TWI847980B - 厄瑞努單抗組成物及其用途 - Google Patents

厄瑞努單抗組成物及其用途 Download PDF

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Publication number
TWI847980B
TWI847980B TW108111646A TW108111646A TWI847980B TW I847980 B TWI847980 B TW I847980B TW 108111646 A TW108111646 A TW 108111646A TW 108111646 A TW108111646 A TW 108111646A TW I847980 B TWI847980 B TW I847980B
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Taiwan
Prior art keywords
composition
variants
errenumumab
hplc
amount
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TW108111646A
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English (en)
Chinese (zh)
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TW202003572A (zh
Inventor
凱尼斯 羅森
諾耶 萊德
蘇明達 哈普阿瑞奇
約瑟 桂格里歐 瑞米瑞茲
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美商安進公司
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/461—Flow patterns using more than one column with serial coupling of separation columns
    • G01N30/463—Flow patterns using more than one column with serial coupling of separation columns for multidimensional chromatography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027—Liquid chromatography

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
TW108111646A 2018-04-02 2019-04-02 厄瑞努單抗組成物及其用途 TWI847980B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862651651P 2018-04-02 2018-04-02
US62/651,651 2018-04-02

Publications (2)

Publication Number Publication Date
TW202003572A TW202003572A (zh) 2020-01-16
TWI847980B true TWI847980B (zh) 2024-07-11

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
TW108111646A TWI847980B (zh) 2018-04-02 2019-04-02 厄瑞努單抗組成物及其用途

Country Status (19)

Country Link
US (2) US11407838B2 (enExample)
EP (1) EP3774881A1 (enExample)
JP (3) JP7840636B2 (enExample)
KR (1) KR20200139720A (enExample)
CN (1) CN111954678A (enExample)
AR (1) AR114722A1 (enExample)
AU (1) AU2019246983B2 (enExample)
BR (1) BR112020019882A2 (enExample)
CA (1) CA3095899A1 (enExample)
CL (2) CL2020002519A1 (enExample)
EA (1) EA202092335A1 (enExample)
IL (1) IL277663A (enExample)
MA (1) MA52202A (enExample)
MX (1) MX2020010320A (enExample)
PH (1) PH12020551618A1 (enExample)
SA (1) SA520420261B1 (enExample)
SG (1) SG11202009629YA (enExample)
TW (1) TWI847980B (enExample)
WO (1) WO2019195185A1 (enExample)

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JO3382B1 (ar) * 2008-12-23 2019-03-13 Amgen Inc أجسام مضادة ترتبط مع مستقبل cgrp بشري
WO2022232376A1 (en) * 2021-04-29 2022-11-03 Amgen Inc. Methods for reducing low molecular weight species of recombinantly-produced proteins
EP4455163A4 (en) * 2021-12-22 2025-12-24 Chugai Pharmaceutical Co Ltd REDUCED BIOLOGICALLY ACTIVE ANTIBODY VARIANT
CN115819589A (zh) * 2022-10-19 2023-03-21 武汉人福创新药物研发中心有限公司 一种培养基及生产抗cgrpr抗体的方法

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Also Published As

Publication number Publication date
EP3774881A1 (en) 2021-02-17
US11407838B2 (en) 2022-08-09
BR112020019882A2 (pt) 2021-01-05
TW202003572A (zh) 2020-01-16
WO2019195185A1 (en) 2019-10-10
AU2019246983B2 (en) 2025-12-18
PH12020551618A1 (en) 2021-08-16
US20220348673A1 (en) 2022-11-03
AR114722A1 (es) 2020-10-07
US20190300617A1 (en) 2019-10-03
SA520420261B1 (ar) 2024-05-23
MA52202A (fr) 2021-02-17
JP2023103323A (ja) 2023-07-26
JP2026034591A (ja) 2026-02-27
CA3095899A1 (en) 2019-10-10
KR20200139720A (ko) 2020-12-14
AU2019246983A1 (en) 2020-10-29
CL2023000491A1 (es) 2023-10-13
JP2021519790A (ja) 2021-08-12
SG11202009629YA (en) 2020-10-29
JP7840636B2 (ja) 2026-04-06
MX2020010320A (es) 2021-01-08
EA202092335A1 (ru) 2021-01-22
CN111954678A (zh) 2020-11-17
IL277663A (en) 2020-11-30
CL2020002519A1 (es) 2021-04-05

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