TWI878203B - 包含pedf-衍生之短肽之組合物及其用途 - Google Patents

包含pedf-衍生之短肽之組合物及其用途 Download PDF

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Publication number
TWI878203B
TWI878203B TW106133749A TW106133749A TWI878203B TW I878203 B TWI878203 B TW I878203B TW 106133749 A TW106133749 A TW 106133749A TW 106133749 A TW106133749 A TW 106133749A TW I878203 B TWI878203 B TW I878203B
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Taiwan
Prior art keywords
pdsp
peptide
seq
pharmaceutical composition
cells
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TW106133749A
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English (en)
Chinese (zh)
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TW201822785A (zh
Inventor
文機 李
林冠吟
曹友平
何宗權
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全福生物科技股份有限公司
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/515—Angiogenesic factors; Angiogenin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Vascular Medicine (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
TW106133749A 2016-10-07 2017-09-29 包含pedf-衍生之短肽之組合物及其用途 TWI878203B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662405522P 2016-10-07 2016-10-07
US62/405,522 2016-10-07

Publications (2)

Publication Number Publication Date
TW201822785A TW201822785A (zh) 2018-07-01
TWI878203B true TWI878203B (zh) 2025-04-01

Family

ID=61831898

Family Applications (1)

Application Number Title Priority Date Filing Date
TW106133749A TWI878203B (zh) 2016-10-07 2017-09-29 包含pedf-衍生之短肽之組合物及其用途

Country Status (10)

Country Link
US (1) US11760784B2 (show.php)
EP (1) EP3596104A4 (show.php)
JP (2) JP7573967B2 (show.php)
KR (2) KR20190066030A (show.php)
CN (1) CN110312732A (show.php)
AU (2) AU2017340245B2 (show.php)
EA (1) EA037698B1 (show.php)
IL (1) IL265796B2 (show.php)
TW (1) TWI878203B (show.php)
WO (2) WO2018067244A1 (show.php)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI902660B (zh) * 2018-04-08 2025-11-01 全福生物科技股份有限公司 Pedf衍生之短肽在治療骨關節炎中的應用
AU2019251091A1 (en) * 2018-04-08 2020-11-26 Brim Biotechnology, Inc. Application of PEDF-derived short peptides in tendon healing
EA202092646A1 (ru) * 2018-05-04 2021-02-11 Брим Байотекнолоджи, Инк. Происходящие из pedf пептиды для промотирования регенерации мейбомиевой железы и их применения
CN111632128B (zh) * 2019-02-14 2022-07-05 三凡生技研发股份有限公司 短链胜肽组合物在预防或治疗干眼症的应用
TWI759610B (zh) * 2019-06-27 2022-04-01 晶碩光學股份有限公司 具有角膜修護功能的眼用產品
WO2021035515A1 (en) * 2019-08-27 2021-03-04 Tsao Yeou Ping Short synthetic peptide and their uses for treating retinal degenerative diseases and/or tissue injuries
TWI744683B (zh) * 2019-08-27 2021-11-01 台灣基督長老教會馬偕醫療財團法人馬偕紀念醫院 短合成胜肽及其治療視網膜退化性疾病和/或組織損傷的用途
KR20230106115A (ko) * 2019-10-06 2023-07-12 브림 바이오테크놀로지, 인코퍼레이티드 Pedf-유래된 짧은 펩타이드 (pdsp)를 포함하는 조성물 및 그것의 사용
CN112206312A (zh) * 2020-11-19 2021-01-12 北京大学第三医院（北京大学第三临床医学院） 一种包含pedf的用于治疗干眼的药物组合物
CN115364199A (zh) * 2021-05-19 2022-11-22 远大医药（中国）有限公司 包含pedf衍生的短肽的组合物及其制备方法和用途
AU2023292282A1 (en) * 2022-06-13 2025-01-23 Brim Biotechnology, Inc. Compositions comprising pedf-derived short peptides for the treatment of dry eye diseases
TW202400628A (zh) * 2022-06-24 2024-01-01 全福生物科技股份有限公司 用於治療神經營養性角膜炎疾病之包含pedf衍生短肽之組合物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2508196A1 (en) * 2011-03-23 2012-10-10 Mackay Memorial Hospital Use of PEDF-derived polypeptides for promoting stem cells proliferation and wound healing
US20150079094A1 (en) * 2013-09-13 2015-03-19 The Penn State Research Foundation Functional Peptide Analogs of PEDF

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6451763B1 (en) * 1992-06-04 2002-09-17 The United States Of America As Represented By The Department Of Health And Human Services Retinal pigmented epithelium derived neurotrophic factor and methods of use
US6797691B1 (en) * 1997-07-23 2004-09-28 Northwestern University Methods and compositions for inhibiting angiogenesis
EP1684692A2 (en) * 2003-10-29 2006-08-02 The Johns Hopkins University Pigment epithelium-derived factor, novel biological activity and methods of use
JP2007528903A (ja) * 2004-03-12 2007-10-18 ジェンベク、インコーポレイティッド 眼における血管漏出を処置するための物質
US20090069241A1 (en) * 2006-02-15 2009-03-12 Yale University Compositions and Methods for Use of Pigment Epithelial Derived Factor (PEDF) Peptide Fragments
EP2537937A3 (en) * 2008-04-29 2013-04-10 Monsanto Technology LLC Genes and uses for plant enhancement
JP2013507373A (ja) * 2009-10-08 2013-03-04 ニューロテック ユーエスエー， インコーポレイテッド 被包された細胞ベースの送達系におけるｐｅｄｆの使用
TWI554521B (zh) * 2011-10-19 2016-10-21 台灣基督長老教會馬偕醫療財團法人馬偕紀念醫院 色素上皮衍生因子衍生之多胜肽於治療禿髮和／或毛髮脫色之用途
JP6228977B2 (ja) * 2012-08-09 2017-11-15 マクカイ メモリアル ホスピタル 筋肉若しくは腱再生又は動脈形成を促進するためのｐｅｄｆ由来のポリペプチドの使用
AU2012390200B2 (en) * 2012-09-19 2017-06-29 Mackay Memorial Hospital Use of pedf-derived polypeptides for preventing and/or ameliorating skin aging
CN104903344B (zh) * 2012-09-20 2018-09-04 财团法人台湾基督长老教会马偕纪念社会事业基金会马偕纪念医院 Pedf衍生的多肽在治疗骨关节炎中的用途

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2508196A1 (en) * 2011-03-23 2012-10-10 Mackay Memorial Hospital Use of PEDF-derived polypeptides for promoting stem cells proliferation and wound healing
US20150079094A1 (en) * 2013-09-13 2015-03-19 The Penn State Research Foundation Functional Peptide Analogs of PEDF

Also Published As

Publication number Publication date
US20190248859A1 (en) 2019-08-15
JP2019533722A (ja) 2019-11-21
EA037698B1 (ru) 2021-05-12
WO2018067217A3 (en) 2019-05-02
JP2022185042A (ja) 2022-12-13
IL265796B2 (en) 2025-02-01
TW201822785A (zh) 2018-07-01
WO2018067244A1 (en) 2018-04-12
CN110312732A (zh) 2019-10-08
EP3596104A1 (en) 2020-01-22
IL265796B1 (en) 2024-10-01
KR20230169375A (ko) 2023-12-15
JP7573967B2 (ja) 2024-10-28
AU2022204557A1 (en) 2022-07-21
IL265796A (en) 2019-06-30
WO2018067217A2 (en) 2018-04-12
US11760784B2 (en) 2023-09-19
EP3596104A4 (en) 2021-02-17
EA201990885A1 (ru) 2019-08-30
KR20190066030A (ko) 2019-06-12
AU2017340245A1 (en) 2019-05-23
AU2017340245B2 (en) 2022-07-21

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