UA120647C2 - Піридопіримідинони та їх застосування як модуляторів рецептора n-метил-d-аспартату - Google Patents
Піридопіримідинони та їх застосування як модуляторів рецептора n-метил-d-аспартату Download PDFInfo
- Publication number
- UA120647C2 UA120647C2 UAA201711077A UAA201711077A UA120647C2 UA 120647 C2 UA120647 C2 UA 120647C2 UA A201711077 A UAA201711077 A UA A201711077A UA A201711077 A UAA201711077 A UA A201711077A UA 120647 C2 UA120647 C2 UA 120647C2
- Authority
- UA
- Ukraine
- Prior art keywords
- methyl
- trifluoromethyl
- pyrazol
- chloro
- pyrimidin
- Prior art date
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Classifications
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
- C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
Landscapes
- Health & Medical Sciences (AREA)
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- Organic Chemistry (AREA)
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- General Health & Medical Sciences (AREA)
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- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
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|---|---|---|---|
| CN2015076617 | 2015-04-15 | ||
| PCT/EP2016/057962 WO2016166078A1 (en) | 2015-04-15 | 2016-04-12 | Pyridopyrimidinones and their use as nmda receptor modulators |
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| UA120647C2 true UA120647C2 (uk) | 2020-01-10 |
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| UAA201711077A UA120647C2 (uk) | 2015-04-15 | 2016-04-12 | Піридопіримідинони та їх застосування як модуляторів рецептора n-метил-d-аспартату |
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| SG (1) | SG11201708294YA (enExample) |
| UA (1) | UA120647C2 (enExample) |
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| EP3055315B1 (en) | 2013-10-11 | 2018-07-25 | F. Hoffmann-La Roche AG | Thiazolopyrimidinones as modulators of nmda receptor activity |
| AU2016248886B2 (en) | 2015-04-15 | 2020-09-10 | F. Hoffmann-La Roche Ag | Pyridopyrimidinones and their use as NMDA receptor modulators |
| SI3386591T1 (sl) | 2015-12-09 | 2020-11-30 | Cadent Therapeutics, Inc. | Heteroaromatski NMDA receptorski modulatorji in njihove uporabe |
| ES2975336T3 (es) | 2016-12-22 | 2024-07-04 | Novartis Ag | Moduladores del receptor NMDA y usos de los mismos |
| JOP20210020A1 (ar) | 2018-08-03 | 2021-01-25 | Cadent Therapeutics Inc | معدلات عطرية غير متجانسة لمستقبل nmda واستخداماتها |
| PE20230609A1 (es) | 2020-05-04 | 2023-04-13 | Amgen Inc | Compuestos heterociclicos como agonistas del receptor de activacion expresado en las celulas mieloides 2 y metodos de uso |
| TW202208355A (zh) | 2020-05-04 | 2022-03-01 | 美商安進公司 | 作為骨髓細胞觸發受體2促效劑之雜環化合物及使用方法 |
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| US6951875B2 (en) * | 2001-10-29 | 2005-10-04 | Hoffmann-La Roche Inc. | Conjugated aromatic compounds with a pyridine substituent |
| US7148226B2 (en) | 2003-02-21 | 2006-12-12 | Agouron Pharmaceuticals, Inc. | Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same |
| AU2004249730A1 (en) * | 2003-06-20 | 2004-12-29 | Novartis Vaccines And Diagnostics, Inc. | Pyridino(1,2-A)pyrimidin-4-one compounds as anticancer agents |
| NL2000397C2 (nl) | 2006-01-05 | 2007-10-30 | Pfizer Prod Inc | Bicyclische heteroarylverbindingen als PDE10 inhibitoren. |
| MX2009008338A (es) * | 2007-02-05 | 2009-08-12 | Xenon Pharmaceuticals Inc | Compuestos de piridopirimidinona de utilidad en el tratamiento de enfermedades o condiciones patologicas mediadas por los canales de sodio. |
| JP6130061B2 (ja) * | 2013-06-19 | 2017-05-17 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | インドリン−２−オン又はピロロ−ピリジン／ピリミジン−２−オン誘導体 |
| EP3055315B1 (en) * | 2013-10-11 | 2018-07-25 | F. Hoffmann-La Roche AG | Thiazolopyrimidinones as modulators of nmda receptor activity |
| AU2016248886B2 (en) | 2015-04-15 | 2020-09-10 | F. Hoffmann-La Roche Ag | Pyridopyrimidinones and their use as NMDA receptor modulators |
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| RU2717665C2 (ru) | 2020-03-24 |
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