TWI879793B - 核酸化合物的製造方法及核酸化合物 - Google Patents

核酸化合物的製造方法及核酸化合物 Download PDF

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Publication number
TWI879793B
TWI879793B TW109129448A TW109129448A TWI879793B TW I879793 B TWI879793 B TW I879793B TW 109129448 A TW109129448 A TW 109129448A TW 109129448 A TW109129448 A TW 109129448A TW I879793 B TWI879793 B TW I879793B
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TW
Taiwan
Prior art keywords
group
formula
nucleic acid
ring
acid compound
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TW109129448A
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English (en)
Chinese (zh)
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TW202115097A (zh
Inventor
金子和平
高橋基將
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日商富士軟片股份有限公司
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Publication of TW202115097A publication Critical patent/TW202115097A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
TW109129448A 2019-08-29 2020-08-28 核酸化合物的製造方法及核酸化合物 TWI879793B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2019157402 2019-08-29
JP2019-157402 2019-08-29

Publications (2)

Publication Number Publication Date
TW202115097A TW202115097A (zh) 2021-04-16
TWI879793B true TWI879793B (zh) 2025-04-11

Family

ID=74684238

Family Applications (1)

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TW109129448A TWI879793B (zh) 2019-08-29 2020-08-28 核酸化合物的製造方法及核酸化合物

Country Status (5)

Country Link
US (1) US12509484B2 (https=)
EP (1) EP4006045A4 (https=)
JP (2) JP7814933B2 (https=)
TW (1) TWI879793B (https=)
WO (1) WO2021039935A1 (https=)

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EP3932899A4 (en) 2019-02-28 2022-04-20 FUJIFILM Corporation METHOD FOR PRODUCING A PEPTIDE COMPOUND, PROTECTIVE GROUP-FORMING REAGENT AND FUSED POLYCYCLIC AROMATIC HYDROCARBON COMPOUND
EP3916000B1 (en) * 2019-02-28 2026-04-08 FUJIFILM Corporation Method for producing peptide compound, protecting group-forming reagent, and aromatic heterocyclic compound
EP4006045A4 (en) 2019-08-29 2022-10-19 FUJIFILM Corporation METHOD FOR PRODUCTION OF A NUCLEIC ACID COMPOUND AND NUCLEIC ACID COMPOUND
EP4293035A4 (en) 2021-02-12 2025-03-05 Ajinomoto Co., Inc. METHOD FOR THE PRODUCTION OF OLIGONUCLEOTIDES
WO2024083746A1 (en) 2022-10-17 2024-04-25 Bachem Holding Ag Method and composition for oligonucleotide synthesis
EP4695265A1 (en) 2023-10-16 2026-02-18 Bachem Holding AG Method and composition for oligonucleotide synthesis
WO2025229953A1 (ja) * 2024-04-30 2025-11-06 住友化学株式会社 オリゴヌクレオチドの製造方法

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TW201734030A (zh) * 2016-03-14 2017-10-01 身體邏輯股份有限公司 用於合成吲哚環核鹼基結合物之組成物及方法
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EP3916000B1 (en) 2019-02-28 2026-04-08 FUJIFILM Corporation Method for producing peptide compound, protecting group-forming reagent, and aromatic heterocyclic compound
EP3932899A4 (en) 2019-02-28 2022-04-20 FUJIFILM Corporation METHOD FOR PRODUCING A PEPTIDE COMPOUND, PROTECTIVE GROUP-FORMING REAGENT AND FUSED POLYCYCLIC AROMATIC HYDROCARBON COMPOUND
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EP4006045A4 (en) 2019-08-29 2022-10-19 FUJIFILM Corporation METHOD FOR PRODUCTION OF A NUCLEIC ACID COMPOUND AND NUCLEIC ACID COMPOUND

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JP5979139B2 (ja) * 2011-05-17 2016-08-24 味の素株式会社 オリゴヌクレオチドの製造方法
US9284344B2 (en) * 2012-05-30 2016-03-15 Hokkaido System Science Co., Ltd. Oligonucleotide synthesis method using highly dispersible liquid-phase support
CN108473526A (zh) * 2015-12-16 2018-08-31 味之素株式会社 寡核苷酸的制备方法以及核苷、核苷酸或寡核苷酸
TW201734030A (zh) * 2016-03-14 2017-10-01 身體邏輯股份有限公司 用於合成吲哚環核鹼基結合物之組成物及方法

Also Published As

Publication number Publication date
JP7776478B2 (ja) 2025-11-26
JP7814933B2 (ja) 2026-02-17
EP4006045A4 (en) 2022-10-19
US12509484B2 (en) 2025-12-30
US20220259255A1 (en) 2022-08-18
JPWO2021039935A1 (https=) 2021-03-04
TW202115097A (zh) 2021-04-16
WO2021039935A1 (ja) 2021-03-04
EP4006045A1 (en) 2022-06-01
JP2024009042A (ja) 2024-01-19

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