UA5585A1 - Спосіб отримання похідних тіазолу та їх солей з лужними металами - Google Patents
Спосіб отримання похідних тіазолу та їх солей з лужними металамиInfo
- Publication number
- UA5585A1 UA5585A1 UA4028404A UA4028404A UA5585A1 UA 5585 A1 UA5585 A1 UA 5585A1 UA 4028404 A UA4028404 A UA 4028404A UA 4028404 A UA4028404 A UA 4028404A UA 5585 A1 UA5585 A1 UA 5585A1
- Authority
- UA
- Ukraine
- Prior art keywords
- salts
- preparation
- alkali metals
- thiazole derivatives
- thiazole
- Prior art date
Links
- 229910052783 alkali metal Inorganic materials 0.000 title abstract 2
- 150000001340 alkali metals Chemical class 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- 150000007979 thiazole derivatives Chemical class 0.000 title abstract 2
- -1 aromatic carbohydrate Chemical class 0.000 abstract 1
- 150000001721 carbon Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 150000007529 inorganic bases Chemical class 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
Abstract
Предметом винаходу є спосіб одержання похідних тіазолу або їх солей з лужними металами. В його сонові лежить взаємодія сполук у середовищі розчинника (ароматичного вуглеводню, простого ефіру або галогенованого вуглеводню) або в присутності органічної або неорганічної основи.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP60228912A JPS62142168A (ja) | 1985-10-16 | 1985-10-16 | チアゾ−ル誘導体及びそれを有効成分とするロイコトリエンきつ抗剤 |
Publications (1)
Publication Number | Publication Date |
---|---|
UA5585A1 true UA5585A1 (uk) | 1994-12-28 |
Family
ID=16883798
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UA4028404A UA5585A1 (uk) | 1985-10-16 | 1986-10-15 | Спосіб отримання похідних тіазолу та їх солей з лужними металами |
Country Status (11)
Country | Link |
---|---|
US (1) | US4902700A (uk) |
EP (1) | EP0219436B1 (uk) |
JP (1) | JPS62142168A (uk) |
KR (1) | KR930006285B1 (uk) |
AU (1) | AU603343B2 (uk) |
CA (1) | CA1326034C (uk) |
DE (1) | DE3689436T2 (uk) |
DK (1) | DK169128B1 (uk) |
HU (1) | HU203228B (uk) |
SU (1) | SU1554763A3 (uk) |
UA (1) | UA5585A1 (uk) |
Families Citing this family (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5258395A (en) * | 1984-11-12 | 1993-11-02 | Yamanouchi Pharmaceutical Co., Ltd. | Thiazole compounds as inhibitors of SRS-A |
JPS63258854A (ja) * | 1987-04-16 | 1988-10-26 | Mitsubishi Kasei Corp | カルボキシスチレン誘導体およびそれを有効成分とする薬剤 |
US4826990A (en) * | 1987-09-30 | 1989-05-02 | American Home Products Corporation | 2-aryl substituted heterocyclic compounds as antiallergic and antiinflammatory agents |
US4895953A (en) * | 1987-09-30 | 1990-01-23 | American Home Products Corporation | 2-Aryl substituted heterocyclic compounds as antiallergic and antiinflammatory agents |
US5037840A (en) * | 1987-11-25 | 1991-08-06 | Merck Frosst Canada, Inc. | Benzothiazoles |
EP0318085A3 (en) * | 1987-11-25 | 1990-03-14 | Merck Frosst Canada Inc. | Heterazole dialkanoic acids |
CA1322005C (en) * | 1987-11-25 | 1993-09-07 | Robert N. Young | Benzoheterazoles |
US4962117A (en) * | 1987-11-25 | 1990-10-09 | Merck Frosst Canada, Inc. | Heterazole dialkanoic acids |
US5004743A (en) * | 1987-11-25 | 1991-04-02 | Merck Frosst Canada, Inc. | Pyridyl styrene dialkanoic acids as anti-leukotriene agents |
ZA894913B (en) * | 1988-07-12 | 1990-03-28 | Ici Pharma | Heterocyclic compounds |
EP0355353B1 (en) * | 1988-07-15 | 1994-03-16 | F. Hoffmann-La Roche Ag | Cycloalkylthiazole derivatives |
US5001140A (en) * | 1989-04-17 | 1991-03-19 | Hoffmann-La Roche Inc. | Cycloalkylthiazoles |
US5045554A (en) * | 1988-11-29 | 1991-09-03 | Monsanto Company | Substituted thiazoles and their use as fungicides |
JPH02169584A (ja) * | 1988-12-22 | 1990-06-29 | Mitsubishi Kasei Corp | ビニルチアゾール誘導体およびそれを有効成分とする薬剤 |
US5089495A (en) * | 1989-01-30 | 1992-02-18 | Imperial Chemical Industries Plc | Heterocyclic thiazole derivatives and pharmaceutical compositions comprising said derivatives |
WO1990011278A1 (en) * | 1989-03-24 | 1990-10-04 | The Green Cross Corporation | Thiazole compounds and applications thereof |
JPH03173874A (ja) * | 1989-09-29 | 1991-07-29 | Mitsubishi Kasei Corp | 新規複素環化合物 |
WO1992000963A1 (en) * | 1990-07-12 | 1992-01-23 | Yoshitomi Pharmaceutical Industries, Ltd. | Styryl compounds and use thereof as medicine |
JP2832923B2 (ja) * | 1990-07-13 | 1998-12-09 | 吉富製薬株式会社 | スチリル化合物およびその医薬用途 |
JP2600644B2 (ja) * | 1991-08-16 | 1997-04-16 | 藤沢薬品工業株式会社 | チアゾリルベンゾフラン誘導体 |
AU3884893A (en) * | 1992-04-10 | 1993-11-18 | Merck Frosst Canada Inc. | Thiazole-substituted benzyl alcohols as leukotriene antagonists |
AU3884993A (en) * | 1992-04-10 | 1993-11-18 | Merck Frosst Canada Inc. | Benzothiazole-substituted benzyl alcohols as leukotriene antagonists |
DE4219765A1 (de) * | 1992-06-17 | 1993-12-23 | Bayer Ag | Substituierte (Benzothiazolyl- und Chinoxalyl-methoxy)phenylessigsäurederivate |
US5273986A (en) * | 1992-07-02 | 1993-12-28 | Hoffmann-La Roche Inc. | Cycloalkylthiazoles |
US5508408A (en) * | 1993-09-10 | 1996-04-16 | Ciba-Geigy Corporation | Quinoline compound |
WO1996033181A1 (en) * | 1995-04-21 | 1996-10-24 | Daiichi Pharmaceutical Co., Ltd. | Ethynylthiazole derivative |
WO1997021691A1 (fr) * | 1995-12-14 | 1997-06-19 | Kaken Pharmaceutical Co., Ltd. | Derives thiazole |
US6376671B1 (en) | 1997-06-17 | 2002-04-23 | Kaken Pharmaceutical Co., Ltd. | 2-sulfamoylbenzoic acid derivatives |
JP2004137284A (ja) * | 1997-06-17 | 2004-05-13 | Kaken Pharmaceut Co Ltd | 2−スルファモイル安息香酸誘導体 |
AU732106B2 (en) * | 1997-06-17 | 2001-04-12 | Kaken Pharmaceutical Co., Ltd. | 2-sulfamoylbenzoic acid derivatives |
US6083966A (en) * | 1998-08-31 | 2000-07-04 | University Of Florida | Thiazoline acid derivatives |
EP1143951A3 (en) * | 1998-09-21 | 2002-02-06 | University Of Florida Research Foundation, Inc. | Antimalarial agents |
EP1214303A1 (en) * | 1999-08-31 | 2002-06-19 | Merck & Co., Inc. | Heterocyclic compounds and methods of use thereof |
DE50009208D1 (de) | 1999-11-25 | 2005-02-17 | Ciba Sc Holding Ag | Hydroxyphenylvinylthiazole |
EP1103180B1 (de) * | 1999-11-25 | 2005-01-12 | Ciba SC Holding AG | Hydroxyphenylvinylthiazole |
JPWO2002087589A1 (ja) * | 2001-04-26 | 2004-08-12 | 第一製薬株式会社 | 薬剤排出ポンプ阻害薬 |
US7056917B2 (en) | 2001-04-26 | 2006-06-06 | Daiichi Pharmaceutical Co., Ltd. | Drug efflux pump inhibitor |
SE0102299D0 (sv) | 2001-06-26 | 2001-06-26 | Astrazeneca Ab | Compounds |
SE0102764D0 (sv) | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
GB0226930D0 (en) | 2002-11-19 | 2002-12-24 | Astrazeneca Ab | Chemical compounds |
BRPI0410348A (pt) | 2003-05-14 | 2006-05-30 | Torreypines Therapeutics Inc | compostos e usos dos mesmos na modulação de amilóide-beta |
WO2005034949A1 (en) * | 2003-09-09 | 2005-04-21 | University Of Florida | Desferrithiocin derivatives and their use as iron chelators |
TW200600086A (en) | 2004-06-05 | 2006-01-01 | Astrazeneca Ab | Chemical compound |
EP1802570A1 (en) | 2004-10-16 | 2007-07-04 | AstraZeneca AB | Process for making phenoxy benzamide compounds |
ES2732625T3 (es) | 2005-04-04 | 2019-11-25 | Univ Florida | Análogos de poliéter de desferritiocina |
TW200714597A (en) | 2005-05-27 | 2007-04-16 | Astrazeneca Ab | Chemical compounds |
AU2006268406C1 (en) | 2005-07-09 | 2011-02-24 | Astrazeneca Ab | Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes |
TW200738621A (en) | 2005-11-28 | 2007-10-16 | Astrazeneca Ab | Chemical process |
JP4836704B2 (ja) * | 2006-08-07 | 2011-12-14 | 中国電力株式会社 | 端子台用保護カバー |
TW200825063A (en) | 2006-10-23 | 2008-06-16 | Astrazeneca Ab | Chemical compounds |
SA07280576B1 (ar) | 2006-10-26 | 2011-06-22 | استرازينيكا ايه بي | مركبات بنزويل أمينو سيكليل غير متجانسة بأعتبارها عوامل منشطة للجلوكوكيناز |
EP2121666A1 (en) | 2006-12-21 | 2009-11-25 | AstraZeneca AB | Novel crystalline compound useful as glk activator |
AU2008229472B2 (en) | 2007-03-15 | 2013-03-14 | University Of Florida Research Foundation, Inc. | Desferrithiocin polyether analogues |
PE20110568A1 (es) | 2008-08-04 | 2011-09-07 | Astrazeneca Ab | Agentes terapeuticos 414 |
EP2166006A1 (en) * | 2008-09-18 | 2010-03-24 | Dompe' S.P.A. | 2-aryl-propionic acids and derivatives and pharmaceutical compositions containing them |
GB0902406D0 (en) | 2009-02-13 | 2009-04-01 | Astrazeneca Ab | Crystalline polymorphic form |
GB0902434D0 (en) | 2009-02-13 | 2009-04-01 | Astrazeneca Ab | Chemical process |
AR076221A1 (es) * | 2009-04-09 | 2011-05-26 | Astrazeneca Ab | Derivado de pirazol [4,5-e] pirimidina y su uso para tratar diabetes y obesidad |
AR076220A1 (es) | 2009-04-09 | 2011-05-26 | Astrazeneca Ab | Derivados de pirazol [4,5 - e] pirimidina |
KR101907535B1 (ko) | 2009-10-02 | 2018-10-15 | 아벡신 에이에스 | 소염제 2-옥소티아졸 및 2-옥소옥사졸 |
CN113398126A (zh) | 2011-12-16 | 2021-09-17 | 佛罗里达大学研究基金会 | 4′-去铁硫素类似物的用途 |
WO2014118195A1 (en) | 2013-01-29 | 2014-08-07 | Avexxin As | Antiinflammatory and antitumor 2-oxothiazoles and 2-oxothiophenes compounds |
AU2014352780A1 (en) | 2013-11-22 | 2016-06-09 | University Of Florida Research Foundation, Inc. | Desferrithiocin analogs and uses thereof |
GB201413695D0 (en) | 2014-08-01 | 2014-09-17 | Avexxin As | Compound |
US10570104B2 (en) | 2015-04-27 | 2020-02-25 | University Of Florida Research Foundation, Incorporated | Metabolically programmed metal chelators and uses thereof |
GB201604318D0 (en) | 2016-03-14 | 2016-04-27 | Avexxin As | Combination therapy |
US11919873B1 (en) | 2023-08-29 | 2024-03-05 | King Faisal University | 1,3-benzothiazol-2-yl-N′-(benzoyloxy)ethanimidamide as an antitumor and antimicrobial compound |
US11912676B1 (en) | 2023-08-29 | 2024-02-27 | King Faisal University | N'-[(4-chlorobenzoyl)oxy]-1,3-benzothiazole-2-carboximidamide as an antitumor and antimicrobial compound |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3137655A (en) * | 1961-03-21 | 1964-06-16 | Glanzstoff Ag | Optical brightening |
DE1670908A1 (de) * | 1967-08-16 | 1971-04-29 | Hoechst Ag | Neue Benzimidazolverbindungen,Verfahren zu ihrer Herstellung und ihre Verwendung als optische Aufhellungsmittel |
US3974282A (en) * | 1972-11-04 | 1976-08-10 | Beecham Group Limited | Hypoglycemic stilbazolte derivatives |
DE2331444A1 (de) * | 1973-06-20 | 1975-01-23 | Hoechst Ag | Neue styryl-benzoxazole, verfahren zu deren herstellung und ihre verwendung als optische aufhellungsmittel |
DE3148291A1 (de) * | 1981-12-05 | 1983-06-09 | Basf Ag, 6700 Ludwigshafen | Harnstoffderivate, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung unerwuenschten pflanzenwuchses |
US4594425A (en) * | 1984-02-09 | 1986-06-10 | American Home Products Corporation | Heterocyclic compounds as antiallergic agents |
US4581457A (en) * | 1984-09-21 | 1986-04-08 | American Home Products Corporation | Heterocyclic sulfonamides |
-
1985
- 1985-10-16 JP JP60228912A patent/JPS62142168A/ja active Granted
-
1986
- 1986-10-15 AU AU63930/86A patent/AU603343B2/en not_active Ceased
- 1986-10-15 CA CA000520544A patent/CA1326034C/en not_active Expired - Fee Related
- 1986-10-15 DK DK494186A patent/DK169128B1/da not_active IP Right Cessation
- 1986-10-15 UA UA4028404A patent/UA5585A1/uk unknown
- 1986-10-15 SU SU864028404A patent/SU1554763A3/ru active
- 1986-10-16 HU HU864318A patent/HU203228B/hu not_active IP Right Cessation
- 1986-10-16 KR KR1019860008678A patent/KR930006285B1/ko not_active IP Right Cessation
- 1986-10-16 DE DE86402327T patent/DE3689436T2/de not_active Expired - Fee Related
- 1986-10-16 EP EP86402327A patent/EP0219436B1/en not_active Expired - Lifetime
-
1988
- 1988-11-28 US US07/279,225 patent/US4902700A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU6393086A (en) | 1987-04-30 |
JPH057386B2 (uk) | 1993-01-28 |
DE3689436T2 (de) | 1994-04-14 |
CA1326034C (en) | 1994-01-11 |
EP0219436B1 (en) | 1993-12-22 |
DK169128B1 (da) | 1994-08-22 |
JPS62142168A (ja) | 1987-06-25 |
EP0219436A3 (en) | 1989-12-27 |
KR870004009A (ko) | 1987-05-06 |
HU203228B (en) | 1991-06-28 |
DK494186A (da) | 1987-04-17 |
SU1554763A3 (ru) | 1990-03-30 |
DK494186D0 (da) | 1986-10-15 |
US4902700A (en) | 1990-02-20 |
HUT47090A (en) | 1989-01-30 |
KR930006285B1 (ko) | 1993-07-12 |
AU603343B2 (en) | 1990-11-15 |
DE3689436D1 (de) | 1994-02-03 |
EP0219436A2 (en) | 1987-04-22 |
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