EA201200727A1 - Фармацевтическая композиция, содержащая гидрохлорид донепезила, полученная из нее таблетка и способ ее получения - Google Patents

Фармацевтическая композиция, содержащая гидрохлорид донепезила, полученная из нее таблетка и способ ее получения

Info

Publication number
EA201200727A1
EA201200727A1 EA201200727A EA201200727A EA201200727A1 EA 201200727 A1 EA201200727 A1 EA 201200727A1 EA 201200727 A EA201200727 A EA 201200727A EA 201200727 A EA201200727 A EA 201200727A EA 201200727 A1 EA201200727 A1 EA 201200727A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pharmaceutical composition
doneed
tablet
producing
composition containing
Prior art date
Application number
EA201200727A
Other languages
English (en)
Other versions
EA023116B1 (ru
Inventor
Юлия Шульце-Наруп
Франк Мускулус
Петер Краасс
Original Assignee
Рациофарм Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Рациофарм Гмбх filed Critical Рациофарм Гмбх
Publication of EA201200727A1 publication Critical patent/EA201200727A1/ru
Publication of EA023116B1 publication Critical patent/EA023116B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

В заявке описана фармацевтическая композиция, пригодная для получения из нее таблеток путем прямого прессования и содержащая гидрохлорид донепезила в полиморфной модификации I. В полученных путем прямого прессования таблетках полиморфная модификация I гидрохлорида донепезила остается стабильной даже при длительном их хранении.
EA201200727A 2005-12-16 2006-12-15 Прессованная лекарственная форма, полученная из фармацевтической композиции, содержащей гидрохлорид донепезила в полиморфной модификации i, и способ получения лекарственной формы EA023116B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005060377A DE102005060377A1 (de) 2005-12-16 2005-12-16 Pharmazeutische Zusammensetzung enthaltend Donepezilhydrochlorid, Tablette hieraus und Verfahren zu deren Herstellung
PCT/EP2006/007990 WO2007073782A1 (de) 2005-12-16 2006-08-11 Pharmazeutische zusammensetzung enthaltend donepezilhydrochlorid, tablette hieraus und verfahren zu deren herstellung

Publications (2)

Publication Number Publication Date
EA201200727A1 true EA201200727A1 (ru) 2013-02-28
EA023116B1 EA023116B1 (ru) 2016-04-29

Family

ID=37770841

Family Applications (2)

Application Number Title Priority Date Filing Date
EA200801339A EA200801339A1 (ru) 2005-12-16 2006-12-15 Фармацевтическая композиция, содержащая гидрохлорид донепезила, полученная из неё таблетка и способ её получения
EA201200727A EA023116B1 (ru) 2005-12-16 2006-12-15 Прессованная лекарственная форма, полученная из фармацевтической композиции, содержащей гидрохлорид донепезила в полиморфной модификации i, и способ получения лекарственной формы

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA200801339A EA200801339A1 (ru) 2005-12-16 2006-12-15 Фармацевтическая композиция, содержащая гидрохлорид донепезила, полученная из неё таблетка и способ её получения

Country Status (6)

Country Link
US (1) US8992976B2 (ru)
CA (1) CA2633356C (ru)
DE (1) DE102005060377A1 (ru)
EA (2) EA200801339A1 (ru)
UA (1) UA93528C2 (ru)
WO (2) WO2007073782A1 (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0614586D0 (en) * 2006-07-22 2006-08-30 Pliva Istrazivacki Inst D O O Pharmaceutical Formulation
DE102007037932A1 (de) * 2007-08-11 2009-02-12 Alfred E. Tiefenbacher Gmbh & Co.Kg Donepezilhydrochlorid in amorpher Form enthaltende Tablette
EP2674150A1 (de) * 2009-01-28 2013-12-18 Labtec GmbH Pharmazeutische Zubereitung mit verbesserter Stabilität des Wirkstoffs
EP2366378A1 (en) 2010-03-01 2011-09-21 Dexcel Pharma Technologies Ltd. Sustained-release donepezil formulations
EP2502620A1 (en) * 2011-03-24 2012-09-26 Krka Tovarna Zdravil, D.D., Novo Mesto Solid pharmaceutical composition comprising donepezil
KR20150092385A (ko) 2014-02-03 2015-08-13 씨제이헬스케어 주식회사 솔리페나신을 포함하는 안정한 제제 및 이의 제조방법
CN107550884B (zh) * 2017-09-19 2018-06-05 扬子江药业集团上海海尼药业有限公司 一种盐酸多奈哌齐胶囊及其制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4956182A (en) * 1989-03-16 1990-09-11 Bristol-Myers Company Direct compression cholestyramine tablet and solvent-free coating therefor
US5110598A (en) * 1989-06-30 1992-05-05 Smithkline Beecham Corp. Intermittent release dosage form
WO1997046526A1 (en) * 1996-06-07 1997-12-11 Eisai Co., Ltd. Stable polymorphs of donepezil (1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine) hydrochloride and process for production
SI21223A (sl) * 2002-06-19 2003-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Farmacevtska formulacija s stabiliziranim amorfnim donepezilijevim kloridom
US20040265375A1 (en) * 2003-04-16 2004-12-30 Platteeuw Johannes J. Orally disintegrating tablets
US20040265372A1 (en) * 2003-06-27 2004-12-30 David Wynn Soft tablet containing high molecular weight cellulosics
US20050232990A1 (en) 2003-12-31 2005-10-20 Garth Boehm Donepezil formulations
US20070224260A1 (en) * 2004-04-15 2007-09-27 Dr. Reddy's Laboratories Limited Dosage Form Having Polymorphic Stability
EA012220B1 (ru) * 2004-10-19 2009-08-28 Крка, Товарна Здравил, Д. Д., Ново Место Твёрдая фармацевтическая композиция, содержащая донепезила гидрохлорид
EP1681048A1 (en) * 2005-01-14 2006-07-19 Krka Tovarna Zdravil, D.D., Novo Mesto Orally disintegrating composition of olanzapine or donepezil

Also Published As

Publication number Publication date
EA200801339A1 (ru) 2008-12-30
CA2633356C (en) 2014-06-03
DE102005060377A1 (de) 2007-06-21
US20080311202A1 (en) 2008-12-18
US8992976B2 (en) 2015-03-31
WO2007073782A1 (de) 2007-07-05
EA023116B1 (ru) 2016-04-29
WO2007073888A2 (de) 2007-07-05
CA2633356A1 (en) 2007-07-05
WO2007073888A3 (de) 2007-11-29
UA93528C2 (ru) 2011-02-25

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU