EA201892703A1 - Водная композиция, содержащая атропин - Google Patents
Водная композиция, содержащая атропинInfo
- Publication number
- EA201892703A1 EA201892703A1 EA201892703A EA201892703A EA201892703A1 EA 201892703 A1 EA201892703 A1 EA 201892703A1 EA 201892703 A EA201892703 A EA 201892703A EA 201892703 A EA201892703 A EA 201892703A EA 201892703 A1 EA201892703 A1 EA 201892703A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- buffer
- atropin
- composition containing
- water composition
- water
- Prior art date
Links
- RKUNBYITZUJHSG-UHFFFAOYSA-N Hyosciamin-hydrochlorid Natural products CN1C(C2)CCC1CC2OC(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-UHFFFAOYSA-N 0.000 title abstract 2
- RKUNBYITZUJHSG-SPUOUPEWSA-N atropine Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)N2C)C(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-SPUOUPEWSA-N 0.000 title abstract 2
- 229960000396 atropine Drugs 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title 1
- 239000000872 buffer Substances 0.000 abstract 7
- 229930003347 Atropine Natural products 0.000 abstract 1
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 abstract 1
- KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical compound NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 abstract 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 abstract 1
- 239000008351 acetate buffer Substances 0.000 abstract 1
- 239000008363 phosphate buffer Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940095064 tartrate Drugs 0.000 abstract 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 abstract 1
- 229960000281 trometamol Drugs 0.000 abstract 1
- 229920003169 water-soluble polymer Polymers 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/08—Mydriatics or cycloplegics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Ophthalmology & Optometry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Emergency Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Photolithography (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SG10201604200P | 2016-05-25 | ||
| PCT/JP2017/019423 WO2017204262A1 (en) | 2016-05-25 | 2017-05-24 | Atropine-containing aqueous composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201892703A1 true EA201892703A1 (ru) | 2019-04-30 |
Family
ID=60411416
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201892703A EA201892703A1 (ru) | 2016-05-25 | 2017-05-24 | Водная композиция, содержащая атропин |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US20210267885A1 (enExample) |
| EP (2) | EP3463360B1 (enExample) |
| JP (6) | JP6590860B2 (enExample) |
| KR (4) | KR102580933B1 (enExample) |
| CN (3) | CN117205210A (enExample) |
| AR (1) | AR108591A1 (enExample) |
| CA (1) | CA3023149C (enExample) |
| EA (1) | EA201892703A1 (enExample) |
| ES (1) | ES2929368T3 (enExample) |
| MY (1) | MY189774A (enExample) |
| PH (1) | PH12018502421A1 (enExample) |
| SG (1) | SG11201809822SA (enExample) |
| TW (3) | TWI791438B (enExample) |
| UA (1) | UA126195C2 (enExample) |
| WO (1) | WO2017204262A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016172712A2 (en) * | 2015-04-23 | 2016-10-27 | Sydnexis, Inc. | Ophthalmic composition |
| US9421199B2 (en) | 2014-06-24 | 2016-08-23 | Sydnexis, Inc. | Ophthalmic composition |
| EP3302426A4 (en) | 2015-05-29 | 2018-12-05 | Sydnexis, Inc. | D2o stabilized pharmaceutical formulations |
| KR20200007769A (ko) | 2017-02-21 | 2020-01-22 | 싱가포르 헬스 서비시즈 피티이 엘티디 | 아트로핀을 포함하는 근시의 발병을 방지 또는 지연하기 위한 조성물 및 방법 |
| US10251875B2 (en) | 2017-05-11 | 2019-04-09 | Nevakar Inc. | Atropine pharmaceutical compositions |
| CN110934816B (zh) * | 2018-09-25 | 2022-04-08 | 沈阳兴齐眼科医院有限公司 | 一种提高低浓度阿托品眼用制剂稳定性的方法 |
| CN110934869B (zh) * | 2018-09-25 | 2023-07-04 | 沈阳兴齐眼药股份有限公司 | 一种阿托品药物组合物和药盒产品 |
| EP3701938B8 (en) | 2019-03-01 | 2024-02-21 | Medivis S.R.L. | Ophthalmic formulations based on atropine |
| TWI907473B (zh) * | 2020-08-04 | 2025-12-11 | 日商參天製藥股份有限公司 | 治療近視、預防近視及/或抑制近視進展之藥劑 |
| AU2021362374A1 (en) * | 2020-10-14 | 2023-05-25 | Santen Pharmaceutical Co., Ltd. | Stable pharmaceutical composition |
| EP4237421A4 (en) | 2020-11-02 | 2024-11-06 | Trethera Corporation | CRYSTALLINE FORMS OF A DEOXYCYTIDINE KINASE INHIBITOR AND THEIR USES |
| WO2022130337A1 (en) * | 2020-12-17 | 2022-06-23 | Sun Pharmaceutical Industries Limited | An aqueous sterile solution of atropine for ophthalmic use |
| EP4088714A1 (en) | 2021-05-10 | 2022-11-16 | Warszawskie Zaklady Farmaceutyczne Polfa S.A. | Ophthalmic pharmaceutical composition comprising atropine |
| EP4088713A1 (en) | 2021-05-10 | 2022-11-16 | Warszawskie Zaklady Farmaceutyczne Polfa S.A. | Ophthalmic pharmaceutical composition comprising atropine |
| US20230120997A1 (en) * | 2021-10-18 | 2023-04-20 | Ocular Science, Inc. | Compositions and methods for myopia control and orthokeratology lenses treatment |
| CN114129511A (zh) * | 2021-12-07 | 2022-03-04 | 河南润弘制药股份有限公司 | 一种具有改进稳定性的硫酸阿托品注射液 |
| CN119110721A (zh) * | 2022-09-11 | 2024-12-10 | 爱尔康公司 | 包含苄基阿托品的水性药物组合物及其用途 |
| JP7665073B1 (ja) | 2024-04-05 | 2025-04-18 | ロート製薬株式会社 | 容器に収容してなる眼科用組成物 |
| JP7723851B1 (ja) * | 2024-11-22 | 2025-08-14 | 参天製薬株式会社 | アトロピン含有水性医薬組成物 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2617508B2 (ja) * | 1988-02-05 | 1997-06-04 | エーザイ株式会社 | 安定なジフェンヒドラミン含有水溶液 |
| US5612027A (en) * | 1995-04-18 | 1997-03-18 | Galin; Miles A. | Controlled release of miotic and mydriatic drugs in the anterior chamber |
| JP3166002B2 (ja) * | 1997-01-27 | 2001-05-14 | 日本車輌製造株式会社 | 自動車の洗浄装置 |
| US20030096831A1 (en) | 2000-01-18 | 2003-05-22 | Stone Richard A. | Ocular growth and nicotinic antagonists |
| BR0210013A (pt) * | 2001-05-25 | 2004-08-10 | Valley Forge Pharmaceuticals | Gel oftálmico de pirenzepina |
| US20070254914A1 (en) * | 2006-05-01 | 2007-11-01 | Non-Profit Organization Chang Gung Memorial Hospital | Low-concentration atropine solution for preventing myopia progression and preparing method thereof |
| JP2007308398A (ja) * | 2006-05-17 | 2007-11-29 | Chang Gung Memorial Hospital | 目薬、及びその製造方法 |
| CA2688811A1 (en) * | 2007-05-21 | 2008-11-27 | Neuroptix Corporation | Ophthalmic formulations of amyloid-beta contrast agents and methods of use thereof |
| CN101327216A (zh) * | 2007-06-22 | 2008-12-24 | 肖正连 | 一种硫酸阿托品眼用即型凝胶 |
| WO2012161655A1 (en) * | 2011-05-23 | 2012-11-29 | Singapore Health Services Pte Ltd | Composition and/or method for reducing and/or preventing myopia progression comprising atropine |
| US9421199B2 (en) * | 2014-06-24 | 2016-08-23 | Sydnexis, Inc. | Ophthalmic composition |
| US20160009705A1 (en) | 2014-06-24 | 2016-01-14 | Sydnexis, Inc. | Ophthalmic composition |
| CN104983739B (zh) * | 2015-06-25 | 2018-01-16 | 成都乾坤动物药业股份有限公司 | 一种多功能药物组合及其制备方法和应用 |
| JP2017102939A (ja) * | 2016-12-26 | 2017-06-08 | 株式会社プロフィールド | オーサリング装置、オーサリング方法、およびプログラム |
| US10251875B2 (en) * | 2017-05-11 | 2019-04-09 | Nevakar Inc. | Atropine pharmaceutical compositions |
-
2017
- 2017-05-24 KR KR1020227039104A patent/KR102580933B1/ko active Active
- 2017-05-24 CA CA3023149A patent/CA3023149C/en active Active
- 2017-05-24 EP EP17802848.6A patent/EP3463360B1/en active Active
- 2017-05-24 UA UAA201812662A patent/UA126195C2/uk unknown
- 2017-05-24 CN CN202311240197.1A patent/CN117205210A/zh active Pending
- 2017-05-24 ES ES17802848T patent/ES2929368T3/es active Active
- 2017-05-24 CN CN201780031738.6A patent/CN109310687B/zh active Active
- 2017-05-24 AR ARP170101418A patent/AR108591A1/es not_active Application Discontinuation
- 2017-05-24 JP JP2017102939A patent/JP6590860B2/ja active Active
- 2017-05-24 US US16/303,686 patent/US20210267885A1/en not_active Abandoned
- 2017-05-24 KR KR1020187037233A patent/KR20190013877A/ko not_active Ceased
- 2017-05-24 EA EA201892703A patent/EA201892703A1/ru unknown
- 2017-05-24 SG SG11201809822SA patent/SG11201809822SA/en unknown
- 2017-05-24 KR KR1020257014231A patent/KR20250067951A/ko active Pending
- 2017-05-24 TW TW106117194A patent/TWI791438B/zh active
- 2017-05-24 KR KR1020237031744A patent/KR102804061B1/ko active Active
- 2017-05-24 CN CN202311238651.XA patent/CN117205209A/zh active Pending
- 2017-05-24 MY MYPI2018001914A patent/MY189774A/en unknown
- 2017-05-24 TW TW110141612A patent/TWI849355B/zh active
- 2017-05-24 WO PCT/JP2017/019423 patent/WO2017204262A1/en not_active Ceased
- 2017-05-24 TW TW112102321A patent/TWI874894B/zh active
- 2017-05-24 EP EP22189717.6A patent/EP4112055A1/en active Pending
-
2018
- 2018-11-16 PH PH12018502421A patent/PH12018502421A1/en unknown
-
2019
- 2019-09-17 JP JP2019168569A patent/JP6886502B2/ja active Active
-
2021
- 2021-05-14 JP JP2021082578A patent/JP7224390B2/ja active Active
-
2023
- 2023-02-07 JP JP2023016850A patent/JP2023058574A/ja not_active Withdrawn
-
2024
- 2024-05-28 US US18/676,396 patent/US20240307305A1/en not_active Abandoned
-
2025
- 2025-03-03 JP JP2025032538A patent/JP2025084921A/ja active Pending
- 2025-09-16 JP JP2025153045A patent/JP2025176149A/ja active Pending
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