MX2009011944A - Derivados de 9-(pirazol-3-il)-9h-purin-2-amina y 3-(pirazol-3-il)-3h-imidazo [4,5-b] piridin-5-amina y su uso para tratamiento de cancer. - Google Patents

Derivados de 9-(pirazol-3-il)-9h-purin-2-amina y 3-(pirazol-3-il)-3h-imidazo [4,5-b] piridin-5-amina y su uso para tratamiento de cancer.

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Publication number
MX2009011944A
MX2009011944A MX2009011944A MX2009011944A MX2009011944A MX 2009011944 A MX2009011944 A MX 2009011944A MX 2009011944 A MX2009011944 A MX 2009011944A MX 2009011944 A MX2009011944 A MX 2009011944A MX 2009011944 A MX2009011944 A MX 2009011944A
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MX
Mexico
Prior art keywords
amine
cancer
treatment
pyraz0l
imidaz0
Prior art date
Application number
MX2009011944A
Other languages
English (en)
Inventor
Audrey Davies
Mei Su
Tao Wang
Stephanos Ioannidis
Michelle Lamb
Hai-Jun Zhang
Original Assignee
Astrazeneca Ab
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Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of MX2009011944A publication Critical patent/MX2009011944A/es

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
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    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
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    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
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    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
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    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings

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  • Chemical & Material Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
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  • Heart & Thoracic Surgery (AREA)
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  • Ophthalmology & Optometry (AREA)
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  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a compuestos de fórmula (I) y a sus composiciones farmacéuticas y métodos de uso. Estos compuestos proporcionan un tratamiento para los trastornos mieloproliferativos y cáncer.
MX2009011944A 2007-05-04 2008-05-02 Derivados de 9-(pirazol-3-il)-9h-purin-2-amina y 3-(pirazol-3-il)-3h-imidazo [4,5-b] piridin-5-amina y su uso para tratamiento de cancer. MX2009011944A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91627007P 2007-05-04 2007-05-04
PCT/GB2008/050321 WO2008135785A1 (en) 2007-05-04 2008-05-02 9- (pyrazol- 3 -yl) - 9h- purine-2 -amine and 3- (pyraz0l-3-yl) -3h-imidaz0 [4, 5-b] pyridin-5-amine derivatives and their use for the treatment of cancer

Publications (1)

Publication Number Publication Date
MX2009011944A true MX2009011944A (es) 2009-12-11

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US (3) US8486966B2 (es)
EP (1) EP2152705A1 (es)
JP (1) JP5415403B2 (es)
KR (1) KR101563372B1 (es)
CN (1) CN101679426A (es)
AR (1) AR066429A1 (es)
AU (1) AU2008247159B2 (es)
BR (1) BRPI0811534A2 (es)
CA (1) CA2684693C (es)
CL (1) CL2008001297A1 (es)
CO (1) CO6251294A2 (es)
EC (1) ECSP099751A (es)
IL (1) IL201691A0 (es)
MX (1) MX2009011944A (es)
MY (1) MY147890A (es)
NZ (1) NZ581633A (es)
PE (1) PE20090238A1 (es)
RU (1) RU2481348C2 (es)
SA (1) SA08290271B1 (es)
TW (1) TWI406864B (es)
UA (1) UA99459C2 (es)
UY (1) UY31065A1 (es)
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ZA (1) ZA200907679B (es)

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IL201691A0 (en) 2010-05-31
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ZA200907679B (en) 2010-07-28
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