AR046978A1 - Derivados de 2-(1h-indolilsulfanil)-bencilamina - Google Patents
Derivados de 2-(1h-indolilsulfanil)-bencilaminaInfo
- Publication number
- AR046978A1 AR046978A1 ARP040104830A ARP040104830A AR046978A1 AR 046978 A1 AR046978 A1 AR 046978A1 AR P040104830 A ARP040104830 A AR P040104830A AR P040104830 A ARP040104830 A AR P040104830A AR 046978 A1 AR046978 A1 AR 046978A1
- Authority
- AR
- Argentina
- Prior art keywords
- atom
- alkyl
- indole
- cycloalkyl
- linked
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente se refiere a derivados de la anilina de formula general (1) y uso. Reivindicacion 1: Un compuesto de la formula general (1); en el cual el átomo de S está unido al indol a través de cualquier anillo carbonado del indol y en el cual R1- R2 se seleccionan independientemente entre H, alqu(en/in)ilo C1-6, cicloalqu(en)ilo C3-8, y cicloalqu(en)ilo C3-8-alqu(en/in)ilo C1-6 o R1 y R2 junto con el N forman un anillo de 4-7 miembros que contiene cero o una ligadura doble, opcionalmente dicho anillo junto con dicho N comprenden un heteroátomo adicional seleccionados entre N, O y S; R3-R12 se seleccionan independientemente entre H, halogeno, ciano, nitro, alqu(en/in)ilo C1-6, cicloalqu(en)ilo C3-8, y cicloalqu(en)ilo C3-8- alqu(en/in)ilo C1-6, amino, alqu(en/in)ilo C1-6amino, di-(alqu(en/in)ilo C1-6)amino, alqu(en/in)ilo C1-6carbonilo, aminocarbonilo, alqu(en/in)ilo C1-6aminocarbonilo, di-(alqu(en/in)ilo C1-6)aminocarbonilo, hidroxi, alqu(en/in)ilo C1-6oxi, alqu(en/in)ilo C1-6tio, halo-alqu(en/in)ilo C1-6, halo-alqu(en/in)ilo C1-6 sulfonilo, halo-alqu(en/in)ilo C1-6 sulfanilo y alqu(en/in)ilo C1-6sulfonilo; y R13 se selecciona entre H, alqu(en/in)ilo C1-6, cicloalqu(en)ilo C3-8, y cicloalqu(en)ilo C3-8- alqu(en/in)ilo C1-6; así como la base libre o una sal del mismo; con la condicion que: cuando el átomo de S está unido a través del átomo Ns 2 del indol, R7 no existe; cuando el átomo de S está unido a través del átomo Ns 3 del indol, R12 no existe; cuando el átomo de S está unido a través del átomo Ns 4 del indol, R8 no existe; cuando el átomo de S está unido a través del átomo Ns 5 del indol, R9 no existe; cuando el átomo de S está unido a través del átomo Ns 6 del indol, R10 no existe; y cuando el átomo de S está unido a través del átomo Ns 7 del indol, R11 no existe.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200301923 | 2003-12-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR046978A1 true AR046978A1 (es) | 2006-01-04 |
Family
ID=36603121
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040104830A AR046978A1 (es) | 2003-12-23 | 2004-12-21 | Derivados de 2-(1h-indolilsulfanil)-bencilamina |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP1860100B1 (es) |
| KR (2) | KR100872022B1 (es) |
| CN (2) | CN101372474A (es) |
| AR (1) | AR046978A1 (es) |
| AT (1) | ATE500220T1 (es) |
| CA (1) | CA2551168C (es) |
| DE (1) | DE602004031680D1 (es) |
| DK (1) | DK1860100T3 (es) |
| EA (2) | EA012752B1 (es) |
| ES (1) | ES2362237T3 (es) |
| HK (1) | HK1103075A1 (es) |
| IS (2) | IS2551B (es) |
| ME (1) | ME01040B (es) |
| MY (1) | MY143038A (es) |
| NO (1) | NO336676B1 (es) |
| NZ (1) | NZ547046A (es) |
| PL (1) | PL1860100T4 (es) |
| PT (1) | PT1860100E (es) |
| RS (1) | RS51899B (es) |
| SG (1) | SG141463A1 (es) |
| SI (1) | SI1860100T1 (es) |
| TW (1) | TWI347183B (es) |
| UA (1) | UA82920C2 (es) |
| ZA (1) | ZA200705870B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101224201B (zh) * | 2007-01-18 | 2011-10-05 | 和泓生物技术（上海）有限公司 | 多巴胺转运蛋白和去甲肾上腺素转运蛋白双重抑制剂的应用 |
| ES2646834T3 (es) * | 2010-08-20 | 2017-12-18 | Amira Pharmaceuticals, Inc. | Inhibidores de autotaxina y usos de los mismos |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3803143A (en) | 1969-09-08 | 1974-04-09 | Eisai Co Ltd | 6-amino alkylene 6,7-dihydro-5h-dibenzo (b,g),(1,5)thiazocines |
| US4018830A (en) | 1969-09-22 | 1977-04-19 | Merck & Co., Inc. | Phenylthioaralkylamines |
| US4055665A (en) | 1974-11-25 | 1977-10-25 | Merck & Co., Inc. | Treating arrythmia with phenylthioaralkylamines |
| US4056632A (en) | 1975-07-21 | 1977-11-01 | Burroughs Wellcome Co. | 2-Hydroxymethyl-2'-aminomethyl-diphenylsulfides and method of use |
| EP0396827A1 (en) | 1989-05-09 | 1990-11-14 | SPOFA Spojené Podniky Pro Zdravotnickou Vyrobu | 2-Phenylthiobenzylamine dervivatives and acid addition salts thereof |
| GB8912971D0 (en) | 1989-06-06 | 1989-07-26 | Wellcome Found | Halogen substituted diphenylsulfides |
| GB9126311D0 (en) | 1991-12-11 | 1992-02-12 | Wellcome Found | Substituted diphenylsulfides |
| CZ293595A3 (cs) | 1995-11-09 | 1999-12-15 | Farmak A. S. | Deriváty N,N-dimethyl-2-(arylthio)benzylaminu, jejich soli, způsoby jejich přípravy a jejich použití v léčivých přípravcích |
| US5912256A (en) * | 1996-06-20 | 1999-06-15 | Eli Lilly And Company | Compounds having effects on serotonin-related systems |
| PT923548E (pt) * | 1996-08-27 | 2003-06-30 | Wyeth Corp | 4-aminoetoxi-indolos como agonistas d2 da dopaminae como ligandos da 5ht1a |
| DE69930381T2 (de) | 1999-04-30 | 2006-12-07 | Trustees Of The University Of Pennsylvania | Spect abbildungsreagenzien für serotonintransporter |
| US6410736B1 (en) | 1999-11-29 | 2002-06-25 | Pfizer Inc. | Biaryl ether derivatives useful as monoamine reuptake inhibitors |
| US6436938B1 (en) | 2001-01-22 | 2002-08-20 | Pfizer Inc. | Combination treatment for depression |
-
2004
- 2004-12-16 TW TW093139107A patent/TWI347183B/zh not_active IP Right Cessation
- 2004-12-21 PL PL07017638T patent/PL1860100T4/pl unknown
- 2004-12-21 EA EA200702258A patent/EA012752B1/ru not_active IP Right Cessation
- 2004-12-21 DE DE602004031680T patent/DE602004031680D1/de active Active
- 2004-12-21 EP EP07017638A patent/EP1860100B1/en active Active
- 2004-12-21 SI SI200431671T patent/SI1860100T1/sl unknown
- 2004-12-21 NZ NZ547046A patent/NZ547046A/en not_active IP Right Cessation
- 2004-12-21 CN CNA2008101447939A patent/CN101372474A/zh active Pending
- 2004-12-21 KR KR1020067011175A patent/KR100872022B1/ko active IP Right Grant
- 2004-12-21 KR KR1020087021534A patent/KR20080092471A/ko not_active Application Discontinuation
- 2004-12-21 ZA ZA200705870A patent/ZA200705870B/xx unknown
- 2004-12-21 AT AT07017638T patent/ATE500220T1/de active
- 2004-12-21 RS RS20110213A patent/RS51899B/en unknown
- 2004-12-21 UA UAA200607149A patent/UA82920C2/uk unknown
- 2004-12-21 MY MYPI20045285A patent/MY143038A/en unknown
- 2004-12-21 DK DK07017638.3T patent/DK1860100T3/da active
- 2004-12-21 ME MEP-2008-66A patent/ME01040B/me unknown
- 2004-12-21 SG SG200802454-9A patent/SG141463A1/en unknown
- 2004-12-21 ES ES07017638T patent/ES2362237T3/es active Active
- 2004-12-21 EA EA200601226A patent/EA010666B1/ru not_active IP Right Cessation
- 2004-12-21 PT PT07017638T patent/PT1860100E/pt unknown
- 2004-12-21 AR ARP040104830A patent/AR046978A1/es not_active Application Discontinuation
- 2004-12-21 CN CN200480038470A patent/CN100591666C/zh not_active Expired - Fee Related
- 2004-12-21 CA CA2551168A patent/CA2551168C/en not_active Expired - Fee Related
-
2006
- 2006-05-15 IS IS8467A patent/IS2551B/is unknown
- 2006-07-24 NO NO20063405A patent/NO336676B1/no not_active IP Right Cessation
-
2007
- 2007-07-13 HK HK07107553.7A patent/HK1103075A1/xx not_active IP Right Cessation
-
2009
- 2009-06-05 IS IS8827A patent/IS2815B/is unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed, e.g., due to non-payment of fee |