UA49005C2 - Похідні камптотецину (варіанти), спосіб їх одержання (варіанти) та фармацевтична композиція на їх основі - Google Patents

Похідні камптотецину (варіанти), спосіб їх одержання (варіанти) та фармацевтична композиція на їх основі

Info

Publication number
UA49005C2
UA49005C2 UA98084449A UA98084449A UA49005C2 UA 49005 C2 UA49005 C2 UA 49005C2 UA 98084449 A UA98084449 A UA 98084449A UA 98084449 A UA98084449 A UA 98084449A UA 49005 C2 UA49005 C2 UA 49005C2
Authority
UA
Ukraine
Prior art keywords
alkyl
variants
hydrogen
aryl
camptothecin
Prior art date
Application number
UA98084449A
Other languages
English (en)
Russian (ru)
Ukrainian (uk)
Inventor
Лучо Мерліні
Серджо Пенко
Франко Цуніно
Original Assignee
Істітуто Націонале Пер Ло Студіо Е Ла Кура Дей Туморі
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11373368&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA49005(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Істітуто Націонале Пер Ло Студіо Е Ла Кура Дей Туморі filed Critical Істітуто Націонале Пер Ло Студіо Е Ла Кура Дей Туморі
Publication of UA49005C2 publication Critical patent/UA49005C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
UA98084449A 1996-02-23 1997-02-19 Похідні камптотецину (варіанти), спосіб їх одержання (варіанти) та фармацевтична композиція на їх основі UA49005C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT96MI000338A IT1282673B1 (it) 1996-02-23 1996-02-23 Derivati della camptotecina e loro uso come agenti antitumorali
PCT/EP1997/000786 WO1997031003A1 (en) 1996-02-23 1997-02-19 Camptothecin derivatives and the use thereof as antitumor agents

Publications (1)

Publication Number Publication Date
UA49005C2 true UA49005C2 (uk) 2002-09-16

Family

ID=11373368

Family Applications (1)

Application Number Title Priority Date Filing Date
UA98084449A UA49005C2 (uk) 1996-02-23 1997-02-19 Похідні камптотецину (варіанти), спосіб їх одержання (варіанти) та фармацевтична композиція на їх основі

Country Status (22)

Country Link
US (2) US6130227A (instruction)
EP (1) EP0885230B1 (instruction)
JP (1) JP4171527B2 (instruction)
KR (1) KR100497906B1 (instruction)
CN (1) CN1107677C (instruction)
AT (1) ATE221071T1 (instruction)
AU (1) AU718361B2 (instruction)
BR (1) BR9707622B1 (instruction)
CZ (1) CZ289268B6 (instruction)
DE (1) DE69714220T2 (instruction)
DK (1) DK0885230T3 (instruction)
EE (1) EE03529B1 (instruction)
ES (1) ES2180932T3 (instruction)
HU (1) HUP9900987A3 (instruction)
IL (1) IL125856A (instruction)
IT (1) IT1282673B1 (instruction)
NZ (1) NZ331126A (instruction)
PT (1) PT885230E (instruction)
RU (1) RU2165935C2 (instruction)
SK (1) SK283217B6 (instruction)
UA (1) UA49005C2 (instruction)
WO (1) WO1997031003A1 (instruction)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000000238A1 (en) * 1998-06-26 2000-01-06 Quanam Medical Corporation Topoisomerase inhibitors for prevention of restenosis
PT1044977E (pt) * 1999-03-09 2002-09-30 Sigma Tau Ind Farmaceuti Derivados de camptotecina com actividade antitumoral
US7105492B2 (en) 1999-03-09 2006-09-12 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Camptothecin derivatives having antitumor activity
AR025587A1 (es) 1999-09-13 2002-12-04 Hoffmann La Roche Formulaciones en dispersion que contienen inhibidores de lipasa
US6950757B2 (en) * 2001-04-11 2005-09-27 Emerald Biostructures, Inc. Screening methods for identifying ligands
RU2319482C2 (ru) * 2001-11-23 2008-03-20 Чугаи Сейяку Кабусики Кайся Способ идентификации противоопухолевых целевых ферментов
DK1487840T3 (da) * 2002-03-01 2007-07-16 Pfizer Italia Srl Krystallinsk polymorf form af irinotecan hydrochlorid
TW200306314A (en) * 2002-04-16 2003-11-16 Tanabe Seiyaku Co Liquid preparation comprising camptothecin derivative and pharmaceutical composition producible by lyophilizing the preparation
US7067666B2 (en) * 2003-06-27 2006-06-27 Research Triangle Institute 7-substituted camptothecin and camptothecin analogs and methods for producing the same
ITRM20030344A1 (it) * 2003-07-14 2005-01-15 Ist Naz Stud Cura Dei Tumori 7-n-poliamminoalchil(ossi)imminometilcamptotecine recanti gruppi protettivi.
TWI333492B (en) * 2003-11-12 2010-11-21 Smithkline Beecham Cork Ltd Crystalline topotecan hydrochloride product and preparation thereof
JP5657205B2 (ja) * 2005-12-21 2015-01-21 シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニＳｉｇｍａ−Ｔａｕ Ｉｎｄｕｓｔｒｉｅ Ｆａｒｍａｃｅｕｔｉｃｈｅ Ｒｉｕｎｉｔｅ Ｓｏｃｉｅｔａ Ｐｅｒ Ａｚｉｏｎｉ 薬物耐性腫瘍の治療
WO2007095389A2 (en) * 2006-02-17 2007-08-23 Novacea, Inc. Treatment of hyperproliferative diseases with camptothecine n-oxide and analogs
CN101033230B (zh) * 2006-03-10 2010-12-08 中国科学院上海药物研究所 一类喜树碱衍生物及其应用
ITMI20061474A1 (it) * 2006-07-26 2008-01-27 Indena Spa Derivati della camptotecina ad attivita antitumorale
CN102731516B (zh) * 2011-04-07 2014-07-02 宁波天衡药业股份有限公司 一类具有抗肿瘤活性的喜树碱衍生物
CN104774209B (zh) * 2014-01-15 2018-06-19 上海海和药物研究开发有限公司 一种9-烯丙基喜树碱衍生物的合成方法
WO2023030364A1 (zh) * 2021-09-01 2023-03-09 上海弼领生物技术有限公司 一种喜树碱类化合物、其制备方法和用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399282A (en) * 1979-07-10 1983-08-16 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives
JPS58154582A (ja) * 1982-03-10 1983-09-14 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体およびその製造法
US5459269A (en) * 1992-06-18 1995-10-17 North Carolina State University 14-halo-camptothecins
US5726181A (en) * 1995-06-05 1998-03-10 Bionumerik Pharmaceuticals, Inc. Formulations and compositions of poorly water soluble camptothecin derivatives
ES2214634T3 (es) * 1996-08-19 2004-09-16 Bionumerik Pharmaceuticals, Inc. Derivados muy lipofilos de la camptotecina.

Also Published As

Publication number Publication date
CN1107677C (zh) 2003-05-07
IL125856A (en) 2001-08-26
HUP9900987A3 (en) 2000-01-28
KR100497906B1 (ko) 2006-03-09
CN1211987A (zh) 1999-03-24
WO1997031003A1 (en) 1997-08-28
SK112798A3 (en) 1999-01-11
BR9707622B1 (pt) 2010-08-10
SK283217B6 (sk) 2003-03-04
JP2000505448A (ja) 2000-05-09
AU1875397A (en) 1997-09-10
CZ289268B6 (cs) 2001-12-12
ITMI960338A0 (instruction) 1996-02-23
DE69714220D1 (de) 2002-08-29
EE9800259A (et) 1999-02-15
IT1282673B1 (it) 1998-03-31
JP4171527B2 (ja) 2008-10-22
NZ331126A (en) 2000-02-28
EE03529B1 (et) 2001-10-15
EP0885230B1 (en) 2002-07-24
ES2180932T3 (es) 2003-02-16
DE69714220T2 (de) 2002-11-14
IL125856A0 (en) 1999-04-11
ATE221071T1 (de) 2002-08-15
US6306868B1 (en) 2001-10-23
BR9707622A (pt) 1999-07-27
US6130227A (en) 2000-10-10
HUP9900987A2 (hu) 1999-08-30
CZ265298A3 (cs) 1999-01-13
RU2165935C2 (ru) 2001-04-27
AU718361B2 (en) 2000-04-13
KR19990087110A (ko) 1999-12-15
DK0885230T3 (da) 2002-11-18
ITMI960338A1 (it) 1997-08-23
EP0885230A1 (en) 1998-12-23
PT885230E (pt) 2002-12-31

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