UA93528C2 - Фармацевтическая композиция, которая содержит кристаллическую модификацию гидрохлорида донепезила, и способ получения из hee комприматов - Google Patents

Фармацевтическая композиция, которая содержит кристаллическую модификацию гидрохлорида донепезила, и способ получения из hee комприматов

Info

Publication number
UA93528C2
UA93528C2 UAA200808077A UAA200808077A UA93528C2 UA 93528 C2 UA93528 C2 UA 93528C2 UA A200808077 A UAA200808077 A UA A200808077A UA A200808077 A UAA200808077 A UA A200808077A UA 93528 C2 UA93528 C2 UA 93528C2
Authority
UA
Ukraine
Prior art keywords
donepezil hydrochloride
pharmaceutical composition
producing
same
composition containing
Prior art date
Application number
UAA200808077A
Other languages
English (en)
Ukrainian (uk)
Inventor
Наруп Юлиа Шульце
Франк Мускулус
Петер Kpaacc
Original Assignee
Ратиофарм Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ратиофарм Гмбх filed Critical Ратиофарм Гмбх
Publication of UA93528C2 publication Critical patent/UA93528C2/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

В заявке описана фармацевтическая композиция, пригодная для получения комприматов, в частности таблеток, путем прямого прессования, и содержащая гидрохлорид донепезила в полиморфной модификации I. В таблетках, полученных путем прямого прессования, полиморфная модификация I гидрохлорида донепезила остается стабильной даже при длительном хранении.
UAA200808077A 2005-12-16 2006-12-15 Фармацевтическая композиция, которая содержит кристаллическую модификацию гидрохлорида донепезила, и способ получения из hee комприматов UA93528C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102005060377A DE102005060377A1 (de) 2005-12-16 2005-12-16 Pharmazeutische Zusammensetzung enthaltend Donepezilhydrochlorid, Tablette hieraus und Verfahren zu deren Herstellung

Publications (1)

Publication Number Publication Date
UA93528C2 true UA93528C2 (ru) 2011-02-25

Family

ID=37770841

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200808077A UA93528C2 (ru) 2005-12-16 2006-12-15 Фармацевтическая композиция, которая содержит кристаллическую модификацию гидрохлорида донепезила, и способ получения из hee комприматов

Country Status (6)

Country Link
US (1) US8992976B2 (ru)
CA (1) CA2633356C (ru)
DE (1) DE102005060377A1 (ru)
EA (2) EA200801339A1 (ru)
UA (1) UA93528C2 (ru)
WO (2) WO2007073782A1 (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0614586D0 (en) * 2006-07-22 2006-08-30 Pliva Istrazivacki Inst D O O Pharmaceutical Formulation
DE102007037932A1 (de) * 2007-08-11 2009-02-12 Alfred E. Tiefenbacher Gmbh & Co.Kg Donepezilhydrochlorid in amorpher Form enthaltende Tablette
EP2674150A1 (de) * 2009-01-28 2013-12-18 Labtec GmbH Pharmazeutische Zubereitung mit verbesserter Stabilität des Wirkstoffs
EP2366378A1 (en) 2010-03-01 2011-09-21 Dexcel Pharma Technologies Ltd. Sustained-release donepezil formulations
EP2502620A1 (en) * 2011-03-24 2012-09-26 Krka Tovarna Zdravil, D.D., Novo Mesto Solid pharmaceutical composition comprising donepezil
KR20150092385A (ko) 2014-02-03 2015-08-13 씨제이헬스케어 주식회사 솔리페나신을 포함하는 안정한 제제 및 이의 제조방법
CN107550884B (zh) * 2017-09-19 2018-06-05 扬子江药业集团上海海尼药业有限公司 一种盐酸多奈哌齐胶囊及其制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4956182A (en) * 1989-03-16 1990-09-11 Bristol-Myers Company Direct compression cholestyramine tablet and solvent-free coating therefor
US5110598A (en) * 1989-06-30 1992-05-05 Smithkline Beecham Corp. Intermittent release dosage form
AU1153097A (en) * 1996-06-07 1998-01-05 Eisai Co. Ltd. Stable polymorphs of donepezil (1-benzyl-4-{(5,6-dimethoxy-1-indanon)-2-yl}methylpiperidine ) hydrochloride and process for production
SI21223A (sl) 2002-06-19 2003-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Farmacevtska formulacija s stabiliziranim amorfnim donepezilijevim kloridom
US20040265375A1 (en) * 2003-04-16 2004-12-30 Platteeuw Johannes J. Orally disintegrating tablets
US20040265372A1 (en) * 2003-06-27 2004-12-30 David Wynn Soft tablet containing high molecular weight cellulosics
CA2552221A1 (en) * 2003-12-31 2005-07-21 Actavis Group Hf Donepezil formulations
EP1734934A4 (en) * 2004-04-15 2012-11-14 Reddys Lab Ltd Dr DOSAGE FORM WITH POLYMORPHAN STABILITY
ES2317313T3 (es) * 2004-10-19 2009-04-16 Krka, Tovarna Zdravil, D.D., Novo Mesto Composicion farmaceutica solida que comprende clorhidrato de donepezilo.
EP1681048A1 (en) * 2005-01-14 2006-07-19 Krka Tovarna Zdravil, D.D., Novo Mesto Orally disintegrating composition of olanzapine or donepezil

Also Published As

Publication number Publication date
WO2007073782A1 (de) 2007-07-05
US8992976B2 (en) 2015-03-31
CA2633356C (en) 2014-06-03
WO2007073888A3 (de) 2007-11-29
WO2007073888A2 (de) 2007-07-05
EA201200727A1 (ru) 2013-02-28
CA2633356A1 (en) 2007-07-05
DE102005060377A1 (de) 2007-06-21
US20080311202A1 (en) 2008-12-18
EA200801339A1 (ru) 2008-12-30
EA023116B1 (ru) 2016-04-29

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