JP6228977B2 - 筋肉若しくは腱再生又は動脈形成を促進するためのpedf由来のポリペプチドの使用 - Google Patents
筋肉若しくは腱再生又は動脈形成を促進するためのpedf由来のポリペプチドの使用 Download PDFInfo
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- JP6228977B2 JP6228977B2 JP2015525704A JP2015525704A JP6228977B2 JP 6228977 B2 JP6228977 B2 JP 6228977B2 JP 2015525704 A JP2015525704 A JP 2015525704A JP 2015525704 A JP2015525704 A JP 2015525704A JP 6228977 B2 JP6228977 B2 JP 6228977B2
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- A—HUMAN NECESSITIES
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- A61K9/00—Medicinal preparations characterised by special physical form
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- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
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- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Health & Medical Sciences (AREA)
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- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
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- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
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- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Description
(1.発明の分野)
以下は、読者に基本的理解を提供するために、本開示の簡単な概要を提供する。この概要は、本開示の広範な全体像ではなく、本発明の鍵となる/重要な要素を特定せず、本発明の範囲の線引きもしない。その唯一の目的は、後に提供する、より詳細な説明への前置きとしての簡単な形で、本明細書に開示されるある種の概念を提供することである。
本特許及び出願は、カラーで製作された少なくとも1つの図面を含有する。カラーの図面を伴うこの特許又は特許出願公開の複写は、請求及び必要な料金の支払い後に、事務所によって提供されることとなる。
添付の図面に関連して以下に提供する詳細な説明は、本発明の実施例の説明を目的とし、本発明の実施例が構成又は利用され得る唯一の形態を表すことを意図しない。この説明は、実施例の目的、及び実施例を構成及び操作するためのステップの順序を述べる。しかし、異なる例によって、同一又は同等の目的及び順序を実現することもできる。
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Claims (4)
- 20〜39アミノ酸残基の長さを有するアミノ酸配列からなる合成ペプチドを含む、対象における筋肉再生、腱再生、又は動脈形成を促進するための医薬組成物であって、該アミノ酸配列が、配列番号:1〜3、5、6、8及び9からなる群から選択される配列を少なくとも含み、該医薬組成物が、持続放出形態で製剤化されている、前記医薬組成物。
- 医薬として許容し得る担体を更に含み、該医薬として許容し得る担体が、アルギン酸、ゼラチン、コラーゲン、及びポリ(ラクチド-コ-グリコリド)からなる群から選択される高分子材料である、請求項1記載の医薬組成物。
- 前記高分子材料が、アルギン酸である、請求項2記載の医薬組成物。
- 筋肉内注射用に製剤化されている、請求項1〜3のいずれか1項記載の医薬組成物。
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/CN2012/079897 WO2014023007A1 (en) | 2012-08-09 | 2012-08-09 | Use of pedf-derived polypeptides for promoting muscle or tendon regeneration or arteriogenesis |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2017082518A Division JP2017165745A (ja) | 2017-04-19 | 2017-04-19 | 筋肉若しくは腱再生又は動脈形成を促進するためのpedf由来のポリペプチドの使用 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2015525786A JP2015525786A (ja) | 2015-09-07 |
JP6228977B2 true JP6228977B2 (ja) | 2017-11-15 |
Family
ID=50067394
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2015525704A Active JP6228977B2 (ja) | 2012-08-09 | 2012-08-09 | 筋肉若しくは腱再生又は動脈形成を促進するためのpedf由来のポリペプチドの使用 |
Country Status (12)
Country | Link |
---|---|
US (1) | US9884012B2 (ja) |
EP (3) | EP3342781B1 (ja) |
JP (1) | JP6228977B2 (ja) |
KR (1) | KR101801198B1 (ja) |
CN (1) | CN104854129B (ja) |
AU (1) | AU2012387503B2 (ja) |
BR (1) | BR112015002828B1 (ja) |
CA (1) | CA2882479C (ja) |
EA (1) | EA033145B1 (ja) |
IL (1) | IL237137B (ja) |
MX (1) | MX360187B (ja) |
WO (1) | WO2014023007A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2017165745A (ja) * | 2017-04-19 | 2017-09-21 | マクカイ メモリアル ホスピタル | 筋肉若しくは腱再生又は動脈形成を促進するためのpedf由来のポリペプチドの使用 |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2895502B1 (en) * | 2012-09-17 | 2018-09-05 | Mackay Memorial Hospital | Use of pedf-derived polypeptides for treating alopecia and/or hair depigmentation |
EP2897976B1 (en) | 2012-09-19 | 2017-08-09 | Mackay Memorial Hospital | Use of pedf-derived peptides for preventing and/or ameliorating skin aging |
US9777048B2 (en) | 2012-09-20 | 2017-10-03 | Mackay Memorial Hospital | Use of PEDF-derived polypeptides for treating osteoarthritis |
KR20230169375A (ko) * | 2016-10-07 | 2023-12-15 | 브림 바이오테크놀로지, 인코퍼레이티드 | Pedf-유래 짧은 펩타이드를 포함하는 조성물 및 그것의 사용 |
JP6522063B2 (ja) * | 2017-08-10 | 2019-05-29 | マクカイ メモリアル ホスピタル | 脱毛症及び/又は毛髪色素脱失を治療するためのpedf由来のポリペプチドの使用 |
CN107602691A (zh) * | 2017-08-22 | 2018-01-19 | 徐州医科大学 | 色素上皮衍生因子的衍生多肽系列对于保护缺血心肌的用途 |
AU2019251091A1 (en) * | 2018-04-08 | 2020-11-26 | Brim Biotechnology, Inc. | Application of PEDF-derived short peptides in tendon healing |
CN115364199A (zh) * | 2021-05-19 | 2022-11-22 | 远大医药(中国)有限公司 | 包含pedf衍生的短肽的组合物及其制备方法和用途 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2003275259A1 (en) * | 2002-09-26 | 2004-04-19 | Northwestern University | Anti-angiogenic fragments of pigment epithelium-derived factor (pedf) |
EP1986676A4 (en) | 2006-02-15 | 2009-11-04 | Univ Yale Inc | COMPOSITIONS AND METHODS USING PIGMENT EPITHELIUM DERIVED FACTOR (PEDF) PEPTIDE FRAGMENTS |
ES2329636B2 (es) * | 2006-02-17 | 2010-07-26 | Universitat De Valencia, Estudi General (Participa Con El 70%) | Uso del factor pedf para inducir la auto-renovacion de celulas madre. |
WO2009116529A1 (ja) * | 2008-03-18 | 2009-09-24 | 国立大学法人 北海道大学 | ポリペプチドおよび当該ポリペプチドを含む医薬組成物 |
WO2010037395A2 (en) | 2008-10-01 | 2010-04-08 | Dako Denmark A/S | Mhc multimers in cancer vaccines and immune monitoring |
CN101544696A (zh) * | 2009-04-24 | 2009-09-30 | 焦春 | 含色素上皮衍生因子的复合物及其制备方法和应用 |
CN102183661B (zh) * | 2011-03-16 | 2014-05-28 | 天津宝瑞生物技术有限公司 | 蛋白质及蛋白质组在制备肝硬化诊断试剂中的应用 |
EP2508196B1 (en) * | 2011-03-23 | 2018-09-26 | Mackay Memorial Hospital | Use of PEDF-derived polypeptides for promoting stem cells proliferation and wound healing |
-
2012
- 2012-08-09 JP JP2015525704A patent/JP6228977B2/ja active Active
- 2012-08-09 EP EP17204186.5A patent/EP3342781B1/en active Active
- 2012-08-09 CN CN201280075699.7A patent/CN104854129B/zh active Active
- 2012-08-09 BR BR112015002828-4A patent/BR112015002828B1/pt active IP Right Grant
- 2012-08-09 EA EA201590329A patent/EA033145B1/ru not_active IP Right Cessation
- 2012-08-09 CA CA2882479A patent/CA2882479C/en active Active
- 2012-08-09 EP EP12882702.9A patent/EP2882772B1/en active Active
- 2012-08-09 KR KR1020157005611A patent/KR101801198B1/ko active IP Right Grant
- 2012-08-09 US US14/420,581 patent/US9884012B2/en active Active
- 2012-08-09 MX MX2015001721A patent/MX360187B/es active IP Right Grant
- 2012-08-09 WO PCT/CN2012/079897 patent/WO2014023007A1/en active Application Filing
- 2012-08-09 EP EP17204179.0A patent/EP3339317A1/en not_active Withdrawn
- 2012-08-09 AU AU2012387503A patent/AU2012387503B2/en active Active
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2015
- 2015-02-08 IL IL237137A patent/IL237137B/en active IP Right Grant
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2017165745A (ja) * | 2017-04-19 | 2017-09-21 | マクカイ メモリアル ホスピタル | 筋肉若しくは腱再生又は動脈形成を促進するためのpedf由来のポリペプチドの使用 |
Also Published As
Publication number | Publication date |
---|---|
EA033145B1 (ru) | 2019-09-30 |
BR112015002828B1 (pt) | 2022-09-13 |
EP3342781A1 (en) | 2018-07-04 |
BR112015002828A2 (ja) | 2017-08-15 |
IL237137A0 (en) | 2015-04-30 |
IL237137B (en) | 2019-01-31 |
NZ705492A (en) | 2016-06-24 |
EP2882772A1 (en) | 2015-06-17 |
CN104854129A (zh) | 2015-08-19 |
MX2015001721A (es) | 2015-07-06 |
CA2882479A1 (en) | 2014-02-13 |
JP2015525786A (ja) | 2015-09-07 |
EP3342781B1 (en) | 2019-07-24 |
US20160000862A1 (en) | 2016-01-07 |
CN104854129B (zh) | 2019-12-31 |
MX360187B (es) | 2018-10-24 |
KR20150058177A (ko) | 2015-05-28 |
CA2882479C (en) | 2018-07-24 |
AU2012387503B2 (en) | 2016-11-03 |
EP3339317A1 (en) | 2018-06-27 |
KR101801198B1 (ko) | 2017-11-24 |
WO2014023007A1 (en) | 2014-02-13 |
AU2012387503A1 (en) | 2015-03-19 |
US9884012B2 (en) | 2018-02-06 |
EP2882772B1 (en) | 2017-12-20 |
EA201590329A1 (ru) | 2015-07-30 |
EP2882772A4 (en) | 2016-01-27 |
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