UA118674C2 - Антитіло до igf-1r з елімінованою здатністю зв'язуватися з fcrn та його застосування для лікування судинних захворювань очей - Google Patents
Антитіло до igf-1r з елімінованою здатністю зв'язуватися з fcrn та його застосування для лікування судинних захворювань очейInfo
- Publication number
- UA118674C2 UA118674C2 UAA201511813A UAA201511813A UA118674C2 UA 118674 C2 UA118674 C2 UA 118674C2 UA A201511813 A UAA201511813 A UA A201511813A UA A201511813 A UAA201511813 A UA A201511813A UA 118674 C2 UA118674 C2 UA 118674C2
- Authority
- UA
- Ukraine
- Prior art keywords
- fcrn
- igf
- antibodies
- treatment
- eye diseases
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Винахід стосується антитіла до IGF-1R з елімінованою здатністю зв'язуватися з FcRn і способів його застосування для лікування судинних захворювань очей.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13165741 | 2013-04-29 | ||
EP14151318 | 2014-01-15 | ||
PCT/EP2014/058418 WO2014177461A1 (en) | 2013-04-29 | 2014-04-25 | Fcrn-binding abolished anti-igf-1r antibodies and their use in the treatment of vascular eye diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
UA118674C2 true UA118674C2 (uk) | 2019-02-25 |
Family
ID=50639475
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA201511813A UA118674C2 (uk) | 2013-04-29 | 2014-04-25 | Антитіло до igf-1r з елімінованою здатністю зв'язуватися з fcrn та його застосування для лікування судинних захворювань очей |
Country Status (21)
Country | Link |
---|---|
US (1) | US20160151487A1 (uk) |
EP (2) | EP3327034A1 (uk) |
JP (2) | JP2016528168A (uk) |
KR (1) | KR20160003803A (uk) |
CN (1) | CN105164158A (uk) |
AU (1) | AU2014261631B2 (uk) |
BR (1) | BR112015027399A2 (uk) |
CA (1) | CA2908653A1 (uk) |
CL (1) | CL2015003174A1 (uk) |
CR (1) | CR20150585A (uk) |
EA (1) | EA034716B1 (uk) |
HK (1) | HK1213577A1 (uk) |
IL (1) | IL274398A (uk) |
MX (2) | MX364861B (uk) |
PE (1) | PE20151925A1 (uk) |
PH (1) | PH12015502469A1 (uk) |
SG (2) | SG10201810481UA (uk) |
TW (2) | TWI653243B (uk) |
UA (1) | UA118674C2 (uk) |
WO (1) | WO2014177461A1 (uk) |
ZA (1) | ZA201507386B (uk) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
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MY172430A (en) | 2013-04-29 | 2019-11-25 | Hoffmann La Roche | Human fcrn-binding modified antibodies and methods of use |
EP3842455A1 (en) * | 2014-01-15 | 2021-06-30 | F. Hoffmann-La Roche AG | Fc-region variants with improved protein a-binding |
EP3094649A1 (en) * | 2014-01-15 | 2016-11-23 | F. Hoffmann-La Roche AG | Fc-region variants with modified fcrn-binding properties |
EP3835318A1 (en) * | 2014-01-15 | 2021-06-16 | F. Hoffmann-La Roche AG | Fc-region variants with modified fcrn- and maintained protein a-binding properties |
BR112017006591A2 (pt) | 2014-11-06 | 2018-01-16 | Hoffmann La Roche | polipeptídeo heterodimérico, formulação farmacêutica e uso de um polipeptídeo heterodimérico |
EP3805400A4 (en) * | 2018-06-04 | 2022-06-29 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule showing changed half-life in cytoplasm |
WO2021000018A1 (en) * | 2019-07-02 | 2021-01-07 | Telix International Pty Ltd | Antibodies for binding psma with reduced affinity for the neonatal fc receptor |
AU2020299024A1 (en) * | 2019-07-02 | 2022-01-20 | Telix Pharmaceuticals (Innovations) Pty Ltd | Antibodies against CAIX with reduced affinity for the neonatal Fc receptor |
WO2021051136A1 (en) * | 2019-09-13 | 2021-03-18 | The University Of Chicago | Methods and compositions for treating staphylococcal infections |
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MX353144B (es) * | 2010-04-20 | 2017-12-20 | Genmab As | Proteinas que contienen fc de anticuerpos heterodimericos y metodos para produccion de las mismas. |
EP2569337A1 (en) | 2010-05-14 | 2013-03-20 | Rinat Neuroscience Corp. | Heterodimeric proteins and methods for producing and purifying them |
CN103429620B (zh) | 2010-11-05 | 2018-03-06 | 酵活有限公司 | 在Fc结构域中具有突变的稳定异源二聚的抗体设计 |
CA2845147A1 (en) | 2011-09-23 | 2013-03-28 | Roche Glycart Ag | Bispecific anti-egfr/anti igf-1r antibodies |
EP2794905B1 (en) | 2011-12-20 | 2020-04-01 | MedImmune, LLC | Modified polypeptides for bispecific antibody scaffolds |
ES2743399T3 (es) | 2012-04-20 | 2020-02-19 | Merus Nv | Métodos y medios para la producción de moléculas heterodiméricas similares a Ig |
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2014
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- 2014-04-25 BR BR112015027399A patent/BR112015027399A2/pt not_active Application Discontinuation
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- 2014-04-25 MX MX2015015059A patent/MX364861B/es active IP Right Grant
- 2014-04-25 CA CA2908653A patent/CA2908653A1/en not_active Abandoned
- 2014-04-25 TW TW103115071A patent/TWI653243B/zh not_active IP Right Cessation
- 2014-04-25 TW TW108105062A patent/TW201920285A/zh unknown
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- 2014-04-25 SG SG10201810481UA patent/SG10201810481UA/en unknown
- 2014-04-25 AU AU2014261631A patent/AU2014261631B2/en not_active Ceased
- 2014-04-25 UA UAA201511813A patent/UA118674C2/uk unknown
- 2014-04-25 EP EP14721295.5A patent/EP2992011B1/en not_active Not-in-force
- 2014-04-25 SG SG11201508910WA patent/SG11201508910WA/en unknown
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- 2014-04-25 PE PE2015002314A patent/PE20151925A1/es unknown
- 2014-04-25 WO PCT/EP2014/058418 patent/WO2014177461A1/en active Application Filing
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2015
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- 2015-10-26 PH PH12015502469A patent/PH12015502469A1/en unknown
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2016
- 2016-02-11 HK HK16101485.2A patent/HK1213577A1/zh unknown
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2019
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Publication number | Publication date |
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KR20160003803A (ko) | 2016-01-11 |
AU2014261631A1 (en) | 2015-10-29 |
MX2015015059A (es) | 2016-02-25 |
ZA201507386B (en) | 2018-05-30 |
EA201501061A1 (ru) | 2016-05-31 |
TWI653243B (zh) | 2019-03-11 |
WO2014177461A1 (en) | 2014-11-06 |
MX2019005299A (es) | 2019-08-29 |
EP2992011A1 (en) | 2016-03-09 |
US20160151487A1 (en) | 2016-06-02 |
CA2908653A1 (en) | 2014-11-06 |
CL2015003174A1 (es) | 2016-06-03 |
HK1213577A1 (zh) | 2016-07-08 |
EP3327034A1 (en) | 2018-05-30 |
JP2016528168A (ja) | 2016-09-15 |
CR20150585A (es) | 2016-01-08 |
SG10201810481UA (en) | 2018-12-28 |
CN105164158A (zh) | 2015-12-16 |
PE20151925A1 (es) | 2015-12-26 |
JP2019167363A (ja) | 2019-10-03 |
MX364861B (es) | 2019-05-09 |
AU2014261631B2 (en) | 2019-02-14 |
EP2992011B1 (en) | 2017-12-13 |
TW201920285A (zh) | 2019-06-01 |
TW201446802A (zh) | 2014-12-16 |
BR112015027399A2 (pt) | 2017-08-29 |
EA034716B1 (ru) | 2020-03-12 |
IL274398A (en) | 2020-06-30 |
SG11201508910WA (en) | 2015-11-27 |
PH12015502469A1 (en) | 2016-02-22 |
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