UA75867C2 - A method of determining the presence of catalytic factor viii allo-antibodies capable of degrading factor viii in a mammal, amino acid sequence inhibiting any site in factor viii molecule being sensible to cleavage by allo-antibodies in factor viii (variants), use of inhibitor of cleavage of factor viii to neutralize a catalytic activity of allo-antibodies to factor viii and pharmaceutical composition containing allo-antibodies being capable of degrading factor viii - Google Patents
A method of determining the presence of catalytic factor viii allo-antibodies capable of degrading factor viii in a mammal, amino acid sequence inhibiting any site in factor viii molecule being sensible to cleavage by allo-antibodies in factor viii (variants), use of inhibitor of cleavage of factor viii to neutralize a catalytic activity of allo-antibodies to factor viii and pharmaceutical composition containing allo-antibodies being capable of degrading factor viii Download PDFInfo
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- UA75867C2 UA75867C2 UA2002010487A UA2002010487A UA75867C2 UA 75867 C2 UA75867 C2 UA 75867C2 UA 2002010487 A UA2002010487 A UA 2002010487A UA 2002010487 A UA2002010487 A UA 2002010487A UA 75867 C2 UA75867 C2 UA 75867C2
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- factor
- antibodies
- allo
- factor viii
- cleavage
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- 230000003993 interaction Effects 0.000 description 1
- VBUWHHLIZKOSMS-RIWXPGAOSA-N invicorp Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=C(O)C=C1 VBUWHHLIZKOSMS-RIWXPGAOSA-N 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- GDBQQVLCIARPGH-ULQDDVLXSA-N leupeptin Chemical compound CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C=O)CCCN=C(N)N GDBQQVLCIARPGH-ULQDDVLXSA-N 0.000 description 1
- 108010052968 leupeptin Proteins 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 230000007310 pathophysiology Effects 0.000 description 1
- 229950000964 pepstatin Drugs 0.000 description 1
- 108010091212 pepstatin Proteins 0.000 description 1
- FAXGPCHRFPCXOO-LXTPJMTPSA-N pepstatin A Chemical compound OC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)CC(C)C FAXGPCHRFPCXOO-LXTPJMTPSA-N 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 239000003805 procoagulant Substances 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 229960002175 thyroglobulin Drugs 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99401841A EP1074842A1 (en) | 1999-07-21 | 1999-07-21 | Catalytic anti-factor VIII allo-antibodies |
| PCT/EP2000/006870 WO2001007918A1 (en) | 1999-07-21 | 2000-07-18 | Catalytic anti-factor viii allo-antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA75867C2 true UA75867C2 (en) | 2006-06-15 |
Family
ID=8242069
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA2002010487A UA75867C2 (en) | 1999-07-21 | 2000-07-18 | A method of determining the presence of catalytic factor viii allo-antibodies capable of degrading factor viii in a mammal, amino acid sequence inhibiting any site in factor viii molecule being sensible to cleavage by allo-antibodies in factor viii (variants), use of inhibitor of cleavage of factor viii to neutralize a catalytic activity of allo-antibodies to factor viii and pharmaceutical composition containing allo-antibodies being capable of degrading factor viii |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US7507540B1 (pt) |
| EP (2) | EP1074842A1 (pt) |
| JP (2) | JP2003505434A (pt) |
| KR (1) | KR100788435B1 (pt) |
| CN (1) | CN1229646C (pt) |
| AU (1) | AU777615B2 (pt) |
| BR (1) | BR0012613A (pt) |
| CA (1) | CA2379818A1 (pt) |
| CZ (1) | CZ2002248A3 (pt) |
| EE (1) | EE200200034A (pt) |
| HK (1) | HK1044372A1 (pt) |
| HU (1) | HUP0201941A3 (pt) |
| IL (1) | IL147700A0 (pt) |
| IS (1) | IS6238A (pt) |
| MX (1) | MXPA02000752A (pt) |
| NO (1) | NO20020253L (pt) |
| NZ (1) | NZ516702A (pt) |
| PL (1) | PL353739A1 (pt) |
| RU (1) | RU2258935C2 (pt) |
| SK (1) | SK862002A3 (pt) |
| TR (1) | TR200200340T2 (pt) |
| UA (1) | UA75867C2 (pt) |
| WO (1) | WO2001007918A1 (pt) |
| ZA (1) | ZA200200351B (pt) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2644698T (pt) | 2010-11-17 | 2018-01-31 | Chugai Pharmaceutical Co Ltd | Molécula multiespecífica de ligação ao antigénio com uma função alternativa à função do fator viii de coagulação do sangue |
| FR2969761A1 (fr) * | 2010-12-22 | 2012-06-29 | Lfb Biotechnologies | Procede de dosage d'anticorps diriges contre le facteur viii |
| TWI701435B (zh) * | 2014-09-26 | 2020-08-11 | 日商中外製藥股份有限公司 | 測定ｆｖｉｉｉ的反應性之方法 |
| TWI700300B (zh) | 2014-09-26 | 2020-08-01 | 日商中外製藥股份有限公司 | 中和具有第ｖｉｉｉ凝血因子（ｆｖｉｉｉ）機能替代活性的物質之抗體 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5744446A (en) * | 1992-04-07 | 1998-04-28 | Emory University | Hybrid human/animal factor VIII |
| AU5602394A (en) * | 1992-11-13 | 1994-06-08 | Duke University | Chimeric blood coagulation proteins |
| US5910481A (en) * | 1995-11-13 | 1999-06-08 | Immuno Ag | Hybrid proteins with modified activity |
| US5744326A (en) * | 1996-03-11 | 1998-04-28 | The Immune Response Corporation | Use of viral CIS-acting post-transcriptional regulatory sequences to increase expression of intronless genes containing near-consensus splice sites |
-
1999
- 1999-07-21 EP EP99401841A patent/EP1074842A1/en not_active Withdrawn
-
2000
- 2000-07-18 EP EP00956204A patent/EP1196782A1/en not_active Withdrawn
- 2000-07-18 RU RU2002101123/15A patent/RU2258935C2/ru not_active IP Right Cessation
- 2000-07-18 WO PCT/EP2000/006870 patent/WO2001007918A1/en active IP Right Grant
- 2000-07-18 NZ NZ516702A patent/NZ516702A/en unknown
- 2000-07-18 CA CA002379818A patent/CA2379818A1/en not_active Abandoned
- 2000-07-18 AU AU68245/00A patent/AU777615B2/en not_active Ceased
- 2000-07-18 KR KR1020027000657A patent/KR100788435B1/ko not_active IP Right Cessation
- 2000-07-18 CN CNB008106339A patent/CN1229646C/zh not_active Expired - Fee Related
- 2000-07-18 TR TR2002/00340T patent/TR200200340T2/xx unknown
- 2000-07-18 IL IL14770000A patent/IL147700A0/xx not_active IP Right Cessation
- 2000-07-18 PL PL00353739A patent/PL353739A1/xx not_active Application Discontinuation
- 2000-07-18 US US10/031,938 patent/US7507540B1/en not_active Expired - Fee Related
- 2000-07-18 UA UA2002010487A patent/UA75867C2/uk unknown
- 2000-07-18 EE EEP200200034A patent/EE200200034A/xx unknown
- 2000-07-18 JP JP2001512295A patent/JP2003505434A/ja active Pending
- 2000-07-18 HU HU0201941A patent/HUP0201941A3/hu unknown
- 2000-07-18 MX MXPA02000752A patent/MXPA02000752A/es unknown
- 2000-07-18 CZ CZ2002248A patent/CZ2002248A3/cs unknown
- 2000-07-18 BR BR0012613-6A patent/BR0012613A/pt not_active Application Discontinuation
- 2000-07-18 SK SK86-2002A patent/SK862002A3/sk unknown
-
2002
- 2002-01-15 ZA ZA200200351A patent/ZA200200351B/en unknown
- 2002-01-16 IS IS6238A patent/IS6238A/is unknown
- 2002-01-17 NO NO20020253A patent/NO20020253L/no not_active Application Discontinuation
- 2002-07-24 HK HK02105463.5A patent/HK1044372A1/zh unknown
-
2009
- 2009-01-16 US US12/320,077 patent/US20090208512A1/en not_active Abandoned
- 2009-07-27 JP JP2009174550A patent/JP2009292823A/ja not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| US20090208512A1 (en) | 2009-08-20 |
| RU2258935C2 (ru) | 2005-08-20 |
| KR20020042618A (ko) | 2002-06-05 |
| EE200200034A (et) | 2003-06-16 |
| NO20020253L (no) | 2002-03-13 |
| AU777615B2 (en) | 2004-10-21 |
| CN1229646C (zh) | 2005-11-30 |
| HUP0201941A2 (en) | 2002-10-28 |
| HK1044372A1 (zh) | 2002-10-18 |
| CZ2002248A3 (cs) | 2002-07-17 |
| EP1196782A1 (en) | 2002-04-17 |
| US7507540B1 (en) | 2009-03-24 |
| IS6238A (is) | 2002-01-16 |
| WO2001007918A1 (en) | 2001-02-01 |
| NO20020253D0 (no) | 2002-01-17 |
| IL147700A0 (en) | 2002-08-14 |
| SK862002A3 (en) | 2002-06-04 |
| CA2379818A1 (en) | 2001-02-01 |
| HUP0201941A3 (en) | 2005-01-28 |
| BR0012613A (pt) | 2002-04-09 |
| JP2009292823A (ja) | 2009-12-17 |
| CN1361865A (zh) | 2002-07-31 |
| PL353739A1 (en) | 2003-12-01 |
| JP2003505434A (ja) | 2003-02-12 |
| KR100788435B1 (ko) | 2007-12-24 |
| AU6824500A (en) | 2001-02-13 |
| TR200200340T2 (tr) | 2003-01-21 |
| NZ516702A (en) | 2003-10-31 |
| EP1074842A1 (en) | 2001-02-07 |
| MXPA02000752A (es) | 2003-07-14 |
| ZA200200351B (en) | 2003-03-26 |
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