UA82395C2 - N-substituted benzimidazolyl c-kit inhibitors - Google Patents

Info

Publication number

UA82395C2

UA82395C2 UAA200602942A UAA200602942A UA82395C2 UA 82395 C2 UA82395 C2 UA 82395C2 UA A200602942 A UAA200602942 A UA A200602942A UA A200602942 A UAA200602942 A UA A200602942A UA 82395 C2 UA82395 C2 UA 82395C2

Authority

UA

Ukraine

Prior art keywords

phenyl

benzimidazole

carboxamide

pyridin

ylmethyl

Prior art date

2003-08-21

Links

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• Global Dossier
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• -1 N-substituted benzimidazolyl Chemical group 0.000 title claims description 31
• 239000003112 inhibitor Substances 0.000 title description 13
• 102000016971 Proto-Oncogene Proteins c-kit Human genes 0.000 title 1
• 108010014608 Proto-Oncogene Proteins c-kit Proteins 0.000 title 1
• 150000001875 compounds Chemical class 0.000 claims abstract description 124
• 150000003839 salts Chemical class 0.000 claims abstract description 57
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 321
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 113
• 125000002572 propoxy group Chemical group [*]OC([H])([H])C(C([H])([H])[H])([H])[H] 0.000 claims description 78
• 239000000203 mixture Substances 0.000 claims description 71
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 53
• 238000000034 method Methods 0.000 claims description 48
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 30
• 125000004122 cyclic group Chemical group 0.000 claims description 27
• 125000000217 alkyl group Chemical group 0.000 claims description 24
• 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims description 24
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 19
• 125000000623 heterocyclic group Chemical group 0.000 claims description 17
• 125000000446 sulfanediyl group Chemical group *S* 0.000 claims description 16
• 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 14
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 14
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 14
• 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims description 13
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• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 12
• JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 12
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• 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims description 9
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• 125000000440 benzylamino group Chemical group [H]N(*)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims description 7
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