UA74003C2 - Hydrochloride salt of 5-[4-[2-(n-methyl-n-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione, a process for preparing thereof and a pharmaceutical composition - Google Patents
Hydrochloride salt of 5-[4-[2-(n-methyl-n-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione, a process for preparing thereof and a pharmaceutical composition Download PDFInfo
- Publication number
- UA74003C2 UA74003C2 UA2003032020A UA2003032020A UA74003C2 UA 74003 C2 UA74003 C2 UA 74003C2 UA 2003032020 A UA2003032020 A UA 2003032020A UA 2003032020 A UA2003032020 A UA 2003032020A UA 74003 C2 UA74003 C2 UA 74003C2
- Authority
- UA
- Ukraine
- Prior art keywords
- hydrochloride
- compound
- methyl
- ethoxy
- pyridyl
- Prior art date
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- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 7
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 title claims description 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- YASAKCUCGLMORW-UHFFFAOYSA-N Rosiglitazone Chemical compound C=1C=CC=NC=1N(C)CCOC(C=C1)=CC=C1CC1SC(=O)NC1=O YASAKCUCGLMORW-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 36
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 62
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 20
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- -1 compound 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione hydrochloride Chemical class 0.000 abstract description 10
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0021865.1A GB0021865D0 (en) | 2000-09-06 | 2000-09-06 | Novel pharmaceutical |
| PCT/GB2001/003991 WO2002020519A1 (en) | 2000-09-06 | 2001-09-05 | The hydrochloride salt of 5-[4-[2-(n-methyl-n-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA74003C2 true UA74003C2 (en) | 2005-10-17 |
Family
ID=9898953
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA2003032020A UA74003C2 (en) | 2000-09-06 | 2001-05-09 | Hydrochloride salt of 5-[4-[2-(n-methyl-n-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione, a process for preparing thereof and a pharmaceutical composition |
Country Status (35)
| Country | Link |
|---|---|
| US (3) | US20040034066A1 (zh) |
| EP (1) | EP1315723B1 (zh) |
| JP (1) | JP2004508369A (zh) |
| KR (1) | KR100770513B1 (zh) |
| CN (1) | CN100558717C (zh) |
| AP (1) | AP1715A (zh) |
| AT (1) | ATE300538T1 (zh) |
| AU (2) | AU8428401A (zh) |
| BG (1) | BG107607A (zh) |
| BR (1) | BR0113713A (zh) |
| CA (1) | CA2421213A1 (zh) |
| CY (1) | CY1105252T1 (zh) |
| CZ (1) | CZ302125B6 (zh) |
| DE (1) | DE60112310T2 (zh) |
| DK (1) | DK1315723T3 (zh) |
| DZ (1) | DZ3475A1 (zh) |
| EA (1) | EA004296B1 (zh) |
| EC (1) | ECSP034505A (zh) |
| ES (1) | ES2244647T3 (zh) |
| GB (1) | GB0021865D0 (zh) |
| HK (1) | HK1057749A1 (zh) |
| HU (1) | HUP0300938A3 (zh) |
| IL (2) | IL154724A0 (zh) |
| MA (1) | MA25908A1 (zh) |
| MX (1) | MXPA03001956A (zh) |
| NO (1) | NO324020B1 (zh) |
| NZ (1) | NZ524548A (zh) |
| OA (1) | OA12375A (zh) |
| PL (1) | PL360578A1 (zh) |
| PT (1) | PT1315723E (zh) |
| SI (1) | SI1315723T1 (zh) |
| SK (1) | SK2632003A3 (zh) |
| UA (1) | UA74003C2 (zh) |
| WO (1) | WO2002020519A1 (zh) |
| ZA (1) | ZA200301809B (zh) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE39384E1 (en) | 1993-09-01 | 2006-11-07 | Smithkline Beecham P.L.C. | Substituted thiazolidinedione derivatives |
| GB0006133D0 (en) | 2000-03-14 | 2000-05-03 | Smithkline Beecham Plc | Novel pharmaceutical |
| DE102005034406A1 (de) * | 2005-07-22 | 2007-02-01 | Ratiopharm Gmbh | Neue Salze von Rosiglitazon |
| US7435741B2 (en) * | 2006-05-09 | 2008-10-14 | Teva Pharmaceutical Industries, Ltd. | 2-N{5-[[4-[2-(methyl-2-pyridinylamino) ethoxy] phenyl]methyl]-2,4-thiazolidinedione} butanedioic acid, methods of preparation and compositions with rosiglitazone maleate |
| JP5063714B2 (ja) * | 2010-01-29 | 2012-10-31 | シャープ株式会社 | 画像読取装置及び画像形成装置 |
| EP2508525A1 (en) | 2011-04-05 | 2012-10-10 | Bayer Pharma Aktiengesellschaft | Substituted 2,3-dihydroimidazo[1,2-c]quinazoline salts |
| RU2487132C1 (ru) * | 2012-07-23 | 2013-07-10 | Общество с ограниченной ответственностью "Метаген" | Производные циклических 5-нитропиридин-2-ил-тиоалкенил-4-дитиокарбаматов, обладающие противогрибковой активностью, и их применение |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG59988A1 (en) * | 1987-09-04 | 1999-02-22 | Beecham Group Plc | Substituted thiazolidinedione derivatives |
| US6288095B1 (en) * | 1987-09-04 | 2001-09-11 | Beecham Group P.L.C. | Compounds |
| GB9124513D0 (en) * | 1991-11-19 | 1992-01-08 | Smithkline Beecham Plc | Novel process |
| US5741803A (en) * | 1992-09-05 | 1998-04-21 | Smithkline Beecham Plc | Substituted thiazolidinedionle derivatives |
| GB9218830D0 (en) * | 1992-09-05 | 1992-10-21 | Smithkline Beecham Plc | Novel compounds |
| US5874454A (en) * | 1993-09-15 | 1999-02-23 | Warner-Lambert Company | Use of thiazolidinedione derivatives in the treatment of polycystic ovary syndrome, gestational diabetes and disease states at risk for progressing to noninsulin-dependent diabetes mellitus |
| EP0896182B1 (fr) * | 1997-07-17 | 2002-04-10 | Interlemo Holding S.A. | Système connecteur |
| CN1183130C (zh) * | 1999-09-24 | 2005-01-05 | 中国人民解放军军事医学科学院毒物药物研究所 | 噻唑烷类衍生物及其医药用途 |
| GB0006133D0 (en) * | 2000-03-14 | 2000-05-03 | Smithkline Beecham Plc | Novel pharmaceutical |
| US6627646B2 (en) * | 2001-07-17 | 2003-09-30 | Sepracor Inc. | Norastemizole polymorphs |
-
2000
- 2000-09-06 GB GBGB0021865.1A patent/GB0021865D0/en not_active Ceased
-
2001
- 2001-05-09 UA UA2003032020A patent/UA74003C2/uk unknown
- 2001-09-05 AU AU8428401A patent/AU8428401A/xx active Pending
- 2001-09-05 NZ NZ524548A patent/NZ524548A/en unknown
- 2001-09-05 CN CNB018010784A patent/CN100558717C/zh not_active Expired - Fee Related
- 2001-09-05 CA CA002421213A patent/CA2421213A1/en not_active Abandoned
- 2001-09-05 CZ CZ20030615A patent/CZ302125B6/cs not_active IP Right Cessation
- 2001-09-05 SK SK263-2003A patent/SK2632003A3/sk unknown
- 2001-09-05 PT PT01963254T patent/PT1315723E/pt unknown
- 2001-09-05 JP JP2002525140A patent/JP2004508369A/ja active Pending
- 2001-09-05 MX MXPA03001956A patent/MXPA03001956A/es active IP Right Grant
- 2001-09-05 PL PL36057801A patent/PL360578A1/xx not_active Application Discontinuation
- 2001-09-05 KR KR1020037003343A patent/KR100770513B1/ko not_active IP Right Cessation
- 2001-09-05 WO PCT/GB2001/003991 patent/WO2002020519A1/en active IP Right Grant
- 2001-09-05 IL IL15472401A patent/IL154724A0/xx unknown
- 2001-09-05 DK DK01963254T patent/DK1315723T3/da active
- 2001-09-05 DE DE60112310T patent/DE60112310T2/de not_active Expired - Lifetime
- 2001-09-05 BR BR0113713-1A patent/BR0113713A/pt not_active Application Discontinuation
- 2001-09-05 AP APAP/P/2003/002758A patent/AP1715A/en active
- 2001-09-05 AT AT01963254T patent/ATE300538T1/de active
- 2001-09-05 AU AU2001284284A patent/AU2001284284B2/en not_active Ceased
- 2001-09-05 OA OA1200300068A patent/OA12375A/en unknown
- 2001-09-05 US US10/363,608 patent/US20040034066A1/en not_active Abandoned
- 2001-09-05 EP EP01963254A patent/EP1315723B1/en not_active Expired - Lifetime
- 2001-09-05 DZ DZ013475A patent/DZ3475A1/fr active
- 2001-09-05 EA EA200300345A patent/EA004296B1/ru not_active IP Right Cessation
- 2001-09-05 ES ES01963254T patent/ES2244647T3/es not_active Expired - Lifetime
- 2001-09-05 SI SI200130386T patent/SI1315723T1/xx unknown
- 2001-09-05 HU HU0300938A patent/HUP0300938A3/hu unknown
-
2003
- 2003-02-28 BG BG107607A patent/BG107607A/bg unknown
- 2003-03-03 IL IL154724A patent/IL154724A/en not_active IP Right Cessation
- 2003-03-05 ZA ZA200301809A patent/ZA200301809B/en unknown
- 2003-03-05 NO NO20031020A patent/NO324020B1/no not_active IP Right Cessation
- 2003-03-06 MA MA27065A patent/MA25908A1/fr unknown
- 2003-03-06 EC EC2003004505A patent/ECSP034505A/es unknown
- 2003-11-25 HK HK03108589A patent/HK1057749A1/xx not_active IP Right Cessation
-
2005
- 2005-08-04 US US11/197,108 patent/US20050282867A1/en not_active Abandoned
- 2005-09-13 CY CY20051101110T patent/CY1105252T1/el unknown
-
2007
- 2007-04-24 US US11/739,132 patent/US20070191435A1/en not_active Abandoned
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