SG10201810481UA - Fcrn-binding abolished anti-igf-1r antibodies and their use in the treatment of vascular eye diseases - Google Patents

Fcrn-binding abolished anti-igf-1r antibodies and their use in the treatment of vascular eye diseases

Info

Publication number
SG10201810481UA
SG10201810481UA SG10201810481UA SG10201810481UA SG10201810481UA SG 10201810481U A SG10201810481U A SG 10201810481UA SG 10201810481U A SG10201810481U A SG 10201810481UA SG 10201810481U A SG10201810481U A SG 10201810481UA SG 10201810481U A SG10201810481U A SG 10201810481UA
Authority
SG
Singapore
Prior art keywords
igf
antibodies
fcrn
treatment
eye diseases
Prior art date
Application number
SG10201810481UA
Inventor
Guido Hartmann
Joerg Thomas Regula
Matthias Rueth
Wolfgang Schaefer
Tilman Schlothauer
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of SG10201810481UA publication Critical patent/SG10201810481UA/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

FcRn-binding abolished anti-IGF-1R antibodies and their use in the treatment of vascular eye diseases The invention provides anti-IGF-1R antibodies with abolished FcRn-binding and methods of using the same for the treatment of vascular eye diseases. [Figure 4]
SG10201810481UA 2013-04-29 2014-04-25 Fcrn-binding abolished anti-igf-1r antibodies and their use in the treatment of vascular eye diseases SG10201810481UA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13165741 2013-04-29
EP14151318 2014-01-15

Publications (1)

Publication Number Publication Date
SG10201810481UA true SG10201810481UA (en) 2018-12-28

Family

ID=50639475

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201508910WA SG11201508910WA (en) 2013-04-29 2014-04-25 Fcrn-binding abolished anti-igf-1r antibodies and their use in the treatment of vascular eye diseases
SG10201810481UA SG10201810481UA (en) 2013-04-29 2014-04-25 Fcrn-binding abolished anti-igf-1r antibodies and their use in the treatment of vascular eye diseases

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG11201508910WA SG11201508910WA (en) 2013-04-29 2014-04-25 Fcrn-binding abolished anti-igf-1r antibodies and their use in the treatment of vascular eye diseases

Country Status (21)

Country Link
US (1) US20160151487A1 (en)
EP (2) EP2992011B1 (en)
JP (2) JP2016528168A (en)
KR (1) KR20160003803A (en)
CN (1) CN105164158A (en)
AU (1) AU2014261631B2 (en)
BR (1) BR112015027399A2 (en)
CA (1) CA2908653A1 (en)
CL (1) CL2015003174A1 (en)
CR (1) CR20150585A (en)
EA (1) EA034716B1 (en)
HK (1) HK1213577A1 (en)
IL (1) IL274398A (en)
MX (2) MX364861B (en)
PE (1) PE20151925A1 (en)
PH (1) PH12015502469A1 (en)
SG (2) SG11201508910WA (en)
TW (2) TW201920285A (en)
UA (1) UA118674C2 (en)
WO (1) WO2014177461A1 (en)
ZA (1) ZA201507386B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
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ES2746136T3 (en) 2013-04-29 2020-03-04 Hoffmann La Roche Modified Human FcRn Binding Antibodies and Methods of Use
CN110903398B (en) * 2014-01-15 2023-08-15 豪夫迈·罗氏有限公司 Fc region variants with modified FCRN and maintained protein A binding properties
KR20160104636A (en) * 2014-01-15 2016-09-05 에프. 호프만-라 로슈 아게 Fc-region variants with improved protein a-binding
WO2015107025A1 (en) * 2014-01-15 2015-07-23 F. Hoffmann-La Roche Ag Fc-region variants with modified fcrn-binding properties
MX2017005150A (en) * 2014-11-06 2017-08-08 Hoffmann La Roche Fc-region variants with modified fcrn- and protein a-binding properties.
US20210238308A1 (en) * 2018-06-04 2021-08-05 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule showing changed half-life in cytoplasm
CA3141471A1 (en) * 2019-07-02 2021-01-07 Michael Paul Wheatcroft Antibodies for binding psma with reduced affinity for the neonatal fc receptor
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WO2021051136A1 (en) * 2019-09-13 2021-03-18 The University Of Chicago Methods and compositions for treating staphylococcal infections

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Also Published As

Publication number Publication date
MX2019005299A (en) 2019-08-29
IL274398A (en) 2020-06-30
EA201501061A1 (en) 2016-05-31
EP3327034A1 (en) 2018-05-30
TWI653243B (en) 2019-03-11
MX364861B (en) 2019-05-09
PH12015502469A1 (en) 2016-02-22
JP2019167363A (en) 2019-10-03
CL2015003174A1 (en) 2016-06-03
KR20160003803A (en) 2016-01-11
AU2014261631A1 (en) 2015-10-29
CN105164158A (en) 2015-12-16
EP2992011A1 (en) 2016-03-09
ZA201507386B (en) 2018-05-30
EA034716B1 (en) 2020-03-12
TW201920285A (en) 2019-06-01
JP2016528168A (en) 2016-09-15
TW201446802A (en) 2014-12-16
MX2015015059A (en) 2016-02-25
UA118674C2 (en) 2019-02-25
SG11201508910WA (en) 2015-11-27
PE20151925A1 (en) 2015-12-26
AU2014261631B2 (en) 2019-02-14
US20160151487A1 (en) 2016-06-02
HK1213577A1 (en) 2016-07-08
EP2992011B1 (en) 2017-12-13
CA2908653A1 (en) 2014-11-06
WO2014177461A1 (en) 2014-11-06
BR112015027399A2 (en) 2017-08-29
CR20150585A (en) 2016-01-08

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