UA77669C2 - Method for producing mixture of d-pantothenic acid and salts thereof - Google Patents
Method for producing mixture of d-pantothenic acid and salts thereof Download PDFInfo
- Publication number
- UA77669C2 UA77669C2 UA2003098597A UA2003098597A UA77669C2 UA 77669 C2 UA77669 C2 UA 77669C2 UA 2003098597 A UA2003098597 A UA 2003098597A UA 2003098597 A UA2003098597 A UA 2003098597A UA 77669 C2 UA77669 C2 UA 77669C2
- Authority
- UA
- Ukraine
- Prior art keywords
- pantothenic acid
- solution
- differs
- calcium
- fermentation
- Prior art date
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- 150000003839 salts Chemical class 0.000 title claims abstract description 26
- 239000000203 mixture Substances 0.000 title claims abstract description 24
- GHOKWGTUZJEAQD-UHFFFAOYSA-N pantothenic acid Chemical compound OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 title abstract description 54
- 238000004519 manufacturing process Methods 0.000 title abstract description 15
- 239000011713 pantothenic acid Substances 0.000 claims abstract description 145
- 229940055726 pantothenic acid Drugs 0.000 claims abstract description 110
- 244000005700 microbiome Species 0.000 claims abstract description 20
- 150000001768 cations Chemical class 0.000 claims abstract description 19
- 238000001035 drying Methods 0.000 claims abstract description 18
- 241001465754 Metazoa Species 0.000 claims abstract description 12
- 239000000654 additive Substances 0.000 claims abstract description 9
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims abstract description 5
- 230000000996 additive effect Effects 0.000 claims abstract description 5
- 229960000310 isoleucine Drugs 0.000 claims abstract description 5
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims abstract description 5
- 238000000034 method Methods 0.000 claims description 102
- 238000000855 fermentation Methods 0.000 claims description 88
- 230000004151 fermentation Effects 0.000 claims description 88
- 239000012528 membrane Substances 0.000 claims description 43
- 229940014662 pantothenate Drugs 0.000 claims description 35
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 24
- 229910052791 calcium Inorganic materials 0.000 claims description 23
- 239000011575 calcium Substances 0.000 claims description 23
- 150000002500 ions Chemical class 0.000 claims description 23
- 230000008569 process Effects 0.000 claims description 23
- 230000015572 biosynthetic process Effects 0.000 claims description 18
- 239000001963 growth medium Substances 0.000 claims description 18
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 16
- 229910052749 magnesium Inorganic materials 0.000 claims description 16
- 239000011777 magnesium Substances 0.000 claims description 16
- 239000000725 suspension Substances 0.000 claims description 13
- 239000007900 aqueous suspension Substances 0.000 claims description 12
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 claims description 9
- 239000000920 calcium hydroxide Substances 0.000 claims description 9
- 229910001861 calcium hydroxide Inorganic materials 0.000 claims description 9
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 8
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 7
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 7
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 claims description 7
- 239000011591 potassium Substances 0.000 claims description 7
- 229960002079 calcium pantothenate Drugs 0.000 claims description 6
- 230000005684 electric field Effects 0.000 claims description 6
- 239000003014 ion exchange membrane Substances 0.000 claims description 6
- 238000006386 neutralization reaction Methods 0.000 claims description 6
- 241000894006 Bacteria Species 0.000 claims description 5
- 230000033228 biological regulation Effects 0.000 claims description 5
- ONSCBWDZUUNMMK-UBKPKTQASA-L magnesium;3-[[(2r)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]propanoate Chemical compound [Mg+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O ONSCBWDZUUNMMK-UBKPKTQASA-L 0.000 claims description 5
- 239000007787 solid Substances 0.000 claims description 5
- 239000000126 substance Substances 0.000 claims description 5
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 4
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 claims description 4
- 239000001095 magnesium carbonate Substances 0.000 claims description 4
- 229910000021 magnesium carbonate Inorganic materials 0.000 claims description 4
- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 claims description 4
- 239000000347 magnesium hydroxide Substances 0.000 claims description 4
- 229910001862 magnesium hydroxide Inorganic materials 0.000 claims description 4
- 241000233866 Fungi Species 0.000 claims description 3
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 3
- UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical class NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 claims description 3
- 238000007493 shaping process Methods 0.000 claims description 3
- 241000894007 species Species 0.000 claims description 3
- BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 claims description 2
- 239000000292 calcium oxide Substances 0.000 claims description 2
- ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 claims description 2
- 238000005342 ion exchange Methods 0.000 claims description 2
- 229910001414 potassium ion Inorganic materials 0.000 claims description 2
- 238000012545 processing Methods 0.000 claims description 2
- 229910001415 sodium ion Inorganic materials 0.000 claims description 2
- 238000012876 topography Methods 0.000 claims 1
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 abstract description 98
- 235000019161 pantothenic acid Nutrition 0.000 abstract description 49
- 238000000909 electrodialysis Methods 0.000 abstract description 23
- 239000004474 valine Substances 0.000 abstract description 4
- 229960004295 valine Drugs 0.000 abstract description 4
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 abstract description 3
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 abstract description 3
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 230000025078 regulation of biosynthetic process Effects 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 150
- 108090000623 proteins and genes Proteins 0.000 description 41
- 238000007792 addition Methods 0.000 description 35
- 239000002609 medium Substances 0.000 description 32
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 26
- 239000000047 product Substances 0.000 description 26
- 210000004027 cell Anatomy 0.000 description 23
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 18
- 239000008103 glucose Substances 0.000 description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 18
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 17
- 239000001110 calcium chloride Substances 0.000 description 16
- 229910001628 calcium chloride Inorganic materials 0.000 description 16
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 14
- 238000000926 separation method Methods 0.000 description 14
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- 239000002243 precursor Substances 0.000 description 13
- 239000012138 yeast extract Substances 0.000 description 13
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 12
- -1 for example Chemical compound 0.000 description 12
- LPUQAYUQRXPFSQ-DFWYDOINSA-M monosodium L-glutamate Chemical compound [Na+].[O-]C(=O)[C@@H](N)CCC(O)=O LPUQAYUQRXPFSQ-DFWYDOINSA-M 0.000 description 11
- 230000001954 sterilising effect Effects 0.000 description 11
- 238000004659 sterilization and disinfection Methods 0.000 description 11
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 10
- 229910052799 carbon Inorganic materials 0.000 description 10
- 235000013923 monosodium glutamate Nutrition 0.000 description 10
- 239000011573 trace mineral Substances 0.000 description 10
- 235000013619 trace mineral Nutrition 0.000 description 10
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 9
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
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- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 8
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 8
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- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 6
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 6
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- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
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- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
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- XKLJHFLUAHKGGU-UHFFFAOYSA-N nitrous amide Chemical compound ON=N XKLJHFLUAHKGGU-UHFFFAOYSA-N 0.000 description 1
- 229910000510 noble metal Inorganic materials 0.000 description 1
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- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 229910000160 potassium phosphate Inorganic materials 0.000 description 1
- 235000011009 potassium phosphates Nutrition 0.000 description 1
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- 229960000268 spectinomycin Drugs 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/12—Animal feeding-stuffs obtained by microbiological or biochemical processes by fermentation of natural products, e.g. of vegetable material, animal waste material or biomass
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Animal Husbandry (AREA)
- Food Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Sustainable Development (AREA)
- Molecular Biology (AREA)
- Physiology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Fodder In General (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10108223A DE10108223A1 (de) | 2001-02-21 | 2001-02-21 | Verfahren zur Herstellung von D-Pantothensäure und/oder deren Salze als Zusatz zu Tierfuttermitteln |
PCT/EP2002/001766 WO2002066666A2 (de) | 2001-02-21 | 2002-02-20 | Verfahren zur herstellung von d-pantothensäure und/oder deren salze als zusatz zu tierfuttermitteln |
Publications (1)
Publication Number | Publication Date |
---|---|
UA77669C2 true UA77669C2 (en) | 2007-01-15 |
Family
ID=7674921
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UA2003098597A UA77669C2 (en) | 2001-02-21 | 2002-02-20 | Method for producing mixture of d-pantothenic acid and salts thereof |
Country Status (23)
Country | Link |
---|---|
US (1) | US7824891B2 (xx) |
EP (1) | EP1362118B1 (xx) |
JP (1) | JP2004531236A (xx) |
KR (1) | KR20030075204A (xx) |
CN (1) | CN1294273C (xx) |
AT (1) | ATE342372T1 (xx) |
AU (1) | AU2002250978B2 (xx) |
BR (1) | BR0207474A (xx) |
CA (1) | CA2438949A1 (xx) |
CZ (1) | CZ20032223A3 (xx) |
DE (2) | DE10108223A1 (xx) |
EE (1) | EE200300406A (xx) |
ES (1) | ES2274967T3 (xx) |
HU (1) | HUP0303304A3 (xx) |
IL (1) | IL157496A0 (xx) |
IN (1) | IN2003CH01315A (xx) |
MX (1) | MX240870B (xx) |
NO (1) | NO20033707L (xx) |
PL (1) | PL363989A1 (xx) |
RU (1) | RU2292397C2 (xx) |
SK (1) | SK10452003A3 (xx) |
UA (1) | UA77669C2 (xx) |
WO (1) | WO2002066666A2 (xx) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10108225A1 (de) * | 2001-02-21 | 2002-10-10 | Basf Ag | Verfahren zur Herstellung von D-Pantothensäure und/oder deren Salze als Zusatz zu Tierfuttermitteln |
DE10344200A1 (de) * | 2003-09-22 | 2005-05-04 | Basf Ag | Verfahren zur Herstellung eines D-Pantothensäure und/oder deren Salze enthaltendes Tierfuttersupplement |
EP3426670A4 (en) * | 2016-03-07 | 2019-11-13 | Glycom A/S | SEPARATION OF OLIGOSACCHARIDES FROM A FERMENTATION BROTH |
BR112020005321A2 (pt) * | 2017-09-19 | 2020-09-24 | Evogene Ltd. | isolados bacterianos biologicamente puros, lisados, caldos de células inteiras, método de obtenção de um isolado bacteriano modificado biologicamente puro, polipeptídeos isolados, construto de ácido nucleico, células vegetais transformadas com um construto de ácido nucleico, planta, composições de matéria, recipiente adaptado para um sistema de irrigação, kits, semente revestida, e, métodos para aumentar uma resistência de uma planta a um inseto e para inibir um inseto em uma planta. |
CN111621541A (zh) * | 2019-02-27 | 2020-09-04 | 上海艾美晶生物科技有限公司 | 使用电渗析技术拆分光学异构体的方法 |
KR20240067580A (ko) | 2022-11-09 | 2024-05-17 | 단국대학교 천안캠퍼스 산학협력단 | 요통경감의자 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB562267A (en) | 1941-08-08 | 1944-06-26 | Hoffmann La Roche | Process for the manufacture of a crystallised, non-hygroscopic calcium salt of d-pantothenic acid |
EP0493060A3 (en) | 1990-12-25 | 1993-04-14 | Takeda Chemical Industries, Ltd. | Production method of d-pantothenic acid and plasmids and microorganisms thereof |
JP3710497B2 (ja) * | 1992-09-25 | 2005-10-26 | ビーエーエスエフ アクチェンゲゼルシャフト | D−パント酸、d−パントテン酸およびそれらの塩の製造法 |
EP0822989B1 (en) * | 1995-04-21 | 2001-03-14 | Takeda Chemical Industries, Ltd. | Process for producing calcium d-pantothenate |
US7267967B1 (en) | 1997-10-04 | 2007-09-11 | Forschungszentrum Julich Gmbh | Nucleic acid encoding pyruvate carboxylase from coryneform glutamicum |
AT407050B (de) | 1997-12-29 | 2000-11-27 | Chemie Linz Gmbh | Verfahren zur herstellung von l-asparaginsäure |
US6110342A (en) * | 1998-07-21 | 2000-08-29 | Archer Daniels Midland Company | Process for production of amino acid hydrochloride and caustic via electrodialysis water splitting |
DE19855313A1 (de) * | 1998-12-01 | 2000-06-08 | Degussa | Verfahren zur fermentativen Herstellung von D-Pantothensäure durch Verstärkung des panD-Gens in Mikroorganismen |
PT1050219E (pt) * | 1999-05-05 | 2003-04-30 | Degussa | Aditivos alimentares para animais contendo acido d-pantotenico e/ou seus sais e processo para a sua preparacao |
US8232081B2 (en) * | 1999-09-21 | 2012-07-31 | Basf Se | Methods and microorganisms for production of panto-compounds |
PL356566A1 (en) * | 1999-09-21 | 2004-06-28 | Basf Aktiengesellschaft | Methods and microorganisms for production of panto-compounds |
FR2799754A1 (fr) * | 1999-10-18 | 2001-04-20 | Roquette Freres | Procede de separation et de purification d'acide lactique a partir d'un milieu de fermentation |
DE10021515A1 (de) * | 2000-05-03 | 2001-11-08 | Degussa | Verfahren zur Herstellung von Erdalkalisalzen der D-Pantothensäure |
MXPA03002345A (es) | 2000-09-20 | 2003-06-30 | Basf Ag | Suplemento alimenticio para animales que contiene acido d-pantotenico y/o sus sales, metodo mejorado para la produccion del mismo, y su uso. |
CN100529068C (zh) | 2001-01-19 | 2009-08-19 | 巴斯福股份公司 | 用于提高泛酸产量的微生物和方法 |
RU2003125653A (ru) | 2001-01-19 | 2005-03-10 | БАСФ Акциенгезельшафт (DE) | Способы улучшенного получения пантотената |
-
2001
- 2001-02-21 DE DE10108223A patent/DE10108223A1/de not_active Withdrawn
-
2002
- 2002-02-20 WO PCT/EP2002/001766 patent/WO2002066666A2/de active IP Right Grant
- 2002-02-20 JP JP2002566370A patent/JP2004531236A/ja active Pending
- 2002-02-20 MX MXPA03007383 patent/MX240870B/es active IP Right Grant
- 2002-02-20 HU HU0303304A patent/HUP0303304A3/hu unknown
- 2002-02-20 PL PL02363989A patent/PL363989A1/xx not_active Application Discontinuation
- 2002-02-20 EP EP02719874A patent/EP1362118B1/de not_active Expired - Lifetime
- 2002-02-20 US US10/468,610 patent/US7824891B2/en not_active Expired - Fee Related
- 2002-02-20 AT AT02719874T patent/ATE342372T1/de not_active IP Right Cessation
- 2002-02-20 DE DE50208413T patent/DE50208413D1/de not_active Expired - Lifetime
- 2002-02-20 ES ES02719874T patent/ES2274967T3/es not_active Expired - Lifetime
- 2002-02-20 AU AU2002250978A patent/AU2002250978B2/en not_active Ceased
- 2002-02-20 BR BR0207474-5A patent/BR0207474A/pt not_active IP Right Cessation
- 2002-02-20 UA UA2003098597A patent/UA77669C2/uk unknown
- 2002-02-20 CA CA002438949A patent/CA2438949A1/en not_active Abandoned
- 2002-02-20 KR KR20037010981A patent/KR20030075204A/ko not_active Application Discontinuation
- 2002-02-20 CN CNB028053303A patent/CN1294273C/zh not_active Expired - Fee Related
- 2002-02-20 RU RU2003128534/13A patent/RU2292397C2/ru not_active IP Right Cessation
- 2002-02-20 EE EEP200300406A patent/EE200300406A/xx unknown
- 2002-02-20 CZ CZ20032223A patent/CZ20032223A3/cs unknown
- 2002-02-20 IL IL15749602A patent/IL157496A0/xx unknown
- 2002-02-20 SK SK1045-2003A patent/SK10452003A3/sk not_active Application Discontinuation
-
2003
- 2003-08-20 NO NO20033707A patent/NO20033707L/no not_active Application Discontinuation
- 2003-08-21 IN IN1315CH2003 patent/IN2003CH01315A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
BR0207474A (pt) | 2004-03-02 |
IL157496A0 (en) | 2004-03-28 |
ATE342372T1 (de) | 2006-11-15 |
JP2004531236A (ja) | 2004-10-14 |
DE50208413D1 (de) | 2006-11-23 |
US7824891B2 (en) | 2010-11-02 |
MX240870B (es) | 2006-10-09 |
RU2003128534A (ru) | 2005-04-10 |
PL363989A1 (en) | 2004-11-29 |
WO2002066666A2 (de) | 2002-08-29 |
AU2002250978B2 (en) | 2007-03-01 |
DE10108223A1 (de) | 2002-10-10 |
CA2438949A1 (en) | 2002-08-29 |
EE200300406A (et) | 2003-12-15 |
IN2003CH01315A (en) | 2005-11-25 |
SK10452003A3 (sk) | 2004-02-03 |
WO2002066666A3 (de) | 2003-07-17 |
CZ20032223A3 (cs) | 2003-11-12 |
NO20033707D0 (no) | 2003-08-20 |
HUP0303304A3 (en) | 2007-09-28 |
CN1492935A (zh) | 2004-04-28 |
ES2274967T3 (es) | 2007-06-01 |
EP1362118B1 (de) | 2006-10-11 |
KR20030075204A (ko) | 2003-09-22 |
HUP0303304A2 (hu) | 2004-01-28 |
US20040072306A1 (en) | 2004-04-15 |
RU2292397C2 (ru) | 2007-01-27 |
NO20033707L (no) | 2003-10-20 |
MXPA03007383A (es) | 2004-03-16 |
EP1362118A2 (de) | 2003-11-19 |
CN1294273C (zh) | 2007-01-10 |
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