UA79752C2 - Active substance combination for medicamentous therapy of nicotine dependency, method of treatment - Google Patents
Active substance combination for medicamentous therapy of nicotine dependency, method of treatment Download PDFInfo
- Publication number
- UA79752C2 UA79752C2 UA2004010209A UA2004010209A UA79752C2 UA 79752 C2 UA79752 C2 UA 79752C2 UA 2004010209 A UA2004010209 A UA 2004010209A UA 2004010209 A UA2004010209 A UA 2004010209A UA 79752 C2 UA79752 C2 UA 79752C2
- Authority
- UA
- Ukraine
- Prior art keywords
- combination
- active substances
- differs
- derivatives
- pharmacologically acceptable
- Prior art date
Links
- 239000013543 active substance Substances 0.000 title claims abstract description 27
- 238000011282 treatment Methods 0.000 title claims abstract description 24
- 238000000034 method Methods 0.000 title claims description 6
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 title abstract description 17
- 229960002715 nicotine Drugs 0.000 title abstract description 17
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 title abstract description 16
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 102000003840 Opioid Receptors Human genes 0.000 claims abstract description 15
- 108090000137 Opioid Receptors Proteins 0.000 claims abstract description 15
- ASUTZQLVASHGKV-JDFRZJQESA-N galanthamine Chemical group O1C(=C23)C(OC)=CC=C2CN(C)CC[C@]23[C@@H]1C[C@@H](O)C=C2 ASUTZQLVASHGKV-JDFRZJQESA-N 0.000 claims description 71
- 229960003980 galantamine Drugs 0.000 claims description 36
- ASUTZQLVASHGKV-UHFFFAOYSA-N galanthamine hydrochloride Natural products O1C(=C23)C(OC)=CC=C2CN(C)CCC23C1CC(O)C=C2 ASUTZQLVASHGKV-UHFFFAOYSA-N 0.000 claims description 35
- WUFQLZTXIWKION-UHFFFAOYSA-N Deoxypeganine Chemical compound C1C2=CC=CC=C2N=C2N1CCC2 WUFQLZTXIWKION-UHFFFAOYSA-N 0.000 claims description 30
- 206010057852 Nicotine dependence Diseases 0.000 claims description 19
- 150000003839 salts Chemical class 0.000 claims description 18
- 208000025569 Tobacco Use disease Diseases 0.000 claims description 16
- 150000001875 compounds Chemical class 0.000 claims description 16
- DQCKKXVULJGBQN-XFWGSAIBSA-N naltrexone Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=O)O)CC1)O)CC1CC1 DQCKKXVULJGBQN-XFWGSAIBSA-N 0.000 claims description 15
- 229960003086 naltrexone Drugs 0.000 claims description 15
- 229940079593 drug Drugs 0.000 claims description 14
- 239000003814 drug Substances 0.000 claims description 14
- VARHXCYGZKSOOO-UHFFFAOYSA-N Deoxyvasicinone Natural products C1=CC=C2C(=O)N(CCC3)C3=NC2=C1 VARHXCYGZKSOOO-UHFFFAOYSA-N 0.000 claims description 13
- 239000000654 additive Chemical class 0.000 claims description 13
- 230000000996 additive effect Effects 0.000 claims description 12
- 239000005557 antagonist Substances 0.000 claims description 10
- 238000002360 preparation method Methods 0.000 claims description 8
- 229940123257 Opioid receptor antagonist Drugs 0.000 claims description 4
- 239000000544 cholinesterase inhibitor Substances 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 claims description 3
- 229940126601 medicinal product Drugs 0.000 claims 5
- 229940122041 Cholinesterase inhibitor Drugs 0.000 claims 2
- ZFSXKSSWYSZPGQ-UHFFFAOYSA-N (2-hydroxycyclopentyl)azanium;chloride Chemical compound Cl.NC1CCCC1O ZFSXKSSWYSZPGQ-UHFFFAOYSA-N 0.000 claims 1
- 239000003405 delayed action preparation Substances 0.000 claims 1
- 239000012458 free base Substances 0.000 claims 1
- 229960000858 naltrexone hydrochloride Drugs 0.000 claims 1
- 239000003401 opiate antagonist Substances 0.000 claims 1
- 238000012876 topography Methods 0.000 claims 1
- 239000000126 substance Substances 0.000 abstract description 22
- 230000001713 cholinergic effect Effects 0.000 abstract description 19
- 230000000903 blocking effect Effects 0.000 abstract 1
- 230000000391 smoking effect Effects 0.000 description 10
- 102000010909 Monoamine Oxidase Human genes 0.000 description 8
- 108010062431 Monoamine oxidase Proteins 0.000 description 8
- 230000000694 effects Effects 0.000 description 8
- 208000007848 Alcoholism Diseases 0.000 description 7
- 241000208125 Nicotiana Species 0.000 description 6
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 6
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 6
- 230000003291 dopaminomimetic effect Effects 0.000 description 6
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 4
- 239000003112 inhibitor Substances 0.000 description 4
- 230000000144 pharmacologic effect Effects 0.000 description 4
- 239000000779 smoke Substances 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- 102100033639 Acetylcholinesterase Human genes 0.000 description 3
- 108010022752 Acetylcholinesterase Proteins 0.000 description 3
- 108010009685 Cholinergic Receptors Proteins 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 3
- 102000034337 acetylcholine receptors Human genes 0.000 description 3
- 229940022698 acetylcholinesterase Drugs 0.000 description 3
- 206010001584 alcohol abuse Diseases 0.000 description 3
- 201000007930 alcohol dependence Diseases 0.000 description 3
- 208000025746 alcohol use disease Diseases 0.000 description 3
- 229930013930 alkaloid Natural products 0.000 description 3
- 229960003638 dopamine Drugs 0.000 description 3
- -1 galantamine cation Chemical class 0.000 description 3
- VOKSWYLNZZRQPF-GDIGMMSISA-N pentazocine Chemical compound C1C2=CC=C(O)C=C2[C@@]2(C)[C@@H](C)[C@@H]1N(CC=C(C)C)CC2 VOKSWYLNZZRQPF-GDIGMMSISA-N 0.000 description 3
- 229960005301 pentazocine Drugs 0.000 description 3
- 102000005962 receptors Human genes 0.000 description 3
- 108020003175 receptors Proteins 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- YQYVFVRQLZMJKJ-JBBXEZCESA-N (+)-cyclazocine Chemical compound C([C@@]1(C)C2=CC(O)=CC=C2C[C@@H]2[C@@H]1C)CN2CC1CC1 YQYVFVRQLZMJKJ-JBBXEZCESA-N 0.000 description 2
- OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 description 2
- 102000003914 Cholinesterases Human genes 0.000 description 2
- 108090000322 Cholinesterases Proteins 0.000 description 2
- WJBLNOPPDWQMCH-MBPVOVBZSA-N Nalmefene Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=C)O)CC1)O)CC1CC1 WJBLNOPPDWQMCH-MBPVOVBZSA-N 0.000 description 2
- 102000019315 Nicotinic acetylcholine receptors Human genes 0.000 description 2
- 108050006807 Nicotinic acetylcholine receptors Proteins 0.000 description 2
- DTQVDTLACAAQTR-UHFFFAOYSA-M Trifluoroacetate Chemical compound [O-]C(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-M 0.000 description 2
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 description 2
- 229960004373 acetylcholine Drugs 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 150000003797 alkaloid derivatives Chemical class 0.000 description 2
- 230000003042 antagnostic effect Effects 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- 210000000748 cardiovascular system Anatomy 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000001055 chewing effect Effects 0.000 description 2
- 229940048961 cholinesterase Drugs 0.000 description 2
- 235000019504 cigarettes Nutrition 0.000 description 2
- 230000001149 cognitive effect Effects 0.000 description 2
- 235000019788 craving Nutrition 0.000 description 2
- 229950002213 cyclazocine Drugs 0.000 description 2
- 230000034994 death Effects 0.000 description 2
- 231100000517 death Toxicity 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 229960003692 gamma aminobutyric acid Drugs 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 229960005297 nalmefene Drugs 0.000 description 2
- 125000004433 nitrogen atom Chemical group N* 0.000 description 2
- 230000003518 presynaptic effect Effects 0.000 description 2
- 210000000063 presynaptic terminal Anatomy 0.000 description 2
- JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical compound N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 238000006722 reduction reaction Methods 0.000 description 2
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 description 2
- 235000019505 tobacco product Nutrition 0.000 description 2
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 description 1
- AXFDDKKRVFMVHY-OFAZKWMESA-N (4r,4as,7s,7ar,12bs)-3-(cyclopropylmethyl)-4a,9-dihydroxyspiro[2,4,5,6,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-7,5'-imidazolidine]-2',4'-dione Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CC[C@]25C(NC(=O)N2)=O)O)CC1)O)CC1CC1 AXFDDKKRVFMVHY-OFAZKWMESA-N 0.000 description 1
- AQCRXZYYMOXFAN-UHFFFAOYSA-N 2-(1-methyl-2-pyrrolidinyl)-pyridine Chemical compound CN1CCCC1C1=CC=CC=N1 AQCRXZYYMOXFAN-UHFFFAOYSA-N 0.000 description 1
- 208000024827 Alzheimer disease Diseases 0.000 description 1
- 241000499945 Amaryllis Species 0.000 description 1
- 238000006711 Chan reduction reaction Methods 0.000 description 1
- 206010012289 Dementia Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 208000010412 Glaucoma Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- UIQMVEYFGZJHCZ-SSTWWWIQSA-N Nalorphine Chemical compound C([C@@H](N(CC1)CC=C)[C@@H]2C=C[C@@H]3O)C4=CC=C(O)C5=C4[C@@]21[C@H]3O5 UIQMVEYFGZJHCZ-SSTWWWIQSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000000474 Poliomyelitis Diseases 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000002998 adhesive polymer Substances 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 230000001270 agonistic effect Effects 0.000 description 1
- 239000000729 antidote Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- SNPPWIUOZRMYNY-UHFFFAOYSA-N bupropion Chemical compound CC(C)(C)NC(C)C(=O)C1=CC=CC(Cl)=C1 SNPPWIUOZRMYNY-UHFFFAOYSA-N 0.000 description 1
- 229960001058 bupropion Drugs 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 231100000357 carcinogen Toxicity 0.000 description 1
- 239000003183 carcinogenic agent Substances 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 239000000064 cholinergic agonist Substances 0.000 description 1
- 230000008094 contradictory effect Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 206010013663 drug dependence Diseases 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 239000002532 enzyme inhibitor Substances 0.000 description 1
- 230000002964 excitative effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000036651 mood Effects 0.000 description 1
- INAXVFBXDYWQFN-XHSDSOJGSA-N morphinan Chemical compound C1C2=CC=CC=C2[C@]23CCCC[C@H]3[C@@H]1NCC2 INAXVFBXDYWQFN-XHSDSOJGSA-N 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- NETZHAKZCGBWSS-CEDHKZHLSA-N nalbuphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]1(O)CC[C@@H]3O)CN2CC1CCC1 NETZHAKZCGBWSS-CEDHKZHLSA-N 0.000 description 1
- 229960000805 nalbuphine Drugs 0.000 description 1
- 229960000938 nalorphine Drugs 0.000 description 1
- 239000003887 narcotic antagonist Substances 0.000 description 1
- 230000003533 narcotic effect Effects 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 210000001640 nerve ending Anatomy 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 230000003088 neuroexcitatory effect Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000002474 noradrenergic effect Effects 0.000 description 1
- 229960002748 norepinephrine Drugs 0.000 description 1
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 150000003014 phosphoric acid esters Chemical class 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 239000011241 protective layer Substances 0.000 description 1
- 229940075993 receptor modulator Drugs 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 229940076279 serotonin Drugs 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 201000009032 substance abuse Diseases 0.000 description 1
- 208000011117 substance-related disease Diseases 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Addiction (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10134038A DE10134038A1 (de) | 2001-07-12 | 2001-07-12 | Wirkstoff-Kombination zur medikamentösen Therapie der Nikotinabhängigkeit |
| PCT/EP2002/007477 WO2003007966A1 (de) | 2001-07-12 | 2002-07-05 | Wirkstoff-kombination zur medikamentösen therapie der nikotinabhängigkeit |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA79752C2 true UA79752C2 (en) | 2007-07-25 |
Family
ID=7691630
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA2004010209A UA79752C2 (en) | 2001-07-12 | 2002-05-07 | Active substance combination for medicamentous therapy of nicotine dependency, method of treatment |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US20040167145A1 (es) |
| EP (1) | EP1404341B1 (es) |
| JP (1) | JP2005502633A (es) |
| KR (1) | KR20040013143A (es) |
| CN (1) | CN1527712A (es) |
| AR (1) | AR034767A1 (es) |
| AT (1) | ATE340576T1 (es) |
| AU (1) | AU2002354856B2 (es) |
| BR (1) | BR0211323A (es) |
| CA (1) | CA2452432C (es) |
| CZ (1) | CZ301204B6 (es) |
| DE (2) | DE10134038A1 (es) |
| DK (1) | DK1404341T3 (es) |
| EA (1) | EA007628B1 (es) |
| ES (1) | ES2274064T3 (es) |
| HK (1) | HK1063159A1 (es) |
| HU (1) | HUP0401013A3 (es) |
| IL (2) | IL159789A0 (es) |
| MX (1) | MXPA04000344A (es) |
| MY (1) | MY131858A (es) |
| NO (1) | NO20040119L (es) |
| NZ (1) | NZ530512A (es) |
| PL (1) | PL367779A1 (es) |
| PT (1) | PT1404341E (es) |
| SK (1) | SK112004A3 (es) |
| UA (1) | UA79752C2 (es) |
| WO (1) | WO2003007966A1 (es) |
| ZA (1) | ZA200400305B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10338544B4 (de) * | 2003-08-19 | 2017-08-31 | Janssen Pharmaceutica N.V. | Buccale Formulierungen des Galanthamins und deren Anwendungen |
| DE10354893B4 (de) * | 2003-11-24 | 2011-03-10 | Hf Arzneimittelforschung Gmbh | Verwendung von Desoxypeganin zur Behandlung schizophrener Psychosen |
| CL2008003507A1 (es) | 2007-11-26 | 2009-11-27 | Neuroderm Ltd | Composicion farmaceutica que comprende nicotina y un inhibidor de la desensibilizacion del receptor de acetilcolina nicotinico (nachr) opipramol; kit farmaceutico; dispositivo medico; y uso para tratar una enfermedad o trastorno del sistema nervioso central o periferico. |
| DE102007058504A1 (de) * | 2007-12-05 | 2009-07-09 | Acino Ag | Transdermales therapeutisches System mit einem Gehalt an einem Modulator für nikotinische Acetylcholinrezeptoren (nAChR) |
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| US3797494A (en) * | 1969-04-01 | 1974-03-19 | Alza Corp | Bandage for the administration of drug by controlled metering through microporous materials |
| US3742951A (en) * | 1971-08-09 | 1973-07-03 | Alza Corp | Bandage for controlled release of vasodilators |
| US3996934A (en) * | 1971-08-09 | 1976-12-14 | Alza Corporation | Medical bandage |
| US4031894A (en) * | 1975-12-08 | 1977-06-28 | Alza Corporation | Bandage for transdermally administering scopolamine to prevent nausea |
| DE3315272C2 (de) * | 1983-04-27 | 1986-03-27 | Lohmann Gmbh & Co Kg, 5450 Neuwied | Pharmazeutisches Produkt und Verfahren zu seiner Herstellung |
| US4573995A (en) * | 1984-10-09 | 1986-03-04 | Alza Corporation | Transdermal therapeutic systems for the administration of naloxone, naltrexone and nalbuphine |
| DE3843239C1 (es) * | 1988-12-22 | 1990-02-22 | Lohmann Therapie Syst Lts | |
| US5519017A (en) * | 1990-03-29 | 1996-05-21 | Lts Lohmann Therapie-Systeme Gmbh + Co. Kg | Pharmaceutic formulation for the treatment of alcoholism |
| DE4010079A1 (de) * | 1990-03-29 | 1991-10-02 | Lohmann Therapie Syst Lts | Pharmazeutische formulierung zur behandlung des alkoholismus |
| US5668117A (en) * | 1991-02-22 | 1997-09-16 | Shapiro; Howard K. | Methods of treating neurological diseases and etiologically related symptomology using carbonyl trapping agents in combination with previously known medicaments |
| DE4301782C1 (de) * | 1993-01-23 | 1994-08-25 | Lohmann Therapie Syst Lts | Verwendung von Galanthamin zur Behandlung der Nicotinabhängigkeit |
| CA2203183C (en) * | 1994-10-21 | 2008-04-08 | Laszlo Czollner | Process for producing derivatives of 4a,5,9,10,11,12,-hexahydro-6h-benzofuro[3a,3,2-ef][2]benzazepine |
| DE19509663A1 (de) * | 1995-03-17 | 1996-09-19 | Lohmann Therapie Syst Lts | Verfahren zur Isolierung von Galanthamin |
| GB9514821D0 (en) * | 1995-07-19 | 1995-09-20 | Sod Conseils Rech Applic | Galanthamine derivatives |
| WO1997018781A1 (en) * | 1995-11-20 | 1997-05-29 | University Of Miami | Method of treating nicotine dependence |
| EP0828489A4 (en) * | 1996-03-13 | 2001-04-04 | Univ Yale | Smoking cessation treatment using naltrexone and related compounds |
| AT403803B (de) * | 1996-04-19 | 1998-05-25 | Sanochemia Ltd | Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln |
| US5965567A (en) * | 1997-07-15 | 1999-10-12 | Albany Medical College | Method for treating nicotine addiction |
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| DE10129265A1 (de) * | 2001-06-18 | 2003-01-02 | Hf Arzneimittelforsch Gmbh | Wirkstoff-Kombination zur medikamentösen Sucht- oder Rauschmitteltherapie |
-
2001
- 2001-07-12 DE DE10134038A patent/DE10134038A1/de not_active Ceased
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2002
- 2002-05-07 UA UA2004010209A patent/UA79752C2/uk unknown
- 2002-07-05 DK DK02751112T patent/DK1404341T3/da active
- 2002-07-05 PT PT02751112T patent/PT1404341E/pt unknown
- 2002-07-05 CA CA002452432A patent/CA2452432C/en not_active Expired - Fee Related
- 2002-07-05 ES ES02751112T patent/ES2274064T3/es not_active Expired - Lifetime
- 2002-07-05 BR BR0211323-6A patent/BR0211323A/pt not_active IP Right Cessation
- 2002-07-05 JP JP2003513572A patent/JP2005502633A/ja not_active Withdrawn
- 2002-07-05 IL IL15978902A patent/IL159789A0/xx unknown
- 2002-07-05 SK SK11-2004A patent/SK112004A3/sk unknown
- 2002-07-05 DE DE50208267T patent/DE50208267D1/de not_active Expired - Lifetime
- 2002-07-05 AT AT02751112T patent/ATE340576T1/de not_active IP Right Cessation
- 2002-07-05 NZ NZ530512A patent/NZ530512A/en not_active IP Right Cessation
- 2002-07-05 PL PL02367779A patent/PL367779A1/xx not_active Application Discontinuation
- 2002-07-05 KR KR10-2004-7000477A patent/KR20040013143A/ko active Search and Examination
- 2002-07-05 CN CNA028139690A patent/CN1527712A/zh active Pending
- 2002-07-05 EA EA200400116A patent/EA007628B1/ru not_active IP Right Cessation
- 2002-07-05 AU AU2002354856A patent/AU2002354856B2/en not_active Ceased
- 2002-07-05 CZ CZ20040019A patent/CZ301204B6/cs not_active IP Right Cessation
- 2002-07-05 EP EP02751112A patent/EP1404341B1/de not_active Expired - Lifetime
- 2002-07-05 US US10/482,961 patent/US20040167145A1/en not_active Abandoned
- 2002-07-05 HU HU0401013A patent/HUP0401013A3/hu unknown
- 2002-07-05 MX MXPA04000344A patent/MXPA04000344A/es active IP Right Grant
- 2002-07-05 WO PCT/EP2002/007477 patent/WO2003007966A1/de active IP Right Grant
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Also Published As
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| EA007628B1 (ru) | 2006-12-29 |
| HUP0401013A3 (en) | 2011-03-28 |
| HK1063159A1 (en) | 2004-12-17 |
| BR0211323A (pt) | 2004-11-30 |
| WO2003007966A1 (de) | 2003-01-30 |
| CZ200419A3 (cs) | 2004-05-12 |
| CA2452432A1 (en) | 2003-01-30 |
| EA200400116A1 (ru) | 2004-08-26 |
| DK1404341T3 (da) | 2007-02-05 |
| EP1404341A1 (de) | 2004-04-07 |
| KR20040013143A (ko) | 2004-02-11 |
| NO20040119L (no) | 2004-01-30 |
| ES2274064T3 (es) | 2007-05-16 |
| IL159789A (en) | 2008-07-08 |
| SK112004A3 (en) | 2004-06-08 |
| ZA200400305B (en) | 2004-05-24 |
| EP1404341B1 (de) | 2006-09-27 |
| AU2002354856B2 (en) | 2007-05-31 |
| CA2452432C (en) | 2009-09-01 |
| IL159789A0 (en) | 2004-06-20 |
| MY131858A (en) | 2007-09-28 |
| CZ301204B6 (cs) | 2009-12-09 |
| DE50208267D1 (de) | 2006-11-09 |
| PL367779A1 (en) | 2005-03-07 |
| HUP0401013A2 (hu) | 2004-08-30 |
| ATE340576T1 (de) | 2006-10-15 |
| NZ530512A (en) | 2007-09-28 |
| CN1527712A (zh) | 2004-09-08 |
| DE10134038A1 (de) | 2003-02-06 |
| PT1404341E (pt) | 2007-01-31 |
| US20040167145A1 (en) | 2004-08-26 |
| MXPA04000344A (es) | 2004-05-04 |
| JP2005502633A (ja) | 2005-01-27 |
| AR034767A1 (es) | 2004-03-17 |
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