UA80046C2 - Thiadiazine compounds, method for obtaning thereof and pharmaceutical composition containing them - Google Patents
Thiadiazine compounds, method for obtaning thereof and pharmaceutical composition containing them Download PDFInfo
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- UA80046C2 UA80046C2 UAA200511454A UAA200511454A UA80046C2 UA 80046 C2 UA80046 C2 UA 80046C2 UA A200511454 A UAA200511454 A UA A200511454A UA A200511454 A UAA200511454 A UA A200511454A UA 80046 C2 UA80046 C2 UA 80046C2
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- 238000000034 method Methods 0.000 title claims description 17
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 8
- 150000008334 thiadiazines Chemical class 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims abstract description 108
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 20
- 239000002253 acid Substances 0.000 claims abstract description 13
- 150000003839 salts Chemical class 0.000 claims abstract description 11
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims abstract description 10
- 125000005843 halogen group Chemical group 0.000 claims abstract description 10
- 239000000654 additive Substances 0.000 claims abstract description 7
- 230000000996 additive effect Effects 0.000 claims abstract description 7
- 125000001544 thienyl group Chemical group 0.000 claims abstract description 7
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims abstract description 3
- 125000002541 furyl group Chemical group 0.000 claims abstract description 3
- 125000002883 imidazolyl group Chemical group 0.000 claims abstract description 3
- ZLTPDFXIESTBQG-UHFFFAOYSA-N isothiazole Chemical compound C=1C=NSC=1 ZLTPDFXIESTBQG-UHFFFAOYSA-N 0.000 claims abstract description 3
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- 125000003277 amino group Chemical group 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 2
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- 230000019771 cognition Effects 0.000 claims description 2
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- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 2
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- ZJYYHGLJYGJLLN-UHFFFAOYSA-N guanidinium thiocyanate Chemical compound SC#N.NC(N)=N ZJYYHGLJYGJLLN-UHFFFAOYSA-N 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000000971 hippocampal effect Effects 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000000626 neurodegenerative effect Effects 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 230000008587 neuronal excitability Effects 0.000 description 1
- 230000007996 neuronal plasticity Effects 0.000 description 1
- MCSAJNNLRCFZED-UHFFFAOYSA-N nitroethane Chemical compound CC[N+]([O-])=O MCSAJNNLRCFZED-UHFFFAOYSA-N 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 239000002664 nootropic agent Substances 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000001991 pathophysiological effect Effects 0.000 description 1
- 210000001871 perforant pathway Anatomy 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000002831 pharmacologic agent Substances 0.000 description 1
- 239000008196 pharmacological composition Substances 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 230000001242 postsynaptic effect Effects 0.000 description 1
- 239000012256 powdered iron Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 229940107700 pyruvic acid Drugs 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 239000012265 solid product Substances 0.000 description 1
- 239000006190 sub-lingual tablet Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 230000024587 synaptic transmission, glutamatergic Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- YBRBMKDOPFTVDT-UHFFFAOYSA-N tert-butylamine Chemical compound CC(C)(C)N YBRBMKDOPFTVDT-UHFFFAOYSA-N 0.000 description 1
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
- 229940100445 wheat starch Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0305448A FR2854634B1 (fr) | 2003-05-05 | 2003-05-05 | Nouveaux derives de thiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| PCT/FR2004/001070 WO2004099217A1 (fr) | 2003-05-05 | 2004-05-04 | Derives de thiadiazine et leur utilisation comme modulateurs positifs des recepteurs ampa |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA80046C2 true UA80046C2 (en) | 2007-08-10 |
Family
ID=33306157
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200511454A UA80046C2 (en) | 2003-05-05 | 2004-04-05 | Thiadiazine compounds, method for obtaning thereof and pharmaceutical composition containing them |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US7476668B2 (pt) |
| EP (1) | EP1620441A1 (pt) |
| JP (1) | JP4461139B2 (pt) |
| KR (1) | KR100741235B1 (pt) |
| CN (1) | CN100363368C (pt) |
| AR (1) | AR044245A1 (pt) |
| AU (1) | AU2004236005B2 (pt) |
| BR (1) | BRPI0410002A (pt) |
| CA (1) | CA2524377C (pt) |
| EA (1) | EA009240B1 (pt) |
| FR (1) | FR2854634B1 (pt) |
| GE (1) | GEP20084318B (pt) |
| HK (1) | HK1088327A1 (pt) |
| MA (1) | MA27732A1 (pt) |
| MX (1) | MXPA05011823A (pt) |
| MY (1) | MY136694A (pt) |
| NO (1) | NO20055695L (pt) |
| NZ (1) | NZ543214A (pt) |
| UA (1) | UA80046C2 (pt) |
| WO (1) | WO2004099217A1 (pt) |
| ZA (1) | ZA200508660B (pt) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602005020462D1 (de) | 2004-08-25 | 2010-05-20 | Essentialis Inc | Pharmazeutische formulierungen von kalium-atp-kanalöffnern und deren verwendungen |
| EP3545958A1 (en) * | 2006-01-05 | 2019-10-02 | Essentialis, Inc. | Salts of potassium atp channel openers and uses thereof |
| US20110218190A1 (en) * | 2008-11-10 | 2011-09-08 | The Regents Of The University Of California | Therapeutic uses of ampa receptor modulators for treatment of motor dysfunction |
| AR082618A1 (es) | 2010-08-10 | 2012-12-19 | Takeda Pharmaceutical | Derivados de tiadiazina, composiciones farmaceuticas y usos |
| JP5901365B2 (ja) * | 2012-03-12 | 2016-04-06 | 株式会社トクヤマ | イミダート化合物の製造方法 |
| CA2915405A1 (en) | 2013-06-13 | 2014-12-18 | Veroscience Llc | Compositions and methods for treating metabolic disorders |
| CN107922328B (zh) | 2015-07-06 | 2020-05-19 | 公立大学法人横滨市立大学 | 和ampa受体特异性结合的新颖化合物 |
| JP6241974B1 (ja) | 2017-01-11 | 2017-12-06 | 公立大学法人横浜市立大学 | 霊長類生体の脳内ａｍｐａ受容体のイメージング方法、プログラム、及びスクリーニング方法 |
| US10680583B1 (en) * | 2019-02-26 | 2020-06-09 | Xilinx, Inc. | Control circuit for and method of controlling an operation of an integrated circuit device |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3733409A (en) * | 1969-05-20 | 1973-05-15 | Schering Corp | Method of treating hypertension using thieno (1,2,4) thiadiazines |
| AU4345297A (en) * | 1996-09-17 | 1998-04-14 | Regents Of The University Of California, The | Benzothiadiazide derivatives and their use as allosteric up-modulators of the ampa receptor |
| HUP0003999A3 (en) * | 1997-07-16 | 2003-03-28 | Novo Nordisk As | Fused 1,2,4-thiadiazine derivatives, their preparation, their use and pharmaceutical compositions containing them |
| RU2214405C2 (ru) * | 1998-02-18 | 2003-10-20 | НьюроСёрч А/С | Новые соединения и их применение в качестве положительных модуляторов амра-рецепторов |
| FR2801587B1 (fr) * | 1999-11-30 | 2002-01-11 | Adir | Nouveaux derives de benzothiadiazines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
-
2003
- 2003-05-05 FR FR0305448A patent/FR2854634B1/fr not_active Expired - Fee Related
-
2004
- 2004-04-05 UA UAA200511454A patent/UA80046C2/uk unknown
- 2004-04-30 MY MYPI20041647A patent/MY136694A/en unknown
- 2004-05-04 WO PCT/FR2004/001070 patent/WO2004099217A1/fr active Application Filing
- 2004-05-04 AU AU2004236005A patent/AU2004236005B2/en not_active Ceased
- 2004-05-04 US US10/555,743 patent/US7476668B2/en not_active Expired - Fee Related
- 2004-05-04 BR BRPI0410002-6A patent/BRPI0410002A/pt not_active IP Right Cessation
- 2004-05-04 JP JP2006505830A patent/JP4461139B2/ja not_active Expired - Fee Related
- 2004-05-04 EA EA200501696A patent/EA009240B1/ru not_active IP Right Cessation
- 2004-05-04 NZ NZ543214A patent/NZ543214A/en not_active IP Right Cessation
- 2004-05-04 CN CNB200480014886XA patent/CN100363368C/zh not_active Expired - Fee Related
- 2004-05-04 AR ARP040101515A patent/AR044245A1/es unknown
- 2004-05-04 GE GEAP20049092A patent/GEP20084318B/en unknown
- 2004-05-04 ZA ZA200508660A patent/ZA200508660B/en unknown
- 2004-05-04 CA CA2524377A patent/CA2524377C/fr not_active Expired - Fee Related
- 2004-05-04 EP EP04742632A patent/EP1620441A1/fr not_active Withdrawn
- 2004-05-04 KR KR1020057020817A patent/KR100741235B1/ko not_active IP Right Cessation
- 2004-05-04 MX MXPA05011823A patent/MXPA05011823A/es active IP Right Grant
-
2005
- 2005-10-21 MA MA28567A patent/MA27732A1/fr unknown
- 2005-12-01 NO NO20055695A patent/NO20055695L/no not_active Application Discontinuation
-
2006
- 2006-08-10 HK HK06108870A patent/HK1088327A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0410002A (pt) | 2006-04-25 |
| CA2524377C (fr) | 2010-08-24 |
| MA27732A1 (fr) | 2006-01-02 |
| CN100363368C (zh) | 2008-01-23 |
| MY136694A (en) | 2008-11-28 |
| EP1620441A1 (fr) | 2006-02-01 |
| FR2854634A1 (fr) | 2004-11-12 |
| FR2854634B1 (fr) | 2005-07-08 |
| MXPA05011823A (es) | 2006-05-25 |
| GEP20084318B (en) | 2008-03-10 |
| HK1088327A1 (en) | 2006-11-03 |
| CA2524377A1 (fr) | 2004-11-18 |
| NO20055695L (no) | 2005-12-01 |
| ZA200508660B (en) | 2007-01-31 |
| CN1798750A (zh) | 2006-07-05 |
| WO2004099217A1 (fr) | 2004-11-18 |
| AU2004236005B2 (en) | 2010-01-21 |
| KR20060006830A (ko) | 2006-01-19 |
| EA200501696A1 (ru) | 2006-06-30 |
| AU2004236005A1 (en) | 2004-11-18 |
| AR044245A1 (es) | 2005-09-07 |
| JP2006525292A (ja) | 2006-11-09 |
| US7476668B2 (en) | 2009-01-13 |
| US20070004709A1 (en) | 2007-01-04 |
| EA009240B1 (ru) | 2007-12-28 |
| JP4461139B2 (ja) | 2010-05-12 |
| KR100741235B1 (ko) | 2007-07-19 |
| NZ543214A (en) | 2009-02-28 |
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