EA201892703A1 - Водная композиция, содержащая атропин - Google Patents

Водная композиция, содержащая атропин

Info

Publication number
EA201892703A1
EA201892703A1 EA201892703A EA201892703A EA201892703A1 EA 201892703 A1 EA201892703 A1 EA 201892703A1 EA 201892703 A EA201892703 A EA 201892703A EA 201892703 A EA201892703 A EA 201892703A EA 201892703 A1 EA201892703 A1 EA 201892703A1
Authority
EA
Eurasian Patent Office
Prior art keywords
buffer
atropin
composition containing
water composition
water
Prior art date
Application number
EA201892703A
Other languages
English (en)
Inventor
Дональд Тан
Роджер Бойерман
Хироюки Асада
Киохеи Такахаси
Кодзи Саканака
Такаси Моримото
Тоёми Фудзисава
Original Assignee
Сингапур Хелт Сервисиз Пте Лтд
Наньян Текнолоджикал Юниверсити
Сантен Фармасьютикал Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=60411416&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201892703(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Сингапур Хелт Сервисиз Пте Лтд, Наньян Текнолоджикал Юниверсити, Сантен Фармасьютикал Ко., Лтд. filed Critical Сингапур Хелт Сервисиз Пте Лтд
Publication of EA201892703A1 publication Critical patent/EA201892703A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/08—Mydriatics or cycloplegics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Ophthalmology & Optometry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Materials For Photolithography (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)

Abstract

В настоящем описании раскрыта водная композиция, содержащая 0,001-0,1% (м/об) атропина или его соли, водорастворимый полимер и буфер (I), которая характеризуется интервалом pH от 6 или ниже, в которой буфер (I) представляет собой по меньшей мере один буфер, выбранный из группы, состоящей из фосфатного буфера, аминокарбоксилатного буфера, карбонатного буфера, ацетатного буфера, тартратного буфера, боратного буфера и трометамола.
EA201892703A 2016-05-25 2017-05-24 Водная композиция, содержащая атропин EA201892703A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SG10201604200P 2016-05-25
PCT/JP2017/019423 WO2017204262A1 (en) 2016-05-25 2017-05-24 Atropine-containing aqueous composition

Publications (1)

Publication Number Publication Date
EA201892703A1 true EA201892703A1 (ru) 2019-04-30

Family

ID=60411416

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201892703A EA201892703A1 (ru) 2016-05-25 2017-05-24 Водная композиция, содержащая атропин

Country Status (15)

Country Link
US (1) US20210267885A1 (ru)
EP (2) EP4112055A1 (ru)
JP (4) JP6590860B2 (ru)
KR (3) KR102580933B1 (ru)
CN (3) CN109310687B (ru)
AR (1) AR108591A1 (ru)
CA (1) CA3023149A1 (ru)
EA (1) EA201892703A1 (ru)
ES (1) ES2929368T3 (ru)
MY (1) MY189774A (ru)
PH (1) PH12018502421A1 (ru)
SG (1) SG11201809822SA (ru)
TW (3) TWI791438B (ru)
UA (1) UA126195C2 (ru)
WO (1) WO2017204262A1 (ru)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9421199B2 (en) 2014-06-24 2016-08-23 Sydnexis, Inc. Ophthalmic composition
AU2018224426B2 (en) * 2017-02-21 2023-05-18 Singapore Health Services Pte Ltd Composition and method for preventing or delaying onset of myopia comprising atropine
RS62817B1 (sr) 2017-05-11 2022-02-28 Vyluma Inc Farmaceutske kompozicije atropina
CN110934816B (zh) 2018-09-25 2022-04-08 沈阳兴齐眼科医院有限公司 一种提高低浓度阿托品眼用制剂稳定性的方法
EP3701938B8 (en) 2019-03-01 2024-02-21 Medivis S.R.L. Ophthalmic formulations based on atropine
MX2023001457A (es) 2020-08-04 2023-04-26 Santen Pharmaceutical Co Ltd Agente para tratar la miopia, prevenir la miopia y/o suprimir la progresion de la miopia.
JP7062846B1 (ja) * 2020-10-14 2022-05-06 参天製薬株式会社 安定な医薬組成物
JP2023548605A (ja) 2020-11-02 2023-11-17 トレセラ コーポレーション デオキシシチジンキナーゼ阻害剤の結晶形態およびその使用
WO2022130337A1 (en) * 2020-12-17 2022-06-23 Sun Pharmaceutical Industries Limited An aqueous sterile solution of atropine for ophthalmic use
EP4088713A1 (en) 2021-05-10 2022-11-16 Warszawskie Zaklady Farmaceutyczne Polfa S.A. Ophthalmic pharmaceutical composition comprising atropine
EP4088714A1 (en) 2021-05-10 2022-11-16 Warszawskie Zaklady Farmaceutyczne Polfa S.A. Ophthalmic pharmaceutical composition comprising atropine
US20230120997A1 (en) * 2021-10-18 2023-04-20 Ocular Science, Inc. Compositions and methods for myopia control and orthokeratology lenses treatment
CN114129511A (zh) * 2021-12-07 2022-03-04 河南润弘制药股份有限公司 一种具有改进稳定性的硫酸阿托品注射液

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2617508B2 (ja) * 1988-02-05 1997-06-04 エーザイ株式会社 安定なジフェンヒドラミン含有水溶液
US20030096831A1 (en) 2000-01-18 2003-05-22 Stone Richard A. Ocular growth and nicotinic antagonists
NZ529615A (en) * 2001-05-25 2005-07-29 Valley Forge Pharmaceuticals Pirenzepine ophthalmic gel
US20070254914A1 (en) * 2006-05-01 2007-11-01 Non-Profit Organization Chang Gung Memorial Hospital Low-concentration atropine solution for preventing myopia progression and preparing method thereof
JP2007308398A (ja) * 2006-05-17 2007-11-29 Chang Gung Memorial Hospital 目薬、及びその製造方法
EP2152255A1 (en) * 2007-05-21 2010-02-17 Neuroptix Corporation Ophthalmic formulations of amyloid- contrast agents and methods of use thereof
WO2012161655A1 (en) 2011-05-23 2012-11-29 Singapore Health Services Pte Ltd Composition and/or method for reducing and/or preventing myopia progression comprising atropine
US9421199B2 (en) * 2014-06-24 2016-08-23 Sydnexis, Inc. Ophthalmic composition
US20160009705A1 (en) 2014-06-24 2016-01-14 Sydnexis, Inc. Ophthalmic composition
JP2017102939A (ja) * 2016-12-26 2017-06-08 株式会社プロフィールド オーサリング装置、オーサリング方法、およびプログラム
RS62817B1 (sr) * 2017-05-11 2022-02-28 Vyluma Inc Farmaceutske kompozicije atropina

Also Published As

Publication number Publication date
TW201808289A (zh) 2018-03-16
CN117205210A (zh) 2023-12-12
CN109310687B (zh) 2023-10-20
JP2018021007A (ja) 2018-02-08
KR102580933B1 (ko) 2023-09-19
KR20230141882A (ko) 2023-10-10
JP2021120404A (ja) 2021-08-19
TW202325296A (zh) 2023-07-01
ES2929368T3 (es) 2022-11-28
WO2017204262A1 (en) 2017-11-30
KR20220154842A (ko) 2022-11-22
JP2020007356A (ja) 2020-01-16
JP6886502B2 (ja) 2021-06-16
EP3463360A4 (en) 2020-01-29
TW202206070A (zh) 2022-02-16
CN109310687A (zh) 2019-02-05
US20210267885A1 (en) 2021-09-02
JP2023058574A (ja) 2023-04-25
CN117205209A (zh) 2023-12-12
KR20190013877A (ko) 2019-02-11
JP7224390B2 (ja) 2023-02-17
TWI791438B (zh) 2023-02-11
EP3463360B1 (en) 2022-08-31
PH12018502421A1 (en) 2019-09-30
UA126195C2 (uk) 2022-08-31
CA3023149A1 (en) 2017-11-30
EP4112055A1 (en) 2023-01-04
AR108591A1 (es) 2018-09-05
MY189774A (en) 2022-03-04
EP3463360A1 (en) 2019-04-10
JP6590860B2 (ja) 2019-10-16
SG11201809822SA (en) 2018-12-28

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