UA81319C2 - 3-fluoro-piperidines as nmda/nr2b antagonists - Google Patents
3-fluoro-piperidines as nmda/nr2b antagonists Download PDFInfo
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- UA81319C2 UA81319C2 UAA200511411A UAA200511411A UA81319C2 UA 81319 C2 UA81319 C2 UA 81319C2 UA A200511411 A UAA200511411 A UA A200511411A UA A200511411 A UAA200511411 A UA A200511411A UA 81319 C2 UA81319 C2 UA 81319C2
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- UA
- Ukraine
- Prior art keywords
- pharmaceutically acceptable
- compound
- acceptable salt
- compound according
- formula
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
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- Pain & Pain Management (AREA)
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- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Tropical Medicine & Parasitology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47593803P | 2003-06-04 | 2003-06-04 | |
| PCT/US2004/017175 WO2004108705A1 (en) | 2003-06-04 | 2004-05-28 | 3-fluoro-piperidines as nmda/nr2b antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA81319C2 true UA81319C2 (en) | 2007-12-25 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200511411A UA81319C2 (en) | 2003-06-04 | 2004-05-28 | 3-fluoro-piperidines as nmda/nr2b antagonists |
Country Status (30)
| Country | Link |
|---|---|
| EP (1) | EP1648882B1 (no) |
| JP (1) | JP3927228B2 (no) |
| KR (1) | KR20060017839A (no) |
| CN (1) | CN1798744A (no) |
| AR (1) | AR044579A1 (no) |
| AT (1) | ATE403651T1 (no) |
| AU (1) | AU2004245522B2 (no) |
| BR (1) | BRPI0410837A (no) |
| CA (1) | CA2527093C (no) |
| CL (1) | CL2004001365A1 (no) |
| CO (1) | CO5700762A2 (no) |
| DE (1) | DE602004015610D1 (no) |
| DK (1) | DK1648882T3 (no) |
| EC (1) | ECSP056192A (no) |
| ES (1) | ES2309540T3 (no) |
| HR (1) | HRP20080490T3 (no) |
| IS (1) | IS8117A (no) |
| MA (1) | MA27781A1 (no) |
| MX (1) | MXPA05013151A (no) |
| MY (1) | MY138547A (no) |
| NO (1) | NO20060020L (no) |
| PE (1) | PE20050245A1 (no) |
| PL (1) | PL1648882T3 (no) |
| PT (1) | PT1648882E (no) |
| RU (1) | RU2339630C2 (no) |
| SI (1) | SI1648882T1 (no) |
| TW (1) | TW200510378A (no) |
| UA (1) | UA81319C2 (no) |
| WO (1) | WO2004108705A1 (no) |
| ZA (1) | ZA200509000B (no) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US20090285862A1 (en) * | 2006-05-03 | 2009-11-19 | Cnsbio Pty Ltd. | Methods and composition for treatment of inflammatory pain |
| CN101663299A (zh) * | 2007-04-23 | 2010-03-03 | 詹森药业有限公司 | 作为快速解离性多巴胺2受体拮抗剂的噻(二)唑类化合物 |
| WO2009000038A1 (en) * | 2007-06-28 | 2008-12-31 | Cnsbio Pty Ltd | Combination methods and compositions for treatment of neuropathic pain |
| IN2012DN06631A (no) | 2010-02-16 | 2015-10-23 | Pfizer | |
| EP2838530B1 (en) | 2012-04-20 | 2017-04-05 | UCB Biopharma SPRL | Methods for treating parkinson's disease |
| CN103936663B (zh) * | 2013-01-23 | 2016-12-28 | 艾琪康医药科技（上海）有限公司 | 一种1-r1-3,3-二氟(或3-氟)-4-r2-4-氨甲基哌啶及其衍生物的制备方法 |
| US9221796B2 (en) | 2014-01-09 | 2015-12-29 | Bristol-Myers Squibb Company | Selective NR2B antagonists |
| US9187506B2 (en) | 2014-01-09 | 2015-11-17 | Bristol-Myers Squibb Company | (R)-3-((3S,4S)-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one and its prodrugs for the treatment of psychiatric disorders |
| AU2015271719A1 (en) | 2014-06-04 | 2016-12-01 | Rugen Holdings (Cayman) Limited | Difluoroethylpyridine derivatives as NR2B NMDA receptor antagonists |
| EP3194403B1 (en) | 2014-09-15 | 2019-02-06 | Rugen Holdings (Cayman) Limited | Pyrrolopyrimidine derivatives as nr2b nmda receptor antagonists |
| WO2016049048A1 (en) * | 2014-09-22 | 2016-03-31 | Rugen Holdings (Cayman) Limited | Treatment of anxiety disorders and autism spectrum disorders |
| BR112017013593A2 (pt) * | 2014-12-23 | 2018-06-19 | Cerecor, Inc. | compostos, composições e métodos |
| EP3253761A4 (en) | 2015-02-04 | 2018-06-20 | Rugen Holdings (Cayman) Limited | 3,3-difluoro-piperidine derivatives as nr2b nmda receptor antagonists |
| KR102613179B1 (ko) * | 2015-06-01 | 2023-12-14 | 뤼겐 홀딩스 (케이맨) 리미티드 | Nr2b nmda 수용체 길항제로서의 3,3-디플루오로피페리딘 카바메이트 헤테로사이클릭 화합물 |
| EP3362441B1 (en) | 2015-10-14 | 2020-08-12 | Bristol-Myers Squibb Company | Selective nr2b antagonists |
| CA3001894A1 (en) | 2015-10-14 | 2017-04-20 | Bristol-Myers Squibb Company | Selective nr2b antagonists |
| BR112019001968A2 (pt) | 2016-08-31 | 2019-05-07 | Eisai R&D Management Co., Ltd. | composto pirazolo[1,5-a]pirimidina |
| WO2018098128A1 (en) | 2016-11-22 | 2018-05-31 | Rugen Holdings (Cayman) Limited | Treatment of autism spectrum disorders, obsessive-compulsive disorder and anxiety disorders |
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| DK1379520T3 (da) * | 2001-02-23 | 2006-08-21 | Merck & Co Inc | N-substituerede ikke-aryl-heterocykliske NMDA/NR2B-antagonister |
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- 2004-05-28 SI SI200430845T patent/SI1648882T1/sl unknown
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