US20020076470A1 - Composition and method - Google Patents
Composition and method Download PDFInfo
- Publication number
- US20020076470A1 US20020076470A1 US09/922,660 US92266001A US2002076470A1 US 20020076470 A1 US20020076470 A1 US 20020076470A1 US 92266001 A US92266001 A US 92266001A US 2002076470 A1 US2002076470 A1 US 2002076470A1
- Authority
- US
- United States
- Prior art keywords
- diet
- pet
- ppm
- accordance
- vitamin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/40—Feeding-stuffs specially adapted for particular animals for carnivorous animals, e.g. cats or dogs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/158—Fatty acids; Fats; Products containing oils or fats
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Definitions
- a companion pet diet meeting ordinary nutritional requirements of an adult pet and further comprising a sufficient amount of an antioxidant or mixture thereof to inhibit the onset of deterioration of the mental capacity of said companion pet in its aged years.
- a further aspect of the invention is a method for inhibiting the deterioration of the mental capacity of an aged companion pet, which comprises feeding said pet in his adult years an antioxidant or mixture thereof at sufficient levels to accomplish this inhibition.
- a companion adult pet diet meeting ordinary nutritional requirements of an adult companion pet and further comprising an antioxidant selected from the group consisting of Vitamin E, vitamin C, alpha-lipoic acid, 1-carnitine and any mixtures thereof in quantities sufficient to inhibit the deterioration of the mental capacity of said pet in its aged years.
- an antioxidant selected from the group consisting of Vitamin E, vitamin C, alpha-lipoic acid, 1-carnitine and any mixtures thereof in quantities sufficient to inhibit the deterioration of the mental capacity of said pet in its aged years.
- a still further aspect of the invention is a method for increasing the mental capacity of an aged companion pet, which comprises feeding the pet in its adult years an amount of an antioxidant or mixture thereof sufficient to increase the mental capacity.
- Another aspect of the invention is a method for increasing the mental capacity of an adult companion pet which comprises feeding the pet an amount of an antioxidant or mixture thereof sufficient to increase the mental capacity of said pet.
- the diet fed to the adult companion pet for example canine and feline is the standard normal diet fed to an animal of that age.
- a typical diet for a canine of 1 to 6 years of age is the standard normal diet fed to an animal of that age.
- TABLE 1 Component Target Protein (% of dry matter) 23 Fat (% of dry matter) 15 Phosphorous (% of dry matter) 0.6 Sodium (% of dry matter) 0.3
- Adding significant quantities of an antioxidant or mixture thereof to the companion adult pet diet can bring about delay of the onset of demonstrative changes in the behavior, particularly the deterioration of mental capacity, as specifically shown by problem-solving capacity, in an aged pet.
- the term, adult is intended to mean, in general, a canine of at least 1 to 6 years and a feline of at least 1 to 6 years.
- An aged dog or cat is 7 years and above.
- the loss of mental capacity for canines and felines has been observed for a number of years. This loss of mental capacity is manifested in numerous ways. For a canine, for example, it can be manifested as disorientation, house soiling, altered sleep-wake patterns, decreased or altered interaction with humans and other pets, and inability to learn and concentrate. These conditions can be manifested in felines as well. Alzheimer's, as exhibited in man, is not found in canines and felines.
- the inventors have succeeded in accomplishing delaying the onset of this deterioration.
- aged pets mental capacity can be maintained for a longer period of time.
- the deterioration of mental capacity can be stopped or delayed.
- Memory and learning ability can be improved.
- Overall mental alertness can be enhanced.
- Age related cognitive decline could be slowed.
- Cognitive Dysfunction Syndrome its progress can be slowed in aged dogs and clinical signs associated with this Syndrome can be controlled. Prophylaxis where appropriate and pets in need of these components are the target group.
- the component in the diet which accomplishes this is an antioxidant or mixture thereof.
- An antioxidant is a material that quenches a free radical. Examples of such materials include foods such as Ginkgo Biloba, citrus pulp, grape pomace, tomato pomace, carrot and spinach, all preferably dried as well as various other materials such as beta-carotene, selenium, coenzyme Q10 (ubiquinone), lutein, tocotrienols, soy isoflavones, S-adenosylmethionine, glutathione, taurine, N-acetylcysteine, Vitamin E, Vitamin C, alpha-lipoic acid, 1-carnitine and the like.
- Vitamin E can be administered as a tocopherol or a mixture of tocopherols and various derivatives thereof such as esters like vitamin E acetate, succinate, palmitate, and the like.
- the alpha form is preferable but beta, gamma and delta forms can be included.
- the d form is preferable but racemic mixtures are acceptable.
- the forms and derivatives will function in a Vitamin E like activity after ingestion by the pet.
- Vitamin C can be administered in this diet as ascorbic acid and its various derivatives thereof such as calcium phosphate salts, cholesteryl salt, 2-monophosphate, and the like which will function in a vitamin C like activity after ingesting by the pet. They can be in any form such as liquid, semisolid, solid and heat stable form.
- Alpha-lipoic acid can be administered into the diet as alpha lipoic acid or as a lipoate derivative as in U.S. Pat. No. 5,621,117, racemic mixtures, salts, esters or amides thereof.
- L-carnitine can be administered in the diet and various derivatives of carnitine such as the salts such as the hydrochloride, fumarate and succinates, as well as acetylated carnitine, and the like can be used.
- the quantities administered in the diet, all as wt % (dry matter basis) of the diet, are calculated as the active material, per se, that is measured as free material.
- the maximum amounts employed should not bring about toxicity.
- At least about 100 ppm or at least about 150 ppm of Vitamin E can be used.
- a preferred range of about 500 to about 1,000 ppm can be employed.
- a maximum of about 2000 ppm or about 1500 ppm is generally not exceeded.
- Vitamin C at least about 50 ppm is used, desirably at least about 75 ppm and more desirably at least about 100 ppm.
- a nontoxic maximum can be employed.
- the quantity of alpha-lipoic acid can vary from at least about 25, desirably at least about 50 ppm, more desirably about 100 ppm. Maximum quantities can vary from about 100 ppm to 600 ppm or to an amount which remains non toxic to the pet. A preferred range is from about 100 ppm to about 200 ppm.
- For felines slightly higher minimums of 1-carnitine can be employed such as about 100 ppm, 200 ppm, and 500 ppm.
- a nontoxic maximum quantity can be employed, for example, less than about 5,000 ppm.
- For canines lower quantities can be employed, for example, less than about 5,000 ppm.
- For canines a preferred range is about 200 ppm to about 400 ppm.
- For felines a preferred range is about 400 ppm to about 600 ppm.
- Beta-carotene at about 1- 15 ppm can be employed.
- Lutein at least about 5 ppm can be employed.
- Tocotrienols at least about 25 ppm can be employed.
- Coenzyme Q10 at least about 25 ppm can be employed.
- S-adenosylmethionine at least about 50 ppm can be employed.
- Taurine at least about 1000 ppm can be employed.
- Soy isoflavones at least about 25 ppm can be used.
- N-acetylcysteine at least about 50 ppm can be used.
- Glutathione at least about 50 ppm can be used.
- Gingko Biloba at least 50 ppm of extract can be used.
- ORAC Oxygen radical absorbing capacity
- any ingredient with an ORAC content >25 umole of Trolox equivalents per gram of dry matter could be used if added at 1% combination with four other 1% ingredients for a total of 5% addition to the diet.
- Landmark discrimination learning requires subjects to select a particular object based on proximity to an object.
- the initial learning is based on the dogs' ability to learn an object discrimination task. We have previously found that the effects of age on discrimination learning depends on task difficulty.
- the adult dogs proceeded on to landmark 1 and 2 testing, where the landmark is moved further away from the positive well.
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Food Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurology (AREA)
- Birds (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Psychiatry (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Fodder In General (AREA)
- Feed For Specific Animals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (20)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/922,660 US20020076470A1 (en) | 2000-10-31 | 2001-08-06 | Composition and method |
US09/978,132 US6914071B2 (en) | 2000-10-31 | 2001-10-16 | Antioxidant containing composition and method |
AU2002231183A AU2002231183A1 (en) | 2000-10-31 | 2001-10-25 | Pet food composition and method |
JP2002538766A JP2004512053A (ja) | 2000-10-31 | 2001-10-25 | ペットフード組成物および方法 |
AT01991459T ATE452540T1 (de) | 2000-10-31 | 2001-10-25 | Zusammensetzung und verfahren |
PCT/US2001/049654 WO2002035943A2 (en) | 2000-10-31 | 2001-10-25 | Pet food composition and method |
DE60140895T DE60140895D1 (de) | 2000-10-31 | 2001-10-25 | Zusammensetzung und verfahren |
CNB018209491A CN1303896C (zh) | 2000-10-31 | 2001-10-25 | 组合物和方法 |
ES01991459T ES2336305T3 (es) | 2000-10-31 | 2001-10-25 | Composicion y metodo. |
DK01991459.7T DK1339292T3 (da) | 2000-10-31 | 2001-10-25 | Sammensætning og fremgangsmåde |
EP01991459.7A EP1339292B2 (en) | 2000-10-31 | 2001-10-25 | Companion pet diet |
CA2427692A CA2427692C (en) | 2000-10-31 | 2001-10-25 | Pet food composition and method |
ARP010105078A AR031283A1 (es) | 2000-10-31 | 2001-10-30 | Composicion y metodo de dieta para animales |
US11/154,210 US8592478B2 (en) | 2000-10-31 | 2005-06-16 | Antioxidant-containing food composition |
JP2007062332A JP2007190029A (ja) | 2000-10-31 | 2007-03-12 | ペットフード組成物および方法 |
US12/336,024 US8592479B2 (en) | 2000-10-31 | 2008-12-16 | Antioxidant-containing food composition for use in enhancing antiviral immunity in companion animals |
US12/336,060 US20090156658A1 (en) | 2000-10-31 | 2008-12-16 | Antioxidant-Containing Food Composition For Use In Inhibiting Histamine Pathways In Companion Animals |
US12/319,287 US8669282B2 (en) | 2000-10-31 | 2008-12-30 | Companion animal compositions including lipoic acid and methods of use thereof |
JP2010137171A JP2010279357A (ja) | 2000-10-31 | 2010-06-16 | ペットフード組成物および方法 |
JP2014130312A JP2014195468A (ja) | 2000-10-31 | 2014-06-25 | ペットフード組成物および方法 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24450400P | 2000-10-31 | 2000-10-31 | |
US25344800P | 2000-11-28 | 2000-11-28 | |
US09/922,660 US20020076470A1 (en) | 2000-10-31 | 2001-08-06 | Composition and method |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/978,132 Continuation-In-Part US6914071B2 (en) | 2000-10-31 | 2001-10-16 | Antioxidant containing composition and method |
Publications (1)
Publication Number | Publication Date |
---|---|
US20020076470A1 true US20020076470A1 (en) | 2002-06-20 |
Family
ID=27399769
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/922,660 Abandoned US20020076470A1 (en) | 2000-10-31 | 2001-08-06 | Composition and method |
US09/978,132 Expired - Lifetime US6914071B2 (en) | 2000-10-31 | 2001-10-16 | Antioxidant containing composition and method |
US11/154,210 Expired - Fee Related US8592478B2 (en) | 2000-10-31 | 2005-06-16 | Antioxidant-containing food composition |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/978,132 Expired - Lifetime US6914071B2 (en) | 2000-10-31 | 2001-10-16 | Antioxidant containing composition and method |
US11/154,210 Expired - Fee Related US8592478B2 (en) | 2000-10-31 | 2005-06-16 | Antioxidant-containing food composition |
Country Status (12)
Country | Link |
---|---|
US (3) | US20020076470A1 (es) |
EP (1) | EP1339292B2 (es) |
JP (4) | JP2004512053A (es) |
CN (1) | CN1303896C (es) |
AR (1) | AR031283A1 (es) |
AT (1) | ATE452540T1 (es) |
AU (1) | AU2002231183A1 (es) |
CA (1) | CA2427692C (es) |
DE (1) | DE60140895D1 (es) |
DK (1) | DK1339292T3 (es) |
ES (1) | ES2336305T3 (es) |
WO (1) | WO2002035943A2 (es) |
Cited By (11)
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WO2006058248A2 (en) | 2004-11-24 | 2006-06-01 | Hill's Pet Nutrition, Inc. | Methods for increasing the immune response in an animal |
US20080038323A1 (en) * | 2004-11-24 | 2008-02-14 | Zicker Steven C | Methods for Improving Liver Clearance of Xenobiotic Substances in an Animal |
US20080206398A1 (en) * | 2004-12-30 | 2008-08-28 | Ryan Yamka | Methods for Enhancing the Quality of Life of a Senior Animal |
US20090004299A1 (en) * | 2004-12-29 | 2009-01-01 | Karen Joy Wedekind | Methods for Inhibiting a Decline in Learning and/or Memory in Animals |
US20090111877A1 (en) * | 2004-12-30 | 2009-04-30 | Hill's Pet Nutrition, Inc. | Methods for Enhancing the Quality of Life of a Senior Animal |
US20090155393A1 (en) * | 2005-07-14 | 2009-06-18 | Steven Curtis Zicker | Method for prolonging the life of animals |
US20090176864A1 (en) * | 2004-11-24 | 2009-07-09 | Hill's Pet Nutrition, Inc. | Methods For Improving Hepatic and Immune Function In An Animal |
US20090182032A1 (en) * | 2000-10-31 | 2009-07-16 | Hill's Pet Nutrition, Inc. | Companion animal compositions including lipoic acid and methods of use thereof |
US20110274808A1 (en) * | 2008-12-30 | 2011-11-10 | Hill's Pet Nutrition, Inc. | Methods for increasing the palatability of companion animal food compositions |
US8592478B2 (en) | 2000-10-31 | 2013-11-26 | Hill's Pet Nutrition, Inc. | Antioxidant-containing food composition |
US8952052B2 (en) | 2008-12-30 | 2015-02-10 | Hill's Pet Nutrition, Inc. | Use of lipoic acid for treating or preventing degenerative joint conditions, osteoarthritis, cartilage damage, and related disorders in companion animals |
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US8642581B1 (en) * | 2000-02-11 | 2014-02-04 | Brian D. Halevie-Goldman | Compositions and methods for the production of S-adenosylmethionine within the body |
US8592479B2 (en) * | 2000-10-31 | 2013-11-26 | Hill's Pet Nutrition, Inc. | Antioxidant-containing food composition for use in enhancing antiviral immunity in companion animals |
US7547450B2 (en) * | 2002-10-24 | 2009-06-16 | Nestec Ltd. | Senior feline food |
AU2004257683B2 (en) * | 2003-07-07 | 2010-09-02 | Hill's Pet Nutrition, Inc. | Compositions for improved oxidative status in companion animals |
BRPI0517563A (pt) * | 2004-11-09 | 2008-10-14 | Hills Pet Nutrition Inc | método para modular expressão de genes em um mamìfero senescente |
FR2884421B1 (fr) * | 2005-04-15 | 2007-08-10 | Virbac Sa | Nouveaux moyens de regulation des troubles du comportement chez les animaux de compagnie |
CN101287460B (zh) * | 2005-08-17 | 2012-04-25 | 希尔氏宠物营养品公司 | 预防和治疗肾病的组合物 |
US20080226696A1 (en) * | 2007-03-15 | 2008-09-18 | Ben Treadwell | Methods of improving learning abilities of aged companion animals |
US20080317884A1 (en) * | 2007-06-22 | 2008-12-25 | Jewell Dennis E | Enhancing Disease Resistance In An Animal |
AU2009333239B2 (en) * | 2008-12-16 | 2012-08-30 | Hill's Pet Nutrition, Inc. | Antioxidant-containing food composition for use in inhibiting histamine pathways in companion animals |
US20110256118A1 (en) * | 2008-12-16 | 2011-10-20 | Hill's Pet Nutrition, Inc. | Antioxidant-containing food composition for use in enhancing antiviral immunity in companion animals |
US20110269828A1 (en) * | 2008-12-30 | 2011-11-03 | Hill's Pet Nutrition, Inc. | Compositions and methods for treating and preventing weight-related disorders in companion animals |
RU2558540C2 (ru) * | 2010-01-06 | 2015-08-10 | Нестек С.А. | Диетические режимы, пригодные для имитации ограничения калорий |
JP2013532128A (ja) * | 2010-05-12 | 2013-08-15 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | 愛玩動物の炎症を抑制および予防し、炎症状態を緩和する方法 |
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2001
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- 2001-10-16 US US09/978,132 patent/US6914071B2/en not_active Expired - Lifetime
- 2001-10-25 DE DE60140895T patent/DE60140895D1/de not_active Expired - Lifetime
- 2001-10-25 WO PCT/US2001/049654 patent/WO2002035943A2/en active Application Filing
- 2001-10-25 DK DK01991459.7T patent/DK1339292T3/da active
- 2001-10-25 CN CNB018209491A patent/CN1303896C/zh not_active Expired - Fee Related
- 2001-10-25 AT AT01991459T patent/ATE452540T1/de not_active IP Right Cessation
- 2001-10-25 JP JP2002538766A patent/JP2004512053A/ja active Pending
- 2001-10-25 EP EP01991459.7A patent/EP1339292B2/en not_active Expired - Lifetime
- 2001-10-25 AU AU2002231183A patent/AU2002231183A1/en not_active Abandoned
- 2001-10-25 ES ES01991459T patent/ES2336305T3/es not_active Expired - Lifetime
- 2001-10-25 CA CA2427692A patent/CA2427692C/en not_active Expired - Fee Related
- 2001-10-30 AR ARP010105078A patent/AR031283A1/es unknown
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2005
- 2005-06-16 US US11/154,210 patent/US8592478B2/en not_active Expired - Fee Related
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2007
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2010
- 2010-06-16 JP JP2010137171A patent/JP2010279357A/ja not_active Ceased
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2014
- 2014-06-25 JP JP2014130312A patent/JP2014195468A/ja active Pending
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US20090182032A1 (en) * | 2000-10-31 | 2009-07-16 | Hill's Pet Nutrition, Inc. | Companion animal compositions including lipoic acid and methods of use thereof |
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US20110274808A1 (en) * | 2008-12-30 | 2011-11-10 | Hill's Pet Nutrition, Inc. | Methods for increasing the palatability of companion animal food compositions |
US8952052B2 (en) | 2008-12-30 | 2015-02-10 | Hill's Pet Nutrition, Inc. | Use of lipoic acid for treating or preventing degenerative joint conditions, osteoarthritis, cartilage damage, and related disorders in companion animals |
US9271957B2 (en) | 2008-12-30 | 2016-03-01 | Colgate-Palmolive Company | Methods of treating or preventing degenerative joint conditions, osteoarthritis, cartilage damage, and related disorders in companion animals |
Also Published As
Publication number | Publication date |
---|---|
CN1303896C (zh) | 2007-03-14 |
EP1339292A2 (en) | 2003-09-03 |
US20020119182A1 (en) | 2002-08-29 |
JP2010279357A (ja) | 2010-12-16 |
AU2002231183A1 (en) | 2002-05-15 |
JP2007190029A (ja) | 2007-08-02 |
JP2004512053A (ja) | 2004-04-22 |
EP1339292B1 (en) | 2009-12-23 |
ATE452540T1 (de) | 2010-01-15 |
JP2014195468A (ja) | 2014-10-16 |
DE60140895D1 (de) | 2010-02-04 |
US20050232976A1 (en) | 2005-10-20 |
DK1339292T3 (da) | 2010-04-12 |
CA2427692C (en) | 2012-01-03 |
WO2002035943A2 (en) | 2002-05-10 |
EP1339292B2 (en) | 2019-09-18 |
CA2427692A1 (en) | 2002-05-10 |
AR031283A1 (es) | 2003-09-17 |
ES2336305T3 (es) | 2010-04-12 |
WO2002035943A3 (en) | 2002-09-19 |
US8592478B2 (en) | 2013-11-26 |
CN1578627A (zh) | 2005-02-09 |
US6914071B2 (en) | 2005-07-05 |
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