UA99459C2 - 9-(pyrazol-3-yl)- 9h-purine-2-amine and 3-(pyraz0l-3-yl)-3h-imidazo[4,5-b]pyridin-5-amine derivatives and their use for the treatment of cancer - Google Patents
9-(pyrazol-3-yl)- 9h-purine-2-amine and 3-(pyraz0l-3-yl)-3h-imidazo[4,5-b]pyridin-5-amine derivatives and their use for the treatment of cancerInfo
- Publication number
- UA99459C2 UA99459C2 UAA200912433A UAA200912433A UA99459C2 UA 99459 C2 UA99459 C2 UA 99459C2 UA A200912433 A UAA200912433 A UA A200912433A UA A200912433 A UAA200912433 A UA A200912433A UA 99459 C2 UA99459 C2 UA 99459C2
- Authority
- UA
- Ukraine
- Prior art keywords
- amine
- cancer
- treatment
- pyraz0l
- imidazo
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- NULQSRGWDFSHJJ-UHFFFAOYSA-N 9-(1h-pyrazol-5-yl)purin-2-amine Chemical compound C12=NC(N)=NC=C2N=CN1C=1C=CNN=1 NULQSRGWDFSHJJ-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000014767 Myeloproliferative disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
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- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
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- C07D473/32—Nitrogen atom
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- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
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- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
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- Communicable Diseases (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Данное изобретение касается соединений формулы (I):(I),их фармацевтических композиций и их применения.Эти соединения обеспечивают лечение миелопролиферативных нарушений и рака.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US91627007P | 2007-05-04 | 2007-05-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
UA99459C2 true UA99459C2 (en) | 2012-08-27 |
Family
ID=39592016
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA200912433A UA99459C2 (en) | 2007-05-04 | 2008-02-05 | 9-(pyrazol-3-yl)- 9h-purine-2-amine and 3-(pyraz0l-3-yl)-3h-imidazo[4,5-b]pyridin-5-amine derivatives and their use for the treatment of cancer |
Country Status (24)
Country | Link |
---|---|
US (3) | US8486966B2 (ru) |
EP (1) | EP2152705A1 (ru) |
JP (1) | JP5415403B2 (ru) |
KR (1) | KR101563372B1 (ru) |
CN (1) | CN101679426A (ru) |
AR (1) | AR066429A1 (ru) |
AU (1) | AU2008247159B2 (ru) |
BR (1) | BRPI0811534A2 (ru) |
CA (1) | CA2684693C (ru) |
CL (1) | CL2008001297A1 (ru) |
CO (1) | CO6251294A2 (ru) |
EC (1) | ECSP099751A (ru) |
IL (1) | IL201691A0 (ru) |
MX (1) | MX2009011944A (ru) |
MY (1) | MY147890A (ru) |
NZ (1) | NZ581633A (ru) |
PE (1) | PE20090238A1 (ru) |
RU (1) | RU2481348C2 (ru) |
SA (1) | SA08290271B1 (ru) |
TW (1) | TWI406864B (ru) |
UA (1) | UA99459C2 (ru) |
UY (1) | UY31065A1 (ru) |
WO (1) | WO2008135785A1 (ru) |
ZA (1) | ZA200907679B (ru) |
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UA99459C2 (en) * | 2007-05-04 | 2012-08-27 | Астразенека Аб | 9-(pyrazol-3-yl)- 9h-purine-2-amine and 3-(pyraz0l-3-yl)-3h-imidazo[4,5-b]pyridin-5-amine derivatives and their use for the treatment of cancer |
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CN102952084A (zh) * | 2012-11-15 | 2013-03-06 | 大连九信生物化工科技有限公司 | 一种4,6-二氯-2-甲硫基-5-硝基嘧啶的合成方法 |
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CN104003943A (zh) * | 2014-05-06 | 2014-08-27 | 南通常佑药业科技有限公司 | 一种替格瑞洛中间体的制备方法 |
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GB201717260D0 (en) | 2017-10-20 | 2017-12-06 | Galapagos Nv | Novel compounds and pharma ceutical compositions thereof for the treatment of inflammatory disorders |
EA202192575A1 (ru) | 2019-03-21 | 2022-01-14 | Онксео | Соединения dbait в сочетании с ингибиторами киназ для лечения рака |
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-
2008
- 2008-02-05 UA UAA200912433A patent/UA99459C2/ru unknown
- 2008-04-30 TW TW097115958A patent/TWI406864B/zh not_active IP Right Cessation
- 2008-04-30 PE PE2008000770A patent/PE20090238A1/es not_active Application Discontinuation
- 2008-05-02 AR ARP080101879A patent/AR066429A1/es unknown
- 2008-05-02 UY UY31065A patent/UY31065A1/es not_active Application Discontinuation
- 2008-05-02 WO PCT/GB2008/050321 patent/WO2008135785A1/en active Application Filing
- 2008-05-02 CN CN200880019785A patent/CN101679426A/zh active Pending
- 2008-05-02 AU AU2008247159A patent/AU2008247159B2/en not_active Ceased
- 2008-05-02 BR BRPI0811534-6A2A patent/BRPI0811534A2/pt not_active IP Right Cessation
- 2008-05-02 JP JP2010507002A patent/JP5415403B2/ja not_active Expired - Fee Related
- 2008-05-02 MY MYPI20094620A patent/MY147890A/en unknown
- 2008-05-02 US US12/598,473 patent/US8486966B2/en not_active Expired - Fee Related
- 2008-05-02 NZ NZ581633A patent/NZ581633A/en not_active IP Right Cessation
- 2008-05-02 EP EP20080737245 patent/EP2152705A1/en not_active Withdrawn
- 2008-05-02 MX MX2009011944A patent/MX2009011944A/es active IP Right Grant
- 2008-05-02 RU RU2009144848/04A patent/RU2481348C2/ru not_active IP Right Cessation
- 2008-05-02 CA CA2684693A patent/CA2684693C/en not_active Expired - Fee Related
- 2008-05-02 KR KR1020097025268A patent/KR101563372B1/ko not_active IP Right Cessation
- 2008-05-03 SA SA8290271A patent/SA08290271B1/ar unknown
- 2008-05-05 CL CL2008001297A patent/CL2008001297A1/es unknown
-
2009
- 2009-10-22 IL IL201691A patent/IL201691A0/en unknown
- 2009-11-02 ZA ZA200907679A patent/ZA200907679B/xx unknown
- 2009-11-09 CO CO09126884A patent/CO6251294A2/es active IP Right Grant
- 2009-11-20 EC EC2009009751A patent/ECSP099751A/es unknown
-
2013
- 2013-06-21 US US13/923,498 patent/US20140155394A1/en not_active Abandoned
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2014
- 2014-07-15 US US14/331,302 patent/US20150011545A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
MY147890A (en) | 2013-01-31 |
AR066429A1 (es) | 2009-08-19 |
WO2008135785A1 (en) | 2008-11-13 |
CA2684693C (en) | 2015-06-23 |
AU2008247159A1 (en) | 2008-11-13 |
AU2008247159B2 (en) | 2011-11-10 |
CL2008001297A1 (es) | 2009-01-16 |
IL201691A0 (en) | 2010-05-31 |
KR20100019988A (ko) | 2010-02-19 |
NZ581633A (en) | 2012-01-12 |
TW200902530A (en) | 2009-01-16 |
TWI406864B (zh) | 2013-09-01 |
US8486966B2 (en) | 2013-07-16 |
CA2684693A1 (en) | 2008-11-13 |
JP2010526128A (ja) | 2010-07-29 |
SA08290271B1 (ar) | 2012-02-07 |
BRPI0811534A2 (pt) | 2014-11-18 |
ZA200907679B (en) | 2010-07-28 |
PE20090238A1 (es) | 2009-04-21 |
CN101679426A (zh) | 2010-03-24 |
RU2009144848A (ru) | 2011-06-10 |
JP5415403B2 (ja) | 2014-02-12 |
US20100324040A1 (en) | 2010-12-23 |
US20150011545A1 (en) | 2015-01-08 |
MX2009011944A (es) | 2009-12-11 |
RU2481348C2 (ru) | 2013-05-10 |
UY31065A1 (es) | 2009-01-05 |
KR101563372B1 (ko) | 2015-10-26 |
ECSP099751A (es) | 2009-12-28 |
CO6251294A2 (es) | 2011-02-21 |
EP2152705A1 (en) | 2010-02-17 |
US20140155394A1 (en) | 2014-06-05 |
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