UA35557C2 - Похідні 1,2,4-оксадіазолілфеноксіалкілізоксазолу, що мають противірусну активність та фармацевтична композиція на їх основі - Google Patents
Похідні 1,2,4-оксадіазолілфеноксіалкілізоксазолу, що мають противірусну активність та фармацевтична композиція на їх основіInfo
- Publication number
- UA35557C2 UA35557C2 UA93003099A UA93003099A UA35557C2 UA 35557 C2 UA35557 C2 UA 35557C2 UA 93003099 A UA93003099 A UA 93003099A UA 93003099 A UA93003099 A UA 93003099A UA 35557 C2 UA35557 C2 UA 35557C2
- Authority
- UA
- Ukraine
- Prior art keywords
- oxadiazolyl
- antiviral activity
- phenoxyalkylisoxazole
- derivatives
- alkoxy
- Prior art date
Links
- 230000000840 anti-viral effect Effects 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- -1 cyckloalkyl Chemical group 0.000 abstract 3
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 125000006371 dihalo methyl group Chemical group 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000004970 halomethyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 125000005113 hydroxyalkoxy group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
- 125000004953 trihalomethyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/869,287 US5349068A (en) | 1992-04-15 | 1992-04-15 | 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA35557C2 true UA35557C2 (uk) | 2001-04-16 |
Family
ID=25353269
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA93003099A UA35557C2 (uk) | 1992-04-15 | 1993-06-15 | Похідні 1,2,4-оксадіазолілфеноксіалкілізоксазолу, що мають противірусну активність та фармацевтична композиція на їх основі |
Country Status (26)
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5349068A (en) * | 1992-04-15 | 1994-09-20 | Sterling Winthrop Inc. | 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents |
| US5552420A (en) * | 1994-05-13 | 1996-09-03 | Sterling Winthrop Inc. | Therapeutic phenoxyalkylazoles and phenoxyalkylazines |
| IL118657A0 (en) * | 1996-06-14 | 1996-10-16 | Arad Dorit | Inhibitors for picornavirus proteases |
| IL122591A0 (en) | 1997-12-14 | 1998-06-15 | Arad Dorit | Pharmaceutical compositions comprising cystein protease inhibitors |
| US6528652B1 (en) | 1999-01-21 | 2003-03-04 | Chronimed | Composition and device for detecting leukocytes in urine |
| US6348324B1 (en) | 1999-01-21 | 2002-02-19 | Hypoguard America Limited | Composition and device for detecting leukocytes in urine |
| AUPQ105499A0 (en) | 1999-06-18 | 1999-07-08 | Biota Scientific Management Pty Ltd | Antiviral agents |
| AUPR213700A0 (en) * | 2000-12-18 | 2001-01-25 | Biota Scientific Management Pty Ltd | Antiviral agents |
| KR20040004705A (ko) * | 2001-06-08 | 2004-01-13 | 시토비아 인크. | 카스파제의 활성제 및 아폽토시스의 유도제로서의 치환된3-아릴-5-아릴-[1,2,4]-옥사디아졸과 유사체 및 이의 용도 |
| US7129359B2 (en) * | 2002-07-09 | 2006-10-31 | National Health Research Institutes | Imidazolidinone compounds |
| US20050027127A1 (en) * | 2001-08-29 | 2005-02-03 | Diana Guy D. | Oxadiazolyl-phenoxyalkylisoxazoles compositions thereof and methods for their use as anti-picornaviral agents |
| CA2459376A1 (en) * | 2001-08-29 | 2003-03-13 | Viropharma Incorporated | Oxadiazolyl-phenoxyalkylisoxazoles, compositions thereof and methods for their use as anti-picornaviral agents |
| ATE465730T1 (de) * | 2001-12-07 | 2010-05-15 | Ana Maria Sandino | Zusammensetzungen zur steigerung des überlebens von wassertieren, die einem rns-virus ausgesetzt sind |
| AU2003215246A1 (en) * | 2002-02-14 | 2003-09-04 | Viropharma Incorporated | Methods of reducing rhinovirus contagion and related compositions |
| JP2006516250A (ja) * | 2002-12-18 | 2006-06-29 | サイトビア インコーポレイティッド | カスパーゼ活性化剤およびアポトーシス誘導物質としての３，５−二置換−［１，２，４］−オキサジアゾールおよびそれらの誘導体ならびにそれらの使用 |
| US7259174B2 (en) * | 2004-05-25 | 2007-08-21 | National Health Research Institutes | Imidazolidinone compounds |
| JP2008509143A (ja) * | 2004-08-04 | 2008-03-27 | シェーリング コーポレイション | 気道疾患の処置のためのプレコナリルを含む薬学的処方物 |
| CA2641605A1 (en) * | 2006-02-09 | 2007-08-23 | Schering Corporation | Pharmaceutical formulations |
| MX2008010353A (es) * | 2006-02-09 | 2009-03-05 | Schering Corp | Formulaciones farmaceuticas. |
| CA2641604A1 (en) * | 2006-02-09 | 2007-08-23 | Schering Corporation | Pharmaceutical formulations |
| WO2008071587A2 (en) | 2006-12-13 | 2008-06-19 | F. Hoffmann-La Roche Ag | 2-(piperidin-4-yl)-4-phenoxy- or phenylamino-pyrimidine derivatives as non-nucleoside reverse transcriptase inhibitors |
| KR101031584B1 (ko) * | 2009-04-21 | 2011-04-27 | 파인오토시스템(주) | 전면부가 개폐되는 차량용 적외선 조사장치 |
| CN103102322B (zh) * | 2011-11-14 | 2016-02-24 | 上海交通大学 | 噁唑类化合物及其制备方法、药物组合物及其用途 |
| MX2020013039A (es) | 2018-08-21 | 2021-02-26 | Kyorin Seiyaku Kk | Derivado de anillo heteroaromatico biciclico. |
| WO2021062189A1 (en) * | 2019-09-27 | 2021-04-01 | Collaborations Pharmaceuticals, Inc. | Isoxazole-3-carboxamide derivatives and their use for treatment of diseases caused by virus infection |
| WO2021209563A1 (en) | 2020-04-16 | 2021-10-21 | Som Innovation Biotech, S.A. | Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4861791A (en) * | 1983-08-29 | 1989-08-29 | Sterling Drug Inc. | Dihydro-oxazolyl substituted-phenyl-aliphatic lower alkyl and their use as antiviral agents |
| US4843087A (en) * | 1983-08-29 | 1989-06-27 | Sterling Drug Inc. | Di-heterocyclic compounds and their use as antiviral agents |
| CA1299176C (en) * | 1985-07-02 | 1992-04-21 | Guy Dominic Diana | Process for preparing isoxazole and furan derivatives |
| ZA846525B (en) * | 1983-08-29 | 1985-04-24 | Sterling Drug Inc | (substituted)phenyl-aliphatic-isoxazoles useful as antiviral agents and preparation thereof |
| GB8619433D0 (en) * | 1986-08-08 | 1986-09-17 | Lilly Industries Ltd | Pharmaceutical compounds |
| NZ234760A (en) * | 1989-08-18 | 1991-09-25 | Sterling Drug Inc | Antiviral oxazole compounds and compositions |
| US4942241A (en) * | 1989-08-21 | 1990-07-17 | Sterling Drug Inc. | 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents |
| US5175178A (en) * | 1989-08-21 | 1992-12-29 | Sterling Drug Inc. | 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents |
| US4945164A (en) * | 1989-08-18 | 1990-07-31 | Sterling Drug Inc. | 1,3,4-Oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents and intermediates thereof |
| US5175177A (en) * | 1991-07-17 | 1992-12-29 | Sterling Drug Inc. | 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents |
| US5349068A (en) * | 1992-04-15 | 1994-09-20 | Sterling Winthrop Inc. | 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents |
-
1992
- 1992-04-15 US US07/869,287 patent/US5349068A/en not_active Expired - Lifetime
-
1993
- 1993-03-31 TW TW082102383A patent/TW239140B/zh not_active IP Right Cessation
- 1993-04-07 CZ CZ93597A patent/CZ285845B6/cs not_active IP Right Cessation
- 1993-04-10 MY MYPI93000665A patent/MY110191A/en unknown
- 1993-04-13 SG SG1996008085A patent/SG50663A1/en unknown
- 1993-04-13 AT AT93201058T patent/ATE189958T1/de active
- 1993-04-13 EP EP93201058A patent/EP0566199B1/en not_active Expired - Lifetime
- 1993-04-13 DK DK93201058T patent/DK0566199T3/da active
- 1993-04-13 ES ES93201058T patent/ES2143487T3/es not_active Expired - Lifetime
- 1993-04-13 PT PT93201058T patent/PT566199E/pt unknown
- 1993-04-13 DE DE69327913T patent/DE69327913T2/de not_active Expired - Lifetime
- 1993-04-14 CA CA002094012A patent/CA2094012C/en not_active Expired - Lifetime
- 1993-04-14 PH PH46044A patent/PH30454A/en unknown
- 1993-04-14 AU AU36881/93A patent/AU666528B2/en not_active Expired
- 1993-04-14 KR KR1019930006244A patent/KR100314158B1/ko not_active Expired - Lifetime
- 1993-04-14 RU RU93004675A patent/RU2114112C1/ru active
- 1993-04-14 IL IL10537293A patent/IL105372A/en not_active IP Right Cessation
- 1993-04-14 HU HU9301084A patent/HU220606B1/hu unknown
- 1993-04-14 NO NO19931366A patent/NO302700B1/no not_active IP Right Cessation
- 1993-04-14 MX MX9302169A patent/MX9302169A/es unknown
- 1993-04-15 NZ NZ247411A patent/NZ247411A/en not_active IP Right Cessation
- 1993-04-15 SK SK353-93A patent/SK279786B6/sk not_active IP Right Cessation
- 1993-04-15 JP JP05088647A patent/JP3103845B2/ja not_active Expired - Lifetime
- 1993-04-15 FI FI931707A patent/FI112229B/fi not_active IP Right Cessation
- 1993-06-15 UA UA93003099A patent/UA35557C2/uk unknown
- 1993-10-01 US US08/131,050 patent/US5464848A/en not_active Expired - Lifetime
-
1995
- 1995-05-19 US US08/444,795 patent/US5643929A/en not_active Expired - Lifetime
- 1995-06-30 HU HU95P/P00642P patent/HU211320A9/hu unknown
-
2000
- 2000-05-24 GR GR20000401183T patent/GR3033486T3/el unknown
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