UA82480C2 - Застосування комбінації донепезилу та мемантину для лікування хвороби альцгеймера - Google Patents
Застосування комбінації донепезилу та мемантину для лікування хвороби альцгеймера Download PDFInfo
- Publication number
- UA82480C2 UA82480C2 UA20041109789A UA20041109789A UA82480C2 UA 82480 C2 UA82480 C2 UA 82480C2 UA 20041109789 A UA20041109789 A UA 20041109789A UA 20041109789 A UA20041109789 A UA 20041109789A UA 82480 C2 UA82480 C2 UA 82480C2
- Authority
- UA
- Ukraine
- Prior art keywords
- disease
- alzheimer
- treatment
- heading
- antagonist
- Prior art date
Links
- 208000024827 Alzheimer disease Diseases 0.000 title claims description 19
- 229940100578 Acetylcholinesterase inhibitor Drugs 0.000 title abstract description 11
- 239000003703 n methyl dextro aspartic acid receptor blocking agent Substances 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 claims abstract description 5
- 206010012289 Dementia Diseases 0.000 claims description 17
- ADEBPBSSDYVVLD-UHFFFAOYSA-N donepezil Chemical compound O=C1C=2C=C(OC)C(OC)=CC=2CC1CC(CC1)CCN1CC1=CC=CC=C1 ADEBPBSSDYVVLD-UHFFFAOYSA-N 0.000 claims description 9
- BUGYDGFZZOZRHP-UHFFFAOYSA-N memantine Chemical compound C1C(C2)CC3(C)CC1(C)CC2(N)C3 BUGYDGFZZOZRHP-UHFFFAOYSA-N 0.000 claims description 8
- 229960004640 memantine Drugs 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 6
- 208000010877 cognitive disease Diseases 0.000 claims description 5
- 229960003530 donepezil Drugs 0.000 claims description 5
- 208000027061 mild cognitive impairment Diseases 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 229940126601 medicinal product Drugs 0.000 claims 1
- 238000012876 topography Methods 0.000 claims 1
- 239000000544 cholinesterase inhibitor Substances 0.000 abstract description 15
- 239000008194 pharmaceutical composition Substances 0.000 abstract description 7
- 150000001875 compounds Chemical class 0.000 description 17
- 201000010099 disease Diseases 0.000 description 17
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 17
- 239000005557 antagonist Substances 0.000 description 14
- 239000002552 dosage form Substances 0.000 description 9
- 208000024891 symptom Diseases 0.000 description 8
- 239000003814 drug Substances 0.000 description 7
- 229940079593 drug Drugs 0.000 description 6
- ASUTZQLVASHGKV-JDFRZJQESA-N galanthamine Chemical compound O1C(=C23)C(OC)=CC=C2CN(C)CC[C@]23[C@@H]1C[C@@H](O)C=C2 ASUTZQLVASHGKV-JDFRZJQESA-N 0.000 description 6
- 239000004480 active ingredient Substances 0.000 description 5
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- 230000006872 improvement Effects 0.000 description 4
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- 229960004136 rivastigmine Drugs 0.000 description 4
- 229960001685 tacrine Drugs 0.000 description 4
- XSVMFMHYUFZWBK-NSHDSACASA-N Rivastigmine Chemical compound CCN(C)C(=O)OC1=CC=CC([C@H](C)N(C)C)=C1 XSVMFMHYUFZWBK-NSHDSACASA-N 0.000 description 3
- 239000002775 capsule Substances 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 229960003980 galantamine Drugs 0.000 description 3
- ASUTZQLVASHGKV-UHFFFAOYSA-N galanthamine hydrochloride Natural products O1C(=C23)C(OC)=CC=C2CN(C)CCC23C1CC(O)C=C2 ASUTZQLVASHGKV-UHFFFAOYSA-N 0.000 description 3
- YLJREFDVOIBQDA-UHFFFAOYSA-N tacrine Chemical compound C1=CC=C2C(N)=C(CCCC3)C3=NC2=C1 YLJREFDVOIBQDA-UHFFFAOYSA-N 0.000 description 3
- 208000030507 AIDS Diseases 0.000 description 2
- 208000009829 Lewy Body Disease Diseases 0.000 description 2
- 201000002832 Lewy body dementia Diseases 0.000 description 2
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- 210000003169 central nervous system Anatomy 0.000 description 2
- 230000003930 cognitive ability Effects 0.000 description 2
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 1
- 208000006888 Agnosia Diseases 0.000 description 1
- 241001047040 Agnosia Species 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 206010002942 Apathy Diseases 0.000 description 1
- 206010003062 Apraxia Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 206010012239 Delusion Diseases 0.000 description 1
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- 208000004547 Hallucinations Diseases 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 239000000935 antidepressant agent Substances 0.000 description 1
- 229940005513 antidepressants Drugs 0.000 description 1
- 239000000164 antipsychotic agent Substances 0.000 description 1
- 229940005529 antipsychotics Drugs 0.000 description 1
- 201000007201 aphasia Diseases 0.000 description 1
- 229940009098 aspartate Drugs 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001713 cholinergic effect Effects 0.000 description 1
- 230000001149 cognitive effect Effects 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 231100000868 delusion Toxicity 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 230000002996 emotional effect Effects 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 239000008240 homogeneous mixture Substances 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 230000006386 memory function Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 230000004899 motility Effects 0.000 description 1
- 230000007659 motor function Effects 0.000 description 1
- 230000002151 myoclonic effect Effects 0.000 description 1
- 230000004770 neurodegeneration Effects 0.000 description 1
- 208000015122 neurodegenerative disease Diseases 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 239000006186 oral dosage form Substances 0.000 description 1
- 239000012057 packaged powder Substances 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000008447 perception Effects 0.000 description 1
- 230000004793 poor memory Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 229940125723 sedative agent Drugs 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 208000012201 sexual and gender identity disease Diseases 0.000 description 1
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- 235000019698 starch Nutrition 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200200844 | 2002-05-31 | ||
| PCT/DK2003/000342 WO2003101458A1 (en) | 2002-05-31 | 2003-05-22 | A combination of an nmda-antagonist and acetylcholine esterase inhibitors for the treatment of alzheimer's disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA82480C2 true UA82480C2 (uk) | 2008-04-25 |
Family
ID=28051666
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA20041109789A UA82480C2 (uk) | 2002-05-31 | 2003-05-22 | Застосування комбінації донепезилу та мемантину для лікування хвороби альцгеймера |
Country Status (9)
| Country | Link |
|---|---|
| KR (1) | KR101016927B1 (zh) |
| CN (1) | CN1655793A (zh) |
| AR (1) | AR040121A1 (zh) |
| CA (1) | CA2426492C (zh) |
| EA (1) | EA007632B1 (zh) |
| IS (1) | IS7558A (zh) |
| PE (1) | PE20040623A1 (zh) |
| UA (1) | UA82480C2 (zh) |
| ZA (1) | ZA200409147B (zh) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA107653U (uk) | 2012-10-01 | 2016-06-24 | Общєство С Огранічєнной Отвєтствєнностью "Валєнта-Інтєллєкт" | Композиція лікарських засобів для лікування та профілактики поведінкових, психічних та когнітивних розладів |
| CN105294450B (zh) * | 2014-05-29 | 2024-05-17 | 广州喜鹊医药有限公司 | 具有神经保护作用的金刚烷胺硝酸酯化合物及其制备和医药应用 |
| WO2018062941A1 (ko) * | 2016-09-30 | 2018-04-05 | 주식회사 바이오파마티스 | 도네페질 또는 그의 약학적으로 허용 가능한 염 및 메만틴 또는 그의 약학적으로 허용 가능한 염을 함유하는 치매 및 인지기능 장애 예방 또는 치료용 약학 조성물 및 이의 제조방법 |
| KR20210072569A (ko) | 2019-12-09 | 2021-06-17 | 주식회사 종근당 | 도네페질 및 메만틴을 포함하는 복합 제제 |
-
2003
- 2003-05-08 CA CA002426492A patent/CA2426492C/en not_active Expired - Fee Related
- 2003-05-22 KR KR1020047019333A patent/KR101016927B1/ko not_active IP Right Cessation
- 2003-05-22 UA UA20041109789A patent/UA82480C2/uk unknown
- 2003-05-22 EA EA200401617A patent/EA007632B1/ru not_active IP Right Cessation
- 2003-05-22 CN CNA038121611A patent/CN1655793A/zh active Pending
- 2003-05-27 AR ARP030101849A patent/AR040121A1/es unknown
- 2003-05-29 PE PE2003000527A patent/PE20040623A1/es not_active Application Discontinuation
-
2004
- 2004-11-11 ZA ZA200409147A patent/ZA200409147B/en unknown
- 2004-11-26 IS IS7558A patent/IS7558A/is unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1655793A (zh) | 2005-08-17 |
| AR040121A1 (es) | 2005-03-16 |
| IS7558A (is) | 2004-11-26 |
| ZA200409147B (en) | 2006-06-28 |
| EA007632B1 (ru) | 2006-12-29 |
| KR20050024296A (ko) | 2005-03-10 |
| CA2426492A1 (en) | 2003-09-16 |
| EA200401617A1 (ru) | 2005-06-30 |
| KR101016927B1 (ko) | 2011-02-28 |
| PE20040623A1 (es) | 2004-09-11 |
| CA2426492C (en) | 2006-10-03 |
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