CN100363368C - 噻二嗪衍生物及其用作正ampa受体调节剂的用途 - Google Patents
噻二嗪衍生物及其用作正ampa受体调节剂的用途 Download PDFInfo
- Publication number
- CN100363368C CN100363368C CNB200480014886XA CN200480014886A CN100363368C CN 100363368 C CN100363368 C CN 100363368C CN B200480014886X A CNB200480014886X A CN B200480014886XA CN 200480014886 A CN200480014886 A CN 200480014886A CN 100363368 C CN100363368 C CN 100363368C
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- CN
- China
- Prior art keywords
- compound
- formula
- group
- branched
- straight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Description
化合物 | EC2×(μM) | EC5×(μM) |
实施例4 | 4.2±0.7 | 11±3 |
实施例6 | 5.4±2.8 | 11.3±4.9 |
Claims (13)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0305448A FR2854634B1 (fr) | 2003-05-05 | 2003-05-05 | Nouveaux derives de thiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
FR03/05448 | 2003-05-05 | ||
PCT/FR2004/001070 WO2004099217A1 (fr) | 2003-05-05 | 2004-05-04 | Derives de thiadiazine et leur utilisation comme modulateurs positifs des recepteurs ampa |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1798750A CN1798750A (zh) | 2006-07-05 |
CN100363368C true CN100363368C (zh) | 2008-01-23 |
Family
ID=33306157
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB200480014886XA Expired - Fee Related CN100363368C (zh) | 2003-05-05 | 2004-05-04 | 噻二嗪衍生物及其用作正ampa受体调节剂的用途 |
Country Status (21)
Country | Link |
---|---|
US (1) | US7476668B2 (zh) |
EP (1) | EP1620441A1 (zh) |
JP (1) | JP4461139B2 (zh) |
KR (1) | KR100741235B1 (zh) |
CN (1) | CN100363368C (zh) |
AR (1) | AR044245A1 (zh) |
AU (1) | AU2004236005B2 (zh) |
BR (1) | BRPI0410002A (zh) |
CA (1) | CA2524377C (zh) |
EA (1) | EA009240B1 (zh) |
FR (1) | FR2854634B1 (zh) |
GE (1) | GEP20084318B (zh) |
HK (1) | HK1088327A1 (zh) |
MA (1) | MA27732A1 (zh) |
MX (1) | MXPA05011823A (zh) |
MY (1) | MY136694A (zh) |
NO (1) | NO20055695L (zh) |
NZ (1) | NZ543214A (zh) |
UA (1) | UA80046C2 (zh) |
WO (1) | WO2004099217A1 (zh) |
ZA (1) | ZA200508660B (zh) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2578224A1 (en) | 2004-08-25 | 2006-03-09 | Essentialis, Inc. | Pharmaceutical formulations of potassium atp channel openers and uses thereof |
AU2006335153B2 (en) | 2006-01-05 | 2012-03-15 | Essentialis, Inc. | Salts of potassium ATP channel openers and uses thereof |
WO2010054336A2 (en) * | 2008-11-10 | 2010-05-14 | The Regents Of The University Of California | Therapeutic uses of ampa receptor modulators for treatment of motor dysfunction |
BR112013002250B1 (pt) | 2010-08-10 | 2020-10-27 | Takeda Pharmaceutical Company Limited | composto, composição farmacêutica, e, uso de um composto |
JP5901365B2 (ja) * | 2012-03-12 | 2016-04-06 | 株式会社トクヤマ | イミダート化合物の製造方法 |
BR112015031249A2 (pt) | 2013-06-13 | 2017-07-25 | Veroscience Llc | método de tratamento, método para tratar um distúrbio metabólico ou um elemento chave do mesmo, método para normalizar um ritmo diário de liberação de dopamina no sumn, método para estimular a liberação de dopamina de neurônios dopaminérgicos no sumn de um indivíduo e composição farmacêutica |
BR112017028639B1 (pt) | 2015-07-06 | 2023-03-21 | Public University Corporation Yokohama City University | Composto que liga especificamente ao receptor ampa, composição farmacêutica que o compreende, uso do mesmo e métodos para a produção do referido composto e para a formação de imagem de um receptor ampa |
JP6241974B1 (ja) | 2017-01-11 | 2017-12-06 | 公立大学法人横浜市立大学 | 霊長類生体の脳内ampa受容体のイメージング方法、プログラム、及びスクリーニング方法 |
US10680583B1 (en) * | 2019-02-26 | 2020-06-09 | Xilinx, Inc. | Control circuit for and method of controlling an operation of an integrated circuit device |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998012185A1 (en) * | 1996-09-17 | 1998-03-26 | The Regents Of The University Of California | Benzothiadiazide derivatives and their use as allosteric up-modulators of the ampa receptor |
WO1999003861A1 (en) * | 1997-07-16 | 1999-01-28 | Novo Nordisk A/S | Fused 1,2,4-thiadiazine derivatives, their preparation and use |
WO1999042456A2 (en) * | 1998-02-18 | 1999-08-26 | Neurosearch A/S | Novel compounds and their use as positive ampa receptor modulators |
CN1402717A (zh) * | 1999-11-30 | 2003-03-12 | 瑟维尔实验室 | 新的苯并噻二嗪衍生物、其制备方法和含有它们的药物组合物 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3733409A (en) * | 1969-05-20 | 1973-05-15 | Schering Corp | Method of treating hypertension using thieno (1,2,4) thiadiazines |
-
2003
- 2003-05-05 FR FR0305448A patent/FR2854634B1/fr not_active Expired - Fee Related
-
2004
- 2004-04-05 UA UAA200511454A patent/UA80046C2/uk unknown
- 2004-04-30 MY MYPI20041647A patent/MY136694A/en unknown
- 2004-05-04 CA CA2524377A patent/CA2524377C/fr not_active Expired - Fee Related
- 2004-05-04 JP JP2006505830A patent/JP4461139B2/ja not_active Expired - Fee Related
- 2004-05-04 EA EA200501696A patent/EA009240B1/ru not_active IP Right Cessation
- 2004-05-04 EP EP04742632A patent/EP1620441A1/fr not_active Withdrawn
- 2004-05-04 WO PCT/FR2004/001070 patent/WO2004099217A1/fr active Application Filing
- 2004-05-04 CN CNB200480014886XA patent/CN100363368C/zh not_active Expired - Fee Related
- 2004-05-04 MX MXPA05011823A patent/MXPA05011823A/es active IP Right Grant
- 2004-05-04 BR BRPI0410002-6A patent/BRPI0410002A/pt not_active IP Right Cessation
- 2004-05-04 ZA ZA200508660A patent/ZA200508660B/en unknown
- 2004-05-04 AR ARP040101515A patent/AR044245A1/es unknown
- 2004-05-04 NZ NZ543214A patent/NZ543214A/en not_active IP Right Cessation
- 2004-05-04 GE GEAP20049092A patent/GEP20084318B/en unknown
- 2004-05-04 AU AU2004236005A patent/AU2004236005B2/en not_active Ceased
- 2004-05-04 US US10/555,743 patent/US7476668B2/en not_active Expired - Fee Related
- 2004-05-04 KR KR1020057020817A patent/KR100741235B1/ko not_active IP Right Cessation
-
2005
- 2005-10-21 MA MA28567A patent/MA27732A1/fr unknown
- 2005-12-01 NO NO20055695A patent/NO20055695L/no not_active Application Discontinuation
-
2006
- 2006-08-10 HK HK06108870A patent/HK1088327A1/xx not_active IP Right Cessation
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998012185A1 (en) * | 1996-09-17 | 1998-03-26 | The Regents Of The University Of California | Benzothiadiazide derivatives and their use as allosteric up-modulators of the ampa receptor |
WO1999003861A1 (en) * | 1997-07-16 | 1999-01-28 | Novo Nordisk A/S | Fused 1,2,4-thiadiazine derivatives, their preparation and use |
WO1999042456A2 (en) * | 1998-02-18 | 1999-08-26 | Neurosearch A/S | Novel compounds and their use as positive ampa receptor modulators |
CN1402717A (zh) * | 1999-11-30 | 2003-03-12 | 瑟维尔实验室 | 新的苯并噻二嗪衍生物、其制备方法和含有它们的药物组合物 |
Also Published As
Publication number | Publication date |
---|---|
GEP20084318B (en) | 2008-03-10 |
US7476668B2 (en) | 2009-01-13 |
CN1798750A (zh) | 2006-07-05 |
US20070004709A1 (en) | 2007-01-04 |
FR2854634A1 (fr) | 2004-11-12 |
MA27732A1 (fr) | 2006-01-02 |
AU2004236005B2 (en) | 2010-01-21 |
EP1620441A1 (fr) | 2006-02-01 |
AU2004236005A1 (en) | 2004-11-18 |
CA2524377C (fr) | 2010-08-24 |
WO2004099217A1 (fr) | 2004-11-18 |
NZ543214A (en) | 2009-02-28 |
MXPA05011823A (es) | 2006-05-25 |
BRPI0410002A (pt) | 2006-04-25 |
UA80046C2 (en) | 2007-08-10 |
ZA200508660B (en) | 2007-01-31 |
EA009240B1 (ru) | 2007-12-28 |
AR044245A1 (es) | 2005-09-07 |
KR20060006830A (ko) | 2006-01-19 |
MY136694A (en) | 2008-11-28 |
NO20055695L (no) | 2005-12-01 |
HK1088327A1 (en) | 2006-11-03 |
EA200501696A1 (ru) | 2006-06-30 |
JP4461139B2 (ja) | 2010-05-12 |
CA2524377A1 (fr) | 2004-11-18 |
JP2006525292A (ja) | 2006-11-09 |
KR100741235B1 (ko) | 2007-07-19 |
FR2854634B1 (fr) | 2005-07-08 |
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Owner name: UNIVERSITY OF LIEGE Free format text: FORMER OWNER: SERVIER LAB Effective date: 20120424 |
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Effective date of registration: 20120424 Address after: liege Patentee after: University of Liege Address before: Kolb tile Patentee before: Laboratoires Therwill |
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Granted publication date: 20080123 Termination date: 20130504 |