EA201590329A1 - Использование полученных из pedf полипептидов для стимуляции регенерации или артериогенеза в мышцах или сухожилиях - Google Patents

Использование полученных из pedf полипептидов для стимуляции регенерации или артериогенеза в мышцах или сухожилиях

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Publication number
EA201590329A1
EA201590329A1 EA201590329A EA201590329A EA201590329A1 EA 201590329 A1 EA201590329 A1 EA 201590329A1 EA 201590329 A EA201590329 A EA 201590329A EA 201590329 A EA201590329 A EA 201590329A EA 201590329 A1 EA201590329 A1 EA 201590329A1
Authority
EA
Eurasian Patent Office
Prior art keywords
arteriogenesis
pedf
muscle
dress
polypeptides obtained
Prior art date
Application number
EA201590329A
Other languages
English (en)
Other versions
EA033145B1 (ru
Inventor
Йеоу-Пин Цао
Цунь-Чуань Хо
Original Assignee
Маккей Мемориал Хоспитал
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Маккей Мемориал Хоспитал filed Critical Маккей Мемориал Хоспитал
Publication of EA201590329A1 publication Critical patent/EA201590329A1/ru
Publication of EA033145B1 publication Critical patent/EA033145B1/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Medicinal Preparation (AREA)

Abstract

Изобретение относится к полученному из PEDF синтетическому пептиду, который имеет 20-39 аминокислотных остатков. Также рассмотрены фармацевтические композиции, содержащие синтетический пептид, и их применение. Пептид является полезным для стимуляции у субъекта регенерации мышц или сухожилий и/или артериогенеза.
EA201590329A 2012-08-09 2012-08-09 Применение полученных из pedf пептидов в стимуляции регенерации мышцы, регенерации сухожилия или артериогенеза EA033145B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2012/079897 WO2014023007A1 (en) 2012-08-09 2012-08-09 Use of pedf-derived polypeptides for promoting muscle or tendon regeneration or arteriogenesis

Publications (2)

Publication Number Publication Date
EA201590329A1 true EA201590329A1 (ru) 2015-07-30
EA033145B1 EA033145B1 (ru) 2019-09-30

Family

ID=50067394

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201590329A EA033145B1 (ru) 2012-08-09 2012-08-09 Применение полученных из pedf пептидов в стимуляции регенерации мышцы, регенерации сухожилия или артериогенеза

Country Status (12)

Country Link
US (1) US9884012B2 (ru)
EP (3) EP3339317A1 (ru)
JP (1) JP6228977B2 (ru)
KR (1) KR101801198B1 (ru)
CN (1) CN104854129B (ru)
AU (1) AU2012387503B2 (ru)
BR (1) BR112015002828B1 (ru)
CA (1) CA2882479C (ru)
EA (1) EA033145B1 (ru)
IL (1) IL237137B (ru)
MX (1) MX360187B (ru)
WO (1) WO2014023007A1 (ru)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9938328B2 (en) 2012-09-17 2018-04-10 Mackay Memorial Hospital Use of PEDF-derived polypeptides for treating alopecia and/or hair depigmentation
US9815878B2 (en) 2012-09-19 2017-11-14 Mackay Memorial Hospital Use of PEDF-derived polypeptides for preventing and/or ameliorating skin aging
CN104903344B (zh) 2012-09-20 2018-09-04 财团法人台湾基督长老教会马偕纪念社会事业基金会马偕纪念医院 Pedf衍生的多肽在治疗骨关节炎中的用途
EA037698B1 (ru) * 2016-10-07 2021-05-12 Брим Байотекнолоджи, Инк. Композиции, содержащие короткие пептиды, полученные из pedf, и их применение
JP2017165745A (ja) * 2017-04-19 2017-09-21 マクカイ メモリアル ホスピタル 筋肉若しくは腱再生又は動脈形成を促進するためのｐｅｄｆ由来のポリペプチドの使用
JP6522063B2 (ja) * 2017-08-10 2019-05-29 マクカイ メモリアル ホスピタル 脱毛症及び／又は毛髪色素脱失を治療するためのｐｅｄｆ由来のポリペプチドの使用
CN107602691A (zh) * 2017-08-22 2018-01-19 徐州医科大学 色素上皮衍生因子的衍生多肽系列对于保护缺血心肌的用途
KR20200142521A (ko) * 2018-04-08 2020-12-22 브림 바이오테크놀로지, 인코퍼레이티드 Pedf-유래 짧은 펩타이드의 힘줄 치유에의 적용
CN115364199A (zh) * 2021-05-19 2022-11-22 远大医药（中国）有限公司 包含pedf衍生的短肽的组合物及其制备方法和用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003275259A1 (en) * 2002-09-26 2004-04-19 Northwestern University Anti-angiogenic fragments of pigment epithelium-derived factor (pedf)
EP1986676A4 (en) * 2006-02-15 2009-11-04 Univ Yale Inc COMPOSITIONS AND METHODS USING PIGMENT EPITHELIUM DERIVED FACTOR (PEDF) PEPTIDE FRAGMENTS
ES2329636B2 (es) * 2006-02-17 2010-07-26 Universitat De Valencia, Estudi General (Participa Con El 70%) Uso del factor pedf para inducir la auto-renovacion de celulas madre.
JPWO2009116529A1 (ja) * 2008-03-18 2011-07-21 国立大学法人北海道大学 ポリペプチドおよび当該ポリペプチドを含む医薬組成物
US20110318380A1 (en) 2008-10-01 2011-12-29 Dako Denmark A/S MHC Multimers in Cancer Vaccines and Immune Monitoring
CN101544696A (zh) * 2009-04-24 2009-09-30 焦春 含色素上皮衍生因子的复合物及其制备方法和应用
CN102183661B (zh) * 2011-03-16 2014-05-28 天津宝瑞生物技术有限公司 蛋白质及蛋白质组在制备肝硬化诊断试剂中的应用
EP2508196B1 (en) 2011-03-23 2018-09-26 Mackay Memorial Hospital Use of PEDF-derived polypeptides for promoting stem cells proliferation and wound healing

Also Published As

Publication number Publication date
AU2012387503B2 (en) 2016-11-03
EP3339317A1 (en) 2018-06-27
CN104854129B (zh) 2019-12-31
EP3342781A1 (en) 2018-07-04
KR101801198B1 (ko) 2017-11-24
BR112015002828A2 (ru) 2017-08-15
EP3342781B1 (en) 2019-07-24
EP2882772A1 (en) 2015-06-17
US9884012B2 (en) 2018-02-06
US20160000862A1 (en) 2016-01-07
MX2015001721A (es) 2015-07-06
IL237137B (en) 2019-01-31
AU2012387503A1 (en) 2015-03-19
MX360187B (es) 2018-10-24
EA033145B1 (ru) 2019-09-30
CN104854129A (zh) 2015-08-19
KR20150058177A (ko) 2015-05-28
CA2882479C (en) 2018-07-24
WO2014023007A1 (en) 2014-02-13
EP2882772B1 (en) 2017-12-20
JP2015525786A (ja) 2015-09-07
JP6228977B2 (ja) 2017-11-15
BR112015002828B1 (pt) 2022-09-13
EP2882772A4 (en) 2016-01-27
CA2882479A1 (en) 2014-02-13
NZ705492A (en) 2016-06-24
IL237137A0 (en) 2015-04-30

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