TWI828817B - 用於治療或預防痛風或高尿酸血症之化合物晶型 - Google Patents

Info

Publication number

TWI828817B

TWI828817B TW108144814A TW108144814A TWI828817B TW I828817 B TWI828817 B TW I828817B TW 108144814 A TW108144814 A TW 108144814A TW 108144814 A TW108144814 A TW 108144814A TW I828817 B TWI828817 B TW I828817B

Authority

TW

Taiwan

Prior art keywords

crystal form

compound

crystalline

dibromo

benzofuran

Prior art date

2018-12-06

Links

• Espacenet
• Global Dossier
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• 201000005569 Gout Diseases 0.000 title claims description 27
• 201000001431 Hyperuricemia Diseases 0.000 title claims description 27
• 150000001875 compounds Chemical class 0.000 title description 75
• ZYHWDBVIUWBPCO-QFFDRWTDSA-N BrC1=C(C(=CC(=C1)C(=O)C1=C(OC2=C1C(=C(C(=C2[2H])[2H])[2H])[2H])C(C)O)Br)O Chemical compound BrC1=C(C(=CC(=C1)C(=O)C1=C(OC2=C1C(=C(C(=C2[2H])[2H])[2H])[2H])C(C)O)Br)O ZYHWDBVIUWBPCO-QFFDRWTDSA-N 0.000 claims abstract description 51
• 239000012453 solvate Substances 0.000 claims abstract description 51
• 238000000634 powder X-ray diffraction Methods 0.000 claims description 90
• YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 75
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• 229940123769 Xanthine oxidase inhibitor Drugs 0.000 claims description 27
• 229940124597 therapeutic agent Drugs 0.000 claims description 20
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• OBWASQILIWPZMG-QZMOQZSNSA-N empagliflozin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1C1=CC=C(Cl)C(CC=2C=CC(O[C@@H]3COCC3)=CC=2)=C1 OBWASQILIWPZMG-QZMOQZSNSA-N 0.000 claims description 8
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• 239000000463 material Substances 0.000 description 18
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• 239000000243 solution Substances 0.000 description 17
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