TWI849355B - 含阿托平之水性組成物及其用途 - Google Patents

含阿托平之水性組成物及其用途 Download PDF

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Publication number
TWI849355B
TWI849355B TW110141612A TW110141612A TWI849355B TW I849355 B TWI849355 B TW I849355B TW 110141612 A TW110141612 A TW 110141612A TW 110141612 A TW110141612 A TW 110141612A TW I849355 B TWI849355 B TW I849355B
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TW
Taiwan
Prior art keywords
aqueous composition
buffer
atropine
buffers
item
Prior art date
Application number
TW110141612A
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English (en)
Chinese (zh)
Other versions
TW202206070A (zh
Inventor
長慧 陳
羅傑 布爾曼
淺田博之
高橋恭平
阪中浩二
森本隆司
藤澤豐實
Original Assignee
新加坡商新加坡保健集團私人有限公司
南洋理工大學
日商參天製藥股份有限公司
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=60411416&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TWI849355(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 新加坡商新加坡保健集團私人有限公司, 南洋理工大學, 日商參天製藥股份有限公司 filed Critical 新加坡商新加坡保健集團私人有限公司
Publication of TW202206070A publication Critical patent/TW202206070A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/08—Mydriatics or cycloplegics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Ophthalmology & Optometry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Materials For Photolithography (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
TW110141612A 2016-05-25 2017-05-24 含阿托平之水性組成物及其用途 TWI849355B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SG10201604200P 2016-05-25
SG10201604200P 2016-05-25

Publications (2)

Publication Number Publication Date
TW202206070A TW202206070A (zh) 2022-02-16
TWI849355B true TWI849355B (zh) 2024-07-21

Family

ID=60411416

Family Applications (3)

Application Number Title Priority Date Filing Date
TW110141612A TWI849355B (zh) 2016-05-25 2017-05-24 含阿托平之水性組成物及其用途
TW106117194A TWI791438B (zh) 2016-05-25 2017-05-24 含阿托平之水性組成物
TW112102321A TWI874894B (zh) 2016-05-25 2017-05-24 含阿托平之水性組成物

Family Applications After (2)

Application Number Title Priority Date Filing Date
TW106117194A TWI791438B (zh) 2016-05-25 2017-05-24 含阿托平之水性組成物
TW112102321A TWI874894B (zh) 2016-05-25 2017-05-24 含阿托平之水性組成物

Country Status (15)

Country Link
US (3) US20210267885A1 (enExample)
EP (2) EP3463360B2 (enExample)
JP (6) JP6590860B2 (enExample)
KR (4) KR102804061B1 (enExample)
CN (3) CN117205210A (enExample)
AR (1) AR108591A1 (enExample)
CA (1) CA3023149C (enExample)
EA (1) EA201892703A1 (enExample)
ES (1) ES2929368T3 (enExample)
MY (1) MY189774A (enExample)
PH (1) PH12018502421A1 (enExample)
SG (1) SG11201809822SA (enExample)
TW (3) TWI849355B (enExample)
UA (1) UA126195C2 (enExample)
WO (1) WO2017204262A1 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9421199B2 (en) 2014-06-24 2016-08-23 Sydnexis, Inc. Ophthalmic composition
WO2016172712A2 (en) * 2015-04-23 2016-10-27 Sydnexis, Inc. Ophthalmic composition
US11052094B2 (en) 2015-05-29 2021-07-06 Sydnexis, Inc. D2O stabilized pharmaceutical formulations
EP3585386A4 (en) 2017-02-21 2020-12-30 Singapore Health Services PTE Ltd COMPOSITION AND PROCESS FOR PREVENTING OR DELAYING THE ONCE OF MYOPIA INCLUDING ATROPINE
EP3970694A1 (en) 2017-05-11 2022-03-23 Vyluma Inc. Atropine pharmaceutical compositions
CN110934869B (zh) * 2018-09-25 2023-07-04 沈阳兴齐眼药股份有限公司 一种阿托品药物组合物和药盒产品
CN114533652B (zh) * 2018-09-25 2024-12-13 沈阳兴齐眼药股份有限公司 药物组合物、其制备方法和用途
MA52857A (fr) 2019-03-01 2021-04-21 Medivis S R L Formulations ophtalmiques à base d'atropine
CA3189821A1 (en) 2020-08-04 2022-02-10 Santen Pharmaceutical Co., Ltd. Agent for treating myopia, preventing myopia and/or suppressing myopia progression
KR20230087514A (ko) * 2020-10-14 2023-06-16 산텐 세이야꾸 가부시키가이샤 안정한 의약 조성물
PE20231656A1 (es) 2020-11-02 2023-10-17 Trethera Corp Formas cristalinas de un inhibidor de cinasa de desoxicitidina y sus usos
WO2022130337A1 (en) * 2020-12-17 2022-06-23 Sun Pharmaceutical Industries Limited An aqueous sterile solution of atropine for ophthalmic use
EP4088713A1 (en) 2021-05-10 2022-11-16 Warszawskie Zaklady Farmaceutyczne Polfa S.A. Ophthalmic pharmaceutical composition comprising atropine
EP4088714A1 (en) 2021-05-10 2022-11-16 Warszawskie Zaklady Farmaceutyczne Polfa S.A. Ophthalmic pharmaceutical composition comprising atropine
US20230120997A1 (en) * 2021-10-18 2023-04-20 Ocular Science, Inc. Compositions and methods for myopia control and orthokeratology lenses treatment
CN114129511A (zh) * 2021-12-07 2022-03-04 河南润弘制药股份有限公司 一种具有改进稳定性的硫酸阿托品注射液
JP7884090B2 (ja) * 2022-09-11 2026-07-02 アルコン インク． ベンジルアトロピンを含む水性医薬組成物及びその使用
WO2025018419A1 (ja) 2023-07-20 2025-01-23 センジュ ユーエスエー、インコーポレイテッド 水性液剤
JP7665073B1 (ja) 2024-04-05 2025-04-18 ロート製薬株式会社 容器に収容してなる眼科用組成物
JP7723851B1 (ja) 2024-11-22 2025-08-14 参天製薬株式会社 アトロピン含有水性医薬組成物

Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2015200361A1 (en) * 2014-06-24 2015-12-30 Sydnexis, Inc. Ophthalmic composition

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US5612027A (en) * 1995-04-18 1997-03-18 Galin; Miles A. Controlled release of miotic and mydriatic drugs in the anterior chamber
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US20030096831A1 (en) 2000-01-18 2003-05-22 Stone Richard A. Ocular growth and nicotinic antagonists
CN1509172A (zh) * 2001-05-25 2004-06-30 ά����ҩ��˾ 哌仑西平眼用凝胶剂
US20070254914A1 (en) * 2006-05-01 2007-11-01 Non-Profit Organization Chang Gung Memorial Hospital Low-concentration atropine solution for preventing myopia progression and preparing method thereof
JP2007308398A (ja) * 2006-05-17 2007-11-29 Chang Gung Memorial Hospital 目薬、及びその製造方法
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WO2012161655A1 (en) * 2011-05-23 2012-11-29 Singapore Health Services Pte Ltd Composition and/or method for reducing and/or preventing myopia progression comprising atropine
US20160009705A1 (en) * 2014-06-24 2016-01-14 Sydnexis, Inc. Ophthalmic composition
CN104983739B (zh) * 2015-06-25 2018-01-16 成都乾坤动物药业股份有限公司 一种多功能药物组合及其制备方法和应用
JP2017102939A (ja) * 2016-12-26 2017-06-08 株式会社プロフィールド オーサリング装置、オーサリング方法、およびプログラム
EP3970694A1 (en) * 2017-05-11 2022-03-23 Vyluma Inc. Atropine pharmaceutical compositions

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Also Published As

Publication number Publication date
KR102804061B1 (ko) 2025-05-07
JP2018021007A (ja) 2018-02-08
EA201892703A1 (ru) 2019-04-30
KR20230141882A (ko) 2023-10-10
JP2023058574A (ja) 2023-04-25
CA3023149C (en) 2024-07-02
EP3463360B1 (en) 2022-08-31
KR20220154842A (ko) 2022-11-22
CN117205209A (zh) 2023-12-12
TW201808289A (zh) 2018-03-16
JP2020007356A (ja) 2020-01-16
JP2025084921A (ja) 2025-06-03
JP2021120404A (ja) 2021-08-19
KR102580933B1 (ko) 2023-09-19
TW202206070A (zh) 2022-02-16
UA126195C2 (uk) 2022-08-31
KR20250067951A (ko) 2025-05-15
JP7224390B2 (ja) 2023-02-17
JP2025176149A (ja) 2025-12-03
EP3463360B2 (en) 2026-07-15
TWI791438B (zh) 2023-02-11
WO2017204262A1 (en) 2017-11-30
PH12018502421A1 (en) 2019-09-30
EP4112055A1 (en) 2023-01-04
JP6886502B2 (ja) 2021-06-16
SG11201809822SA (en) 2018-12-28
US20210267885A1 (en) 2021-09-02
MY189774A (en) 2022-03-04
CA3023149A1 (en) 2017-11-30
CN109310687B (zh) 2023-10-20
TW202325296A (zh) 2023-07-01
EP3463360A1 (en) 2019-04-10
CN117205210A (zh) 2023-12-12
AR108591A1 (es) 2018-09-05
ES2929368T3 (es) 2022-11-28
EP3463360A4 (en) 2020-01-29
US20260183235A1 (en) 2026-07-02
KR20190013877A (ko) 2019-02-11
US20240307305A1 (en) 2024-09-19
JP6590860B2 (ja) 2019-10-16
TWI874894B (zh) 2025-03-01
CN109310687A (zh) 2019-02-05

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