon, Apterokarpos, Astronium, Baronia, saponins/sapogenins sugars Bonetiella, Bouea, Buchanania, Campnosperma, as sucrose, oligosaccharides Cardenasiodendron, Choerospondias, Comocladia, or sugar alcohols Cotinus, Cyrtocarpa, Dracontomelon, Drimycarpus, Ebandoua, Euleria, Euroschinus, Faguetia, Fegimanra, Gluta, Haematostaphis, Haplorhus, Harpephyllum, Heeria, Holigarna, Koordersiodendron, Lannea, Laurophyllus, Lithrea, Loxopterigium, Loxostylis, Mangifera, Mauria, Melanochyla, Metopium,
• Genera 110 Adenocalymna, quercetins, ursolic acid, Amphilophium, Amphitecna, Anemopaegma, Argylia, saponins, sapogenins Arrabidaea, Astianthus, Barnettia, Bignonia, Callichlamys, oligosaccharides, sucrose, Campsidium, Campsis, Catalpa, Catophractes, sugar Ceratophytum, Chilopsis, Clytostoma, Colea, Crescentia, Cuspidaria, Cybistax, Delostoma, Deplanchea, Digomphia, Dinklageodoxa, Distictella, Distictis, Dolichandra, Dolichandrone, Eccremocarpus, Ekmanianthe, Fernandoa, Fridericia, Gardnerodoxa, Glaziova, Godmania, Haplolophium, Haplophragma, Heterophragma, Hier
• APG (1998) Eudicot; core cyanidins, flavonols e.g. Eudicot; Rosid; Eurosid II; Malvales. Species 180. Genera kaempferol and quercetin; 30; Adansonia, Aguiaria, Bernoullia, Bombacopsis, sucrose Bombax, Catostemma, Cavanillesia, Ceiba, Chorisia, Coelostegia, Cullenia, Durio, Eriotheca, Gyranthera, Huberodendron, Kostermansia, Matisia, Neesia, Neobuchia, Ochroma, Pachira, Patinoa, Phragmotheca, Pseudobombax, Quararibea, Rhodognaphalon, Rhodagnaphalopsis, Scleronema, Septotheca, Spirotheca.
• Caricaceae Taxonomy Subclass Dicotyledonae; Crassinucelli. mustard-oils, alkaloids, Dahlgren's Superorder Violiflorae; Violales. Cronquist's saponins/sapogenins Subclass Dilleniidae; Violales.
• APG (1998) Eudicot; core Eudicot; Rosid; Eurosid II; Brassicales. Species 55. Genera 4; Carica, Cylicomorpha, Jacaratia, Jarilla.
• an extract or a mixture of extracts Prior to the administration to a patient an extract or a mixture of extracts are typically diluted by combination with a pharmacologically compatible solvent, e.g., ethanol or water to produce a therapeutic solution.
• a pharmacologically compatible solvent e.g., ethanol or water
• the amount or concentration of the extract or mixed extracts in the therapeutic solution ranges from 0.0001 to 10.0 weight percent of the total weight of the solution.
• the extract or mixture of extracts is present in a therapeutically effective amount, that is, an amount such that the extract or mixture of extracts can be administered in a therapeutically effective amount through conventional oral, nasal, aerosol, topical, intravenous, peritoneal, etc. means.
• the term “amount” as used herein refers to a quantity or to a concentration, as appropriate to the context.
• the amount of extract(s) that constitutes a therapeutically effective amount varies according to factors such as the potency of the extract(s) the route of administration of the formulation, and the mechanical system used to administer the formulation.
• a therapeutically effective amount of a particular extract or mixture of extracts can be selected by those of ordinary skill in the art with due consideration of such factors.
• a therapeutically effective amount will be from about 0.005 parts weight to about 2 parts by weight based on 100 parts by weight of the therapeutic solution, or if in solid form, e.g., tablet or capsule, 0.001 to 10 parts by weight of the weight of the tablet or capsule.
• either solid or fluid unit dosage forms can be prepared.
• the extract or extract mixture is mixed into formulations with conventional ingredients, such as talc, magnesium stearate, dicalcium phosphate, magnesium aluminum silicate, calcium sulfate, starch, lactose, acacia, methylcelluose, and functionally similar materials as pharmaceutical diluents or carriers.
• Capsules are prepared by mixing the extract or extract mixture with an inert pharmaceutical diluent and filling the mixture into a hard gelatin capsule of appropriate size.
• Soft gelatin capsules are prepared by machine encapsulation of a slurry of the extract or extract mixture with an acceptable vegetable oil, light liquid petrolatum or other inert oil.
• Fluid unit dosage forms for oral administration such as syrups, elixirs and suspensions can be prepared.
• the water soluble forms can be dissolved in an aqueous vehicle together with sugar, aromatic flavoring agents and preservatives to form a syrup.
• An elixir is prepared by using a hydroalcoholic (e.g., ethanol) vehicle with suitable sweeteners such as sugar and saccharin, together with an aromatic flavoring agent.
• Suspensions can be prepared with an aqueous vehicle with the aid of a suspending agent such as acacia, tragacanth, methylcellulose and the like.
• the therapeutic extract or extract mixture is prepared in an queous solution in a concentration of from about 1 to about 100 mg/ml. More typically, the concentration is from about 10 to about 20 mg/ml.
• the formulation which is sterile, is suitable for various parenteral routes including intra-dermal, intraarticular, intra-muscular, intravascular, and subcutaneous.
• compositions may include, depending on the formulation desired, pharmaceutically-acceptable, non-toxic carriers or diluents, which include vehicles commonly used to form pharmaceutical compositions for animal or human administration.
• diluent is selected so as not to unduly affect the biological activity of the combination.
• examples of such diluents which are especially useful for injectable formulations are water, the various saline solutions, Ringer's solution, dextrose include additives such as other carriers; adjuvants; or nontoxic, nontherapeutic, nonimmunogenic stabilizers and the like.
• excipients can be included in the formulation.
• examples include cosolvents, surfactants, oils, humectants, emollients, preservatives, stabilizers and antioxidants.
• Any pharmacologically acceptable buffer may be used, e.g., tris or phosphate buffers.
• Effective amounts of diluents, additives and excipients are those amounts which are effective to obtain a pharmaceutically acceptable formulation in terms of solubility, biological activity, etc.
• unit dosage form refers to physically discrete units suitable as unitary dosages for human subjects and animals, each unit containing a predetermined quantity of active material calculated to produce the desired pharmaceutical effect in association with the required pharmaceutical diluent, carrier or vehicle.
• the specifications for the unit dosage forms of this invention are dictated by and dependent on (a) the unique characteristics of the active material and the particular effect to be achieved and (b) the limitations inherent in the art of compounding such an active material for use in humans and animals.
• unit dosage forms are tablets, capsules, pills, powder packets, wafers, suppositories, granules, cachets, teaspoonfuls, dropperfuls, ampoules, vials, aerosols with metered discharges, segregated multiples of any of the foregoing, and other forms as herein described.
• a formulation of the invention includes a therapeutic extract(s) which may be formulated with conventional, pharmaceutically acceptable, vehicles for topical, oral or parenteral administration.
• Formulations may also include small amounts of adjuvants such as buffers and preservatives to maintain isotonicity, physiological and pH stability.
• adjuvants such as buffers and preservatives to maintain isotonicity, physiological and pH stability.
• Means of preparation, formulation and administration are known to those of skill. See generally Remington's Pharmaceutical Science 15 th ed., Mack Publishing Co., Easton, Pa. (1980).
• Slow or extended-release delivery systems including any of a number of biopolymers (biological-based systems), systems employing liposomes, and polymeric delivery systems, can be utilized with the extracts described herein to provide a continuous or longterm source of therapeutic compound.
• Such slow release systems are applicable to formulations for topical, ophthalmic, oral, and parenteral use.
• the inventive therapeutic extract or extract mixture is usually by oral administration as a solution.
• therapy e.g., intra-dermal, intra-articular, intramusular or intravenous
• the resultant medicament extract e.g., from a single plant or a mixture of any of the afore-mentioned plants, has been found to be effective in treating AIDS but also in treating associated conditions related to AIDS.
• associated conditions include recurrent and persistent fever, chronic diarrhea, dermatitis, generalized lymphodenpathy, persistent cough, general pain, tuberculosis, and amenorrhea.
• the mixture comprised Anoceae (10 to 20 weight percent), Anarcadiaceae (15-20 weight percent), Araceae (15 to 20 weight percent) Bombacaceae (20 weight percent), Caricaceae (15 to 20 weight percent), and Combretaceae (3 to 10 weight percent).
• the mixture was then diluted with water to give about 10 weight percent extract solution.
• the solution was administered to each patient at a dose of 3 tablespoons three times per day.
• TABLE III Symptom Approximate Recovery Time (Average) R/P Fever 1 Week Chronic Diarrhea 1 Week Dermatitis 3 Weeks Generalizied Lymphodenpathy 4 Weeks Cough 2 Weeks General Pain 4 Weeks Tuberculosis 12 Weeks Amenorrhea 1 Week

Landscapes

• Health & Medical Sciences (AREA)
• Natural Medicines & Medicinal Plants (AREA)
• Life Sciences & Earth Sciences (AREA)
• Medicinal Chemistry (AREA)
• Veterinary Medicine (AREA)
• Public Health (AREA)
• General Health & Medical Sciences (AREA)
• Chemical & Material Sciences (AREA)
• Animal Behavior & Ethology (AREA)
• Pharmacology & Pharmacy (AREA)
• Engineering & Computer Science (AREA)
• Microbiology (AREA)
• Alternative & Traditional Medicine (AREA)
• Epidemiology (AREA)
• Mycology (AREA)
• Medical Informatics (AREA)
• Botany (AREA)
• Biotechnology (AREA)
• Organic Chemistry (AREA)
• General Chemical & Material Sciences (AREA)
• Chemical Kinetics & Catalysis (AREA)
• Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
• Bioinformatics & Cheminformatics (AREA)
• Immunology (AREA)
• Virology (AREA)
• Reproductive Health (AREA)
• Oncology (AREA)
• Pulmonology (AREA)
• Communicable Diseases (AREA)
• Molecular Biology (AREA)
• AIDS & HIV (AREA)
• Rheumatology (AREA)
• Pain & Pain Management (AREA)
• Gynecology & Obstetrics (AREA)
• Pregnancy & Childbirth (AREA)
• Tropical Medicine & Parasitology (AREA)
• Endocrinology (AREA)
• Dermatology (AREA)
• Medicines Containing Plant Substances (AREA)
• Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Priority Applications (24)

Applications Claiming Priority (1)

Related Child Applications (1)

Publications (1)

Family

ID=31991298

Family Applications (5)

Family Applications After (4)

Country Status (16)

Cited By (3)

Families Citing this family (13)

Family Cites Families (14)

• 2002
  • 2002-09-12 US US10/241,973 patent/US20040052868A1/en not_active Abandoned
• 2003
  • 2003-09-11 OA OA1200500068A patent/OA12921A/en unknown
  • 2003-09-11 KR KR1020097016128A patent/KR100989297B1/ko not_active IP Right Cessation
  • 2003-09-11 CA CA2498108A patent/CA2498108C/en not_active Expired - Lifetime
  • 2003-09-11 AP AP2005003266A patent/AP2147A/xx active
  • 2003-09-11 EP EP03752162A patent/EP1545570A2/en not_active Withdrawn
  • 2003-09-11 EA EA200500481A patent/EA013683B1/ru not_active IP Right Cessation
  • 2003-09-11 MX MXPA05002781A patent/MXPA05002781A/es active IP Right Grant
  • 2003-09-11 JP JP2004536410A patent/JP2006503036A/ja active Pending
  • 2003-09-11 KR KR1020057004333A patent/KR20050051661A/ko active Search and Examination
  • 2003-09-11 BR BR0314104-7A patent/BR0314104A/pt not_active Application Discontinuation
  • 2003-09-11 NZ NZ577096A patent/NZ577096A/en not_active IP Right Cessation
  • 2003-09-11 KR KR1020107012737A patent/KR101017879B1/ko not_active IP Right Cessation
  • 2003-09-11 WO PCT/US2003/028295 patent/WO2004024071A2/en active Application Filing
  • 2003-09-11 AU AU2003270469A patent/AU2003270469B2/en not_active Ceased
  • 2003-09-11 NZ NZ591136A patent/NZ591136A/xx not_active IP Right Cessation
  • 2003-09-11 CN CNA038239272A patent/CN1688328A/zh active Pending
• 2004
  • 2004-07-30 US US10/902,993 patent/US7749544B2/en not_active Expired - Fee Related
• 2005
  • 2005-03-10 IL IL167391A patent/IL167391A/en not_active IP Right Cessation
• 2006
  • 2006-01-19 ZA ZA200502756A patent/ZA200502756B/en unknown
• 2009
  • 2009-11-26 AU AU2009240851A patent/AU2009240851A1/en not_active Withdrawn
• 2010
  • 2010-07-01 US US12/828,956 patent/US20100266715A1/en not_active Abandoned
• 2013
  • 2013-07-24 US US13/949,613 patent/US8771763B2/en not_active Expired - Fee Related
• 2014
  • 2014-04-24 US US14/261,171 patent/US20140234454A1/en not_active Abandoned

Also Published As

Similar Documents

Legal Events