UA73071C2 - Improved method for processing activated protein c - Google Patents
Improved method for processing activated protein c Download PDFInfo
- Publication number
- UA73071C2 UA73071C2 UA99105788A UA99105788A UA73071C2 UA 73071 C2 UA73071 C2 UA 73071C2 UA 99105788 A UA99105788 A UA 99105788A UA 99105788 A UA99105788 A UA 99105788A UA 73071 C2 UA73071 C2 UA 73071C2
- Authority
- UA
- Ukraine
- Prior art keywords
- activated protein
- protein
- des
- buffer
- mentioned
- Prior art date
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4866—Protein C (3.4.21.69)
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6464—Protein C (3.4.21.69)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Vascular Medicine (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4525597P | 1997-04-28 | 1997-04-28 | |
| PCT/US1998/008384 WO1998048822A1 (en) | 1997-04-28 | 1998-04-24 | Improved methods for processing activated protein c |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA73071C2 true UA73071C2 (en) | 2005-06-15 |
Family
ID=21936854
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA99105788A UA73071C2 (en) | 1997-04-28 | 1998-04-24 | Improved method for processing activated protein c |
| UA99105884A UA55448C2 (uk) | 1997-04-28 | 1998-04-24 | Стійка ліофілізована лікарська форма з активованим білком с (варіанти) та виріб, який її містить |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA99105884A UA55448C2 (uk) | 1997-04-28 | 1998-04-24 | Стійка ліофілізована лікарська форма з активованим білком с (варіанти) та виріб, який її містить |
Country Status (35)
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|---|---|
| US (4) | US6159468A (de) |
| EP (2) | EP0875252B1 (de) |
| JP (2) | JP4383546B2 (de) |
| KR (2) | KR100564189B1 (de) |
| CN (2) | CN1235638C (de) |
| AR (2) | AR015598A1 (de) |
| AT (1) | ATE285788T1 (de) |
| AU (2) | AU743531B2 (de) |
| BR (2) | BR9809304B1 (de) |
| CA (2) | CA2288143C (de) |
| CO (2) | CO4940438A1 (de) |
| CZ (1) | CZ298429B6 (de) |
| DE (1) | DE69828330T2 (de) |
| DK (1) | DK0875252T3 (de) |
| EA (2) | EA004881B1 (de) |
| EG (1) | EG23685A (de) |
| ES (1) | ES2234072T3 (de) |
| HK (1) | HK1016472A1 (de) |
| HU (2) | HU224826B1 (de) |
| ID (2) | ID22933A (de) |
| IL (2) | IL132502A0 (de) |
| IN (2) | IN187157B (de) |
| MY (2) | MY118591A (de) |
| NO (2) | NO995134L (de) |
| NZ (2) | NZ337828A (de) |
| PE (2) | PE84799A1 (de) |
| PL (2) | PL195090B1 (de) |
| PT (1) | PT875252E (de) |
| SI (1) | SI0875252T1 (de) |
| SV (2) | SV1998000050A (de) |
| TR (2) | TR199902631T2 (de) |
| TW (2) | TW585871B (de) |
| UA (2) | UA73071C2 (de) |
| WO (2) | WO1998048822A1 (de) |
| ZA (2) | ZA983497B (de) |
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| BR9809304B1 (pt) * | 1997-04-28 | 2011-02-08 | formulação liofilizada estável, processo para preparação da mesma, bem como forma de dosagem unitária. | |
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| IL142255A0 (en) * | 1998-11-13 | 2002-03-10 | Lilly Co Eli | Method of treating heparin-induced thrombocytopenia |
| ES2195655T3 (es) * | 1998-11-20 | 2003-12-01 | Lilly Co Eli | Procedimiento para tratar fiebre hemorragica virica con proteina c. |
| AU1723200A (en) * | 1998-11-23 | 2000-06-13 | Eli Lilly And Company | Method of treating sickle cell disease and thalassemia |
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| WO2009089620A1 (en) * | 2008-01-15 | 2009-07-23 | The Universityof British Columbia | Protein c rs2069915 as a response predictor to survival and administration of activated protein c or protein c-like compound |
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| EP2834635A4 (de) | 2012-04-03 | 2015-09-02 | Smiths Medical Asd Inc | Zusammensetzungen mit einem heparinakkumulationsmittel und verfahren dafür |
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| AU2014391082B2 (en) | 2014-04-16 | 2020-04-09 | Zz Biotech Llc | Treatment of abnormal cutaneous scarring |
| US11058750B2 (en) | 2015-12-03 | 2021-07-13 | Mor Research Applications Ltd. | Compositions and methods for treatment of ocular diseases |
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| CN108159399B (zh) * | 2017-12-29 | 2020-07-24 | 华中科技大学同济医学院附属同济医院 | 一种凝血蛋白酶aPC在防治糖尿病心肌病药物中的应用 |
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| BR9809304B1 (pt) * | 1997-04-28 | 2011-02-08 | formulação liofilizada estável, processo para preparação da mesma, bem como forma de dosagem unitária. | |
| HUP0001237A3 (en) | 1997-10-20 | 2002-01-28 | Lilly Co Eli | Methods for treating vascular disorders |
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1998
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- 1998-04-24 JP JP54722198A patent/JP4383547B2/ja not_active Expired - Lifetime
- 1998-04-24 AR ARP980101908A patent/AR012010A1/es active IP Right Grant
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1999
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2000
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