US20030108537A1 - Dietary supplement enhancing the muscular energy metabolism, comprising an alkanoyl carnitine and ribosee - Google Patents
Dietary supplement enhancing the muscular energy metabolism, comprising an alkanoyl carnitine and ribosee Download PDFInfo
- Publication number
- US20030108537A1 US20030108537A1 US10/048,590 US4859002A US2003108537A1 US 20030108537 A1 US20030108537 A1 US 20030108537A1 US 4859002 A US4859002 A US 4859002A US 2003108537 A1 US2003108537 A1 US 2003108537A1
- Authority
- US
- United States
- Prior art keywords
- carnitine
- ribose
- supplement
- propionyl
- isovaleryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 235000015872 dietary supplement Nutrition 0.000 title claims abstract description 11
- -1 alkanoyl carnitine Chemical compound 0.000 title claims abstract description 10
- 230000003387 muscular Effects 0.000 title claims abstract description 8
- 229960004203 carnitine Drugs 0.000 title claims description 17
- 230000037149 energy metabolism Effects 0.000 title abstract description 3
- 230000002708 enhancing effect Effects 0.000 title abstract description 3
- HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 claims abstract description 46
- PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 claims abstract description 46
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 claims abstract description 46
- UFAHZIUFPNSHSL-MRVPVSSYSA-N O-propanoyl-L-carnitine Chemical compound CCC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C UFAHZIUFPNSHSL-MRVPVSSYSA-N 0.000 claims description 38
- IGQBPDJNUXPEMT-SNVBAGLBSA-N isovaleryl-L-carnitine Chemical compound CC(C)CC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C IGQBPDJNUXPEMT-SNVBAGLBSA-N 0.000 claims description 36
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 claims description 34
- 239000002253 acid Substances 0.000 claims description 18
- 206010021143 Hypoxia Diseases 0.000 claims description 14
- RDHQFKQIGNGIED-MRVPVSSYSA-N O-acetyl-L-carnitine Chemical compound CC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C RDHQFKQIGNGIED-MRVPVSSYSA-N 0.000 claims description 14
- 150000003839 salts Chemical class 0.000 claims description 12
- 239000013589 supplement Substances 0.000 claims description 12
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- 241000976983 Anoxia Species 0.000 claims description 11
- 230000007953 anoxia Effects 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 11
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 9
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- 238000000034 method Methods 0.000 claims description 7
- 239000010452 phosphate Substances 0.000 claims description 6
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 5
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- 230000002035 prolonged effect Effects 0.000 claims description 5
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims description 4
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 claims description 4
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 4
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims description 4
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 4
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims description 4
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- AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical compound OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 claims description 4
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- QNAYBMKLOCPYGJ-UHFFFAOYSA-N D-alpha-Ala Natural products CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 claims description 2
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- QNAYBMKLOCPYGJ-UWTATZPHSA-N L-Alanine Natural products C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 claims description 2
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- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims description 2
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- 235000014852 L-arginine Nutrition 0.000 claims description 2
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims description 2
- 229930182816 L-glutamine Natural products 0.000 claims description 2
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims description 2
- 229930182844 L-isoleucine Natural products 0.000 claims description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims description 2
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- AFVFQIVMOAPDHO-UHFFFAOYSA-M Methanesulfonate Chemical compound CS([O-])(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-M 0.000 claims description 2
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- QWYFHHGCZUCMBN-SECBINFHSA-N O-butanoyl-L-carnitine Chemical compound CCCC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C QWYFHHGCZUCMBN-SECBINFHSA-N 0.000 claims description 2
- VSNFQQXVMPSASB-SNVBAGLBSA-N O-valeroyl-L-carnitine Chemical compound CCCCC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C VSNFQQXVMPSASB-SNVBAGLBSA-N 0.000 claims description 2
- RJFAYQIBOAGBLC-BYPYZUCNSA-N Selenium-L-methionine Chemical compound C[Se]CC[C@H](N)C(O)=O RJFAYQIBOAGBLC-BYPYZUCNSA-N 0.000 claims description 2
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- 229960003767 alanine Drugs 0.000 claims description 2
- RNBGYGVWRKECFJ-ZXXMMSQZSA-N alpha-D-fructofuranose 1,6-bisphosphate Chemical compound O[C@H]1[C@H](O)[C@](O)(COP(O)(O)=O)O[C@@H]1COP(O)(O)=O RNBGYGVWRKECFJ-ZXXMMSQZSA-N 0.000 claims description 2
- RWHOZGRAXYWRNX-VFUOTHLCSA-N alpha-D-glucose 1,6-bisphosphate Chemical compound O[C@H]1[C@H](O)[C@@H](COP(O)(O)=O)O[C@H](OP(O)(O)=O)[C@@H]1O RWHOZGRAXYWRNX-VFUOTHLCSA-N 0.000 claims description 2
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/02—Monosaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A—HUMAN NECESSITIES
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P3/02—Nutrients, e.g. vitamins, minerals
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Definitions
- the present invention relates to a health food/dietary supplement comprising as its characterising ingredients an alkanoyl L-carnitine selected from the group consisting of isovaleryl L-carnitine and propionyl L-carnitine or their pharmacologically acceptable salts or mixtures of the same and a monosaccharide pentose, particularly ribose or its phosphorylated analogues.
- an alkanoyl L-carnitine selected from the group consisting of isovaleryl L-carnitine and propionyl L-carnitine or their pharmacologically acceptable salts or mixtures of the same and a monosaccharide pentose, particularly ribose or its phosphorylated analogues.
- composition is extremely effective in exerting a potent stimulation of muscular energy metabolism, and can thus be profitably used in the prevention of myocardial insufficiency and in post-infarct conditions, as well as in the course of prolonged muscular effort during physical and sporting exercises, owing to the unexpected synergistic effect exerted by its components.
- Isovaleryl L-carnitine a natural component of the pool of carnitines, presents specific activity at lysosomal level and on the cytosolic movements of calcium. It is therefore capable of intervening in proteolytic processes such as occur during intense, prolonged effort and of protecting a number of organs, such as the liver, against the action of toxic substances.
- Propionyl L-carnitine exerts an intense antioxidant effect and is particularly effective in enhancing the peripheral circulation and cardiac functional capacity.
- propionyl L-carnitine transferase possesses a greater affinity for propionyl L-carnitine than for L-carnitine, and consequently propionyl L-carnitine possesses a higher degree of specificity for cardiac and skeletal muscle.
- propionyl L-carnitine transferase transporting the propionyl group, increases the uptake of this component by the muscle cells, which may be of particular importance for energy purposes, in that the propionate can be used by the mitochondria as an anapleurotic substrate and provide energy in the absence of oxygen.
- Ribose is a monosaccharide pentose which is important in the body for the synthesis of nucleotides and other metabolic products. It is formed by conversion of glucose via the pentose phosphates.
- ribokinase ribose is phosphorylated to ribose-5-phosphate which, through the production of 5-phosphoribosyl-1-pyrophosphate (PRPP), can be used for the synthesis of nucleotides necessary for the production of ATP.
- PRPP in addition to intervening in the production of ATP, is also important for the synthesis of nucleotides such as adenine and hypoxanthine and of ribonucleotides and deoxyribo-nucleotides.
- composition comprising a combination of the following as its characterising components:
- an alkanoyl L-carnitine selected from the group comprising isovaleryl L-carnitine, propionyl L-carnitine or their pharmacologically acceptable salts or mixtures of the same;
- ribose or a phosphorylate derivative thereof constitutes an effective health food/dietary supplement for the prevention of states of myocardial or skeletal muscle dysfuntion related to conditions of anoxia or insufficient energy supply as occurring in coronary or post-bifarct disorders or during prolonged physical activity and muscle fatigue, owing to the potent and unexpected synergistic effect exerted by its components.
- the dietary supplement according to the present invention may additionally contain
- a “carnitine” selected from the group comprising L-carnitine, acetyl L-carnitine, butyryl L-carnitine and valeryl L-carnitine, or their pharmacologically acceptable salts or mixtures of the same.
- weight-to-weight ratios of the above-mentioned components (a):(b):(c) range from 1:1:1 to 1:10:2.
- this unexpected synergistic effect on the increase in energy capabilities at both cardiac and muscular level exerted by the combination according to the present invention enables it to be used in the prevention of both myocardial insufficiency and of muscle fatigue such as occur in cases of myocardial ischaemia or in the course of intense muscular effort due to prolonged physical exercise or sporting activity.
- the anoxic state was obtained by introducing 100% N 2 instead of O 2 into the bath.
- the method described by Strehler was adopted (Strehler B. L. Methods in Enzymology 111 N.Y. Acad. Press., 879, 1957).
- Coronary occlusion and the resulting myocardial anoxia lead after 5-8 minutes, to the onset of arrhythmias.
- ventricular ectopic contractions were counted for a period of 30 minutes after ligation both in control rats and in rats that had received slow injections into the left ventricle, 15 minutes before ligation, of a solution containing isovaleryl L-carnitine alone (100 mg/kg), propionyl L-carnitine alone (100 mg/kg), or carnitine combination alone consisting of propionyl L-carnitine (25 mg/kg), acetyl L-carnitine (25 mg/kg) and isovaleryl L-carnitine (25 mg/kg) or ribose alone (100 mg/kg), or a combination of ribose plus isovaleryl L-carnitine or propionyl L-carnitine or a combination of ribose plus carnitine combination at the doses described above.
- compositions according to the present invention are given hereinbelow: Lozenges, capsules, tablets 1) Propionyl L-carnitine 500 mg Ribose 500 mg 2) Isovaleryl L-carnitine 500 mg Ribose 500 mg 3) Propionyl L-carnitine 125 mg Acetyl L-carnitine 125 mg L-carnitine 125 mg Isovaleryl L-carnitine 125 mg Ribose 500 mg Granulates or vials 4) Propionyl L-carnitine 1 g Ribose 1 g 5) Isovaleryl L-carnitine 1 g Ribose 1 g 6) Propionyl L-carnitine 1 g Ribose 2.5 g 7) Propionyl L-carnitine 250 mg Acetyl L-carnitine 250 mg Isovaleryl L-carnitine 250 mg L-carnitine 250 mg Ribose 2.5 g 8) Propionyl L-carnitine 250 mg Ace
- a pharmacologically acceptable salt of the various carnitines mentioned in the present invention is, in addition to the respective inner salts, any salt of these with an acid which does not give rise to unwanted toxic or side effects.
- acids are well known to pharmacologists and to experts in pharmaceutical technology.
- Non-limiting examples of such salts are the following: chloride; bromide; iodide; aspartate, acid aspartate; citrate, acid citrate; tartrate; phosphate, acid phosphate; fumarate, acid fumarate; glycerophosphate; glucose phosphate; lactate; maleate, acid maleate; mucate; orotate; oxalate, acid oxalate; sulphate, acid sulphate; trichloroacetate; trifluoroacetate and methane sulphonate.
- isovaleryl L-carnitine acid fumarate (U.S. Pat. No. 5,227,58) is particularly preferred.
- the supplement of the invention may further comprise vitamins, coenzymes, mineral substances, aminoacids and antioxidants.
- the supplement may be manufactured in the form of tablets, lozenges, capsules, pills, granulates, syrups, vials or drops.
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Neurology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/604,390 US20070116743A1 (en) | 2000-06-14 | 2006-11-27 | Dietary supplement enhancing the muscular energy metabolism, comprising an alkanoyl carnitine and ribose |
| US12/753,368 US8518455B2 (en) | 2000-06-14 | 2010-04-02 | Dietary supplement enhancing the muscular energy metabolism, comprising an alkanoyl carnitine and ribose |
| US13/952,083 US8747906B2 (en) | 2000-06-14 | 2013-07-26 | Dietary supplement enhancing the muscular energy metabolism, comprising an alkanoyl carnitine and ribose |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2000RM000323A IT1317043B1 (it) | 2000-06-14 | 2000-06-14 | Integratore alimentare potenziante il metabolismo energeticomuscolare, comprendente una alcanoil l-carnitina e ribosio. |
| ITRM2000A000323 | 2000-06-14 |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US11/604,390 Continuation-In-Part US20070116743A1 (en) | 2000-06-14 | 2006-11-27 | Dietary supplement enhancing the muscular energy metabolism, comprising an alkanoyl carnitine and ribose |
| US11/604,390 Continuation US20070116743A1 (en) | 2000-06-14 | 2006-11-27 | Dietary supplement enhancing the muscular energy metabolism, comprising an alkanoyl carnitine and ribose |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| US20030108537A1 true US20030108537A1 (en) | 2003-06-12 |
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| US10/048,590 Abandoned US20030108537A1 (en) | 2000-06-14 | 2001-01-06 | Dietary supplement enhancing the muscular energy metabolism, comprising an alkanoyl carnitine and ribosee |
| US11/604,390 Abandoned US20070116743A1 (en) | 2000-06-14 | 2006-11-27 | Dietary supplement enhancing the muscular energy metabolism, comprising an alkanoyl carnitine and ribose |
| US12/753,368 Expired - Fee Related US8518455B2 (en) | 2000-06-14 | 2010-04-02 | Dietary supplement enhancing the muscular energy metabolism, comprising an alkanoyl carnitine and ribose |
| US13/952,083 Expired - Fee Related US8747906B2 (en) | 2000-06-14 | 2013-07-26 | Dietary supplement enhancing the muscular energy metabolism, comprising an alkanoyl carnitine and ribose |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
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| US11/604,390 Abandoned US20070116743A1 (en) | 2000-06-14 | 2006-11-27 | Dietary supplement enhancing the muscular energy metabolism, comprising an alkanoyl carnitine and ribose |
| US12/753,368 Expired - Fee Related US8518455B2 (en) | 2000-06-14 | 2010-04-02 | Dietary supplement enhancing the muscular energy metabolism, comprising an alkanoyl carnitine and ribose |
| US13/952,083 Expired - Fee Related US8747906B2 (en) | 2000-06-14 | 2013-07-26 | Dietary supplement enhancing the muscular energy metabolism, comprising an alkanoyl carnitine and ribose |
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| AT (1) | ATE265216T1 (xx) |
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| CA (1) | CA2381339C (xx) |
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| HU (1) | HU228642B1 (xx) |
| IL (1) | IL148038A0 (xx) |
| IT (1) | IT1317043B1 (xx) |
| MX (1) | MXPA02001550A (xx) |
| NO (1) | NO20020731L (xx) |
| PL (1) | PL199641B1 (xx) |
| PT (1) | PT1292312E (xx) |
| SK (2) | SK287308B6 (xx) |
| TR (1) | TR200401096T4 (xx) |
| WO (1) | WO2001095915A1 (xx) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004112511A2 (en) * | 2003-06-26 | 2004-12-29 | Mcleod Donald M | Supplement for restoring growth hormone levels |
| US20080176809A1 (en) * | 2007-01-23 | 2008-07-24 | Herrick James D | Use of D-ribose to treat cardiac arrhythmias |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITRM20020545A1 (it) * | 2002-10-30 | 2004-04-30 | Chementecno Srl | Integratore energetico e vitaminico minerale ad azione ergogenica per la prevenzione della fatica muscolare. |
| GB0306394D0 (en) * | 2003-03-20 | 2003-04-23 | Univ Nottingham | Carnitine retention |
| GB0606864D0 (en) * | 2006-04-05 | 2006-05-17 | Univ Nottingham | Increades fatty acid oxidation |
| CN101356971B (zh) * | 2007-07-30 | 2012-11-07 | 石药集团中奇制药技术（石家庄）有限公司 | 一种用于抗疲劳耐缺氧的保健食品组合物 |
| CN105232564A (zh) * | 2008-08-20 | 2016-01-13 | 生物能生命科学公司 | D-核糖用于改善心肺功能的用途 |
| GB2510374A (en) * | 2013-01-31 | 2014-08-06 | Christopher Francis Bennett | Formulation comprising N-acetylcarnitine and D-ribose |
| GB201304112D0 (en) * | 2013-03-07 | 2013-04-24 | Univ Nottingham | Modulation of energy expenditure |
| WO2017075289A1 (en) | 2015-10-27 | 2017-05-04 | Cytozyme Animal Nutrition, Inc. | Animal nutrition compositions and related methods |
| US10674746B2 (en) | 2015-10-27 | 2020-06-09 | Cytozyme Animal Nutrition, Inc. | Animal nutrition compositions and related methods |
| ITUB20155250A1 (it) * | 2015-11-24 | 2017-05-24 | Apuzzo Dario | Nuova composizione nutraceutica, somministrabile per via orale, utile per esercitare una potente stimolazione del metabolismo, in particolare del metabolismo energetico muscolare. |
| DE102016002090A1 (de) | 2016-02-22 | 2017-08-24 | Ribomedica S. L. | Komposition für die Nahrungsergänzung menschlicher Ernährung und deren Verwendung |
Family Cites Families (7)
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|---|---|---|---|---|
| DE3785667T2 (de) * | 1986-09-17 | 1994-07-21 | Clintec Nutrition Co | Zusatznahrung bzw. therapie für personen mit risiko oder in behandlung für arteriosklerotische vaskuläre, kardiovaskuläre und/oder thrombotische erkrankungen. |
| US6294520B1 (en) * | 1989-03-27 | 2001-09-25 | Albert T. Naito | Material for passage through the blood-brain barrier |
| US5397786A (en) * | 1993-01-08 | 1995-03-14 | Simone; Charles B. | Rehydration drink |
| IT1291127B1 (it) * | 1997-04-01 | 1998-12-29 | Sigma Tau Ind Farmaceuti | Integratore alimentare per soggetti dediti ad intensa e prolungata attivita' fisica |
| US6159942A (en) * | 1998-06-19 | 2000-12-12 | Bioenergy, Inc. | Compositions for increasing energy in vivo |
| DE69929128T2 (de) * | 1998-08-31 | 2006-06-29 | Nipro Corp. | Nährstoffinfusionspräparat |
| US6579544B1 (en) * | 2000-05-31 | 2003-06-17 | Nutriex, L.L.C. | Method for supplementing the diet |
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2000
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2001
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- 2001-04-24 SK SK1729-2002A patent/SK287308B6/sk not_active IP Right Cessation
- 2001-06-01 WO PCT/IT2001/000283 patent/WO2001095915A1/en active IP Right Grant
- 2001-06-01 SK SK210-2002A patent/SK2102002A3/sk unknown
- 2001-06-01 DE DE60103055T patent/DE60103055T2/de not_active Expired - Lifetime
- 2001-06-01 PL PL352578A patent/PL199641B1/pl unknown
- 2001-06-01 CZ CZ2002366A patent/CZ2002366A3/cs unknown
- 2001-06-01 AT AT01941001T patent/ATE265216T1/de active
- 2001-06-01 CA CA002381339A patent/CA2381339C/en not_active Expired - Fee Related
- 2001-06-01 PT PT01941001T patent/PT1292312E/pt unknown
- 2001-06-01 MX MXPA02001550A patent/MXPA02001550A/es active IP Right Grant
- 2001-06-01 AU AU74487/01A patent/AU782367B2/en not_active Ceased
- 2001-06-01 ES ES01941001T patent/ES2219531T3/es not_active Expired - Lifetime
- 2001-06-01 EP EP01941001A patent/EP1292312B1/en not_active Expired - Lifetime
- 2001-06-01 IL IL14803801A patent/IL148038A0/xx unknown
- 2001-06-01 HU HU0202496A patent/HU228642B1/hu not_active IP Right Cessation
- 2001-06-01 TR TR2004/01096T patent/TR200401096T4/xx unknown
- 2001-06-01 DK DK01941001T patent/DK1292312T3/da active
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2002
- 2002-02-13 NO NO20020731A patent/NO20020731L/no not_active Application Discontinuation
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2006
- 2006-11-27 US US11/604,390 patent/US20070116743A1/en not_active Abandoned
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2010
- 2010-04-02 US US12/753,368 patent/US8518455B2/en not_active Expired - Fee Related
-
2013
- 2013-07-26 US US13/952,083 patent/US8747906B2/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004112511A2 (en) * | 2003-06-26 | 2004-12-29 | Mcleod Donald M | Supplement for restoring growth hormone levels |
| WO2004112511A3 (en) * | 2003-06-26 | 2005-04-07 | Donald M Mcleod | Supplement for restoring growth hormone levels |
| US20080176809A1 (en) * | 2007-01-23 | 2008-07-24 | Herrick James D | Use of D-ribose to treat cardiac arrhythmias |
| US8101581B2 (en) * | 2007-01-23 | 2012-01-24 | Bioenergy, Inc. | Use of D-ribose to treat cardiac arrhythmias |
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| AS | Assignment |
Owner name: SIGMA-TAU HEALTHSCIENCE S.P.A., ITALY Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:POLA, PIETRO;REEL/FRAME:013834/0397 Effective date: 20011221 |
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