UA82920C2 - 2-(1h-indolylsulfanyl)-benzyl amine derivatives as selective serotonine reuptake ingibitors (ssri) - Google Patents
2-(1h-indolylsulfanyl)-benzyl amine derivatives as selective serotonine reuptake ingibitors (ssri) Download PDFInfo
- Publication number
- UA82920C2 UA82920C2 UAA200607149A UAA200607149A UA82920C2 UA 82920 C2 UA82920 C2 UA 82920C2 UA A200607149 A UAA200607149 A UA A200607149A UA A200607149 A UAA200607149 A UA A200607149A UA 82920 C2 UA82920 C2 UA 82920C2
- Authority
- UA
- Ukraine
- Prior art keywords
- ylsulfanyl
- indol
- benzyl
- methylamine
- methyl
- Prior art date
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- -1 2-(1h-indolylsulfanyl)-benzyl Chemical group 0.000 title claims description 74
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 title claims description 67
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 claims description 367
- 150000001875 compounds Chemical class 0.000 claims description 316
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 211
- 229910052739 hydrogen Inorganic materials 0.000 claims description 183
- 239000001257 hydrogen Substances 0.000 claims description 183
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 84
- ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 claims description 55
- WGQKYBSKWIADBV-UHFFFAOYSA-N benzylamine Chemical compound NCC1=CC=CC=C1 WGQKYBSKWIADBV-UHFFFAOYSA-N 0.000 claims description 50
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 49
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 claims description 41
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- 239000002253 acid Substances 0.000 claims description 24
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 claims description 24
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims description 24
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- LCRYQHWBRQFUOO-UHFFFAOYSA-N 2-methyl-3h-1,2-benzothiazole Chemical compound C1=CC=C2SN(C)CC2=C1 LCRYQHWBRQFUOO-UHFFFAOYSA-N 0.000 claims 3
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- OJURWUUOVGOHJZ-UHFFFAOYSA-N methyl 2-[(2-acetyloxyphenyl)methyl-[2-[(2-acetyloxyphenyl)methyl-(2-methoxy-2-oxoethyl)amino]ethyl]amino]acetate Chemical compound C=1C=CC=C(OC(C)=O)C=1CN(CC(=O)OC)CCN(CC(=O)OC)CC1=CC=CC=C1OC(C)=O OJURWUUOVGOHJZ-UHFFFAOYSA-N 0.000 claims 2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200301923 | 2003-12-23 | ||
| PCT/DK2004/000894 WO2005061455A1 (en) | 2003-12-23 | 2004-12-21 | 2-(1h-indolylsulfanyl)-benzyl amine derivatives as ssri |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA82920C2 true UA82920C2 (en) | 2008-05-26 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200607149A UA82920C2 (en) | 2003-12-23 | 2004-12-21 | 2-(1h-indolylsulfanyl)-benzyl amine derivatives as selective serotonine reuptake ingibitors (ssri) |
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|---|---|
| EP (1) | EP1860100B1 (zh) |
| KR (2) | KR20080092471A (zh) |
| CN (2) | CN101372474A (zh) |
| AR (1) | AR046978A1 (zh) |
| AT (1) | ATE500220T1 (zh) |
| CA (1) | CA2551168C (zh) |
| DE (1) | DE602004031680D1 (zh) |
| DK (1) | DK1860100T3 (zh) |
| EA (2) | EA010666B1 (zh) |
| ES (1) | ES2362237T3 (zh) |
| HK (1) | HK1103075A1 (zh) |
| IS (2) | IS2551B (zh) |
| ME (1) | ME01040B (zh) |
| MY (1) | MY143038A (zh) |
| NO (1) | NO336676B1 (zh) |
| NZ (1) | NZ547046A (zh) |
| PL (1) | PL1860100T4 (zh) |
| PT (1) | PT1860100E (zh) |
| RS (1) | RS51899B (zh) |
| SG (1) | SG141463A1 (zh) |
| SI (1) | SI1860100T1 (zh) |
| TW (1) | TWI347183B (zh) |
| UA (1) | UA82920C2 (zh) |
| ZA (1) | ZA200705870B (zh) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101224201B (zh) * | 2007-01-18 | 2011-10-05 | 和泓生物技术（上海）有限公司 | 多巴胺转运蛋白和去甲肾上腺素转运蛋白双重抑制剂的应用 |
| ES2646834T3 (es) * | 2010-08-20 | 2017-12-18 | Amira Pharmaceuticals, Inc. | Inhibidores de autotaxina y usos de los mismos |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3803143A (en) | 1969-09-08 | 1974-04-09 | Eisai Co Ltd | 6-amino alkylene 6,7-dihydro-5h-dibenzo (b,g),(1,5)thiazocines |
| US4018830A (en) | 1969-09-22 | 1977-04-19 | Merck & Co., Inc. | Phenylthioaralkylamines |
| US4055665A (en) | 1974-11-25 | 1977-10-25 | Merck & Co., Inc. | Treating arrythmia with phenylthioaralkylamines |
| US4056632A (en) | 1975-07-21 | 1977-11-01 | Burroughs Wellcome Co. | 2-Hydroxymethyl-2'-aminomethyl-diphenylsulfides and method of use |
| EP0396827A1 (en) | 1989-05-09 | 1990-11-14 | SPOFA Spojené Podniky Pro Zdravotnickou Vyrobu | 2-Phenylthiobenzylamine dervivatives and acid addition salts thereof |
| GB8912971D0 (en) | 1989-06-06 | 1989-07-26 | Wellcome Found | Halogen substituted diphenylsulfides |
| GB9126311D0 (en) | 1991-12-11 | 1992-02-12 | Wellcome Found | Substituted diphenylsulfides |
| CZ293595A3 (cs) | 1995-11-09 | 1999-12-15 | Farmak A. S. | Deriváty N,N-dimethyl-2-(arylthio)benzylaminu, jejich soli, způsoby jejich přípravy a jejich použití v léčivých přípravcích |
| US5912256A (en) * | 1996-06-20 | 1999-06-15 | Eli Lilly And Company | Compounds having effects on serotonin-related systems |
| DK0923548T3 (da) * | 1996-08-27 | 2003-06-23 | Wyeth Corp | 4-Aminoethoxyindoler som dopamin-D2-agonister og som 5HT 1A-ligander |
| CA2372481A1 (en) | 1999-04-30 | 2000-11-09 | The Trustees Of The University Of Pennsylvania | Spect imaging agents for serotonin transporters |
| US6410736B1 (en) | 1999-11-29 | 2002-06-25 | Pfizer Inc. | Biaryl ether derivatives useful as monoamine reuptake inhibitors |
| US6436938B1 (en) | 2001-01-22 | 2002-08-20 | Pfizer Inc. | Combination treatment for depression |
-
2004
- 2004-12-16 TW TW093139107A patent/TWI347183B/zh not_active IP Right Cessation
- 2004-12-21 SI SI200431671T patent/SI1860100T1/sl unknown
- 2004-12-21 AT AT07017638T patent/ATE500220T1/de active
- 2004-12-21 CN CNA2008101447939A patent/CN101372474A/zh active Pending
- 2004-12-21 AR ARP040104830A patent/AR046978A1/es not_active Application Discontinuation
- 2004-12-21 PL PL07017638T patent/PL1860100T4/pl unknown
- 2004-12-21 ES ES07017638T patent/ES2362237T3/es active Active
- 2004-12-21 DK DK07017638.3T patent/DK1860100T3/da active
- 2004-12-21 DE DE602004031680T patent/DE602004031680D1/de active Active
- 2004-12-21 RS RS20110213A patent/RS51899B/en unknown
- 2004-12-21 EP EP07017638A patent/EP1860100B1/en active Active
- 2004-12-21 ME MEP-2008-66A patent/ME01040B/me unknown
- 2004-12-21 ZA ZA200705870A patent/ZA200705870B/xx unknown
- 2004-12-21 PT PT07017638T patent/PT1860100E/pt unknown
- 2004-12-21 SG SG200802454-9A patent/SG141463A1/en unknown
- 2004-12-21 CA CA2551168A patent/CA2551168C/en not_active Expired - Fee Related
- 2004-12-21 EA EA200601226A patent/EA010666B1/ru not_active IP Right Cessation
- 2004-12-21 KR KR1020087021534A patent/KR20080092471A/ko not_active Application Discontinuation
- 2004-12-21 KR KR1020067011175A patent/KR100872022B1/ko active IP Right Grant
- 2004-12-21 EA EA200702258A patent/EA012752B1/ru not_active IP Right Cessation
- 2004-12-21 CN CN200480038470A patent/CN100591666C/zh not_active Expired - Fee Related
- 2004-12-21 MY MYPI20045285A patent/MY143038A/en unknown
- 2004-12-21 NZ NZ547046A patent/NZ547046A/en not_active IP Right Cessation
- 2004-12-21 UA UAA200607149A patent/UA82920C2/uk unknown
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2006
- 2006-05-15 IS IS8467A patent/IS2551B/is unknown
- 2006-07-24 NO NO20063405A patent/NO336676B1/no not_active IP Right Cessation
-
2007
- 2007-07-13 HK HK07107553.7A patent/HK1103075A1/xx not_active IP Right Cessation
-
2009
- 2009-06-05 IS IS8827A patent/IS2815B/is unknown
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