UA73931C2

UA73931C2 - Morpholine derivatives, a method for the preparation thereof and pharmaceutical agents containing said derivatives

Morpholine derivatives, a method for the preparation thereof and pharmaceutical agents containing said derivatives Download PDF

Info

Publication number: UA73931C2
Authority: UA; Ukraine
Prior art keywords: formula; compound; mixture; differs; trifluoromethyl
Prior art date: 1999-03-25

Application number

UA2001096121A

Other languages

English (en)

Ukrainian (uk)

Original Assignee

Sanofi Aventis

Priority date

1999-03-25

Filing date

2000-03-21

Publication date

2005-10-17

2000-03-21 Application filed by Sanofi Aventis filed Critical Sanofi Aventis

2005-10-17 Publication of UA73931C2 publication Critical patent/UA73931C2/uk

Links

238000000034 method Methods 0.000 title claims abstract description 76
238000002360 preparation method Methods 0.000 title description 23
150000002780 morpholines Chemical class 0.000 title description 3
239000008177 pharmaceutical agent Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 claims abstract description 299
150000003839 salts Chemical class 0.000 claims abstract description 42
238000004519 manufacturing process Methods 0.000 claims abstract description 34
239000012453 solvate Substances 0.000 claims abstract description 22
150000004677 hydrates Chemical class 0.000 claims abstract description 21
150000007522 mineralic acids Chemical class 0.000 claims abstract description 13
150000007524 organic acids Chemical class 0.000 claims abstract description 13
QDZOEBFLNHCSSF-PFFBOGFISA-N (2S)-2-[[(2R)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2R)-2-amino-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-N-[(2R)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]pentanediamide Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)NC(=O)[C@@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](N)CCCNC(N)=N)C1=CC=CC=C1 QDZOEBFLNHCSSF-PFFBOGFISA-N 0.000 claims abstract description 10
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-1 1-azetidinyl Chemical group 0.000 claims description 37
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125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 2
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125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims description 2
125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 2
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