UA120647C2 - Піридопіримідинони та їх застосування як модуляторів рецептора n-метил-d-аспартату - Google Patents
Піридопіримідинони та їх застосування як модуляторів рецептора n-метил-d-аспартату Download PDFInfo
- Publication number
- UA120647C2 UA120647C2 UAA201711077A UAA201711077A UA120647C2 UA 120647 C2 UA120647 C2 UA 120647C2 UA A201711077 A UAA201711077 A UA A201711077A UA A201711077 A UAA201711077 A UA A201711077A UA 120647 C2 UA120647 C2 UA 120647C2
- Authority
- UA
- Ukraine
- Prior art keywords
- methyl
- trifluoromethyl
- pyrazol
- chloro
- pyrimidin
- Prior art date
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Classifications
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
- C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
Landscapes
- Health & Medical Sciences (AREA)
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- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
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- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
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| CN2015076617 | 2015-04-15 | ||
| PCT/EP2016/057962 WO2016166078A1 (en) | 2015-04-15 | 2016-04-12 | Pyridopyrimidinones and their use as nmda receptor modulators |
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| UA120647C2 true UA120647C2 (uk) | 2020-01-10 |
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| UAA201711077A UA120647C2 (uk) | 2015-04-15 | 2016-04-12 | Піридопіримідинони та їх застосування як модуляторів рецептора n-метил-d-аспартату |
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| SG (1) | SG11201708294YA (enExample) |
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| BR112016007563B1 (pt) | 2013-10-11 | 2022-12-20 | F. Hoffmann-La Roche Ag | Tiazolopirimidinonas, seus usos, e composição farmacêutica |
| SG11201708294YA (en) | 2015-04-15 | 2017-11-29 | Hoffmann La Roche | Pyridopyrimidinones and their use as nmda receptor modulators |
| ES2821010T3 (es) | 2015-12-09 | 2021-04-23 | Cadent Therapeutics Inc | Moduladores heteroaromáticos del receptor NMDA y usos de los mismos |
| CA3047403A1 (en) | 2016-12-22 | 2018-06-28 | Cadent Therapeutics, Inc. | Nmda receptor modulators and uses thereof |
| CA3108519A1 (en) | 2018-08-03 | 2020-04-30 | Cadent Therapeutics, Inc. | Heteroaromatic nmda receptor modulators and uses thereof |
| TW202208355A (zh) | 2020-05-04 | 2022-03-01 | 美商安進公司 | 作為骨髓細胞觸發受體2促效劑之雜環化合物及使用方法 |
| JP7741100B2 (ja) | 2020-05-04 | 2025-09-17 | アムジェン インコーポレイテッド | ミエロイド細胞に発現するトリガー受容体２アゴニストとしての複素環化合物及び使用方法 |
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| US6951875B2 (en) * | 2001-10-29 | 2005-10-04 | Hoffmann-La Roche Inc. | Conjugated aromatic compounds with a pyridine substituent |
| US7148226B2 (en) | 2003-02-21 | 2006-12-12 | Agouron Pharmaceuticals, Inc. | Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same |
| EP1636225B1 (en) * | 2003-06-20 | 2010-02-24 | Novartis Vaccines and Diagnostics, Inc. | Pyridino 1,2-a pyrimidin-4-one compounds as anticancer agents |
| NL2000397C2 (nl) | 2006-01-05 | 2007-10-30 | Pfizer Prod Inc | Bicyclische heteroarylverbindingen als PDE10 inhibitoren. |
| JP2010518026A (ja) * | 2007-02-05 | 2010-05-27 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | ナトリウムチャネルが介在する疾患または状態の治療に有用なピリドピリミジノン化合物 |
| WO2014202493A1 (en) * | 2013-06-19 | 2014-12-24 | F. Hoffmann-La Roche Ag | Indolin-2-one or pyrrolo-pyridin/pyrimidin-2-one derivatives |
| BR112016007563B1 (pt) | 2013-10-11 | 2022-12-20 | F. Hoffmann-La Roche Ag | Tiazolopirimidinonas, seus usos, e composição farmacêutica |
| SG11201708294YA (en) | 2015-04-15 | 2017-11-29 | Hoffmann La Roche | Pyridopyrimidinones and their use as nmda receptor modulators |
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| KR20170137137A (ko) | 2017-12-12 |
| RU2717665C2 (ru) | 2020-03-24 |
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| AU2016248886A1 (en) | 2017-10-12 |
| CN107531696A (zh) | 2018-01-02 |
| IL254921A0 (en) | 2017-12-31 |
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