UA58983U - Способ изготовления средства для лечения туберкулеза - Google Patents
Способ изготовления средства для лечения туберкулеза Download PDFInfo
- Publication number
- UA58983U UA58983U UAU201013554U UAU201013554U UA58983U UA 58983 U UA58983 U UA 58983U UA U201013554 U UAU201013554 U UA U201013554U UA U201013554 U UAU201013554 U UA U201013554U UA 58983 U UA58983 U UA 58983U
- Authority
- UA
- Ukraine
- Prior art keywords
- solution
- sodium
- injections
- aminosalicylate
- water
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract description 10
- 201000008827 tuberculosis Diseases 0.000 title abstract description 10
- 238000004519 manufacturing process Methods 0.000 title abstract description 7
- 239000000203 mixture Substances 0.000 title abstract description 4
- 239000000243 solution Substances 0.000 abstract description 35
- 229940113720 aminosalicylate Drugs 0.000 abstract description 16
- 239000011734 sodium Substances 0.000 abstract description 16
- 229910052708 sodium Inorganic materials 0.000 abstract description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 14
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract description 13
- 239000008215 water for injection Substances 0.000 abstract description 13
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 abstract description 9
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 abstract description 6
- 238000004090 dissolution Methods 0.000 abstract description 4
- 238000011045 prefiltration Methods 0.000 abstract description 3
- 235000010265 sodium sulphite Nutrition 0.000 abstract description 3
- 238000001914 filtration Methods 0.000 abstract description 2
- 238000002156 mixing Methods 0.000 abstract description 2
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 abstract 1
- 239000005977 Ethylene Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 description 12
- 230000001954 sterilising effect Effects 0.000 description 12
- 238000004659 sterilization and disinfection Methods 0.000 description 12
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 10
- 239000003814 drug Substances 0.000 description 10
- 229940079593 drug Drugs 0.000 description 9
- 230000032683 aging Effects 0.000 description 5
- 238000001802 infusion Methods 0.000 description 5
- 230000007774 longterm Effects 0.000 description 5
- 238000004321 preservation Methods 0.000 description 5
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 4
- 239000013543 active substance Substances 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- PANBYUAFMMOFOV-UHFFFAOYSA-N sodium;sulfuric acid Chemical compound [Na].OS(O)(=O)=O PANBYUAFMMOFOV-UHFFFAOYSA-N 0.000 description 4
- 238000003860 storage Methods 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- BDDLHHRCDSJVKV-UHFFFAOYSA-N 7028-40-2 Chemical compound CC(O)=O.CC(O)=O.CC(O)=O.CC(O)=O BDDLHHRCDSJVKV-UHFFFAOYSA-N 0.000 description 3
- 235000014698 Brassica juncea var multisecta Nutrition 0.000 description 3
- 229910052782 aluminium Inorganic materials 0.000 description 3
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 3
- 244000275904 brauner Senf Species 0.000 description 3
- 229940072185 drug for treatment of tuberculosis Drugs 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 229920001971 elastomer Polymers 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 230000007721 medicinal effect Effects 0.000 description 3
- WUBBRNOQWQTFEX-UHFFFAOYSA-N 4-aminosalicylic acid Chemical compound NC1=CC=C(C(O)=O)C(O)=C1 WUBBRNOQWQTFEX-UHFFFAOYSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 2
- 241000187479 Mycobacterium tuberculosis Species 0.000 description 2
- BNOODXBBXFZASF-UHFFFAOYSA-N [Na].[S] Chemical compound [Na].[S] BNOODXBBXFZASF-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- -1 disodium salt ethylenediamine sodium sulfuric acid Chemical compound 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- AEUTYOVWOVBAKS-UWVGGRQHSA-N ethambutol Chemical compound CC[C@@H](CO)NCCN[C@@H](CC)CO AEUTYOVWOVBAKS-UWVGGRQHSA-N 0.000 description 2
- 229910052742 iron Inorganic materials 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 150000002739 metals Chemical class 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 208000010444 Acidosis Diseases 0.000 description 1
- 208000035859 Drug effect increased Diseases 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 208000034970 Heterotopic Ossification Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- QILXPCHTWXAUHE-UHFFFAOYSA-N [Na].NCCN Chemical compound [Na].NCCN QILXPCHTWXAUHE-UHFFFAOYSA-N 0.000 description 1
- HJCUCLCJVVFBTD-UHFFFAOYSA-N [Na].[Na].S(O)(O)(=O)=O Chemical compound [Na].[Na].S(O)(O)(=O)=O HJCUCLCJVVFBTD-UHFFFAOYSA-N 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000007950 acidosis Effects 0.000 description 1
- 208000026545 acidosis disease Diseases 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000001355 anti-mycobacterial effect Effects 0.000 description 1
- 239000000729 antidote Substances 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 159000000007 calcium salts Chemical group 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 230000000973 chemotherapeutic effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 230000001066 destructive effect Effects 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 229960000285 ethambutol Drugs 0.000 description 1
- 229960002001 ethionamide Drugs 0.000 description 1
- AEOCXXJPGCBFJA-UHFFFAOYSA-N ethionamide Chemical compound CCC1=CC(C(N)=S)=CC=N1 AEOCXXJPGCBFJA-UHFFFAOYSA-N 0.000 description 1
- 229940071106 ethylenediaminetetraacetate Drugs 0.000 description 1
- 230000005713 exacerbation Effects 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229940049413 rifampicin and isoniazid Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Способ изготовления средства для лечения туберкулеза включает смешивание натрия пара-аминосалицилата, натрия сернистокислого безводного и воды для инъекций. В резервуаре с 800 мл воды для инъекций, охлажденной до температуре 15-25 °C, сначала растворяют 0,2- динатриевой соли этилендиаминотетрауксусной кислоты и 4,75- натрия сернистокислого безводного в течение 5-10 минут. После полного растворения компонентов загружают 27,0- порошка натрия пара-аминосалицилата и растворяют его в течение 10-15 минут. Раствор в резервуаре доводят водой для инъекций до 1000 мл, далее отбирают пробы для анализа, и при соответствии раствора определенным показателям его фильтруют через фильтр предварительной фильтрации типа ФТВ с порогом задержки 1 мкм и фильтр типа "Pall" с порогом задержки 0,2 мкм.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| UAU201013554U UA58983U (ru) | 2010-11-15 | 2010-11-15 | Способ изготовления средства для лечения туберкулеза |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| UAU201013554U UA58983U (ru) | 2010-11-15 | 2010-11-15 | Способ изготовления средства для лечения туберкулеза |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA58983U true UA58983U (ru) | 2011-04-26 |
Family
ID=50343905
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAU201013554U UA58983U (ru) | 2010-11-15 | 2010-11-15 | Способ изготовления средства для лечения туберкулеза |
Country Status (1)
| Country | Link |
|---|---|
| UA (1) | UA58983U (ru) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014017999A1 (ru) * | 2012-07-24 | 2014-01-30 | Gumeniuk Mykola Ivanovych | Способ изготовления средства для лечения туберкулеза |
-
2010
- 2010-11-15 UA UAU201013554U patent/UA58983U/ru unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014017999A1 (ru) * | 2012-07-24 | 2014-01-30 | Gumeniuk Mykola Ivanovych | Способ изготовления средства для лечения туберкулеза |
| EA028883B1 (ru) * | 2012-07-24 | 2018-01-31 | Мыкола Ивановыч Гуменюк | Способ изготовления средства для лечения туберкулеза |
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