UA50753C2 - Translated By PlajКОМПЛЕКСЫ КАСКАДНЫХ ПОЛИМЕРОВ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКОЕ СРЕДСТВО - Google Patents
Translated By PlajКОМПЛЕКСЫ КАСКАДНЫХ ПОЛИМЕРОВ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКОЕ СРЕДСТВОInfo
- Publication number
- UA50753C2 UA50753C2 UA98073923A UA98073923A UA50753C2 UA 50753 C2 UA50753 C2 UA 50753C2 UA 98073923 A UA98073923 A UA 98073923A UA 98073923 A UA98073923 A UA 98073923A UA 50753 C2 UA50753 C2 UA 50753C2
- Authority
- UA
- Ukraine
- Prior art keywords
- cascade
- reproduction
- independently represent
- multiplicity
- polymer complexes
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/12—Macromolecular compounds
- A61K49/124—Macromolecular compounds dendrimers, dendrons, hyperbranched compounds
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
- Plural Heterocyclic Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Abstract
Комплексы каскадных полимеров, содержащие а) комплексообразующие лиганды общей формулы (I), где А означает азотсодержащее каскадное ядро базисной мультиплетности a, X и Y, независимо друг от друга, простую связь или каскадное репродуктивное мономерное звено репродуктивной мультиплетности х или у, Z и W, независимо друг от друга, означают каскадное репродуктивное мономерное звено репродуктивной мультиплетности z или w, К означает остаток комплексообразователя, а означает числа от 2 до 12, х, у, z и w, независимо друг от друга, означают числа 1-4, при условии, что, по меньшей мере, два репродуктивных мономерных звена различны, что для произведения мультиплетностей действительно и что, по меньшей мере, одно из каскадных репродуктивных мономерных звеньев X, Y, Z, W означает репродуктивное мономерное звено 1,4,7,10-тетраазациклододекана или 1,4,8,11-тетраазациклотетрадекана, б) по меньшей мере, 16 ионов элемента порядковых номеров 20-29, 39, 42, 44 или 57-83, в) при необходимости, катионы неорганических и/или органических оснований, аминокислот или амидов аминокислот, а также г) при необходимости, ацилированные концевые аминогруппы, являющиеся ценными соединениями для диагностики и терапии.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19549286A DE19549286A1 (de) | 1995-12-22 | 1995-12-22 | Kaskaden-Polymer-Komplexe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel |
| PCT/EP1996/005315 WO1997023245A1 (de) | 1995-12-22 | 1996-11-29 | Kaskaden-polymer-komplexe, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA50753C2 true UA50753C2 (ru) | 2002-11-15 |
Family
ID=7781739
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA98073923A UA50753C2 (ru) | 1995-12-22 | 1996-11-29 | Translated By PlajКОМПЛЕКСЫ КАСКАДНЫХ ПОЛИМЕРОВ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКОЕ СРЕДСТВО |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6057419A (ru) |
| EP (1) | EP0868202B1 (ru) |
| JP (1) | JP4031041B2 (ru) |
| KR (1) | KR100461476B1 (ru) |
| AT (1) | ATE222776T1 (ru) |
| BG (1) | BG63105B1 (ru) |
| CA (1) | CA2241187A1 (ru) |
| CZ (1) | CZ294238B6 (ru) |
| DE (2) | DE19549286A1 (ru) |
| DK (1) | DK0868202T3 (ru) |
| ES (1) | ES2181924T3 (ru) |
| IL (1) | IL124677A (ru) |
| MX (1) | MX9804860A (ru) |
| NO (1) | NO314545B1 (ru) |
| NZ (1) | NZ323397A (ru) |
| PL (1) | PL187835B1 (ru) |
| PT (1) | PT868202E (ru) |
| RU (1) | RU2197495C2 (ru) |
| SK (1) | SK283334B6 (ru) |
| TW (1) | TW520377B (ru) |
| UA (1) | UA50753C2 (ru) |
| WO (1) | WO1997023245A1 (ru) |
| ZA (1) | ZA9610822B (ru) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19652387A1 (de) * | 1996-12-04 | 1998-06-10 | Schering Ag | Macrocyclische Metallkomplexcarbonsäuren, ihre Verwendung sowie Verfahren zu ihrer Herstellung |
| DE19728954C1 (de) * | 1997-06-30 | 1999-04-22 | Schering Ag | Saccharid-Konjugate, diese enthaltende pharmazeutische Mittel, Verfahren zu ihrer Herstellung und ihre Verwendung |
| DE19744003B4 (de) * | 1997-09-26 | 2004-07-08 | Schering Ag | Kontrastmittel für das Infarkt- und Nekroseimaging |
| DE19758105A1 (de) * | 1997-12-18 | 1999-06-24 | Schering Ag | Dendritische Polymer-Saccharid-Konjugate, diese enthaltende pharmazeutische Mittel, Verfahren zu ihrer Herstellung und ihre Verwendung |
| US7405320B2 (en) * | 1998-06-22 | 2008-07-29 | Immunomedics, Inc. | Therapeutic and diagnostic conjugates for use with multispecific antibodies |
| FR2841258A1 (fr) * | 2002-06-20 | 2003-12-26 | Pf Medicament | Procede et preparation de mononegavirus recombinants et leurs applications |
| JP5518465B2 (ja) * | 2006-03-14 | 2014-06-11 | マリンクロッド エルエルシー | テトラアザ大員環誘導体の金属錯体 |
| DE102007002726A1 (de) * | 2007-01-18 | 2008-07-31 | Bayer Schering Pharma Aktiengesellschaft | Neue Kaskaden-Polymer-Komplexe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel |
| WO2014197763A1 (en) * | 2013-06-07 | 2014-12-11 | The Board Of Regents Of The University Of Teas System | Molecular design toward dual-modality probes for radioisotope-based imaging (pet or spect) and mri |
| EP3101012A1 (en) | 2015-06-04 | 2016-12-07 | Bayer Pharma Aktiengesellschaft | New gadolinium chelate compounds for use in magnetic resonance imaging |
| JP7034160B2 (ja) | 2016-11-28 | 2022-03-11 | バイエル・ファルマ・アクティエンゲゼルシャフト | 磁気共鳴画像法に使用するための高緩和度ガドリニウムキレート化合物 |
| PE20211471A1 (es) | 2018-11-23 | 2021-08-05 | Bayer Ag | Formulacion de medios de contraste y proceso para prepararlos |
| RU2706705C1 (ru) * | 2019-03-28 | 2019-11-20 | Федеральное государственное бюджетное учреждение науки Иркутский институт химии им.А.Е.Фаворского Сибирского отделения Российской академии наук | Водорастворимые магнитоактивные нанобиокомпозиты флавоноидных комплексов гадолиния на основе природного конъюгата арабиногалактана с биофлавоноидами и способ получения этих нанобиокомпозитов |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5527524A (en) * | 1986-08-18 | 1996-06-18 | The Dow Chemical Company | Dense star polymer conjugates |
| DE3938992A1 (de) * | 1989-11-21 | 1991-05-23 | Schering Ag | Kaskadenpolymer-gebundene komplexbildner, deren komplexe und konjugate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| DE4344460A1 (de) * | 1993-12-22 | 1995-06-29 | Schering Ag | Metallkomplexe von dendrimeren Makromolekülen, diese enthaltende diagnostische Mittel sowie Verfahren zur Herstellung der Komplexe und Mittel |
| GB9404208D0 (en) * | 1994-03-04 | 1994-04-20 | Nycomed Salutar Inc | Chelants |
| GB9407812D0 (en) * | 1994-04-20 | 1994-06-15 | Nycomed Salutar Inc | Compounds |
| DE4425857A1 (de) * | 1994-07-07 | 1996-01-11 | Schering Ag | Kaskaden-Polymer-Komplexe, Verfahren zur ihrer Herstellung und diese enthaltende pharmazeutische Mittel |
| US5919433A (en) * | 1996-12-04 | 1999-07-06 | Schering Aktiengesellschaft | Macrocyclic metal complex carboxylic acids, their use as well as process for their production |
-
1995
- 1995-12-22 DE DE19549286A patent/DE19549286A1/de not_active Withdrawn
-
1996
- 1996-11-29 CA CA002241187A patent/CA2241187A1/en not_active Abandoned
- 1996-11-29 SK SK854-98A patent/SK283334B6/sk unknown
- 1996-11-29 ES ES96941055T patent/ES2181924T3/es not_active Expired - Lifetime
- 1996-11-29 EP EP96941055A patent/EP0868202B1/de not_active Expired - Lifetime
- 1996-11-29 US US09/077,773 patent/US6057419A/en not_active Expired - Fee Related
- 1996-11-29 DE DE59609603T patent/DE59609603D1/de not_active Expired - Fee Related
- 1996-11-29 NZ NZ323397A patent/NZ323397A/xx unknown
- 1996-11-29 RU RU98113782/04A patent/RU2197495C2/ru not_active IP Right Cessation
- 1996-11-29 WO PCT/EP1996/005315 patent/WO1997023245A1/de active IP Right Grant
- 1996-11-29 AT AT96941055T patent/ATE222776T1/de not_active IP Right Cessation
- 1996-11-29 KR KR10-1998-0704746A patent/KR100461476B1/ko not_active IP Right Cessation
- 1996-11-29 PT PT96941055T patent/PT868202E/pt unknown
- 1996-11-29 JP JP52325197A patent/JP4031041B2/ja not_active Expired - Fee Related
- 1996-11-29 IL IL12467796A patent/IL124677A/xx not_active IP Right Cessation
- 1996-11-29 DK DK96941055T patent/DK0868202T3/da active
- 1996-11-29 PL PL32797796A patent/PL187835B1/pl not_active IP Right Cessation
- 1996-11-29 UA UA98073923A patent/UA50753C2/ru unknown
- 1996-11-29 CZ CZ19981981A patent/CZ294238B6/cs not_active IP Right Cessation
- 1996-12-20 ZA ZA9610822A patent/ZA9610822B/xx unknown
- 1996-12-20 TW TW085115801A patent/TW520377B/zh not_active IP Right Cessation
-
1998
- 1998-06-17 MX MX9804860A patent/MX9804860A/es unknown
- 1998-06-19 BG BG102565A patent/BG63105B1/bg unknown
- 1998-06-22 NO NO19982903A patent/NO314545B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP4031041B2 (ja) | 2008-01-09 |
| IL124677A (en) | 2005-03-20 |
| TW520377B (en) | 2003-02-11 |
| IL124677A0 (en) | 1998-12-06 |
| DE59609603D1 (de) | 2002-10-02 |
| PT868202E (pt) | 2003-01-31 |
| PL187835B1 (pl) | 2004-10-29 |
| KR100461476B1 (ko) | 2005-04-06 |
| ATE222776T1 (de) | 2002-09-15 |
| BG102565A (en) | 1999-06-30 |
| EP0868202A1 (de) | 1998-10-07 |
| US6057419A (en) | 2000-05-02 |
| ZA9610822B (en) | 1997-06-27 |
| MX9804860A (es) | 1998-10-31 |
| KR19990076638A (ko) | 1999-10-15 |
| SK283334B6 (sk) | 2003-06-03 |
| NO982903L (no) | 1998-06-22 |
| EP0868202B1 (de) | 2002-08-28 |
| CZ198198A3 (cs) | 1998-09-16 |
| RU2197495C2 (ru) | 2003-01-27 |
| ES2181924T3 (es) | 2003-03-01 |
| CZ294238B6 (cs) | 2004-11-10 |
| CA2241187A1 (en) | 1997-07-03 |
| NO314545B1 (no) | 2003-04-07 |
| PL327977A1 (en) | 1999-01-04 |
| WO1997023245A1 (de) | 1997-07-03 |
| DK0868202T3 (da) | 2002-12-09 |
| DE19549286A1 (de) | 1997-06-26 |
| JP2000510880A (ja) | 2000-08-22 |
| NZ323397A (en) | 1999-11-29 |
| NO982903D0 (no) | 1998-06-22 |
| BG63105B1 (bg) | 2001-04-30 |
| SK85498A3 (en) | 1998-11-04 |
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