UA121389C2 - Борвмісні інгібітори протеасом для застосування після первинної протиракової терапії - Google Patents

Борвмісні інгібітори протеасом для застосування після первинної протиракової терапії Download PDF

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Publication number
UA121389C2
UA121389C2 UAA201612860A UAA201612860A UA121389C2 UA 121389 C2 UA121389 C2 UA 121389C2 UA A201612860 A UAA201612860 A UA A201612860A UA A201612860 A UAA201612860 A UA A201612860A UA 121389 C2 UA121389 C2 UA 121389C2
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UA
Ukraine
Prior art keywords
dose
therapy
treatment
ixazomib
formula
Prior art date
Application number
UAA201612860A
Other languages
English (en)
Ukrainian (uk)
Inventor
Ай-Мінь Хой
Ай-Минь Хой
Ричард Лаботка
Неерай Ґупта
Неерай ГУПТА
Картхік Венкатакришнан
Картхик Венкатакришнан
Ґохой Луі
Гохой Луи
Original Assignee
Мілленніум Фармасьютікалз, Інк.
Милленниум Фармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Мілленніум Фармасьютікалз, Інк., Милленниум Фармасьютикалз, Инк. filed Critical Мілленніум Фармасьютікалз, Інк.
Publication of UA121389C2 publication Critical patent/UA121389C2/uk

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/69Boron compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/145Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/3533,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/4261,3-Thiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05Dipeptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06Tripeptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07Tetrapeptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/485Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4858Organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4866Organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
UAA201612860A 2014-05-20 2015-05-19 Борвмісні інгібітори протеасом для застосування після первинної протиракової терапії UA121389C2 (uk)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462000991P 2014-05-20 2014-05-20
US201462019600P 2014-07-01 2014-07-01
US201462088154P 2014-12-05 2014-12-05
PCT/US2015/031633 WO2015179443A1 (en) 2014-05-20 2015-05-19 Boron-containing proteasome inhibitors for use after primary cancer therapy

Publications (1)

Publication Number Publication Date
UA121389C2 true UA121389C2 (uk) 2020-05-25

Family

ID=54554652

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201612860A UA121389C2 (uk) 2014-05-20 2015-05-19 Борвмісні інгібітори протеасом для застосування після первинної протиракової терапії

Country Status (21)

Country Link
US (5) US20150335668A1 (enExample)
EP (1) EP3145526A1 (enExample)
JP (2) JP2017524652A (enExample)
KR (2) KR102509950B1 (enExample)
CN (1) CN106659761A (enExample)
AU (2) AU2015264272A1 (enExample)
BR (1) BR112016026774A8 (enExample)
CA (1) CA2949517A1 (enExample)
CL (1) CL2016002948A1 (enExample)
CR (1) CR20160577A (enExample)
EA (1) EA201692332A1 (enExample)
IL (2) IL249025B (enExample)
MA (1) MA39964A (enExample)
MX (2) MX2016015267A (enExample)
PH (1) PH12016502301A1 (enExample)
SG (2) SG10202003693RA (enExample)
TN (1) TN2016000492A1 (enExample)
TW (1) TWI746422B (enExample)
UA (1) UA121389C2 (enExample)
UY (1) UY36132A (enExample)
WO (1) WO2015179443A1 (enExample)

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US11414437B2 (en) 2017-07-28 2022-08-16 Chengdu Origin Biotechnology Limited Company Borate compound, and synthesis method therefor and uses thereof
US20250059213A1 (en) * 2021-12-06 2025-02-20 Pretzel Therapeutics, Inc. Lonp1 inhibitors, uses and methods

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Publication number Publication date
BR112016026774A8 (pt) 2021-07-13
CL2016002948A1 (es) 2017-03-31
EA201692332A1 (ru) 2017-04-28
CN106659761A (zh) 2017-05-10
IL249025B (en) 2020-05-31
JP2019147837A (ja) 2019-09-05
JP6906564B2 (ja) 2021-07-21
MX2021009044A (es) 2021-09-21
AU2021200370B2 (en) 2022-11-03
SG11201609259VA (en) 2016-12-29
SG10202003693RA (en) 2020-05-28
TWI746422B (zh) 2021-11-21
NZ725948A (en) 2024-01-26
CA2949517A1 (en) 2015-11-26
US20200171061A1 (en) 2020-06-04
CR20160577A (es) 2017-01-06
US11241448B2 (en) 2022-02-08
US20190125773A1 (en) 2019-05-02
IL274042A (en) 2020-06-30
TW201613570A (en) 2016-04-16
KR20220097553A (ko) 2022-07-07
KR102509950B1 (ko) 2023-03-14
AU2021200370A1 (en) 2021-03-18
BR112016026774A2 (pt) 2017-08-15
KR20170005042A (ko) 2017-01-11
WO2015179443A1 (en) 2015-11-26
TN2016000492A1 (en) 2018-04-04
US20210177871A1 (en) 2021-06-17
IL249025A0 (en) 2017-01-31
US20150335668A1 (en) 2015-11-26
JP2017524652A (ja) 2017-08-31
EP3145526A1 (en) 2017-03-29
PH12016502301A1 (en) 2017-02-13
US20190343851A1 (en) 2019-11-14
MA39964A (fr) 2015-11-26
KR102481856B1 (ko) 2022-12-26
UY36132A (es) 2015-11-30
AU2015264272A1 (en) 2016-11-24
MX2016015267A (es) 2017-02-22

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