UA101414C2 - Аминотетрагидропираны как ингибиторы дипептидилпептидазы-iv для лечения или предупреждения диабета - Google Patents

Аминотетрагидропираны как ингибиторы дипептидилпептидазы-iv для лечения или предупреждения диабета Download PDF

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UA101414C2
UA101414C2 UAA201107305A UAA201107305A UA101414C2 UA 101414 C2 UA101414 C2 UA 101414C2 UA A201107305 A UAA201107305 A UA A201107305A UA A201107305 A UAA201107305 A UA A201107305A UA 101414 C2 UA101414 C2 UA 101414C2
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compounds
mmol
inhibitors
dpp
pyran
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UAA201107305A
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English (en)
Ukrainian (uk)
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Тесфайе Бифту
Пин Чень
Джейсон М. Кокс
Энн Э. Вебер
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Мерк Шарп Енд Доме Корп.
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Application filed by Мерк Шарп Енд Доме Корп. filed Critical Мерк Шарп Енд Доме Корп.
Publication of UA101414C2 publication Critical patent/UA101414C2/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

Данное изобретение относится к новым замещенным аминотетрагидропиранам структурной формулы I, которые являются ингибиторами фермента дипептидилпептидаза-IV и которые применяют для лечения или предупреждения заболеваний, в которые привлечен фермент дипептидилпептидаза-IV, таких как диабет, особенно диабет 2 типа. Данное изобретение также связано с фармацевтическими композициями, которые содержат эти соединения, и применением этих соединений и композиций для предупреждения и лечения таких заболеваний, в которые привлечен фермент дипептидилпептидаза-IV.(I)
UAA201107305A 2008-11-13 2009-11-11 Аминотетрагидропираны как ингибиторы дипептидилпептидазы-iv для лечения или предупреждения диабета UA101414C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19917908P 2008-11-13 2008-11-13
PCT/US2009/063976 WO2010056708A1 (en) 2008-11-13 2009-11-11 Aminotetrahydropyrans as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes

Publications (1)

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UA101414C2 true UA101414C2 (ru) 2013-03-25

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US (8) US8143289B2 (ru)
EP (4) EP2676960B1 (ru)
JP (2) JP4854825B1 (ru)
KR (2) KR101260162B1 (ru)
CN (1) CN102272136B (ru)
AR (1) AR074306A1 (ru)
AU (1) AU2009314191B2 (ru)
BR (1) BRPI0921375B8 (ru)
CA (1) CA2742783C (ru)
CL (1) CL2011001082A1 (ru)
CO (1) CO6382129A2 (ru)
CR (1) CR20110257A (ru)
CY (1) CY1114617T1 (ru)
DK (1) DK2358717T3 (ru)
DO (1) DOP2011000128A (ru)
EA (1) EA018613B1 (ru)
EC (1) ECSP11011044A (ru)
ES (1) ES2432191T3 (ru)
GE (1) GEP20135724B (ru)
HK (1) HK1154849A1 (ru)
HN (1) HN2011001256A (ru)
HR (1) HRP20130924T1 (ru)
IL (2) IL212485A (ru)
JO (1) JO2870B1 (ru)
MA (1) MA32887B1 (ru)
MX (1) MX2011005044A (ru)
MY (1) MY150787A (ru)
NI (1) NI201100081A (ru)
NZ (1) NZ592826A (ru)
PA (1) PA8848201A1 (ru)
PE (1) PE20120027A1 (ru)
PL (1) PL2358717T3 (ru)
PT (1) PT2358717E (ru)
RS (1) RS52946B (ru)
SI (1) SI2358717T1 (ru)
SV (1) SV2011003903A (ru)
TN (1) TN2011000201A1 (ru)
TW (1) TWI398443B (ru)
UA (1) UA101414C2 (ru)
WO (1) WO2010056708A1 (ru)

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