UA120407C2 - Інгібітор алкінілпіридинпролілгідроксилази та спосіб його отримання та застосування в медицині - Google Patents
Інгібітор алкінілпіридинпролілгідроксилази та спосіб його отримання та застосування в медицині Download PDFInfo
- Publication number
- UA120407C2 UA120407C2 UAA201804628A UAA201804628A UA120407C2 UA 120407 C2 UA120407 C2 UA 120407C2 UA A201804628 A UAA201804628 A UA A201804628A UA A201804628 A UAA201804628 A UA A201804628A UA 120407 C2 UA120407 C2 UA 120407C2
- Authority
- UA
- Ukraine
- Prior art keywords
- compound
- hydroxy
- pharmaceutically acceptable
- acceptable salt
- mmol
- Prior art date
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Classifications
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
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- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
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- Diabetes (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510648342.9A CN105130888A (zh) | 2015-10-09 | 2015-10-09 | 炔基吡啶类脯氨酰羟化酶抑制剂、其制备方法和医药用途 |
| PCT/CN2015/095728 WO2017059623A1 (zh) | 2015-10-09 | 2015-11-27 | 炔基吡啶类脯氨酰羟化酶抑制剂、其制备方法和医药用途 |
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| UA120407C2 true UA120407C2 (uk) | 2019-11-25 |
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| UAA201804628A UA120407C2 (uk) | 2015-10-09 | 2015-11-27 | Інгібітор алкінілпіридинпролілгідроксилази та спосіб його отримання та застосування в медицині |
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| EP (1) | EP3360862B1 (OSRAM) |
| JP (1) | JP6635562B2 (OSRAM) |
| KR (1) | KR20180063229A (OSRAM) |
| CN (2) | CN105130888A (OSRAM) |
| AU (1) | AU2015411258B2 (OSRAM) |
| BR (1) | BR112018005969A2 (OSRAM) |
| CA (1) | CA3000040A1 (OSRAM) |
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| SI (1) | SI3360862T1 (OSRAM) |
| UA (1) | UA120407C2 (OSRAM) |
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Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105130888A (zh) * | 2015-10-09 | 2015-12-09 | 中国药科大学 | 炔基吡啶类脯氨酰羟化酶抑制剂、其制备方法和医药用途 |
| CN107417605A (zh) * | 2017-08-02 | 2017-12-01 | 江苏艾立康药业股份有限公司 | 作用于脯氨酰羟化酶的吡啶衍生化合物 |
| UA125565C2 (uk) | 2017-10-25 | 2022-04-20 | Джянгсу Хенгруй Медісін Ко., Лтд. | Кристалічна форма алкінілпіридинового інгібітора пролілгідроксилази та спосіб її отримання |
| CN110240562B (zh) * | 2018-03-08 | 2022-04-12 | 江苏恒瑞医药股份有限公司 | 一种脯氨酰羟化酶抑制剂的可药用盐、晶型及其制备方法 |
| US20210206720A1 (en) * | 2018-05-24 | 2021-07-08 | Suzhou Suncadia Biopharmaceuticals Co., Ltd. | Method for preparing alkynyl pyridine prolyl hydroxylase inhibitor |
| CN109593084B (zh) * | 2019-01-23 | 2021-09-28 | 中国药科大学 | 脯氨酰羟化酶小分子光敏前药及其制备方法与应用 |
| EP3936119A1 (en) * | 2019-03-04 | 2022-01-12 | Jiangsu Hengrui Medicine Co., Ltd. | Pharmaceutical composition of prolyl hydroxylase inhibitor and preparation method therefor |
| WO2022036188A1 (en) * | 2020-08-14 | 2022-02-17 | Akebia Therapeutics, Inc. | Phd inhibitor compounds, compositions, and methods of use |
| CN112741834A (zh) * | 2021-02-07 | 2021-05-04 | 复旦大学附属中山医院 | HIF-1α降解抑制剂在制备酮体水平升高的冠心病药物中的应用 |
| CN116120340B (zh) * | 2021-11-15 | 2023-10-31 | 艾立康药业股份有限公司 | 一种吡啶并噁嗪类化合物及其制备方法、组合物和用途 |
| CN116514710B (zh) * | 2022-01-21 | 2024-07-05 | 中国药科大学 | 环取代炔基吡啶甲酰甘氨酸衍生物、制备方法、药物组合物和应用 |
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| DE4410480A1 (de) * | 1994-03-25 | 1995-09-28 | Hoechst Ag | Sulfonamidocarbonylpyridin-2-carbonsäureesteramide sowie ihre Pyridin-N-oxide, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| ATE485264T1 (de) * | 2006-06-26 | 2010-11-15 | Warner Chilcott Co Llc | Prolylhydroxylase-hemmer und verfahren zu ihrer anwendung |
| AU2007334321B2 (en) * | 2006-12-18 | 2012-03-08 | Amgen Inc. | Azaquinolone based compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof |
| TW200845991A (en) * | 2007-01-12 | 2008-12-01 | Smithkline Beecham Corp | N-substituted glycine derivatives: hydroxylase inhibitors |
| TW201141839A (en) * | 2010-04-19 | 2011-12-01 | Daiichi Sankyo Co Ltd | Substituted 5-hydroxypyrimidine-4-carboxamide compounds |
| US9738604B2 (en) * | 2010-09-03 | 2017-08-22 | Duke University | Ethynylbenzene derivatives |
| JP6099644B2 (ja) | 2011-07-22 | 2017-03-22 | ベイジン ベータ ファーマシューティカルズ カンパニー， リミテッド | プロリルヒドロキシラーゼ阻害剤としての化合物の多形体、およびその使用 |
| CN105130888A (zh) * | 2015-10-09 | 2015-12-09 | 中国药科大学 | 炔基吡啶类脯氨酰羟化酶抑制剂、其制备方法和医药用途 |
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- 2015-11-27 WO PCT/CN2015/095728 patent/WO2017059623A1/zh not_active Ceased
- 2015-11-27 DK DK15905721.5T patent/DK3360862T3/da active
- 2015-11-27 CN CN201580079971.2A patent/CN107848976B/zh active Active
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- 2015-11-27 KR KR1020187012413A patent/KR20180063229A/ko not_active Ceased
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| EP3360862B1 (en) | 2020-04-22 |
| BR112018005969A2 (pt) | 2018-10-16 |
| HUE049409T2 (hu) | 2020-10-28 |
| ES2794002T3 (es) | 2020-11-17 |
| CN105130888A (zh) | 2015-12-09 |
| PL3360862T3 (pl) | 2020-09-21 |
| CN107848976B (zh) | 2020-11-17 |
| AU2015411258B2 (en) | 2020-09-17 |
| EP3360862A1 (en) | 2018-08-15 |
| US20180305317A1 (en) | 2018-10-25 |
| PT3360862T (pt) | 2020-05-27 |
| MX2018003832A (es) | 2018-06-18 |
| EP3360862A4 (en) | 2018-08-15 |
| LT3360862T (lt) | 2020-07-10 |
| JP6635562B2 (ja) | 2020-01-29 |
| SI3360862T1 (sl) | 2020-08-31 |
| HRP20200907T1 (hr) | 2020-09-04 |
| MX379007B (es) | 2025-03-11 |
| DK3360862T3 (da) | 2020-06-02 |
| CA3000040A1 (en) | 2017-04-13 |
| US10889546B2 (en) | 2021-01-12 |
| RU2692494C1 (ru) | 2019-06-25 |
| HK1247613A1 (zh) | 2018-09-28 |
| WO2017059623A1 (zh) | 2017-04-13 |
| JP2018529690A (ja) | 2018-10-11 |
| AU2015411258A1 (en) | 2018-05-10 |
| KR20180063229A (ko) | 2018-06-11 |
| CN107848976A (zh) | 2018-03-27 |
| US20200407319A1 (en) | 2020-12-31 |
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