US20020082302A1 - Process for the preparation of aryloctanoyl amides - Google Patents
Process for the preparation of aryloctanoyl amides Download PDFInfo
- Publication number
- US20020082302A1 US20020082302A1 US10/014,400 US1440001A US2002082302A1 US 20020082302 A1 US20020082302 A1 US 20020082302A1 US 1440001 A US1440001 A US 1440001A US 2002082302 A1 US2002082302 A1 US 2002082302A1
- Authority
- US
- United States
- Prior art keywords
- alkyl
- formula
- process according
- compound
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 0 *NC(=O)[C@H]([4*])C[C@H](O)C(N)C[C@@H]([3*])CC1=CC=C([2*])C([1*])=C1 Chemical compound *NC(=O)[C@H]([4*])C[C@H](O)C(N)C[C@@H]([3*])CC1=CC=C([2*])C([1*])=C1 0.000 description 23
- PEVJBTAQTGEXTR-RXKCGJBRSA-N C.CCCCOC1=CC(C[C@@H](CCl)C(C)C)=CC=C1OC.COCCCOC1=CC(C[C@@H](CC([C@@H]2C[C@@H](C(C)C)[C@]3(O2)O[C@@H](C2=CC=CC=C2)[C@H](C)N3C)N(O)CC2=CC=CC=C2)C(C)C)=CC=C1OC Chemical compound C.CCCCOC1=CC(C[C@@H](CCl)C(C)C)=CC=C1OC.COCCCOC1=CC(C[C@@H](CC([C@@H]2C[C@@H](C(C)C)[C@]3(O2)O[C@@H](C2=CC=CC=C2)[C@H](C)N3C)N(O)CC2=CC=CC=C2)C(C)C)=CC=C1OC PEVJBTAQTGEXTR-RXKCGJBRSA-N 0.000 description 1
- OAVKTUXIQPCHHL-FUJDEKNSSA-N CC(C)[C@@H]1C[C@@H](C=O)O[C@]12O[C@@H](C1=CC=CC=C1)[C@H](C)N2C Chemical compound CC(C)[C@@H]1C[C@@H](C=O)O[C@]12O[C@@H](C1=CC=CC=C1)[C@H](C)N2C OAVKTUXIQPCHHL-FUJDEKNSSA-N 0.000 description 1
- NAKXKVRMYHGLBH-FTSNLURZSA-N CC(C)[C@@H]1C[C@@H](C=[N+]([O-])CC2=CC=CC=C2)O[C@]12O[C@@H](C1=CC=CC=C1)[C@H](C)N2C Chemical compound CC(C)[C@@H]1C[C@@H](C=[N+]([O-])CC2=CC=CC=C2)O[C@]12O[C@@H](C1=CC=CC=C1)[C@H](C)N2C NAKXKVRMYHGLBH-FTSNLURZSA-N 0.000 description 1
- SNUBXWZAKGSKIF-FUJDEKNSSA-N CC(C)[C@@H]1C[C@@H](CO)O[C@]12O[C@@H](C1=CC=CC=C1)[C@H](C)N2C Chemical compound CC(C)[C@@H]1C[C@@H](CO)O[C@]12O[C@@H](C1=CC=CC=C1)[C@H](C)N2C SNUBXWZAKGSKIF-FUJDEKNSSA-N 0.000 description 1
- AGJSCTROHOMEDF-DXXCODDNSA-N COC1=CC=C(C[C@@H](C[C@H](N)[C@@H](O)C[C@H](C(=O)NCC(C)(C)C(N)=O)C(C)C)C(C)C)C=C1O1CCC1OC Chemical compound COC1=CC=C(C[C@@H](C[C@H](N)[C@@H](O)C[C@H](C(=O)NCC(C)(C)C(N)=O)C(C)C)C(C)C)C=C1O1CCC1OC AGJSCTROHOMEDF-DXXCODDNSA-N 0.000 description 1
- HAWOASLFJUQUNL-PPYQFJQJSA-N COC1=CC=C(C[C@@H](C[C@H](NCC2=CC=CC=C2)[C@@H](O)C[C@H](C(=O)NCC(C)(C)C(N)=O)C(C)C)C(C)C)C=C1O1CCC1OC Chemical compound COC1=CC=C(C[C@@H](C[C@H](NCC2=CC=CC=C2)[C@@H](O)C[C@H](C(=O)NCC(C)(C)C(N)=O)C(C)C)C(C)C)C=C1O1CCC1OC HAWOASLFJUQUNL-PPYQFJQJSA-N 0.000 description 1
- VDTZQPHQAISVEI-QXUYBEEESA-N COCCCOC1=CC(C[C@@H](C[C@@H](O)[C@@H]2C[C@@H](C(C)C)C(=O)O2)C(C)C)=CC=C1OC Chemical compound COCCCOC1=CC(C[C@@H](C[C@@H](O)[C@@H]2C[C@@H](C(C)C)C(=O)O2)C(C)C)=CC=C1OC VDTZQPHQAISVEI-QXUYBEEESA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/16—Preparation of optical isomers
- C07C231/18—Preparation of optical isomers by stereospecific synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/342,254 US6670507B2 (en) | 2000-12-14 | 2003-01-15 | Process for the preparation of aryloctanoyl amides |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH2442/00 | 2000-12-14 | ||
| CH24422000 | 2000-12-14 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US10/342,254 Continuation US6670507B2 (en) | 2000-12-14 | 2003-01-15 | Process for the preparation of aryloctanoyl amides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| US20020082302A1 true US20020082302A1 (en) | 2002-06-27 |
Family
ID=4569276
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US10/014,400 Abandoned US20020082302A1 (en) | 2000-12-14 | 2001-12-14 | Process for the preparation of aryloctanoyl amides |
| US10/342,254 Expired - Fee Related US6670507B2 (en) | 2000-12-14 | 2003-01-15 | Process for the preparation of aryloctanoyl amides |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US10/342,254 Expired - Fee Related US6670507B2 (en) | 2000-12-14 | 2003-01-15 | Process for the preparation of aryloctanoyl amides |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20020082302A1 (es) |
| EP (1) | EP1215201B1 (es) |
| AT (1) | ATE342887T1 (es) |
| CY (1) | CY1107575T1 (es) |
| DE (1) | DE60123911T2 (es) |
| DK (1) | DK1215201T3 (es) |
| ES (1) | ES2274847T3 (es) |
| PT (1) | PT1215201E (es) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0212410D0 (en) * | 2002-05-29 | 2002-07-10 | Novartis Ag | Organic compounds |
| US20060154926A1 (en) * | 2002-06-11 | 2006-07-13 | Elan Pharmaceuticals, Inc. | Methods of treating alzheimer's disease using aryl alkanoic acid amides |
| GB0327839D0 (en) * | 2003-12-01 | 2003-12-31 | Novartis Ag | Organic compounds |
| GB0419361D0 (en) * | 2004-08-31 | 2004-10-06 | Novartis Ag | Organic compounds |
| GB0511686D0 (en) * | 2005-06-08 | 2005-07-13 | Novartis Ag | Organic compounds |
| GB0521083D0 (en) | 2005-10-17 | 2005-11-23 | Novartis Ag | Organic compounds |
| GB2431644A (en) * | 2005-10-25 | 2007-05-02 | Novartis Ag | Synthesis of aryl-octanoyl amide compounds |
| GB2431643A (en) * | 2005-10-25 | 2007-05-02 | Novartis Ag | Synthesis of aryl-octanoyl amide compounds |
| GB2431652A (en) * | 2005-10-25 | 2007-05-02 | Novartis Ag | Alternative synthesis of aryl-octanoyl amide compounds |
| GB2431646A (en) * | 2005-10-25 | 2007-05-02 | Novartis Ag | Alternative synthesis of aryl-octanoyl amide compounds |
| GB2431650A (en) * | 2005-10-25 | 2007-05-02 | Novartis Ag | Alternative synthesis of aryl-octanoyl amide compounds |
| GB2431654A (en) * | 2005-10-25 | 2007-05-02 | Novartis Ag | Alternative synthesis of aryl-octanoyl amide compounds |
| GB2431640A (en) * | 2005-10-25 | 2007-05-02 | Novartis Ag | Alternative synthesis of aryl-octanoyl amide compounds |
| GB2431651A (en) * | 2005-10-25 | 2007-05-02 | Novartis Ag | Synthesis of aryl-octanoyl amide compounds |
| GB2431645A (en) * | 2005-10-25 | 2007-05-02 | Novartis Ag | Alternative synthesis of aryl-octanoyl amide compounds |
| GB2431648A (en) * | 2005-10-25 | 2007-05-02 | Novartis Ag | Alternative synthesis of aryl-octanoyl amide compounds |
| GB2431647A (en) * | 2005-10-25 | 2007-05-02 | Novartis Ag | Synthesis of aryl-octanoyl amide compounds |
| GB0522789D0 (en) | 2005-11-08 | 2005-12-14 | Novartis Ag | Organic compounds |
| EP2062874B1 (en) | 2007-11-20 | 2014-12-17 | KRKA, tovarna zdravil, d.d., Novo mesto | Process and intermediates for the preparation of aliskiren |
| EP2189442B1 (en) | 2008-11-20 | 2014-10-01 | Krka Tovarna Zdravil, D.D., Novo Mesto | Process and intermediates for the preparation of aliskiren |
| US8203005B2 (en) | 2009-10-29 | 2012-06-19 | Carbo Design Llc | Manufacturing process for enantiomerically pure 8-aryloctanoic acids as Aliskiren |
| WO2011064790A1 (en) * | 2009-11-30 | 2011-06-03 | Avra Laboratories Pvt. Ltd | A novel process for making aliskiren, its novel intermediates and certain novel compounds |
| US8703976B2 (en) | 2011-10-02 | 2014-04-22 | Milan Soukup | Manufacturing process for 8-aryloctanoic acids such as Aliskiren |
| CN113546633B (zh) * | 2021-07-27 | 2022-07-01 | 云南大学 | 一种镨基磁性催化剂及其制备方法和应用 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY119161A (en) * | 1994-04-18 | 2005-04-30 | Novartis Ag | Delta-amino-gamma-hydroxy-omega-aryl-alkanoic acid amides with enzyme especially renin inhibiting activities |
-
2001
- 2001-12-06 PT PT01128462T patent/PT1215201E/pt unknown
- 2001-12-06 DE DE60123911T patent/DE60123911T2/de not_active Expired - Lifetime
- 2001-12-06 ES ES01128462T patent/ES2274847T3/es not_active Expired - Lifetime
- 2001-12-06 EP EP01128462A patent/EP1215201B1/en not_active Expired - Lifetime
- 2001-12-06 DK DK01128462T patent/DK1215201T3/da active
- 2001-12-06 AT AT01128462T patent/ATE342887T1/de active
- 2001-12-14 US US10/014,400 patent/US20020082302A1/en not_active Abandoned
-
2003
- 2003-01-15 US US10/342,254 patent/US6670507B2/en not_active Expired - Fee Related
-
2006
- 2006-12-19 CY CY20061101815T patent/CY1107575T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2274847T3 (es) | 2007-06-01 |
| EP1215201B1 (en) | 2006-10-18 |
| ATE342887T1 (de) | 2006-11-15 |
| PT1215201E (pt) | 2007-02-28 |
| CY1107575T1 (el) | 2013-03-13 |
| DE60123911T2 (de) | 2007-05-31 |
| EP1215201A2 (en) | 2002-06-19 |
| US20030176717A1 (en) | 2003-09-18 |
| DE60123911D1 (de) | 2006-11-30 |
| DK1215201T3 (da) | 2007-01-29 |
| US6670507B2 (en) | 2003-12-30 |
| EP1215201A3 (en) | 2003-01-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| STCB | Information on status: application discontinuation |
Free format text: EXPRESSLY ABANDONED -- DURING EXAMINATION |