UA80838C2 - Water-soluble polymer alkanals - Google Patents

Water-soluble polymer alkanals

Info

Publication number
UA80838C2
UA80838C2 UAA200503295A UA2005003295A UA80838C2 UA 80838 C2 UA80838 C2 UA 80838C2 UA A200503295 A UAA200503295 A UA A200503295A UA 2005003295 A UA2005003295 A UA 2005003295A UA 80838 C2 UA80838 C2 UA 80838C2
Authority
UA
Ukraine
Prior art keywords
water
polymer alkanals
soluble polymer
alkanals
acetals
Prior art date
Application number
UAA200503295A
Other languages
English (en)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of UA80838C2 publication Critical patent/UA80838C2/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/10Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00Ethers; Compounds having groups, groups or groups
    • C07C43/30Compounds having groups
    • C07C43/315Compounds having groups containing oxygen atoms singly bound to carbon atoms not being acetal carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/30Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00Compounds having —CHO groups
    • C07C47/02Saturated compounds having —CHO groups bound to acyclic carbon atoms or to hydrogen
    • C07C47/198Saturated compounds having —CHO groups bound to acyclic carbon atoms or to hydrogen containing ether groups, groups, groups, or groups
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/26Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds
    • C08G65/2603Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing oxygen
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32Polymers modified by chemical after-treatment
    • C08G65/329Polymers modified by chemical after-treatment with organic compounds
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/34Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
    • C08G65/48Polymers modified by chemical after-treatment
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2203/00Applications
    • C08L2203/02Applications for biomedical use

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Polyethers (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Peptides Or Proteins (AREA)
  • Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
UAA200503295A 2002-09-09 2003-09-09 Water-soluble polymer alkanals UA80838C2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40925102P 2002-09-09 2002-09-09
US45658003P 2003-03-19 2003-03-19
PCT/US2003/028221 WO2004022630A2 (en) 2002-09-09 2003-09-09 Water-soluble polymer alkanals

Publications (1)

Publication Number Publication Date
UA80838C2 true UA80838C2 (en) 2007-11-12

Family

ID=31981629

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200503295A UA80838C2 (en) 2002-09-09 2003-09-09 Water-soluble polymer alkanals

Country Status (22)

Country Link
US (5) US7157546B2 (de)
EP (1) EP1546235B1 (de)
JP (2) JP4764630B2 (de)
KR (2) KR20050093856A (de)
AP (2) AP2005003249A0 (de)
AU (1) AU2003270454B2 (de)
BR (1) BR0314172A (de)
CA (1) CA2498167C (de)
EA (1) EA200500475A1 (de)
EC (1) ECSP055654A (de)
ES (1) ES2897470T3 (de)
GE (1) GEP20074193B (de)
HR (2) HRP20050319A2 (de)
IS (1) IS7789A (de)
MA (1) MA27401A1 (de)
MX (1) MXPA05002620A (de)
NO (2) NO20051077L (de)
NZ (2) NZ538624A (de)
PL (1) PL375883A1 (de)
RS (2) RS20050202A (de)
UA (1) UA80838C2 (de)
WO (1) WO2004022630A2 (de)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7053150B2 (en) 2000-12-18 2006-05-30 Nektar Therapeutics Al, Corporation Segmented polymers and their conjugates
DK3025726T3 (da) 2002-01-18 2019-12-09 Biogen Ma Inc Polyalkylenpolymerforbindelser og anvendelser deraf
DE10209822A1 (de) * 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Kopplung niedermolekularer Substanzen an ein modifiziertes Polysaccharid
DE10209821A1 (de) 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Kopplung von Proteinen an ein modifiziertes Polysaccharid
KR20050093856A (ko) 2002-09-09 2005-09-23 넥타르 테라퓨틱스 에이엘, 코포레이션 수용성 중합체 알카날
RU2329274C2 (ru) 2002-09-11 2008-07-20 Фрезениус Каби Дойчланд Гмбх Способ получения производных гидроксиалкилкрахмала
RS20050502A (en) * 2002-12-26 2007-08-03 Mountain View Pharmaceuticals Inc., Polymer conjugates of interferon- beta with enhanced biological potency
EP1628618A4 (de) * 2002-12-26 2009-09-09 Mountain View Pharmaceuticals Polymerkonjugate aus zytokinen, chemokinen, wachstumsfaktoren, polypeptidhormonen und antagonisten davon mit konservierter rezeptorbindender aktivität
CA2788505C (en) * 2003-02-26 2018-09-04 Nektar Therapeutics Polymer-factor viii moiety conjugates
US7947261B2 (en) 2003-05-23 2011-05-24 Nektar Therapeutics Conjugates formed from polymer derivatives having particular atom arrangements
GB0314472D0 (en) 2003-06-20 2003-07-23 Warwick Effect Polymers Ltd Polymer
SG145746A1 (en) * 2003-08-08 2008-09-29 Fresenius Kabi De Gmbh Conjugates of hydroxyalkyl starch and g-csf
WO2005014655A2 (en) 2003-08-08 2005-02-17 Fresenius Kabi Deutschland Gmbh Conjugates of hydroxyalkyl starch and a protein
EP1732609B1 (de) * 2004-03-11 2012-07-11 Fresenius Kabi Deutschland GmbH Konjugate von hydroxyalkyl-stärke und einem protein
TWI417303B (zh) * 2004-03-11 2013-12-01 Fresenius Kabi De Gmbh 經由還原胺化作用製得之羥烷基澱粉及蛋白質的接合物
MXPA06010505A (es) * 2004-03-15 2006-12-19 Nektar Therapeutics Al Corp Composiciones y conjugados, basados en polimeros, de inhibidores de ingreso de vih.
US20050215710A1 (en) * 2004-03-23 2005-09-29 Gegg Colin V Jr Chemically modified protein compositions and methods
MX2007000568A (es) * 2004-07-16 2007-03-30 Nektar Therapeutics Al Corp Conjugados de una fraccion gm-csf y un polimero.
CN101010105A (zh) * 2004-08-31 2007-08-01 法玛西雅厄普约翰有限责任公司 甘油支化的聚乙二醇人生长激素缀合物、其制备方法及其使用方法
EP2502941A1 (de) * 2004-10-25 2012-09-26 Intezyne Technologies Inc. Heterobifunktionelles Poly(ethylenglykol) und seine Verwendungen
KR20070110902A (ko) * 2005-03-11 2007-11-20 프레제니우스 카비 도이치란트 게엠베하 비활성 출발 물질로부터 생물활성 당단백질의 생산
WO2007010552A2 (en) * 2005-03-17 2007-01-25 Serum Institute Of India Limited N- terminal peg conjugate of erythropoietin
WO2006102659A2 (en) * 2005-03-23 2006-09-28 Nektar Therapeutics Al, Corporation CONJUGATES OF AN hGH MOIETY AND A POLYMER
EP1762250A1 (de) * 2005-09-12 2007-03-14 Fresenius Kabi Deutschland GmbH Konjugate welche durch chemische Ligation zwischen Hydroxyalkylstärken und aktiven Substanzen mit Bildung eines Thiazolidin-Ringes entstehen
ES2390286T3 (es) 2005-12-16 2012-11-08 Nektar Therapeutics Conjugados poliméricos de GLP-1
EP1834963A1 (de) * 2006-03-13 2007-09-19 Siegfried Ltd. Di-Polymer-Konjugate von Proteinen und Verfahren zur deren Erstellung
CA2861601A1 (en) * 2006-04-27 2007-11-08 Intezyne Technologies, Inc. Poly (ethylene glycol) containing chemically disparate endgroups
CL2008002399A1 (es) 2007-08-16 2009-01-02 Pharmaessentia Corp Conjugado sustancialmente puro que posee una porcion polimerica, una porcion proteica (interferon alfa 2b) y un ligante alifatico de 1 a 10 atomos de carbono, util en el tratamiento de las hepatitis b o c.
EP2070951A1 (de) 2007-12-14 2009-06-17 Fresenius Kabi Deutschland GmbH Verfahren zur Herstellung eines Hydroxyalkylstärkederivats mit zwei Linkern
EP2070950A1 (de) 2007-12-14 2009-06-17 Fresenius Kabi Deutschland GmbH Hydroxyalkylstärkederivate und deren Herstellungsverfahren
EP2254601B1 (de) * 2008-02-08 2019-05-29 Nektar Therapeutics Oligomer-cannabinoid-konjugate
KR100967833B1 (ko) * 2008-05-20 2010-07-05 아이디비켐(주) 고순도의 폴리에틸렌글리콜 알데하이드 유도체의 제조방법
AR072850A1 (es) * 2008-07-31 2010-09-22 Pharmaessentia Corp Conjugados peptido-polimero
US8492503B2 (en) 2008-09-11 2013-07-23 Nektar Therapeutics Polymeric alpha-hydroxy aldehyde and ketone reagents and conjugation method
US20110171312A1 (en) * 2008-09-19 2011-07-14 Nektar Therapeutics Modified therapeutic peptides, methods of their preparation and use
EP2341942A1 (de) * 2008-09-19 2011-07-13 Nektar Therapeutics Polymerkonjugate aus therapeutischen peptiden
GB0823309D0 (en) * 2008-12-19 2009-01-28 Univ Bath Functionalising reagents and their uses
UA104031C2 (uk) * 2009-07-14 2013-12-25 Зе Скріпс Рісьорч Інстітьют Диференціація мезенхімальних стовбурових клітин
CN103119055A (zh) 2010-05-17 2013-05-22 塞比克斯公司 聚乙二醇化c肽
RU2447083C1 (ru) * 2010-07-20 2012-04-10 Закрытое Акционерное Общество "Биокад" НОВЫЙ ФУНКЦИОНАЛЬНО АКТИВНЫЙ ВЫСОКООЧИЩЕННЫЙ СТАБИЛЬНЫЙ КОНЪЮГАТ ИНТЕРФЕРОНА α С ПОЛИЭТИЛЕНГЛИКОЛЕМ, ПРЕДСТАВЛЕННЫЙ ОДНИМ ПОЗИЦИОННЫМ ИЗОМЕРОМ ПЭГ-NαH-ИФН, С УМЕНЬШЕННОЙ ИММУНОГЕННОСТЬЮ, С ПРОЛОНГИРОВАННЫМ БИОЛОГИЧЕСКИМ ДЕЙСТВИЕМ, ПРИГОДНЫЙ ДЛЯ МЕДИЦИНСКОГО ПРИМЕНЕНИЯ, И ИММУНОБИОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ
WO2012054822A1 (en) 2010-10-22 2012-04-26 Nektar Therapeutics Pharmacologically active polymer-glp-1 conjugates
RS61854B1 (sr) * 2010-11-12 2021-06-30 Nektar Therapeutics Konjugati il-2 dela i polimera
EP2540325B1 (de) * 2011-06-27 2016-08-10 Greatbatch Ltd. Antimikrobielle Beschichtung auf Peptid-Basis
EP2592103A1 (de) * 2011-11-08 2013-05-15 Adriacell S.p.A. Polymeraldehydderivate
US9327034B2 (en) 2011-12-14 2016-05-03 University Of Tsukuba, A Japanese National University Branched polyethylene glycol and use thereof
UY35368A (es) 2013-03-08 2014-10-31 Irm Llc Péptidos y composiciones para el tratamiento de daño articular
US9301971B2 (en) 2013-03-08 2016-04-05 Novartis Ag Peptides and compositions for treatment of joint damage
JP6106104B2 (ja) 2014-01-16 2017-03-29 信越化学工業株式会社 末端にアミノ基を有する狭分散ポリアルキレングリコール誘導体の製造方法
JP6106103B2 (ja) * 2014-01-16 2017-03-29 信越化学工業株式会社 末端にアミノ基を有する狭分散ポリアルキレングリコール誘導体の製造方法、並びにこれに用いる新規なアセタール基含有アルコール化合物及びそのアルカリ金属塩
GB201419108D0 (en) 2014-10-27 2014-12-10 Glythera Ltd Materials and methods relating to linkers for use in antibody drug conjugates
KR102540109B1 (ko) 2014-11-06 2023-06-02 파마에센시아 코퍼레이션 Peg화된 인터페론의 투약 요법
TW202027794A (zh) 2018-10-03 2020-08-01 瑞士商諾華公司 血管生成素樣3多肽之持續遞送

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4002531A (en) * 1976-01-22 1977-01-11 Pierce Chemical Company Modifying enzymes with polyethylene glycol and product produced thereby
JPS5695142A (en) * 1979-12-28 1981-08-01 T Hasegawa Co Ltd Preparation of aliphatic aldehyde
US5037969A (en) 1986-07-03 1991-08-06 Takeda Chemical Industries, Ltd. Glycosyl derivatives and use thereof
JPS63152393A (ja) * 1986-07-03 1988-06-24 Takeda Chem Ind Ltd グリコシル誘導体
US5510418A (en) * 1988-11-21 1996-04-23 Collagen Corporation Glycosaminoglycan-synthetic polymer conjugates
WO1990005534A1 (en) 1988-11-23 1990-05-31 Genentech, Inc. Polypeptide derivatives
US5252714A (en) * 1990-11-28 1993-10-12 The University Of Alabama In Huntsville Preparation and use of polyethylene glycol propionaldehyde
JPH06233816A (ja) 1993-02-12 1994-08-23 Toyobo Co Ltd 血液浄化吸着材
US5840900A (en) * 1993-10-20 1998-11-24 Enzon, Inc. High molecular weight polymer-based prodrugs
US5919455A (en) 1993-10-27 1999-07-06 Enzon, Inc. Non-antigenic branched polymer conjugates
US5627662A (en) * 1994-04-28 1997-05-06 Xerox Corporation Digital imaging system using two-dimensional input sensor array and output light valve
FR2724459B1 (fr) 1994-09-14 1997-05-09 Univ Compiegne Tech Electrophorese capillaire d'affinite, matrice d'affinite pour la mise en oeuvre de cette electrophorese et son procede de fabrication
US5824784A (en) * 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
US5672662A (en) * 1995-07-07 1997-09-30 Shearwater Polymers, Inc. Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
US5736543A (en) * 1996-04-03 1998-04-07 The Regents Of The University Of California Benzoxazines for enhancing synaptic response
US5990237A (en) * 1997-05-21 1999-11-23 Shearwater Polymers, Inc. Poly(ethylene glycol) aldehyde hydrates and related polymers and applications in modifying amines
JPH11322916A (ja) 1998-05-11 1999-11-26 Kazunori Kataoka ビオチン残基を片末端に有するヘテロテレケリツクポリマー
US6420555B1 (en) * 1998-06-16 2002-07-16 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Imidazolyl derivatives
AU1325400A (en) * 1998-10-26 2000-05-15 University Of Utah Research Foundation Method for preparation of polyethylene glycol aldehyde derivatives
CA2352538A1 (en) 1998-11-30 2000-06-08 Eli Lilly And Company Erythropoietic compounds
JP2000303090A (ja) * 1999-04-20 2000-10-31 T Hasegawa Co Ltd 香料組成物
DE60026073T2 (de) * 1999-12-22 2006-09-28 Nektar Therapeutics Al, Corp., Huntsville Sterisch gehinderte derivate von wasserlöslichen polymeren
TW593427B (en) 2000-12-18 2004-06-21 Nektar Therapeutics Al Corp Synthesis of high molecular weight non-peptidic polymer derivatives
MXPA04004336A (es) * 2001-11-07 2005-05-16 Nektar Therapeutics Al Corp Polimeros ramificados y sus conjugados.
BR0214451A (pt) 2001-11-20 2006-05-30 Pharmacia Corp conjugados do hormÈnio do crescimento humano quimicamente modificado
US20030171285A1 (en) * 2001-11-20 2003-09-11 Finn Rory F. Chemically-modified human growth hormone conjugates
US6956135B2 (en) * 2001-12-11 2005-10-18 Sun Bio, Inc. Monofunctional polyethylene glycol aldehydes
AU2002357806A1 (en) 2001-12-11 2003-06-23 Sun Bio, Inc. Novel monofunctional polyethylene glycol aldehydes
US6916962B2 (en) * 2001-12-11 2005-07-12 Sun Bio, Inc. Monofunctional polyethylene glycol aldehydes
DK3025726T3 (da) 2002-01-18 2019-12-09 Biogen Ma Inc Polyalkylenpolymerforbindelser og anvendelser deraf
JP4074618B2 (ja) * 2002-04-26 2008-04-09 株式会社プライムポリマー 吸音体、吸音構造体およびこれらの製造方法
PT1539857E (pt) 2002-07-24 2007-01-31 Hoffmann La Roche Derivados de aldeído de polietileno glicol
KR20050093856A (ko) * 2002-09-09 2005-09-23 넥타르 테라퓨틱스 에이엘, 코포레이션 수용성 중합체 알카날
US20040142870A1 (en) * 2002-11-20 2004-07-22 Finn Rory F. N-terminally monopegylated human growth hormone conjugates, process for their preparation, and methods of use thereof
TWI281864B (en) * 2002-11-20 2007-06-01 Pharmacia Corp N-terminally monopegylated human growth hormone conjugates and process for their preparation
US6961962B1 (en) * 2004-09-09 2005-11-08 Morning Pride Manufacturing, L.L.C. Combined closure and liner zippers employing common zipper tapes and protective garment employing said combined zippers
JP5084245B2 (ja) 2006-06-07 2012-11-28 関西ペイント株式会社 澱粉系塗料組成物

Also Published As

Publication number Publication date
ECSP055654A (es) 2005-05-30
NZ538624A (en) 2007-01-26
PL375883A1 (en) 2005-12-12
IS7789A (is) 2005-04-08
US8076412B2 (en) 2011-12-13
KR20050057281A (ko) 2005-06-16
HRP20050320A2 (en) 2006-12-31
US7511094B2 (en) 2009-03-31
EP1546235A2 (de) 2005-06-29
EP1546235B1 (de) 2021-10-20
HRP20050319A2 (en) 2006-12-31
WO2004022630A3 (en) 2004-04-15
WO2004022630A2 (en) 2004-03-18
US7157546B2 (en) 2007-01-02
US8853325B2 (en) 2014-10-07
GEP20074193B (en) 2007-09-10
BR0314172A (pt) 2005-07-26
NZ540490A (en) 2007-10-26
CA2498167A1 (en) 2004-03-18
RS20050203A (en) 2007-08-03
NO20051077L (no) 2005-04-08
NO20051078L (no) 2005-04-08
US7838595B2 (en) 2010-11-23
MA27401A1 (fr) 2005-06-01
US20120065429A1 (en) 2012-03-15
EA200500475A1 (ru) 2005-10-27
CA2498167C (en) 2012-03-20
JP4764630B2 (ja) 2011-09-07
ES2897470T3 (es) 2022-03-01
MXPA05002620A (es) 2005-05-05
KR20050093856A (ko) 2005-09-23
AP2005003249A0 (en) 2005-03-31
AU2003270454B2 (en) 2010-05-20
KR100974843B1 (ko) 2010-08-11
AU2003270454A1 (en) 2004-03-29
US20040116649A1 (en) 2004-06-17
US20060194940A1 (en) 2006-08-31
AP2005003246A0 (en) 2005-03-31
JP2005350470A (ja) 2005-12-22
RS20050202A (en) 2007-08-03
US20090234070A1 (en) 2009-09-17
US20110034737A1 (en) 2011-02-10
JP2005538224A (ja) 2005-12-15

Similar Documents

Publication Publication Date Title
RS20050203A (en) Water-soluble polymer alkanals
WO2004075923A3 (en) Polymer-factor viii moiety conjugates
MX2008001706A (es) Conjugados de una porcion g-csf y un polimero.
WO2006019950A3 (en) Conjugates of a gm-csf moiety and a polymer
GB2442374A (en) Crosslinkable polymer compositions
BR0314831A (pt) Conjugados de polìmeros com antigenicidade diminuìda, seus métodos de preparação e usos
AU2003245325A1 (en) Substituted quinazolinone compounds
TW200635576A (en) Releasable polymeric conjugates based on aliphatic biodegradable linkers
CY1110169T1 (el) Μεθοδος παρασκευης πολυμερων με χαρακτηριστικες δραστικες ομαδες απο πολυμερεις αλκοολες
CA2527686A1 (en) Cellulose powder
GB2436996B (en) Rigid amines
WO2003016282A3 (en) Substituted 1h-dihydropyrazoles, their preparation and use
EP1553117A4 (de) Polymerfestelektrolyt
TNSN05254A1 (en) Derivatives of 2-acylamino-4-phenylthiazole, preparation method thereof and application of same in therapeutics
WO2006102659A3 (en) CONJUGATES OF AN hGH MOIETY AND A POLYMER
RS20050876A (en) Novel pyridopyrazines and use thereof as kinase m odulators
EP1709699B8 (de) Konjugierte polymere, deren darstellung und verwendung
HK1103552A1 (en) Dibenzosilol polymers, their preparation and uses
WO2009139905A3 (en) Conjugates of a cholinesterase moiety and a polymer
IL159554A0 (en) Tricyclic imidazopyridine derivatives and pharmaceutical compositions containing the same
TNSN05055A1 (en) Water-soluble polymer alkanals
WO2003063824A3 (en) Pharmaceutical composition
WO2006089228A3 (en) Conjugates of an epo moiety and a polymer
TNSN05056A1 (en) Water-soluble polymer alkanals
RS88704A (en) Acyl-3-carboxyphenylurea derivatives, method for production and use thereof